| Assay ID | Title | Year | Journal | Article |
|---|
| AID31777 | Tested for inhibition of AChE-induced Abeta aggregation in the peripheral sites of the human enzyme at a concentration of 100 uM | 2003 | Journal of medicinal chemistry, Jun-05, Volume: 46, Issue:12
| 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. |
| AID314093 | Inhibition of human AchE-induced amyloid beta aggregation at 100 uM | 2008 | Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
| Multi-target-directed ligands to combat neurodegenerative diseases. |
| AID31621 | Inhibitory potency was evaluated against recombinant human AChE | 2003 | Journal of medicinal chemistry, Jun-05, Volume: 46, Issue:12
| 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. |
| AID462783 | Inhibition of human BuChE preincubated for 20 mins before substrate addition by Ellman's method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. |
| AID462782 | Inhibition of human recombinant AChE preincubated for 20 mins before substrate addition by Ellman's method | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. |
| AID462787 | Inhibition of amyloid beta (1-42) self-aggregation at 10 uM after 24 hrs by thioflavin T-based fluorometric assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. |
| AID314091 | Inhibition of human AchE | 2008 | Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
| Multi-target-directed ligands to combat neurodegenerative diseases. |
| AID296909 | Inhibition of human recombinant AChE | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. |
| AID1379010 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 180 secs by spectrophotometric analysis | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID1379019 | Antioxidant activity assessed as inhibition of AAPH-induced peroxyl radical generation measured as trolox equivalent preincubated for 15 mins followed by AAPH addition measured every min for 120 mins by ORAC-FL assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID640564 | Inhibition of BuChE | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease. |
| AID241141 | Inhibitory concentration Acetylcholinesterase | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors. |
| AID1379012 | Selectivity index, ratio of IC50 for equine serum BChE to IC50 for electric eel AChE | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID296910 | Inhibition of human recombinant BChE | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. |
| AID44295 | Inhibitory potency was evaluated against isolated Butyrylcholinesterase | 2003 | Journal of medicinal chemistry, Jun-05, Volume: 46, Issue:12
| 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. |
| AID1632240 | Inhibition of acetylcholinesterase (unknown origin) | 2016 | Bioorganic & medicinal chemistry, 10-01, Volume: 24, Issue:19
| Coumarin derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies. |
| AID1360320 | Inhibition of human AChE | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and β-secretase inhibition activities. |
| AID296911 | Inhibition of human AChE-mediated beta amyloid 1-40 aggregation at 100 uM | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
| Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. |
| AID31502 | Inhibitory potency was evaluated against recombinant human AChE | 2003 | Journal of medicinal chemistry, Jun-05, Volume: 46, Issue:12
| 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. |
| AID462784 | Selectivity ratio of IC50 for human BuChE to human recombinant AChE | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. |
| AID315645 | Inhibition of human recombinant AChE by Ellman method | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
| Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. |
| AID1379011 | Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 180 secs by spectrophotometric analysis | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID1379020 | Inhibition of HFIP pretreated amyloid beta (1 to 42) (unknown origin) self-aggregation at 20 uM after 48 hrs by thioflavin T fluorescence assay relative to control | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID462786 | Inhibition of human recombinant AChE-induced amyloid beta (1-40) aggregation at 100 uM by thioflavin T fluorescence assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. |
| AID1486228 | Inhibition of recombinant human AChE using acetylthiocholine as substrate by Ellman's method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15
| Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety. |
| AID1796570 | Cholinesterase Inhibition Assay from Article 10.1021/jm0340602: \\3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function | 2003 | Journal of medicinal chemistry, Jun-05, Volume: 46, Issue:12
| 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |