Compounds > norbergenin

Page last updated: 2024-12-06

norbergenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

norbergenin: bergenin derivative isolated from the root of Ardisia crenata [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Ardisia crenata	species	[no description available]	Primulaceae	A plant family of the order ERICALES, class MAGNOLIOPSIDA, with flowers having both stamens and pistil, producing encapsulated fruits.[MeSH]

Cross-References

ID Source	ID
PubMed CID	90476206
CHEMBL ID	3823447
MeSH ID	M0176276

Synonyms (15)

Synonym
79595-97-4
norbergenin
bs9up8b38p ,
CHEMBL3823447
EX-A5118
MS-24600
(2r,3s,4s,4ar,10bs)-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)-3,4,4a,10b-tetrahydro-2h-pyrano[3,2-c]isochromen-6-one
(2R,3S,4S,4AR,10BS)-3,4,8,9,10-PENTAHYDROXY-2-(HYDROXYMETHYL)-3,4,4A,10B-TETRAHYDROPYRANO[3,2-C]ISOCHROMEN-6(2H)-ONE
CS-0173323
HY-N9447
pyrano(3,2-c)(2)benzopyran-6(2h)-one, 3,4,4a,10b-tetrahydro-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)-, (2r-(2.alpha.,3.beta.,4.alpha.,4a.alpha.,10b.beta.))-
demethylbergenin
pyrano(3,2-c)(2)benzopyran-6(2h)-one, 3,4,4a,10b-tetrahydro-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)-, (2r,3s,4s,4ar,10bs)-
(2r,3s,4s,4ar,10bs)-3,4,4a,10b-tetrahydro-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)pyrano(3,2-c)(2)benzopyran-6(2h)-one
AKOS040759641

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID1311778	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of iNOS levels by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311758	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 50 umol/L after 24 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311783	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of COX2 levels by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311785	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of PGE2 levels by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311782	Inhibition of NFkappaB signaling pathway in LPS-stimulated mouse RAW264.7 cells by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311784	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of NO levels by ELISA	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311759	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in cell viability at 50 umol/L after 24 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (10.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (40.00)	29.6817
2010's	4 (40.00)	24.3611
2020's	1 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	2.13	1	0	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.13	1	0	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
sucrose Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.	1.97	1	0	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent
catechin Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.	2.01	1	0	catechin	antioxidant; plant metabolite
bergenin bergenin: RN refers to (2R-(2alpha,3beta,4alpha,4aalpha,10bbeta))-isomer; structure	2.74	3	0	trihydroxybenzoic acid	metabolite
isocoumarins Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.. isocoumarin : The simplest member of the class of isocoumarins that is 1H-isochromene which is substituted by an oxo group at position 1.	2.08	1	0	isocoumarins
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.13	1	0	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
cytellin cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982	1.97	1	0
stigmasterol stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.	1.97	1	0	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols; stigmastane sterol	plant metabolite
spinasterol spinasterol: RN given refers to alpha-spinasterol ((3beta,5alpha,22E)-isomer)	1.97	1	0	steroid
myricetin [no description available]	2.13	1	0	7-hydroxyflavonol; hexahydroxyflavone	antineoplastic agent; antioxidant; cyclooxygenase 1 inhibitor; food component; geroprotector; hypoglycemic agent; plant metabolite
lyoniside lyoniside: see also eleutherosides & syringin for eleutheroside B: 118-34-3; RN given refers to (3beta)-isomer	1.97	1	0
11-o-galloylbergenin 11-O-galloylbergenin: analgesic and anti-inflammatory; structure in first source	2.13	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.6	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.6	1	0
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	0	2.03	1	0
Adjuvant Arthritis [description not available]	0	2.03	1	0