Compounds > norbergenin
Page last updated: 2024-09-23

norbergenin

Description

norbergenin: bergenin derivative isolated from the root of Ardisia crenata [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Ardisia crenataspecies[no description available]PrimulaceaeA plant family of the order ERICALES, class MAGNOLIOPSIDA, with flowers having both stamens and pistil, producing encapsulated fruits.[MeSH]

Cross-References

ID SourceID
PubMed CID90476206
CHEMBL ID3823447
MeSH IDM0176276

Synonyms (15)

Synonym
79595-97-4
norbergenin
bs9up8b38p ,
CHEMBL3823447
EX-A5118
MS-24600
(2r,3s,4s,4ar,10bs)-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)-3,4,4a,10b-tetrahydro-2h-pyrano[3,2-c]isochromen-6-one
(2R,3S,4S,4AR,10BS)-3,4,8,9,10-PENTAHYDROXY-2-(HYDROXYMETHYL)-3,4,4A,10B-TETRAHYDROPYRANO[3,2-C]ISOCHROMEN-6(2H)-ONE
CS-0173323
HY-N9447
pyrano(3,2-c)(2)benzopyran-6(2h)-one, 3,4,4a,10b-tetrahydro-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)-, (2r-(2.alpha.,3.beta.,4.alpha.,4a.alpha.,10b.beta.))-
demethylbergenin
pyrano(3,2-c)(2)benzopyran-6(2h)-one, 3,4,4a,10b-tetrahydro-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)-, (2r,3s,4s,4ar,10bs)-
(2r,3s,4s,4ar,10bs)-3,4,4a,10b-tetrahydro-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)pyrano(3,2-c)(2)benzopyran-6(2h)-one
AKOS040759641

Bioassays (7)

Assay IDTitleYearJournalArticle
AID1311778Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of iNOS levels by ELISA2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311758Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 50 umol/L after 24 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311783Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of COX2 levels by ELISA2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311785Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of PGE2 levels by ELISA2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311782Inhibition of NFkappaB signaling pathway in LPS-stimulated mouse RAW264.7 cells by ELISA2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311784Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as downregulation of NO levels by ELISA2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
AID1311759Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in cell viability at 50 umol/L after 24 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's4 (40.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
gallic acid[no description available]medium10trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
indomethacin[no description available]medium10aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
bergenin[no description available]medium30trihydroxybenzoic acidmetabolite
resveratrol[no description available]medium10resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
myricetin[no description available]medium107-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
11-o-galloylbergenin[no description available]medium10
isocoumarins[no description available]medium10isocoumarins
catechin[no description available]medium10catechinantioxidant;
plant metabolite
stigmasterol[no description available]medium103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol		plant metabolite
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
spinasterol[no description available]medium10steroid
lyoniside[no description available]medium10
cytellin[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Adjuvant Arthritis0low10
Arthritis, Adjuvant0low10
Arthritis, Adjuvant-Induced0low10
Arthritis, Collagen-Induced0low10
Arthritis, Experimental0low10
Collagen Arthritis0low10
Inflammation0low10
Innate Inflammatory Response0low10
Neuroblastoma0low10

Research Highlights

Long-term Use (1)

ArticleYear
Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming.
Frontiers in immunology, Volume: 14		2023
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]