Page last updated: 2024-08-16

resveratrol and sirolimus

resveratrol has been researched along with sirolimus in 62 studies

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (6.45)	29.6817
2010's	46 (74.19)	24.3611
2020's	12 (19.35)	2.80

Authors

Authors	Studies
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P	1
Chen, Y; Feng, F; Li, Q; Liu, W; Liu, Y; Sun, H; Xing, S	1
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S	1
Blagosklonny, MV	2
Chen, Y; Li, B; Liu, CG; Liu, X; Ren, X; Wu, H; Yang, JM; Zhu, H	1
Kaeberlein, M	1
Armour, SM; Baur, JA; Hsieh, SN; Land-Bracha, A; Sinclair, DA; Thomas, SM	1
Allison, DB; Nagy, TR; Smith, DL	1
Kroemer, G; Madeo, F; Tavernarakis, N	1
Astle, CM; Baur, JA; Boyd, AR; de Cabo, R; Fernandez, E; Flurkey, K; Harrison, DE; Javors, MA; Miller, RA; Nadon, NL; Nelson, JF; Orihuela, CJ; Pletcher, S; Sharp, ZD; Sinclair, D; Starnes, JW; Strong, R; Wilkinson, JE	1
Eng, C; He, X; Orloff, M; Wang, Y; Zhu, J	1
Criollo, A; Galluzzi, L; Kroemer, G; Madeo, F; Maiuri, MC; Malik, SA; Markaki, M; Megalou, E; Michaud, M; Morselli, E; Palikaras, K; Pasparaki, A; Tavernarakis, N; Vitale, I	1
Ebersole, J; González, O; Novak, MJ; Tobia, C	1
BenYounès, A; Harper, F; Kroemer, G; Maiuri, MC; Malik, SA; Mariño, G; Shen, S	1
Boylan, JM; Gruppuso, PA; Tatar, M; Villa-Cuesta, E	1
Guo, JZ; He, Y; Lu, D; Song, R; Sun, L; Wang, WM; Xiao, CJ; Zhang, W; Zhong, LM; Zong, Y	1
Bai, X; Cai, G; Chen, X; Ding, R; Feng, Z; Fu, B; Liu, F; Liu, W; Sun, L; Zhang, S; Zhuo, L	1
Castillo-Pichardo, L; Dharmawardhane, SF	1
Bourzac, K	1
Blagosklonny, MV; Demidenko, ZN; Leontieva, OV; Paszkiewicz, G	1
Darzynkiewicz, Z; Halicka, HD; Hsieh, TC; Lee, YS; Li, J; Wu, JM; Zhao, H	1
Duan, WJ; He, RR; Kurihara, H; Li, YF; Liu, FL; Su, WW; Tsoi, B; Yao, XS; Yuan, WL	1
Kitada, M; Koya, D	1
Han, C; He, F; He, H; Li, L; Liu, D; Liu, H; Ma, S; Pan, Z; Wan, H; Wang, J; Wei, S; Xu, F; Xu, H	1
Cohen, H; Gabay, O; Ruppin, E; Yizhak, K	1
Alayev, A; Berger, SM; Holz, MK; Snyder, RB; Sun, Y; Yu, JJ	1
Guo, S; Khaitovich, P; Somel, M; Zhao, G	1
Selman, C	1
Aresu, G; Athanasakis, E; Avolio, E; Barchiesi, A; Beltrami, AP; Beltrami, CA; Caragnano, A; Cesselli, D; Emanueli, C; Finato, N; Gianfranceschi, G; Katare, R; Livi, U; Madeddu, P; Mazzega, E; Meloni, M; Palma, A; Scoles, G; Toffoletto, B; Vascotto, C	1
Alayev, A; Berger, SM; Holz, MK; Kramer, MY; Schwartz, NS	1
Alayev, A; Holz, MK; Li, C; Salamon, RS; Schwartz, NS; Sun, Y; Yu, JJ	1
Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; Pedro, JM; Pizarro-Estrella, E; Rodríguez-Arribas, M; Yakhine-Diop, SM	1
Garten, A; Händel, N; Kässner, F; Kiess, W; Körner, A; Leipert, J; Schuster, S	1
Cai, SH; Chen, JL; Deng, J; Duan, WJ; He, RR; Kurihara, H; Li, YF; Liu, FL; Tsoi, B; Wang, Q; Wu, YP; Yuan, WL	1
Alayev, A; Berman, AY; Holz, MK; Salamon, RS; Schwartz, NS; Wiener, SL	1
Libert, C; Van Cauwenberghe, C; Vandenbroucke, RE; Vandendriessche, C	1
Huffman, DM; LeBrasseur, NK; Schafer, MJ	1
Bae, JW; Hyun, DW; Jung, MJ; Kim, MS; Kim, PS; Lee, J; Shin, NR; Whon, TW; Yun, JH	1
He, YH; Jing, T; Li, TT; Li, YX; Lin, R; Wang, WR; Yang, XF; Zhang, JY; Zhang, W	1
Anderson, RM; Balasubramanian, P; Mattison, JA	1
Chu, H; Jiang, S; Liu, L; Liu, Q; Qiu, J; Wan, W; Wang, J; Xue, Y; Zheng, S; Zhu, X; Zou, H	1
Chen, J; Fei, DD; Hu, CH; Huang, WT; Jin, Y; Liu, N; Lu, YB; Lv, YJ; Pang, DL; Sui, BD; Xuan, K; Zhao, P; Zheng, CX; Zhou, CH	1
Byun, S; Lee, E; Lee, KW	1
Ding, DF; Dong, CL; Lu, YB; Ma, JH; Pan, ML; Xu, XH; Ye, XL; Yong, HJ; You, N; You, Q	1
Klimova, B; Kuca, K; Novotny, M	1
Arevalo-Garcia, R; Marti-Nicolovius, M	1
Cai, GY; Chen, XM; Wang, SY	1
Kim, DU; Kim, SW; Kwak, B	1
Bernier, M; de Cabo, R; Di Germanio, C; Moats, JM; Palliyaguru, DL	1
Adamcova, E; Alwasel, S; Harrath, AH; Mai, A; Mansour, L; Mlyncek, M; Rotili, D; Sirotkin, AV	1
Angella, L; Caleo, M; Cecchini, M; Del Grosso, A; Giordano, N; Moscardini, A; Rocchiccioli, S; Tonazzini, I	1
Choi, YJ	1
Bian, P; Hu, W; Li, L; Liu, C	1
Benedetti, F; Buriani, A; Fortinguerra, S; Scapagnini, G; Sorrenti, V; Zella, D	1
Cipolli, W; Jimenez, AG; Lalwani, S	1
Brandon, AE; Cogger, VC; Cooney, GJ; Gokarn, R; Hunt, NJ; James, DE; Le Couteur, DG; Parker, BL; Pulpitel, T; Raubenheimer, D; Senior, AM; Simpson, SJ; Solon-Biet, SM; Wali, JA	1
Islam, MK; Lian, HK; Lim, JCW; Sagineedu, SR; Selvarajoo, N; Stanslas, J	1
Chen, L; Huang, S; Ji, T; Liu, B; Liu, C; Xu, C; Yang, L; Zhang, H; Zhang, N; Zhang, R; Zhu, C	1
Li, J; Lin, W; Long, G; Pan, P	1
Cole, AG; Gupta, N; Holz, MK; Ingledue, R; Kopras, EJ; McCormack, FX; McMahan, S; Robbins, N; Singla, A; Swigris, J; Zhang, B; Zhou, Y	1
Chorilli, M; Di Filippo, LD; Dos Reis, LR; Duarte, JL; Luiz, MT; Marena, GD; Oliveira Silva, VA; Sábio, RM; Sousa Araújo, VH; Souza Fernandes, L	1

Reviews

17 review(s) available for resveratrol and sirolimus

Article	Year
An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug discovery today, 2007, Volume: 12, Issue:5-6 Topics: Aging; Animals; Antioxidants; Caloric Restriction; Cell Cycle Proteins; Cellular Senescence; Drug Delivery Systems; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Longevity; Metformin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Resveratrol; Saccharomyces cerevisiae Proteins; Sirolimus; Sirtuins; Stilbenes	2007
Validation of anti-aging drugs by treating age-related diseases. Aging, 2009, Mar-28, Volume: 1, Issue:3 Topics: Aging; Animals; Antibiotics, Antineoplastic; Antioxidants; Biomarkers; Chronic Disease; Humans; Hypoglycemic Agents; Metformin; Resveratrol; Sirolimus; Stilbenes; Validation Studies as Topic	2009
Calorie restriction: what recent results suggest for the future of ageing research. European journal of clinical investigation, 2010, Volume: 40, Issue:5 Topics: Animals; Antimetabolites; Biomedical Research; Biomimetics; Caloric Restriction; Deoxyglucose; Enzyme Inhibitors; Hypoglycemic Agents; Longevity; Metformin; Primates; Quality of Life; Resveratrol; Sirolimus; Stilbenes	2010
Caloric restriction and chronic inflammatory diseases. Oral diseases, 2012, Volume: 18, Issue:1 Topics: Adaptive Immunity; Animals; Biomimetics; Caloric Restriction; Cardiovascular Diseases; Chronic Disease; Diabetes Mellitus; Humans; Immunity, Innate; Inflammation; Inflammation Mediators; Insulin-Like Growth Factor I; Metformin; Periodontitis; Resveratrol; Signal Transduction; Sirolimus; Sirtuins; Stilbenes; TOR Serine-Threonine Kinases	2012
Dietary restriction and the pursuit of effective mimetics. The Proceedings of the Nutrition Society, 2014, Volume: 73, Issue:2 Topics: Animals; Caloric Restriction; Energy Intake; Genetic Variation; Health; Humans; Longevity; Metformin; Resveratrol; Sirolimus; Stilbenes	2014
Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases? Current topics in medicinal chemistry, 2015, Volume: 15, Issue:21 Topics: Animals; Autophagy; Disease Models, Animal; Food; Humans; Isothiocyanates; Lithium; Neurodegenerative Diseases; Resveratrol; Sirolimus; Spermidine; Stilbenes; Sulfoxides; Trehalose; Valproic Acid	2015
Caloric restriction: beneficial effects on brain aging and Alzheimer's disease. Mammalian genome : official journal of the International Mammalian Genome Society, 2016, Volume: 27, Issue:7-8 Topics: Aging; Alzheimer Disease; Biomimetics; Brain; Caloric Restriction; Energy Metabolism; Humans; Resveratrol; Sirolimus; Stilbenes	2016
Energetic interventions for healthspan and resiliency with aging. Experimental gerontology, 2016, 12-15, Volume: 86 Topics: Aging; Caloric Restriction; Diet; Energy Intake; Exercise; Female; Humans; Longevity; Male; Metformin; Resveratrol; Sirolimus; Stilbenes	2016
Nutrition, metabolism, and targeting aging in nonhuman primates. Ageing research reviews, 2017, Volume: 39 Topics: Aging; Animals; Caloric Restriction; Fibroblast Growth Factors; Humans; Longevity; Macaca mulatta; Nutritional Status; Peroxisome Proliferator-Activated Receptors; Research; Resveratrol; Sirolimus; Stilbenes	2017
Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer. International journal of molecular sciences, 2017, Sep-12, Volume: 18, Issue:9 Topics: Adaptive Immunity; Animals; Autoimmune Diseases; Autophagy; Benzylisoquinolines; Cholecalciferol; Humans; Immune System Diseases; Immunity, Innate; Indoles; Infections; Isoquinolines; Lysosomes; Maprotiline; Metformin; Neoplasms; Phenols; Pyrroles; Resveratrol; Sirolimus; Spermidine; Stilbenes; Tetrahydroisoquinolines; Trehalose	2017
Anti-Aging Drugs - Prospect of Longer Life? Current medicinal chemistry, 2018, Volume: 25, Issue:17 Topics: Animals; Humans; Longevity; Metformin; NAD; Quality of Life; Resveratrol; Sirolimus; Stilbenes	2018
[Caloric restriction and memory during aging]. Revista de neurologia, 2018, 06-16, Volume: 66, Issue:12 Topics: Aged; Aged, 80 and over; Aging; Animals; Brain Chemistry; Caloric Restriction; Diet, Mediterranean; Female; Humans; Longevity; Male; Maze Learning; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Middle Aged; Models, Animal; Multicenter Studies as Topic; Rats; Rats, Inbred Strains; Resveratrol; Sirolimus	2018
Energy restriction in renal protection. The British journal of nutrition, 2018, Volume: 120, Issue:10 Topics: Aging; Animals; Autophagy; Caloric Restriction; Diet; Energy Metabolism; Female; Humans; Inflammation; Insulin; Kidney; Kidney Diseases; Male; Metformin; Models, Animal; Oxidative Stress; Phosphorus; Resveratrol; Salts; Sirolimus; Sirtuin 1	2018
Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions. Mechanisms of ageing and development, 2019, Volume: 180 Topics: Animals; Caloric Restriction; Frailty; Humans; Longevity; Metformin; Resveratrol; Sirolimus	2019
Shedding Light on the Effects of Calorie Restriction and its Mimetics on Skin Biology. Nutrients, 2020, May-24, Volume: 12, Issue:5 Topics: Animals; Caloric Restriction; Dermatologic Agents; Fasting; Humans; Inflammation; Metformin; Peroxisome Proliferator-Activated Receptors; Resveratrol; Sirolimus; Skin; Skin Aging; Wound Healing	2020
Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways. Viruses, 2020, 12-17, Volume: 12, Issue:12 Topics: Animals; Antiviral Agents; Host-Pathogen Interactions; Humans; Metformin; Resveratrol; Signal Transduction; Sirolimus; Virus Diseases; Virus Replication	2020
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment. Mini reviews in medicinal chemistry, 2022, Volume: 22, Issue:20 Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Fluorouracil; Humans; Metformin; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Sirolimus; TOR Serine-Threonine Kinases	2022

Other Studies

45 other study(ies) available for resveratrol and sirolimus

Article	Year
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship	2012
p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. Journal of medicinal chemistry, 2020, 09-24, Volume: 63, Issue:18 Topics: Animals; Atherosclerosis; Autophagy; Humans; Neurodegenerative Diseases; Osteitis Deformans; Protein Domains; Sequestosome-1 Protein; Signal Transduction; Tumor Suppressor Proteins	2020
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2. Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2 Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones	2022
Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy, 2009, Volume: 5, Issue:6 Topics: Apoptosis Regulatory Proteins; Autophagy; Base Sequence; Beclin-1; Cell Line, Tumor; Consensus Sequence; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; MicroRNAs; Molecular Sequence Data; Neoplasms; Oligonucleotide Array Sequence Analysis; Resveratrol; Sirolimus; Stilbenes; Vacuoles	2009
Resveratrol and rapamycin: are they anti-aging drugs? BioEssays : news and reviews in molecular, cellular and developmental biology, 2010, Volume: 32, Issue:2 Topics: Aging; Animals; Anti-Bacterial Agents; Antioxidants; Clinical Trials as Topic; Humans; Longevity; Resveratrol; Signal Transduction; Sirolimus; Stilbenes	2010
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging, 2009, Jun-03, Volume: 1, Issue:6 Topics: Animals; Autophagy; Cell Line; Humans; Mice; Quercetin; Resveratrol; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Stilbenes	2009
Can autophagy promote longevity? Nature cell biology, 2010, Volume: 12, Issue:9 Topics: Aging; Animals; Autophagy; Caenorhabditis elegans; Caloric Restriction; Cellular Senescence; Cytoprotection; Drosophila melanogaster; Humans; Immune System; Immunity; Longevity; Mice; Receptor, IGF Type 1; Resveratrol; Saccharomyces cerevisiae; Sirolimus; Sirtuin 1; Spermidine; Stilbenes; Tumor Suppressor Protein p53	2010
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. The journals of gerontology. Series A, Biological sciences and medical sciences, 2011, Volume: 66, Issue:2 Topics: Aging; Animals; Female; Genetic Heterogeneity; Longevity; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Resveratrol; Simvastatin; Sirolimus; Stilbenes	2011
Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer letters, 2011, Feb-28, Volume: 301, Issue:2 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Immunoblotting; Inhibitory Concentration 50; Membrane Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Resveratrol; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases	2011
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell death & disease, 2010, Volume: 1 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Autophagy; Caenorhabditis elegans; Caloric Restriction; Cell Line, Tumor; Humans; Longevity; Resveratrol; RNA Interference; RNA, Small Interfering; Sirolimus; Sirtuin 1; Stilbenes; Tumor Suppressor Protein p53	2010
Neuroendocrine regulation of autophagy by leptin. Cell cycle (Georgetown, Tex.), 2011, Sep-01, Volume: 10, Issue:17 Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Enzyme Activation; Female; HeLa Cells; Humans; Leptin; Liver; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Muscle, Skeletal; Plasmids; Receptors, Leptin; Recombinant Fusion Proteins; Resveratrol; Signal Transduction; Sirolimus; Spermidine; Stilbenes; Time Factors; TOR Serine-Threonine Kinases; Transfection	2011
Resveratrol inhibits protein translation in hepatic cells. PloS one, 2011, Volume: 6, Issue:12 Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Enzyme Activation; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-4F; Liver; Liver Neoplasms; Phosphorylation; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Stability; Proto-Oncogene Proteins c-akt; Rats; Resveratrol; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Transcription Factors	2011
Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. PloS one, 2012, Volume: 7, Issue:2 Topics: Animals; Cell Survival; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Gene Expression Regulation; I-kappa B Proteins; Inflammation; Interleukin-1beta; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Microglia; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; Proto-Oncogene Proteins c-akt; Resveratrol; RNA, Messenger; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha	2012
SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence. Mechanisms of ageing and development, 2012, Volume: 133, Issue:6 Topics: Animals; Cells, Cultured; Cellular Senescence; Enzyme Inhibitors; Gene Silencing; Hyperglycemia; Male; Mesangial Cells; Niacinamide; Rats; Rats, Wistar; Resveratrol; Sirolimus; Sirtuin 1; Stilbenes; TOR Serine-Threonine Kinases; Vitamin B Complex	2012
Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Nutrition and cancer, 2012, Volume: 64, Issue:7 Topics: Adenylate Kinase; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Catechin; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation; Humans; Mice; Mice, SCID; Polyphenols; Proto-Oncogene Proteins c-akt; Quercetin; Quinazolines; Resveratrol; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Vitis; Xenograft Model Antitumor Assays	2012
Interventions: Live long and prosper. Nature, 2012, Dec-06, Volume: 492, Issue:7427 Topics: Age of Onset; Aging; Animal Diseases; Animals; Biomedical Research; Caloric Restriction; Cardiovascular Diseases; Female; Gene Expression Profiling; Geriatrics; Humans; Longevity; Macaca mulatta; Male; Mice; Models, Animal; Neoplasms; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Resveratrol; Sirolimus; Sirtuins; Somatomedins; Stilbenes; TOR Serine-Threonine Kinases	2012
Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet. Cell death & disease, 2013, Jan-24, Volume: 4 Topics: Animals; Cell Line, Tumor; Cellular Senescence; Diet, High-Fat; Humans; Hyperinsulinism; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Insulin Resistance; Male; Mice; Obesity; Resveratrol; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Transcription, Genetic; Weight Gain	2013
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging, 2012, Volume: 4, Issue:12 Topics: Adaptor Proteins, Signal Transducing; Aspirin; Ataxia Telangiectasia Mutated Proteins; Berberine; Cell Cycle Proteins; Cell Line, Tumor; Cellular Senescence; Cholecalciferol; Deoxyglucose; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Flow Cytometry; Histones; Humans; Laser Scanning Cytometry; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidative Stress; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins	2012
Autophagy is involved in the effects of resveratrol on prevention of splenocyte apoptosis caused by oxidative stress in restrained mice. Molecular nutrition & food research, 2013, Volume: 57, Issue:7 Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Ascorbic Acid; Autophagy; Beclin-1; In Situ Nick-End Labeling; Male; Membrane Potential, Mitochondrial; Mice; Microtubule-Associated Proteins; Oxidative Stress; Reactive Oxygen Species; Resveratrol; Sirolimus; Spleen; Stilbenes; T-Lymphocyte Subsets; Up-Regulation	2013
The use of calorie restriction mimetics to study aging. Methods in molecular biology (Clifton, N.J.), 2013, Volume: 1048 Topics: Aging; Animals; Antioxidants; Biomimetics; Caloric Restriction; Immunosuppressive Agents; Longevity; Male; Mice; Mice, Inbred C57BL; Models, Animal; Resveratrol; Sirolimus; Sirtuin 1; Stilbenes; TOR Serine-Threonine Kinases	2013
RETRACTED: Role of mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes. Molecular and cellular endocrinology, 2014, 01-25, Volume: 382, Issue:1 Topics: Animals; Cell Proliferation; Cells, Cultured; Feeding Behavior; Geese; Gene Expression Regulation; Hepatocytes; Lipid Metabolism; Liver; Male; Mammals; Niacinamide; Resveratrol; RNA, Messenger; Sirolimus; Sirtuin 1; Stilbenes	2014
Model-based identification of drug targets that revert disrupted metabolism and its application to ageing. Nature communications, 2013, Volume: 4 Topics: Aging; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Algorithms; Caloric Restriction; Computer Simulation; Eicosanoids; Gene Expression Regulation, Fungal; Genome, Fungal; Genome, Human; Hormesis; Humans; Longevity; Metabolic Networks and Pathways; Models, Biological; Molecular Targeted Therapy; Reactive Oxygen Species; Resveratrol; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Stilbenes	2013
Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells. Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:3 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cells, Cultured; Drug Synergism; Humans; Lymphangioleiomyomatosis; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Proto-Oncogene Proteins c-akt; Resveratrol; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins	2014
Evolution of human longevity uncoupled from caloric restriction mechanisms. PloS one, 2014, Volume: 9, Issue:1 Topics: Adult; Aging; Animals; Brain; Caloric Restriction; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation; Humans; Longevity; Macaca mulatta; Male; Mice; Pan troglodytes; Resveratrol; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases	2014
Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction. Stem cells (Dayton, Ohio), 2014, Volume: 32, Issue:9 Topics: Animals; Cellular Senescence; Disease Models, Animal; Female; Humans; Mice; Mice, SCID; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Resveratrol; Signal Transduction; Sirolimus; Stem Cell Transplantation; Stilbenes	2014
The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells. Journal of cellular biochemistry, 2015, Volume: 116, Issue:3 Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Estrogen Receptor alpha; Female; Humans; Mechanistic Target of Rapamycin Complex 1; Models, Biological; Multiprotein Complexes; Proto-Oncogene Proteins c-akt; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Up-Regulation	2015
Effects of combining rapamycin and resveratrol on apoptosis and growth of TSC2-deficient xenograft tumors. American journal of respiratory cell and molecular biology, 2015, Volume: 53, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Drug Therapy, Combination; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphangioleiomyomatosis; Mechanistic Target of Rapamycin Complex 1; Mice, SCID; Multiprotein Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Resveratrol; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Treatment Outcome; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Uterine Neoplasms; Xenograft Model Antitumor Assays	2015
Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity. Nutrition and cancer, 2016, Volume: 68, Issue:2 Topics: Adipocytes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; G1 Phase Cell Cycle Checkpoints; Humans; Lipoma; Phosphorylation; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Resveratrol; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Stilbenes	2016
A SIRT3/AMPK/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages. Free radical biology & medicine, 2016, Volume: 95 Topics: AMP-Activated Protein Kinase Kinases; Animals; Antioxidants; Antipyrine; Apoptosis; Ascorbic Acid; Autophagy; Edaravone; Gene Expression Regulation; Macrophages; Membrane Potential, Mitochondrial; Mice; Oxidative Stress; Protein Kinases; RAW 264.7 Cells; Reactive Oxygen Species; Resveratrol; Sirolimus; Sirtuin 3; Stilbenes; Stress, Psychological	2016
Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer. Journal of cellular physiology, 2017, Volume: 232, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line; Cell Movement; Cell Proliferation; Embryo, Mammalian; Enzyme Activation; Fibroblasts; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Proto-Oncogene Proteins c-akt; Resveratrol; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins; Urinary Bladder Neoplasms	2017
Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice. Scientific reports, 2016, 07-29, Volume: 6 Topics: Animals; Bacteria; Blood Glucose; Clostridium; Diet, High-Fat; Gastrointestinal Microbiome; Glucose Intolerance; Glucose Tolerance Test; Insulin; Intestines; Lactococcus; Male; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Inbred C57BL; Obesity; Resveratrol; Signal Transduction; Sirolimus; Stilbenes	2016
SIRT1 Regulates the Inflammatory Response of Vascular Adventitial Fibroblasts through Autophagy and Related Signaling Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 41, Issue:2 Topics: Adventitia; Animals; Autophagy; Benzamides; Cells, Cultured; Fibroblasts; Heterocyclic Compounds, 3-Ring; Interleukin-1beta; Interleukin-6; Male; Naphthols; NLR Family, Pyrin Domain-Containing 3 Protein; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Resveratrol; RNA, Small Interfering; Signal Transduction; Sirolimus; Sirtuin 1; Stilbenes; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha	2017
Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway. Journal of dermatological science, 2017, Volume: 87, Issue:2 Topics: Animals; Biopsy; Bleomycin; Cells, Cultured; Collagen; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Gene Knockdown Techniques; Humans; Immunohistochemistry; Mice; Mice, Inbred C3H; Phosphorylation; Real-Time Polymerase Chain Reaction; Resveratrol; RNA, Messenger; Scleroderma, Systemic; Signal Transduction; Sirolimus; Sirtuin 1; Skin; Stilbenes; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha	2017
Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application. Aging cell, 2017, Volume: 16, Issue:5 Topics: Acetyl-CoA Carboxylase; Administration, Cutaneous; Aging; AMP-Activated Protein Kinases; Animals; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Activation; Female; Gene Expression Regulation; Metformin; Mice; Neovascularization, Physiologic; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Resveratrol; Ribosomal Protein S6 Kinases; Sirolimus; Skin; Skin Aging; Stilbenes; Tumor Suppressor Protein p53; Wound Healing; Wounds, Nonpenetrating	2017
Resveratrol transcriptionally regulates miRNA-18a-5p expression ameliorating diabetic nephropathy via increasing autophagy. European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:21 Topics: Adenine; Animals; Ataxia Telangiectasia Mutated Proteins; Autophagy; Caspase 3; Cell Line; Creatinine; Diabetes Mellitus, Experimental; Down-Regulation; Male; Mice; Mice, Obese; MicroRNAs; Microtubule-Associated Proteins; Resveratrol; RNA Interference; RNA, Small Interfering; Sirolimus; Stilbenes; Up-Regulation	2017
Phosphodiesterase 4B is an effective therapeutic target in colorectal cancer. Biochemical and biophysical research communications, 2019, 01-15, Volume: 508, Issue:3 Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Azepines; Carcinogenesis; Cell Line, Tumor; Colorectal Neoplasms; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; Phosphodiesterase 4 Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Resveratrol; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Triazoles	2019
Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells. European journal of pharmacology, 2019, Jul-05, Volume: 854 Topics: Apoptosis; Biological Products; Caspase 3; Cell Line; Cell Proliferation; Female; Humans; Ovary; Protein Kinase Inhibitors; Quinazolinones; Resveratrol; Sirolimus; Sirtuin 1; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53	2019
Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease. Neurobiology of disease, 2019, Volume: 129 Topics: Animals; Autophagy; Biomarkers; Brain; Leukodystrophy, Globoid Cell; Mice; Resveratrol; Sciatic Nerve; Sirolimus	2019
Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved. Archives of biochemistry and biophysics, 2020, 08-15, Volume: 689 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Humans; Mice, Inbred BALB C; Mice, Nude; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Resveratrol; Signal Transduction; Sirolimus; Thyroid Cancer, Papillary; Thyroid Neoplasms; TOR Serine-Threonine Kinases	2020
Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age. GeroScience, 2021, Volume: 43, Issue:4 Topics: Animals; Dogs; Fibroblasts; Longevity; Metformin; Resveratrol; Sirolimus	2021
Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin. Cell metabolism, 2021, 12-07, Volume: 33, Issue:12 Topics: Animals; Liver; Metformin; Mice; Proteome; Resveratrol; Sirolimus	2021
Neuroprotection of resveratrol against cadmium-poisoning acts through dual inhibition of mTORC1/2 signaling. Neuropharmacology, 2022, 11-15, Volume: 219 Topics: Animals; Cadmium; Caspase 3; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Neuroprotection; Phosphorylation; Polyphenols; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Resveratrol; Sirolimus; TOR Serine-Threonine Kinases	2022
Effects of Resveratrol on Hepatitis B Virus Replication: In vitro and in vivo Experiments. Intervirology, 2022, Volume: 65, Issue:4 Topics: Beclin-1; Hepatitis B; Hepatitis B virus; Humans; MicroRNAs; Resveratrol; Sirolimus; Virus Replication	2022
Safety and Efficacy of Combined Resveratrol and Sirolimus in Lymphangioleiomyomatosis. Chest, 2023, Volume: 163, Issue:5 Topics: Forced Expiratory Volume; Humans; Lymphangioleiomyomatosis; Middle Aged; Quality of Life; Resveratrol; Sirolimus; Vascular Endothelial Growth Factor D	2023
Design of rapamycin and resveratrol coloaded liposomal formulation for breast cancer therapy. Nanomedicine (London, England), 2023, Volume: 18, Issue:10 Topics: Antioxidants; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Liposomes; Resveratrol; Sirolimus	2023