resveratrol has been researched along with metformin in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (4.17) | 29.6817 |
| 2010's | 47 (65.28) | 24.3611 |
| 2020's | 22 (30.56) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, S; Han, J; Li, Z; Liu, T; Wang, M; Wu, M | 1 |
| Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S | 1 |
| Spinney, L | 1 |
| Blagosklonny, MV | 2 |
| Allison, DB; Nagy, TR; Smith, DL | 1 |
| Kim, BJ; Kim, GH; Kim, GS; Kim, SW; Kim, YS; Koh, JM; Lee, KU; Lee, SH; Lee, SY; Lee, YS | 1 |
| Cha, HJ; Choi, JS; Kim, JJ; Kim, WS; Lee, JS; Lee, SJ; Min, HG; Park, KY | 1 |
| Ebersole, J; González, O; Novak, MJ; Tobia, C | 1 |
| Carling, D; Gamblin, SJ; Hardie, DG | 1 |
| Boghossian, S; Hawash, A | 1 |
| Platanias, LC; Vakana, E | 1 |
| Bagul, PK; Banerjee, SK; Bastia, T; Chakravarty, S; Madhusudana, K; Matapally, S; Middela, H; Padiya, R; Reddy, BR | 1 |
| Darzynkiewicz, Z; Halicka, HD; Hsieh, TC; Lee, YS; Li, J; Wu, JM; Zhao, H | 1 |
| Hofer, A; Kladt, N; Lellek, V; Noe, N; Schauß, A; Tischner, C; Wenz, T | 1 |
| Selman, C | 1 |
| Valero, T | 1 |
| Burkewitz, K; Mair, WB; Zhang, Y | 1 |
| Huang, F; Kou, J; Li, J; Liu, B; Liu, K; Qi, L; Sun, Y; Wang, M; Xiao, N | 1 |
| Finley, J | 1 |
| Bauer, PV; Duca, FA; Hamr, SC; Lam, TK | 1 |
| Gao, H; Guo, Q; Teng, S; Wu, Y; Xu, R; Zhang, E | 1 |
| Beauloye, C; Bertrand, L; Daskalopoulos, EP; Dufeys, C; Horman, S | 1 |
| Huang, F; Kou, J; Li, A; Li, J; Li, X; Liu, B; Liu, K; Qi, LW; Qiu, Z; Wang, L | 1 |
| Doonan, BB; Hsieh, TC; Lee, YS; Wu, JM | 1 |
| Huffman, DM; LeBrasseur, NK; Schafer, MJ | 1 |
| Huang, F; Li, A; Li, J; Liu, B; Liu, K; Zhang, S | 1 |
| Feng, X; Hou, T; Li, A; Liu, B; Liu, K; Zhang, N; Zhao, W | 1 |
| Frendo-Cumbo, S; MacPherson, RE; Wright, DC | 1 |
| Bagul, PK; Banerjee, SK; Chakravarty, S; Jhelum, P; Kaur, G; Kumar, A; Kumar, KP; Maitra, S; Reddy, BR | 1 |
| Kang, L; Li, J; Li, Y; Liu, J; Liu, Y; Qi, Z; Shen, Y; Wang, X; Yang, L; Yang, Y; Zhang, Q; Zhu, M; Zu, L | 1 |
| Bozza, MT; Carneiro, VC; Feijó, DF; Giarola, NL; Lannes-Vieira, J; Mata-Santos, H; Medei, E; Meyer-Fernandes, JR; Paiva, CN; Paula-Neto, HA; Ramos, IP; Vicentino, AR; Vilar-Pereira, G | 1 |
| de Ligt, M; Hansen, J; Hesselink, MK; Kunz, I; Moonen-Kornips, E; Phielix, E; Schaart, G; Schrauwen, P; Schrauwen-Hinderling, VB; Timmers, S; van de Weijer, T | 1 |
| Asiedu, MN; Dib-Hajj, SD; Dussor, G; Han, C; Price, TJ; Waxman, SG | 1 |
| Cai, GY; Chen, XM; Cui, SY; Dong, D; Fu, B; Guo, YN; Hong, Q; Lv, Y; Ning, YC; Wang, JC | 1 |
| deCabo, R; Maxwell, N; Shapiro, D; Stockinger, J; Valdez, G | 1 |
| Barger, JL; Cray, NL; Hester, SN; Mastaloudis, A; Newton, MA; Prolla, TA; Pugh, TD; Vann, JM; Weindruch, R; Wood, SM | 1 |
| Chen, J; Fei, DD; Hu, CH; Huang, WT; Jin, Y; Liu, N; Lu, YB; Lv, YJ; Pang, DL; Sui, BD; Xuan, K; Zhao, P; Zheng, CX; Zhou, CH | 1 |
| Asiedu, MN; Burton, MD; Dussor, G; Hughes, T; Inyang, K; Lian, B; Mazhar, K; Mejia, GL; Price, TJ; Tillu, DV | 1 |
| Byun, S; Lee, E; Lee, KW | 1 |
| Klimova, B; Kuca, K; Novotny, M | 1 |
| Akash, MSH; Munawar, SM; Rehman, K; Saeed, K | 1 |
| Ceylan, S; Eraldemır, C; Furat Rencber, S; Guzel, E; Kum, T; Kurnaz Ozbek, S; Sezer, Z | 1 |
| Asadollah, AS; Effat, F; Keihan, GS; Mehdi, F | 1 |
| Cai, GY; Chen, XM; Wang, SY | 1 |
| Gonzalez, S; Hillson, O; Rallis, C | 1 |
| Bernier, M; de Cabo, R; Di Germanio, C; Moats, JM; Palliyaguru, DL | 1 |
| Dulak, J; Florczyk-Soluch, U; Frołow, M; Józkowicz, A; Kachamakova-Trojanowska, N; Klóska, D; Markiewicz, J; Niżankowski, R; Nowak, WN; Stępniewski, J; Taha, H; Walter, Z | 1 |
| Bedi, B; Goldberg, JB; Hart, CM; Koval, M; Maurice, NM; Sadikot, RT; Yuan, Z | 1 |
| Frendo-Cumbo, S; MacPherson, REK; Yang, AJT | 1 |
| Banaszewska, B; Pawelczyk, L; Spaczynski, R | 1 |
| Amini, P; Farhood, B; Motevaseli, E; Musa, AE; Najafi, M; Pooladvand, V; Saffar, H; Shabeeb, D; Yahyapour, R | 1 |
| Timm, KN; Tyler, DJ | 1 |
| Dludla, PV; Gabuza, KB; Johnson, R; Louw, J; Mazibuko-Mbeje, SE; Mokgalaboni, K; Muller, CJF; Mxinwa, V; Nkambule, BB; Nyambuya, TM; Orlando, P; Silvestri, S; Tiano, L | 1 |
| Bagul, PK; Banerjee, SK; Rai, RC | 1 |
| Choi, YJ | 1 |
| Hong, SW; Kim, MJ; Kwon, H; Lee, J; Lee, WY; Park, SE; Rhee, EJ | 1 |
| Benedetti, F; Buriani, A; Fortinguerra, S; Scapagnini, G; Sorrenti, V; Zella, D | 1 |
| Cipolli, W; Jimenez, AG; Lalwani, S | 1 |
| Chai, HC; Chua, KH; Lim, SK; Mahendran, R; Ong, KC | 1 |
| Hou, X; Ma, H; Shu, L; Song, G; Wang, C | 1 |
| Brandon, AE; Cogger, VC; Cooney, GJ; Gokarn, R; Hunt, NJ; James, DE; Le Couteur, DG; Parker, BL; Pulpitel, T; Raubenheimer, D; Senior, AM; Simpson, SJ; Solon-Biet, SM; Wali, JA | 1 |
| Howlett, LA; Jones, SA; Lancaster, MK | 1 |
| Cao, Y; Cheng, T; Gao, X; Li, W; Liu, B; Lü, J; Lu, Q; Pan, X; Wang, C; Yu, W | 1 |
| Islam, MK; Lian, HK; Lim, JCW; Sagineedu, SR; Selvarajoo, N; Stanslas, J | 1 |
| Chan, KLA; Poonprasartporn, A | 1 |
| Chen, YY; Cheng, PW; Ho, CY; Sun, GC; Tseng, CJ; Wu, TT; Yeh, TC | 1 |
| Lalo, U; Nezis, IP; Pankratov, Y | 1 |
| Ehtesham, E; Habib, SH; Hassan, S; Malik, MO; Rauf, B; Shah, M | 1 |
| Chen, M; Duan, P; Gao, H; Gong, Y; Li, J; Lu, A; Xie, J; Xu, H | 1 |
| Akbarizadeh, AR; Fatehi, R; Firouzabadi, N; Rashedinia, M; Zamani, M | 1 |
| Abbas, SM; Al-Sayaghi, KM; Albadrani, MS; Ali Fadlalmola, H; El-Amin, EI; Elhusein, AM; Ibrahim, SE; Mamanao, DM; Swamy, DV | 1 |
26 review(s) available for resveratrol and metformin
| Article | Year |
|---|---|
An anti-aging drug today: from senescence-promoting genes to anti-aging pill.
Topics: Aging; Animals; Antioxidants; Caloric Restriction; Cell Cycle Proteins; Cellular Senescence; Drug Delivery Systems; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Longevity; Metformin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Resveratrol; Saccharomyces cerevisiae Proteins; Sirolimus; Sirtuins; Stilbenes | 2007 |
Validation of anti-aging drugs by treating age-related diseases.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Antioxidants; Biomarkers; Chronic Disease; Humans; Hypoglycemic Agents; Metformin; Resveratrol; Sirolimus; Stilbenes; Validation Studies as Topic | 2009 |
Calorie restriction: what recent results suggest for the future of ageing research.
Topics: Animals; Antimetabolites; Biomedical Research; Biomimetics; Caloric Restriction; Deoxyglucose; Enzyme Inhibitors; Hypoglycemic Agents; Longevity; Metformin; Primates; Quality of Life; Resveratrol; Sirolimus; Stilbenes | 2010 |
Caloric restriction and chronic inflammatory diseases.
Topics: Adaptive Immunity; Animals; Biomimetics; Caloric Restriction; Cardiovascular Diseases; Chronic Disease; Diabetes Mellitus; Humans; Immunity, Innate; Inflammation; Inflammation Mediators; Insulin-Like Growth Factor I; Metformin; Periodontitis; Resveratrol; Signal Transduction; Sirolimus; Sirtuins; Stilbenes; TOR Serine-Threonine Kinases | 2012 |
AMP-activated protein kinase: also regulated by ADP?
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Binding Sites; Electron Transport; Energy Metabolism; Enzyme Activation; Fungal Proteins; Glucose; Glycogen; Humans; Metformin; Mitochondria; Phosphorylation; Protein Conformation; Resveratrol; Stilbenes; Transcription, Genetic; Yeasts | 2011 |
Chemoprevention in colorectal cancer--where we stand and what we have learned from twenty year's experience.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Anticarcinogenic Agents; Colorectal Neoplasms; Histone Deacetylase Inhibitors; Humans; Metformin; Precancerous Conditions; Resveratrol; Selective Estrogen Receptor Modulators; Stilbenes | 2012 |
AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.
Topics: AMP-Activated Protein Kinase Kinases; Genes, abl; Hematologic Neoplasms; Humans; Leukemia; Metformin; Phosphatidylinositol 3-Kinase; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Stilbenes; TOR Serine-Threonine Kinases | 2011 |
Dietary restriction and the pursuit of effective mimetics.
Topics: Animals; Caloric Restriction; Energy Intake; Genetic Variation; Health; Humans; Longevity; Metformin; Resveratrol; Sirolimus; Stilbenes | 2014 |
AMPK at the nexus of energetics and aging.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Aspirin; Energy Metabolism; Humans; Metabolic Diseases; Metformin; Mitochondria; Neoplasms; Resveratrol; Stilbenes | 2014 |
AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation.
Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Berberine; Cardiomegaly; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Humans; Metformin; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Resveratrol; Ribonucleotides; Signal Transduction; Stilbenes; Thiazolidinediones; Wound Healing | 2016 |
Energetic interventions for healthspan and resiliency with aging.
Topics: Aging; Caloric Restriction; Diet; Energy Intake; Exercise; Female; Humans; Longevity; Male; Metformin; Resveratrol; Sirolimus; Stilbenes | 2016 |
Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer.
Topics: Adaptive Immunity; Animals; Autoimmune Diseases; Autophagy; Benzylisoquinolines; Cholecalciferol; Humans; Immune System Diseases; Immunity, Innate; Indoles; Infections; Isoquinolines; Lysosomes; Maprotiline; Metformin; Neoplasms; Phenols; Pyrroles; Resveratrol; Sirolimus; Spermidine; Stilbenes; Tetrahydroisoquinolines; Trehalose | 2017 |
Anti-Aging Drugs - Prospect of Longer Life?
Topics: Animals; Humans; Longevity; Metformin; NAD; Quality of Life; Resveratrol; Sirolimus; Stilbenes | 2018 |
Energy restriction in renal protection.
Topics: Aging; Animals; Autophagy; Caloric Restriction; Diet; Energy Metabolism; Female; Humans; Inflammation; Insulin; Kidney; Kidney Diseases; Male; Metformin; Models, Animal; Oxidative Stress; Phosphorus; Resveratrol; Salts; Sirolimus; Sirtuin 1 | 2018 |
Prospects of Pharmacological Interventions to Organismal Aging.
Topics: Aging; Animals; Aspirin; Growth Hormone; Humans; Metformin; Resveratrol; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions.
Topics: Animals; Caloric Restriction; Frailty; Humans; Longevity; Metformin; Resveratrol; Sirolimus | 2019 |
Current and future aspects of several adjunctive treatment strategies in polycystic ovary syndrome.
Topics: Antioxidants; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Inositol; Melatonin; Metformin; Polycystic Ovary Syndrome; Resveratrol; Vitamin B Complex | 2019 |
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Caloric Restriction; Cardiotoxicity; Doxorubicin; Enzyme Activation; Enzyme Activators; Exercise; Heart Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Mitochondria, Heart; Myocytes, Cardiac; Resveratrol; Ribonucleotides; Signal Transduction; Thiazolidinediones | 2020 |
Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-associated Complications: A Systematic Review of Preclinical Studies.
Topics: Animals; Antioxidants; Diabetes Complications; Dietary Supplements; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin; Resveratrol; Treatment Outcome | 2020 |
Shedding Light on the Effects of Calorie Restriction and its Mimetics on Skin Biology.
Topics: Animals; Caloric Restriction; Dermatologic Agents; Fasting; Humans; Inflammation; Metformin; Peroxisome Proliferator-Activated Receptors; Resveratrol; Sirolimus; Skin; Skin Aging; Wound Healing | 2020 |
Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways.
Topics: Animals; Antiviral Agents; Host-Pathogen Interactions; Humans; Metformin; Resveratrol; Signal Transduction; Sirolimus; Virus Diseases; Virus Replication | 2020 |
Natural-derived compounds and their mechanisms in potential autosomal dominant polycystic kidney disease (ADPKD) treatment.
Topics: Antioxidants; Chalcones; Curcumin; Diterpenes; Diterpenes, Kaurane; Emodin; Epoxy Compounds; Estrogen Antagonists; Flavanones; Humans; Hypoglycemic Agents; Metformin; Phenanthrenes; Plant Extracts; Polycystic Kidney, Autosomal Dominant; Protein Kinase Inhibitors; Quercetin; Resveratrol | 2021 |
Pharmacy and Exercise as Complimentary Partners for Successful Cardiovascular Ageing.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Diseases; Cardiovascular System; Exercise; Humans; Metformin; Peptidyl-Dipeptidase A; Pharmacy; Quality of Life; Receptors, Adrenergic; Resveratrol | 2022 |
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Fluorouracil; Humans; Metformin; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review.
Topics: Bibliometrics; Cataract; Curcumin; Humans; Lanosterol; Metformin; Oxysterols; Resveratrol | 2022 |
Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.
Topics: Female; Humans; Metformin; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Resveratrol; Testosterone | 2023 |
2 trial(s) available for resveratrol and metformin
| Article | Year |
|---|---|
Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial.
Topics: Adult; Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Metformin; Middle Aged; Resveratrol; Stilbenes | 2016 |
Treatment with combined resveratrol and myoinositol ameliorates endocrine, metabolic alterations and perceived stress response in women with PCOS: a double-blind randomized clinical trial.
Topics: Adiponectin; Adult; Female; Follicle Stimulating Hormone; Humans; Inositol; Insulin; Luteinizing Hormone; Metformin; Obesity; Pioglitazone; Polycystic Ovary Syndrome; Resveratrol; Stress, Psychological; Testosterone; Young Adult | 2023 |
44 other study(ies) available for resveratrol and metformin
| Article | Year |
|---|---|
Design and synthesis of 3-(4-pyridyl)-5-(4-sulfamido-phenyl)-1,2,4-oxadiazole derivatives as novel GSK-3β inhibitors and evaluation of their potential as multifunctional anti-Alzheimer agents.
Topics: Alzheimer Disease; Animals; Cognition; Drug Design; Enzyme Inhibitors; Glucose; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Oxadiazoles; Reactive Oxygen Species | 2021 |
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2022 |
Gerontology: eat your cake and have it.
Topics: Aging; Animals; Caloric Restriction; Cellular Senescence; Drug Evaluation, Preclinical; Drug Industry; Energy Intake; Energy Metabolism; Geriatrics; Ghrelin; Humans; Insulin; Longevity; Metformin; Peptide Hormones; Randomized Controlled Trials as Topic; Reproduction; Resveratrol; Sirtuins; Stilbenes; Time Factors | 2006 |
AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts.
Topics: Adenylate Kinase; Animals; Apoptosis; Blotting, Western; Bone Resorption; Catechin; Cell Differentiation; Cell Survival; Cells, Cultured; Macrophage Colony-Stimulating Factor; MAP Kinase Kinase Kinases; Metformin; Mice; Mice, Inbred ICR; Osteoclasts; Osteogenesis; Pyrazoles; Pyrimidines; RANK Ligand; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Stilbenes | 2010 |
Negative regulation of stress-induced matrix metalloproteinase-9 by Sirt1 in skin tissue.
Topics: Animals; Biocatalysis; Cells, Cultured; Collagen Type IV; Dermis; Female; Fibroblasts; Gene Expression; Gene Expression Regulation, Enzymologic; Humans; Keratinocytes; Matrix Metalloproteinase 9; Metformin; Mice; Mice, Hairless; Resveratrol; Sirtuin 1; Skin; Stilbenes; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2010 |
Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats.
Topics: Animals; Ascorbic Acid; Blood Glucose; Body Weight; Catalase; Eating; Fructose; Glucose Tolerance Test; Glutathione; Insulin; Insulin Resistance; Liver; Male; Metabolic Syndrome; Metformin; NF-E2-Related Factor 2; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triglycerides; Uric Acid | 2012 |
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.
Topics: Adaptor Proteins, Signal Transducing; Aspirin; Ataxia Telangiectasia Mutated Proteins; Berberine; Cell Cycle Proteins; Cell Line, Tumor; Cellular Senescence; Cholecalciferol; Deoxyglucose; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Flow Cytometry; Histones; Humans; Laser Scanning Cytometry; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidative Stress; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins | 2012 |
Defining the action spectrum of potential PGC-1α activators on a mitochondrial and cellular level in vivo.
Topics: Aminoimidazole Carboxamide; Animals; Bezafibrate; HeLa Cells; Humans; Metformin; Mice; Mitochondrial Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Resveratrol; Ribonucleotides; Rosiglitazone; Signal Transduction; Stilbenes; Thiazolidinediones; Transcription Factors | 2014 |
Mitochondrial biogenesis: pharmacological approaches.
Topics: Animals; DNA, Mitochondrial; Humans; Metformin; Mitochondria; Mitochondrial Diseases; Resveratrol; Stilbenes | 2014 |
Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.
Topics: Adipokines; Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aorta; Culture Media, Conditioned; Diet; Fructose; Metformin; NF-kappa B; Palmitic Acid; Rats; Resveratrol; Ribonucleotides; Sirtuin 1; Sodium Salicylate; Stilbenes; Vasodilation | 2014 |
Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation.
Topics: Alternative Splicing; AMP-Activated Protein Kinases; Animals; Berberine; DNA, Mitochondrial; Enzyme Activation; Exons; Gene Expression Regulation; Humans; Lamin Type A; Metformin; Models, Biological; Mutation; Nuclear Proteins; Oxidative Phosphorylation; Phosphorylation; Point Mutation; Progeria; Resveratrol; RNA-Binding Proteins; Serine-Arginine Splicing Factors; Stilbenes | 2014 |
Glucoregulatory Relevance of Small Intestinal Nutrient Sensing in Physiology, Bariatric Surgery, and Pharmacology.
Topics: Animals; Bariatric Surgery; Blood Glucose; Brain; Glucose; Glycemic Load; Humans; Hypoglycemic Agents; Intestine, Small; Liver; Metformin; Nutritional Physiological Phenomena; Resveratrol; Stilbenes | 2015 |
Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway.
Topics: Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; E1A-Associated p300 Protein; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Metformin; Resveratrol; Signal Transduction; Sirtuin 1; Stilbenes; Tumor Suppressor Protein p53 | 2015 |
The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibrosis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Male; Metformin; Mice; Mice, Inbred ICR; Resveratrol; Stilbenes; Structure-Activity Relationship | 2016 |
Combined metformin and resveratrol confers protection against UVC-induced DNA damage in A549 lung cancer cells via modulation of cell cycle checkpoints and DNA repair.
Topics: A549 Cells; Aging; Antineoplastic Agents, Phytogenic; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 2; Cyclin B1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Damage; DNA Repair; G1 Phase Cell Cycle Checkpoints; Histones; Humans; Metformin; Oncogene Proteins; Resveratrol; Retinoblastoma Protein; Ribonucleotide Reductases; Signal Transduction; Stilbenes; Tumor Suppressor Protein p53; Ultraviolet Rays | 2016 |
Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Apoptosis; Cell Differentiation; Diabetes Mellitus, Experimental; Dynamins; Endoplasmic Reticulum Stress; Gene Expression Regulation; Inflammasomes; Metformin; Mice; Mitochondria; Mitochondrial Dynamics; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphorylation; Reactive Oxygen Species; Resveratrol; Stilbenes | 2016 |
Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue.
Topics: 3T3-L1 Cells; Adipose Tissue; Administration, Oral; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diet, High-Fat; Diglycerides; Fatty Acids; Feeding Behavior; Glucose; Hypoxia; Inflammation; Insulin; Insulin Resistance; Lipolysis; Male; Metformin; Mice; Mice, Inbred ICR; Models, Biological; Muscles; Resveratrol; Signal Transduction; Stilbenes | 2016 |
Beneficial effects of combined resveratrol and metformin therapy in treating diet-induced insulin resistance.
Topics: Adiposity; Animals; Blood Glucose; Diet, High-Fat; Drug Therapy, Combination; Inflammation Mediators; Insulin Resistance; Male; Metformin; Mice; Mice, Inbred C57BL; Oncogene Protein v-akt; Organ Specificity; Resveratrol; Stilbenes | 2016 |
Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats.
Topics: Animals; Antioxidants; Anxiety Disorders; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Epigenesis, Genetic; Fructose; Gene Expression Regulation; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Prediabetic State; Rats; Resveratrol; Sirtuin 1; Sirtuins; Stilbenes | 2016 |
Metformin potentiates anti-tumor effect of resveratrol on pancreatic cancer by down-regulation of VEGF-B signaling pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Synergism; Humans; Hypoglycemic Agents; Metformin; Mice, Nude; Pancreatic Neoplasms; Resveratrol; RNA Interference; Signal Transduction; Stilbenes; Vascular Endothelial Growth Factor B; Xenograft Model Antitumor Assays | 2016 |
Resveratrol Reverses Functional Chagas Heart Disease in Mice.
Topics: Animals; Antioxidants; Chagas Cardiomyopathy; Cyclic N-Oxides; Disease Models, Animal; Female; Male; Metformin; Mice; Mice, Inbred BALB C; Oxidative Stress; Resveratrol; Spin Labels; Stilbenes | 2016 |
The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.
Topics: AMP-Activated Protein Kinases; Analgesics; Anesthetics, Local; Animals; Binding Sites; Biphenyl Compounds; Drug Evaluation, Preclinical; HEK293 Cells; Hot Temperature; Humans; Male; meta-Aminobenzoates; Metformin; NAV1.7 Voltage-Gated Sodium Channel; Neural Conduction; Pain; Patch-Clamp Techniques; Pyrones; Rats; Rats, Sprague-Dawley; Reaction Time; Recombinant Fusion Proteins; Resveratrol; Sensory Receptor Cells; Sodium Channel Blockers; Stilbenes; Thiazoles; Thiophenes; Trigeminal Ganglion | 2017 |
Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling.
Topics: Adult; Aging; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Caloric Restriction; Cells, Cultured; Cellular Senescence; Epithelial-Mesenchymal Transition; Glucose; Humans; Hypoglycemic Agents; Kidney Tubules, Proximal; Male; Metformin; Microscopy, Fluorescence; Rats, Sprague-Dawley; Resveratrol; Signal Transduction; Stilbenes; TOR Serine-Threonine Kinases | 2017 |
Caloric Restriction Mimetics Slow Aging of Neuromuscular Synapses and Muscle Fibers.
Topics: Aging; Animals; Antioxidants; Caloric Restriction; Cells, Cultured; Disease Models, Animal; Energy Metabolism; Hypoglycemic Agents; Immunohistochemistry; Metformin; Mice; Mice, Inbred C57BL; Motor Disorders; Muscle Fibers, Skeletal; Neuromuscular Junction; Resveratrol; Stilbenes; Synapses | 2017 |
Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics.
Topics: 2,4-Dinitrophenol; Adipose Tissue, White; Aging; Animals; Bezafibrate; Caloric Restriction; Carnitine; Citrate (si)-Synthase; Gene Expression Profiling; Gene Expression Regulation; Glycated Hemoglobin; Interferon-gamma; Male; Metformin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Muscle, Skeletal; Myocardium; Neocortex; Pioglitazone; Quercetin; Resveratrol; Sirtuin 3; Stilbenes; Thiazolidinediones; Tumor Necrosis Factor-alpha | 2017 |
Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application.
Topics: Acetyl-CoA Carboxylase; Administration, Cutaneous; Aging; AMP-Activated Protein Kinases; Animals; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Activation; Female; Gene Expression Regulation; Metformin; Mice; Neovascularization, Physiologic; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Resveratrol; Ribosomal Protein S6 Kinases; Sirolimus; Skin; Skin Aging; Stilbenes; Tumor Suppressor Protein p53; Wound Healing; Wounds, Nonpenetrating | 2017 |
Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Male; Metformin; Mice, Inbred ICR; Neurons; Pain; Pain Threshold; Postoperative Complications; Resveratrol; Signal Transduction; Stilbenes | 2017 |
Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model.
Topics: Animals; Antioxidants; Blood Glucose; Calcium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Hyperglycemia; Insulin; Insulin Resistance; Magnesium; Male; Metformin; Rats; Resveratrol; Stilbenes; Vitamin E | 2018 |
Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Count; Dehydroepiandrosterone; Disease Models, Animal; Drug Therapy, Combination; Female; Hormones; Lipid Peroxidation; Metformin; Ovarian Follicle; Ovarian Reserve; Ovary; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Resveratrol; Sirtuin 1; Stilbenes; Tumor Necrosis Factor-alpha; Vagina | 2018 |
The Effects of Resveratrol, Metformin, Cold and Strength Training on the Level of Perilipin 5 in the Heart, Skeletal Muscle and Brown Adipose Tissues in Mouse.
Topics: Adipose Tissue, Brown; Animals; Cold Temperature; Gene Expression Regulation; Lipid Metabolism; Male; Metformin; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myocardium; Perilipin-5; Physical Conditioning, Animal; Resveratrol; Stilbenes | 2018 |
Atorvastatin and Conditioned Media from Atorvastatin-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity
Topics: AC133 Antigen; Antigens, CD34; Aspirin; Atorvastatin; Cells, Cultured; Culture Media, Conditioned; Hematopoietic Stem Cells; Heme Oxygenase-1; Humans; Immunoassay; Isothiocyanates; Leukocytes, Mononuclear; Metformin; Neovascularization, Physiologic; Phenotype; Resveratrol; Sulfoxides | 2019 |
Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction.
Topics: 4-Butyrolactone; Apoptosis; Bronchi; Cell Line; Cell Respiration; DNA Damage; DNA, Mitochondrial; Epithelial Cells; Homoserine; Host-Pathogen Interactions; Humans; Metformin; Mitochondria; Models, Biological; Organelle Biogenesis; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Reactive Oxygen Species; Resveratrol | 2019 |
Resveratrol and Metformin Recover Prefrontal Cortex AMPK Activation in Diet-Induced Obese Mice but Reduce BDNF and Synaptophysin Protein Content.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Autophagy; Blood Glucose; Brain-Derived Neurotrophic Factor; Diet, High-Fat; Enzyme Activation; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Mice; Mice, Inbred C57BL; Obesity; Prefrontal Cortex; Resveratrol; Synaptophysin; TOR Serine-Threonine Kinases | 2019 |
Protective Effect of Metformin, Resveratrol and Alpha-lipoic Acid on Radiation- Induced Pneumonitis and Fibrosis: A Histopathological Study.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Hypoglycemic Agents; Lung; Male; Metformin; Mice; Neutrophil Infiltration; Pulmonary Fibrosis; Radiation Injuries; Radiation Pneumonitis; Radiation-Protective Agents; Resveratrol; Thioctic Acid | 2019 |
NLRP3 inflammasome drives inflammation in high fructose fed diabetic rat liver: Effect of resveratrol and metformin.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fructose; Hypoglycemic Agents; Inflammasomes; Inflammation; Insulin Resistance; Liver; Male; Metformin; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Resveratrol | 2020 |
Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Enzyme Activators; Exenatide; Metformin; Muscle, Smooth, Vascular; Phosphates; RANK Ligand; Rats; Resveratrol; Signal Transduction; Vascular Calcification | 2020 |
Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age.
Topics: Animals; Dogs; Fibroblasts; Longevity; Metformin; Resveratrol; Sirolimus | 2021 |
Comparative analysis of long non‑coding RNA expression profiles induced by resveratrol and metformin treatment for hepatic insulin resistance.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Insulin Resistance; Liver; Male; Metformin; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; RNA, Long Noncoding; RNA, Messenger; Signal Transduction | 2021 |
Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin.
Topics: Animals; Liver; Metformin; Mice; Proteome; Resveratrol; Sirolimus | 2021 |
Metformin inhibits the tumor-promoting effect of low-dose resveratrol, and enhances the anti-tumor activity of high-dose resveratrol by increasing its reducibility in triple negative breast cancer.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Metformin; Resveratrol; Triple Negative Breast Neoplasms; Tumor Microenvironment | 2022 |
Label-free study of intracellular glycogen level in metformin and resveratrol-treated insulin-resistant HepG2 by live-cell FTIR spectroscopy.
Topics: Biosensing Techniques; Glycogen; Humans; Insulin; Insulin Resistance; Metformin; Resveratrol; Spectroscopy, Fourier Transform Infrared | 2022 |
Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus.
Topics: Animals; Cataract; Diabetes Mellitus; Fructose; Metformin; NADP; NADPH Oxidases; Oxidative Stress; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Resveratrol; Sodium-Glucose Transporter 2 | 2022 |
Impact of Autophagy Impairment on Experience- and Diet-Related Synaptic Plasticity.
Topics: Animals; Autophagy; Beclin-1; Diet; Hippocampus; Mammals; Metformin; Mice; Neuronal Plasticity; Resveratrol; Synapses; Synaptic Transmission | 2022 |
Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution.
Topics: Autophagy; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cisplatin; Diabetes Mellitus, Type 2; Female; G1 Phase Cell Cycle Checkpoints; Humans; Male; MCF-7 Cells; Metformin; Resveratrol | 2023 |