Compounds > nimbidiol
Page last updated: 2024-10-14

nimbidiol

Description

nimbidiol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11334829
CHEMBL ID202413
MeSH IDM0480469

Synonyms (3)

Synonym
CHEMBL202413
nimbidiol
(4as,10as)-6,7-dihydroxy-1,1,4a-trimethyl-3,4,10,10a-tetrahydro-2h-phenanthren-9-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1872893Inhibition of rat intestinal lactase preincubated for 10 mins followed by substrate addition2022European journal of medicinal chemistry, May-05, Volume: 235Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
AID1872891Inhibition of rat intestinal sucrase preincubated for 10 mins followed by substrate addition2022European journal of medicinal chemistry, May-05, Volume: 235Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
AID1872890Inhibition of rat intestinal maltase preincubated for 10 mins followed by substrate addition2022European journal of medicinal chemistry, May-05, Volume: 235Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
AID260365Antitumor activity against human cervical carcinoma HeLa cell line2006Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes.
AID1872897Inhibition of baker's yeast sucrase preincubated for 10 mins followed by substrate addition2022European journal of medicinal chemistry, May-05, Volume: 235Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
AID260367Antitumor activity against human nasopharyngeal carcinoma CNE cell line2006Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes.
AID1872896Inhibition of Aspergillus niger maltase preincubated for 10 mins followed by substrate addition2022European journal of medicinal chemistry, May-05, Volume: 235Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
AID260368Antitumor activity against human breast adenocarcinoma MCF7 cell line2006Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes.
AID260366Antitumor activity against human lung adenocarcinoma A549 cell line2006Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes.
AID1872895Inhibition of rat intestinal gluco-amylase preincubated for 10 mins followed by substrate addition2022European journal of medicinal chemistry, May-05, Volume: 235Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
AID1872892Inhibition of rat intestinal isomaltase preincubated for 10 mins followed by substrate addition2022European journal of medicinal chemistry, May-05, Volume: 235Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
AID1872894Inhibition of rat intestinal trehalase preincubated for 10 mins followed by substrate addition2022European journal of medicinal chemistry, May-05, Volume: 235Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
catechol
[no description available]		2.0510catecholsallelochemical;
genotoxin;
plant metabolite
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		3.5110catechinantioxidant;
plant metabolite
acarbose
[no description available]		3.5110tetrasaccharide derivativeEC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
geroprotector;
hypoglycemic agent
totarol
totarol: structure given in first source; isolated from the bark of Podocarpus nagi		2.0210diterpenoidmetabolite
ferruginol
ferruginol: structure in first source. ferruginol : An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.		2.0210abietane diterpenoid;
carbotricyclic compound;
meroterpenoid;
phenols		antibacterial agent;
antineoplastic agent;
plant metabolite;
protective agent
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		3.5110resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
citral
citral: Xref geranial: geraniol is also available; Xref neral: nerol is also available; vitamin A antagonist; oxygenated monoterpene; inhibits cytosolic dehydrogenases; structure. citral : An enal that consists of octa-2,6-dienal bearing methyl substituents at positions 3 and 7. A mixture of the two geometric isomers geranial and neral, it is the major constituent (75-85%) of oil of lemon grass, the volatile oil of Cymbopogon citratus, or of C. flexuosus. It also occurs in oils of verbena, lemon, and orange.		3.5110enal;
monoterpenoid;
polyprenal		plant metabolite;
volatile oil component
3,3',4,5'-tetrahydroxystilbene
3,3',4,5'-tetrahydroxystilbene: demethyl derivative of isorhapontigenin; structure in first source; a Syk kinase inhibitor; found in heartwood of FABACEAE; inhibitor of photosynthesis in spinach chloroplasts; may be inhibitor of plant growth; RN given refers to (E)-isomer. piceatannol : A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.		3.5110catechols;
polyphenol;
resorcinols;
stilbenol		antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor
4-methoxycinnamic acid
[no description available]		3.5110cinnamic acids
scopoletin
[no description available]		3.5110hydroxycoumarinplant growth regulator;
plant metabolite
genistein
[no description available]		3.51107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
ethyl 4-methoxycinnamate
ethyl 4-methoxycinnamate: an antifungal agent isolated from Curcumba zedoaria		3.5110
andrographolide
[no description available]		3.5110carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol		anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Infections, Gram-Positive
[description not available]		02.0510
Bacterial Skin Diseases
[description not available]		02.0510
Gram-Positive Bacterial Infections
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.		02.0510
Skin Diseases, Bacterial
Skin diseases caused by bacteria.		02.0510
Diabetes Mellitus, Adult-Onset
[description not available]		02.0810
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.		02.0810