Page last updated: 2024-09-28

beta-Glucuronidase Deficiency

Synonyms(6)

Synonym
Sly Disease
GUSB Deficiency
Mucopolysaccharidosis Type VII
Sly Syndrome
beta-Glucuronidase Deficiency
Mucopolysaccharidosis 7

Research Excerpts

Research

Studies (33)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's4 (12.12)12.5806
2000's14 (42.42)18.1394
2010's13 (39.39)28.8240
2020's2 (6.06)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cytosine0low10
thymine0low10
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid0low10
erythrosine0low10
fluorouracil0low10
bromodeoxyuridine0low20
methionine0low10
mannitol0low10
thiazoles0low10
4-methoxyamphetamine0low10
thiazolyl blue0low10
fluorexon0low10
metaperiodate0low10
n-acetylneuraminic acid0low10
mannose-6-phosphate0low10
elastin0low20
phalloidine0low10
resveratrol0low10
mannose 1-phosphate0low10
dermatan sulfate0low10
osteoprotegerin0low10
genistein0low10
natriuretic peptide, c-type0low20
hoe 333420low10
heparitin sulfate0low20
transforming growth factor beta0low10
amyloid beta-peptides0low10
chondroitin sulfates0low10
eye0low40

Protein Targets (452)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0112
5-hydroxytryptamine receptor 2A0112
5-hydroxytryptamine receptor 1A0113
5-hydroxytryptamine receptor 1B0112
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0112
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0011
Sodium-dependent serotonin transporter0202
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
arylsulfatase A4004
euchromatic histone-lysine N-methyltransferase 26006
chromobox protein homolog 14004
flap endonuclease 13003
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Integrin beta-32103
Integrin alpha-IIb2103
Glutamate receptor 10213
Glutamate receptor 25218
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10202
Glutamate receptor 10112
Glutamate receptor 20101
Glutamate receptor ionotropic, NMDA 1 0202
Glutamate receptor ionotropic, kainate 10202
Glutamate receptor ionotropic, kainate 20202
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30202
Glutamate receptor ionotropic, kainate 30101
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor 40202
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, kainate 40101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20202
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 40101
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Glutamate receptor ionotropic, NMDA 3A0202
Glutamate receptor 40101
Glutamate receptor 30101
interleukin 82002
pregnane X receptor2002
RAR-related orphan receptor gamma6006
ATAD5 protein, partial5005
TDP1 protein5005
Microtubule-associated protein tau4004
AR protein6006
aldehyde dehydrogenase 1 family, member A14004
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor4004
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha7007
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha6006
bromodomain adjacent to zinc finger domain 2B2002
IDH14004
nuclear receptor subfamily 1, group I, member 21001
cellular tumor antigen p53 isoform a3003
Nuclear hormone receptor family member daf-120011
nuclear factor erythroid 2-related factor 2 isoform 22002
thyroid hormone receptor beta isoform 25005
serine/threonine-protein kinase mTOR isoform 13003
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
geminin6006
peripheral myelin protein 223003
survival motor neuron protein isoform d4004
muscarinic acetylcholine receptor M11001
Voltage-dependent calcium channel gamma-2 subunit5005
Thymidine kinase, cytosolic0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Nuclear receptor ROR-gamma2002
Spike glycoprotein2002
Thymidine kinase0001
Thymidylate kinase0101
ATPase family AAA domain-containing protein 54004
Ataxin-24004
GLI family zinc finger 36006
Deoxycytidine kinase0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Beta-lactamase2002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Genome polyprotein 0112
Luciferase4004
acetylcholinesterase2002
chaperonin-containing TCP-1 beta subunit homolog1001
phosphopantetheinyl transferase1001
SMAD family member 23003
Fumarate hydratase1001
GLS protein3003
SMAD family member 33003
thioredoxin glutathione reductase1001
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 43003
farnesoid X nuclear receptor4004
G3003
cytochrome P450 2D63003
polyprotein1001
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor2002
activating transcription factor 63003
thyrotropin-releasing hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x4004
Bloom syndrome protein isoform 13003
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform a3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eyes absent homolog 2 isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I2002
DNA polymerase kappa isoform 12002
histone acetyltransferase KAT2A isoform 11001
relaxin receptor 1 isoform 11001
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Cellular tumor antigen p535005
Flavin reductase (NADPH)0011
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
ATP-dependent phosphofructokinase3003
large T antigen0202
Multidrug resistance-associated protein 1 0001
Chain A, Uracil Phosphoribosyltransferase0101
endonuclease IV1001
glp-1 receptor, partial3003
Skn7p0001
thioredoxin reductase3003
hypoxia-inducible factor 1 alpha subunit1001
Thrombopoietin2002
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)4004
EWS/FLI fusion protein2002
nonstructural protein 11001
67.9K protein3003
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma3003
peripheral myelin protein 22 isoform 13003
hemoglobin subunit beta1001
huntingtin isoform 22002
nuclear factor erythroid 2-related factor 2 isoform 14004
Vpr1001
muscleblind-like protein 1 isoform 12002
lamin isoform A-delta104004
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Solute carrier family 22 member 80001
Bile salt export pump0101
Epidermal growth factor receptor0202
Amyloid-beta precursor protein1113
Thymidylate synthase0101
Aromatase0404
Canalicular multispecific organic anion transporter 10101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, Estrogen receptor 1 (alpha)0101
Chain A, Ferritin light chain1001
Chain A, Transthyretin0011
Chain A, Transthyretin0011
acid sphingomyelinase1001
BRCA12002
15-lipoxygenase, partial1001
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
Neuraminidase 0101
glucocerebrosidase1001
Parkin2002
P532002
Alpha-mannosidase0101
pyruvate kinase2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
hexokinase-4 isoform 12002
NPC intracellular cholesterol transporter 1 precursor2002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
histone deacetylase 9 isoform 32002
glucokinase regulatory protein2002
glycogen synthase kinase-3 beta isoform 10011
DNA polymerase beta2002
mitogen-activated protein kinase 11001
ras-related protein Rab-9A2002
tyrosine-protein kinase Yes1001
nuclear receptor ROR-gamma isoform 12002
cytochrome P450 3A4 isoform 12002
M-phase phosphoprotein 82002
lethal factor (plasmid)1001
pyruvate kinase PKM isoform b1001
Gamma-aminobutyric acid receptor subunit pi2002
Maltase-glucoamylase, intestinal0202
5-hydroxytryptamine receptor 40202
Steroid hormone receptor ERR20101
Tyrosine-protein kinase ABL10203
Pancreatic triacylglycerol lipase0101
Triosephosphate isomerase0101
Transthyretin0112
Estrogen receptor0314
Glucocorticoid receptor0001
Sex hormone-binding globulin0011
Tyrosine-protein kinase Fyn0101
Cyclin-dependent kinase 10101
ATP-dependent translocase ABCB10113
Ornithine decarboxylase1001
Androgen receptor0102
Sialidase0101
Solute carrier family 2, facilitated glucose transporter member 10101
Tyrosinase0303
Steroid hormone receptor ERR10101
Cyclin-dependent kinase 40101
Ornithine decarboxylase0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Proto-oncogene tyrosine-protein kinase Src0101
Cystic fibrosis transmembrane conductance regulator0011
17-beta-hydroxysteroid dehydrogenase type 10101
Solute carrier family 2, facilitated glucose transporter member 40101
G2/mitotic-specific cyclin-B10101
Dipeptidyl peptidase 40101
Aldo-keto reductase family 1 member B10101
Androgen receptor0101
Gamma-aminobutyric acid receptor subunit beta-12002
Protein kinase C alpha type0112
cAMP-dependent protein kinase catalytic subunit alpha0101
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0202
Amine oxidase [flavin-containing] A 0101
Prostaglandin G/H synthase 10202
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
G1/S-specific cyclin-D10101
Thromboxane-A synthase 0101
Cruzipain0101
DNA (cytosine-5)-methyltransferase 10101
Amine oxidase [flavin-containing] B0202
Dipeptidyl peptidase 40202
Proteasome subunit beta type-50101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Adenosine receptor A2a0202
Gamma-aminobutyric acid receptor subunit alpha-62002
Adenosine receptor A10202
Adenosine receptor A2a0101
Substance-P receptor0101
RAC-alpha serine/threonine-protein kinase0101
Cystic fibrosis transmembrane conductance regulator0011
Testosterone 17-beta-dehydrogenase 30101
17-beta-hydroxysteroid dehydrogenase type 20101
Acetylcholinesterase0101
Alpha-glucosidase MAL320101
Signal transducer and activator of transcription 30101
Tyrosine-protein kinase CSK0101
Tyrosine-protein kinase ABL20101
Tyrosine-protein kinase SYK0101
Dual specificity mitogen-activated protein kinase kinase 40101
Quinone oxidoreductase0001
Histamine H2 receptor2002
Xanthine dehydrogenase/oxidase0101
Cytoplasmic tyrosine-protein kinase BMX0101
Death-associated protein kinase 10101
Mitogen-activated protein kinase 100101
Oxysterols receptor LXR-beta0101
Amine oxidase [flavin-containing] B0101
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Xanthine dehydrogenase/oxidase0101
MO15-related protein kinase Pfmrk 0101
Sodium-dependent dopamine transporter 0202
Aldehyde oxidase0101
Oxysterols receptor LXR-alpha0101
Mitogen-activated protein kinase 140101
Tissue alpha-L-fucosidase0101
Substance-K receptor0101
Integrase 0101
GABA theta subunit2002
Estrogen receptor beta0213
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0101
Gamma-aminobutyric acid receptor subunit epsilon2002
Prenyltransferase homolog0002
Carboxylic ester hydrolase 0101
Solute carrier organic anion transporter family member 1B30202
Dipeptidyl peptidase 30101
DNA (cytosine-5)-methyltransferase 3-like0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Sialidase-20202
DNA (cytosine-5)-methyltransferase 3A0101
Solute carrier organic anion transporter family member 1B10202
USP1 protein, partial1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
TAR DNA-binding protein 431001
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Carbonic anhydrase 40202
Carbonic anhydrase 5A, mitochondrial0202
Carbonic anhydrase 90202
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Large neutral amino acids transporter small subunit 10101
Sialidase-40101
Sialidase-10101
Sialidase-30101
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
ClpP1001
caspase 7, apoptosis-related cysteine protease1001
regulator of G-protein signaling 41001
caspase-31001
M18 aspartyl aminopeptidase0101
cathepsin L10101
lysosomal alpha-glucosidase preproprotein1001
atrial natriuretic peptide receptor 2 precursor1001
nuclear factor NF-kappa-B p105 subunit isoform 10011
FAD-linked sulfhydryl oxidase ALR0001
DNA polymerase iota isoform a (long)1001
Vif0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
POsterior Segregation0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0011
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Acetylcholinesterase0101
Polyphenol oxidase 20101
Carbonic anhydrase 120101
Lysine-specific histone demethylase 1A0101
Transient receptor potential cation channel subfamily A member 10112
Myc proto-oncogene protein0102
Cytochrome P450 1A10101
Cytochrome P450 1A20101
Prostaglandin G/H synthase 10112
Tyrosine-protein kinase Lck0101
Cholinesterase0101
Cathepsin D0101
Carbonic anhydrase 30101
Aldo-keto reductase family 1 member B10202
Luciferin 4-monooxygenase0101
Cytochrome P450 3A40202
Neuronal acetylcholine receptor subunit alpha-40101
DNA polymerase alpha catalytic subunit0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Leukotriene A-4 hydrolase0101
Breakpoint cluster region protein0102
Cytochrome P450 2C9 0101
Neuronal acetylcholine receptor subunit beta-20101
Tyrosinase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0213
Tyrosine-protein phosphatase non-receptor type 10101
Estrogen receptor0011
Nuclear factor NF-kappa-B p105 subunit0101
Endothelin receptor type B1001
Acetylcholinesterase0101
Carbonic anhydrase 60101
Sucrase-isomaltase, intestinal0101
Sodium-dependent noradrenaline transporter 0213
Endothelin-1 receptor1001
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Cytochrome P450 2C190101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
Cannabinoid receptor 10101
D(1A) dopamine receptor1001
Alpha-glucosidase MAL120101
Prostaglandin G/H synthase 20101
Cholinesterase0101
Inositol monophosphatase 11001
Nuclear factor NF-kappa-B p100 subunit 0101
Squalene synthase0101
Transcription factor p650101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0001
Bcl-2-like protein 10101
Serine/threonine-protein kinase PAK 10101
Nuclear factor erythroid 2-related factor 20012
Cytochrome P450 1B10202
N1L 0101
NAD(P)H dehydrogenase [quinone] 10002
Tubulin beta-2B chain0101
Lysosomal alpha-glucosidase0101
Transient receptor potential cation channel subfamily A member 10101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
NAD-dependent protein deacetylase sirtuin-20011
Carbonic anhydrase 130101
Rap guanine nucleotide exchange factor 41001
NAD-dependent protein deacetylase sirtuin-10013
Carbonic anhydrase 150101
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Carbonic anhydrase 140101
Zinc finger protein mex-50011
Carbonic anhydrase 5B, mitochondrial0101
Thymidine phosphorylase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]