Tuberostemonine is an alkaloid isolated from the roots of the plant *Stemona tuberosa*. It has shown significant biological activity, including anti-inflammatory, antimicrobial, and anticancer properties. Researchers are studying tuberostemonine to investigate its potential as a therapeutic agent for various diseases. The compound exhibits complex structures and unique biological properties, leading to continued interest in its synthesis and structure-activity relationship studies.'
tuberostemonine: alkaloid from Stemona japonica with anthelmintic action; structure given in first source; an azapine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Stemona | genus | A plant genus of the family Stemonaceae. Members contain STILBENES and phenyl BENZOFURANS.[MeSH] | Stemonaceae | A small plant family of the order Liliales, subclass Liliidae, class Liliopsida (monocotyledons).[MeSH] |
| Stemona japonica | species | [no description available] | Stemonaceae | A small plant family of the order Liliales, subclass Liliidae, class Liliopsida (monocotyledons).[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 100781 |
| CHEMBL ID | 517375 |
| CHEBI ID | 69383 |
| SCHEMBL ID | 19197310 |
| MeSH ID | M0105668 |
| Synonym |
|---|
| TIMTEC1_001671 |
| 6879-01-2 |
| tuberostemonine |
| NCGC00017300-02 |
| HMS1538L21 |
| CHEMBL517375 |
| chebi:69383 , |
| nsc 366235 |
| tubero-stemonine |
| stenine, 2-(tetrahydro-4-methyl-5-oxo-2-furanyl)-, (2beta(2s,4s))- |
| S9056 |
| tuberstemonine |
| AC-34126 |
| GYOGHROCTSEKDY-JJDZUBOLSA-N |
| furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2h)-one, 8-ethyldodecahydro-11-methyl-2-[(2s,4s)-tetrahydro-4-methyl-5-oxo-2-furanyl]-, (2s,7ar,8r,8as,11s,11as,11br,11cr)- |
| SCHEMBL19197310 |
| mfcd11111456 |
| AKOS030632869 |
| Q27137722 |
| HY-N0352 |
| BS-17448 |
| (2s,31r,7ar,8r,8as,11s,11as,11br)-8-ethyl-11-methyl-2-((2s,4s)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2h)-one |
| CCG-268357 |
| CS-0008906 |
| (1r,3s,9r,10r,11s,14s,15s,16r)-10-ethyl-14-methyl-3-[(2s,4s)-4-methyl-5-oxooxolan-2-yl]-12-oxa-4-azatetracyclo[7.6.1.04,16.011,15]hexadecan-13-one |
Tuberostemonine (TS) is an alkaloid-type phytochemical from Stemona tuberosa.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Tuberostemonine (TS) is an alkaloid-type phytochemical from Stemona tuberosa." | ( The therapeutic effects of tuberostemonine against cigarette smoke-induced acute lung inflammation in mice. Bae, H; Beak, H; Jung, J; Jung, KH; Kim, J; Park, S; Shin, D, 2016) | 1.45 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Tuberostemonine alkaloids inhibit inflammation by suppressing the expression of inflammatory mediators such as cyclooxygenase and nitric oxide synthase." | ( Suppression of IL-2 production and proliferation of CD4(+) T cells by tuberostemonine O. Gyeong Jeong, M; Jung Jang, E; Kil, YS; Kyeong Kim, H; Kyoung Seo, E; Oh, S; Ryeon Park, H; Sook Hwang, E, 2014) | 1.36 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " tuberosa, showing outstanding repellency but no toxic effects." | ( Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. Brem, B; Greger, H; Hofer, O; Pacher, T; Seger, C; Vajrodaya, S, 2002) | 0.31 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " In this work, plasma pharmacokinetic and biodistribution characteristics of the three alkaloids after oral administration of Stemonae Radix are investigated using a rapid and sensitive UPLC-Q-TOF-HDMS method." | ( Ultra-performance liquid-chromatography with tandem mass spectrometry performing pharmacokinetic and biodistribution studies of croomine, neotuberostemonine and tuberostemonine alkaloids absorbed in the rat plasma after oral administration of Stemonae Rad Dong, W; Sun, H; Wang, W; Wang, X; Zhang, A, 2012) | 0.58 |
| Role | Description |
|---|---|
| metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| alkaloid | Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID377037 | Ex vivo inhibition of leukotriene formation in calcium ionophore activated human neutrophilic granulocyte at 50 uM by ELISA | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species. |
| AID1101952 | Antifeedant activity against fifth instar larvae of Spodoptera littoralis at 0.001 ug/cm2 after 24 hr by leaf disk choice assay | 2002 | Journal of agricultural and food chemistry, Oct-23, Volume: 50, Issue:22 | Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. |
| AID1101950 | Toxicity in neonate larvae of Spodoptera littoralis at 133 ug/dm2 after 48 hr | 2002 | Journal of agricultural and food chemistry, Oct-23, Volume: 50, Issue:22 | Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. |
| AID1101957 | Antifeedant activity against fifth instar larvae of Spodoptera littoralis assessed as inhibition of feeding without tasting treated leaf disk at 1 ug/cm2 after 24 hr by leaf disk choice assay | 2002 | Journal of agricultural and food chemistry, Oct-23, Volume: 50, Issue:22 | Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. |
| AID1101949 | Toxicity in neonate larvae of Spodoptera littoralis assessed as survival at 100 ug/larvae treated directly into hemolymph after 48 hr | 2002 | Journal of agricultural and food chemistry, Oct-23, Volume: 50, Issue:22 | Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. |
| AID1101959 | Insecticidal activity against neonate larvae of Spodoptera littoralis after 5 days | 2002 | Journal of agricultural and food chemistry, Oct-23, Volume: 50, Issue:22 | Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. |
| AID1101955 | Antifeedant activity against fifth instar larvae of Spodoptera littoralis assessed as 5 to 20% of total area of treated leaf disks in each petri dish consumed at 0.01 ug/cm2 after 24 hr by leaf disk choice assay | 2002 | Journal of agricultural and food chemistry, Oct-23, Volume: 50, Issue:22 | Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. |
| AID377036 | Ex vivo inhibition of leukotriene formation in calcium ionophore activated human neutrophilic granulocyte by ELISA | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species. |
| AID1101958 | Growth inhibition of neonate larvae of Spodoptera littoralis after 5 days | 2002 | Journal of agricultural and food chemistry, Oct-23, Volume: 50, Issue:22 | Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. |
| AID1101956 | Antifeedant activity against fifth instar larvae of Spodoptera littoralis assessed as inhibition of feeding without tasting treated leaf disk at 0.1 ug/cm2 after 24 hr by leaf disk choice assay | 2002 | Journal of agricultural and food chemistry, Oct-23, Volume: 50, Issue:22 | Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 11 (36.67) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.29) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (3.33%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 29 (96.67%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||