Gangliosidoses

A group of autosomal recessive lysosomal storage disorders marked by the accumulation of GANGLIOSIDES. They are caused by impaired enzymes or defective cofactors required for normal ganglioside degradation in the LYSOSOMES. Gangliosidoses are classified by the specific ganglioside accumulated in the defective degradation pathway.

Synonym
Gangliosidoses

Excerpt	Reference
"The gangliosidoses are hereditary diseases with a recessive mode of inheritance and are caused by a genetically induced enzymatic block, which results in the accumulation of gangliosides in various tissues of the body, mainly in the brain."	( Adachi, M; Schneck, L; Volk, BW, 1975)
"GM2-gangliosidoses are neurological disorders caused by a genetic deficiency of either the beta-hexosaminidase A or the GM2 activator, a glycolipid binding protein."	( Sandhoff, K; Schnabel, D; Schröder, M; Suzuki, K, 1991)
"Gangliosidoses are very rare neurological diseases based on specific enzyme defects."	( Schwab, ME; Vassella, F, 1984)
"GM1 and GM2 gangliosidoses are progressive neurodegenerative diseases which accumulate intralysosomal gangliosides--and to a lesser extent oligosaccharides--chiefly in the central and peripheral nervous system owing to deficiencies of beta-galactosidase and hexosaminidases A or/and B, respectively."	( Goebel, HH, 1984)
"The GM1 gangliosidoses are clinically characterized by the combination of a degenerative process in the brain and of storage phenomena in extra-neural tissues, particularly in bones and visceral organs."	( Kohlschütter, A, 1984)
"GM1 and GM2 gangliosidoses are progressive neurodegenerative lysosomal storage diseases resulting from the excessive accumulation of GM1 and GM2 gangliosides in the lysosomes, respectively."	( Hasegawa, D; Kawaguchi, H; Kohyama, M; Nakamoto, Y; Ochiai, K; Takahashi, K; Tsuboi, M; Uchida, K; Yabuki, A; Yamato, O, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	236 (79.73)	23.3326
1990's	43 (14.53)	12.5806
2000's	10 (3.38)	18.1394
2010's	5 (1.69)	28.8240
2020's	2 (0.68)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	3	0
choline	low	1	0
chlorine	low	3	0
glycine	low	4	0
pyridoxine	low	2	0
uric acid	low	2	0
fluoxetine	low	1	0
imipramine	low	1	0
perhexiline	low	1	0
phenylmethylsulfonyl fluoride	low	1	0
sodium fluoride	low	1	0
trihexyphenidyl	low	1	0
carbachol	low	1	0
serine	low	1	0
aspartic acid	low	1	0
galactose	low	7	0
leucine	low	1	0
lactose	low	1	0
methionine	low	1	0
phenylalanine	low	1	0
cycloheximide	low	2	0
mannitol	low	1	0
asparagine	low	1	0
histidine	low	2	0
tryptophan	low	1	0
arginine	low	3	0
taurocholic acid	low	5	0
thiazoles	low	1	0
chenodeoxycholic acid	low	1	0
lithium carbonate	low	1	0
fucose	low	4	0
mannose	low	8	0
mercury	low	1	0
aluminum chloride	low	1	0
acetylglucosamine	low	6	0
ferric chloride	low	1	0
ammonium chloride	low	2	0
phytanic acid	low	1	0
1-deoxynojirimycin	medium	3	1
glutamic acid	low	2	0
acetylgalactosamine	low	1	0
phorbol 12,13-dibutyrate	low	1	0
colforsin	low	1	0
fenoxycarb	low	1	0
miglustat	medium	2	1
glucose, (beta-d)-isomer	low	1	0
5-bromo-4-chloro-3-indolyl beta-galactoside	low	1	0
metaperiodate	low	1	0
delphinidin	low	1	0
phorbol-12,13-dibenzoate	low	1	0
leupeptin	low	2	0
nitrophenylgalactosides	low	1	0
1-phenyl-2-decanoylamino-3-morpholino-1-propanol	low	1	0
4-methylumbelliferyl 2-acetamido-2-deoxy-beta-d-glucopyranoside	low	2	0
sulforhodamine 101	low	1	0
2'-(4-methylumbelliferyl)-alpha-d-n-acetylneuraminic acid	low	1	0
n-acetylglucosaminylasparagine	low	2	0
2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	low	1	0
4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-glucopyranoside	low	3	0
glycerophosphoinositol 4,5-bisphosphate	low	1	0
beta-d-galactopyranosylmethyl-4-nitrophenyltriazene	low	1	0
biotin	low	1	0
migalastat	low	1	0
cholic acid	low	1	0
deoxycholic acid	low	1	0
leupeptins	low	2	0
glycogen	low	2	0
arabinose	low	1	0
n-acetylneuraminic acid	low	4	0
glucosamine	low	4	0
elastin	low	1	0
resveratrol	low	1	0
keratan sulfate	low	1	0
isofagomine	low	1	0
phorbol-12,13-didecanoate	low	1	0
isomethyleugenol	low	1	0
stilbenes	low	1	0
safranine t	low	1	0
sodium taurodeoxycholate	low	2	0
lithium	low	1	0
cystine	low	1	0
sodium borohydride	low	1	0
myelin basic protein	low	1	0
sphingosine	low	1	0
bilirubin	low	1	0
psychosine	low	1	0
hymecromone	low	6	0
n-acetylglucosamine thiazoline	low	1	0
cytochalasin b	low	1	0
aluminum	low	1	0
methylazoxymethanol acetate	low	1	0
cysteine	low	1	0
pepstatin	low	1	0
cdw17 antigen	low	2	0
ganglioside, gd1b	low	1	0
trisialoganglioside gt1	low	1	0
asialo gm1 ganglioside	low	3	0
i(3)so3-galactosylceramide	low	2	0
flag peptide	low	1	0
mocetinostat	low	1	0
g(m2) ganglioside	low	84	0
g(m1) ganglioside	medium	153	0
acid phosphatase	low	3	0
nad	low	1	0
cholera toxin, b subunit (50-64)	low	1	0
phosphatidylcholines	low	1	0
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	low	1	0
ganglioside, gd1a	low	2	0
glycolipids	low	20	0
piperidines	low	2	0
heparitin sulfate	low	1	0
g(m3) ganglioside	low	5	0
chondroitin sulfates	low	1	0
ganglio-n-triaosylceramide	low	2	0
guanosine 5'-o-(3-thiotriphosphate)	low	1	0
guanylyl imidodiphosphate	low	1	0
eye	low	5	0
concanavalin a	low	7	0
phosphorus radioisotopes	low	1	0

Protein Targets (973)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
glucocerebrosidase	5	0	0	5
Alpha-mannosidase	0	1	0	1
alpha-galactosidase	5	0	0	5
Trehalase	0	3	0	3
lysosomal alpha-glucosidase preproprotein	4	0	0	4
Trehalase	0	1	0	1
Maltase-glucoamylase, intestinal	0	4	0	4
Trehalase	0	3	0	3
Lysosomal acid glucosylceramidase	0	5	0	6
Alpha-galactosidase A	0	2	0	2
Alpha-glucosidase MAL62	0	2	0	2
Lactase-phlorizin hydrolase	0	3	0	3
Lysosomal alpha-glucosidase	0	5	0	5
Beta-glucosidase A	0	2	0	2
Sucrase-isomaltase, intestinal	0	3	0	3
Alpha-1B adrenergic receptor	0	5	0	5
Sucrase-isomaltase, intestinal	0	5	0	5
Alpha-1D adrenergic receptor	0	5	0	5
Beta-glucosidase	0	2	0	2
Protein-lysine 6-oxidase	0	4	0	4
Alpha-mannosidase 2	0	2	0	2
Glycogen debranching enzyme	0	4	0	4
Glycogen debranching enzyme	0	2	0	2
Alpha-glucosidase MAL32	0	1	0	1
Alpha-1A adrenergic receptor	0	5	0	5
Oligo-1,6-glucosidase IMA1	0	1	0	1
Alpha-glucosidase MAL12	0	3	0	3
Oxysterols receptor LXR-beta	0	1	0	1
Spike glycoprotein	3	0	1	4
Alpha-amylase	0	1	0	1
Trehalose synthase/amylase TreS	0	2	0	2
Lactase-phlorizin hydrolase	0	5	0	5
Oxysterols receptor LXR-alpha	0	1	0	1
Neutral alpha-glucosidase AB	0	2	0	2
Ceramide glucosyltransferase	0	3	0	3
Lysosomal acid glucosylceramidase	0	2	0	2
Probable maltase-glucoamylase 2	0	1	0	1
Beta-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	4	0	4
Cytosolic beta-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	5	0	5
Putative alpha-glucosidase	0	2	0	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	6	0	8
Cannabinoid receptor 1	0	1	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	8	0	0	8
phosphopantetheinyl transferase	7	0	0	7
NFKB1 protein, partial	1	0	0	1
GLS protein	4	0	0	4
thyroid stimulating hormone receptor	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
cytochrome P450 2C19 precursor	2	0	0	2
chromobox protein homolog 1	11	0	0	11
flap endonuclease 1	3	0	0	3
DNA polymerase iota isoform a (long)	5	0	0	5
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	7	0	0	7
Carbonic anhydrase 1	0	5	0	12
Carbonic anhydrase 2	0	5	0	12
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	6
Amino acid transporter	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Ferritin light chain	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
arylsulfatase A	4	0	0	4
Bloom syndrome protein isoform 1	6	0	0	6
lamin isoform A-delta10	11	0	0	11
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	6	3	12
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	6	3	12
Glutamate receptor ionotropic, NMDA 2B	0	6	3	12
Glutamate receptor ionotropic, NMDA 2C	0	6	3	12
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Glutamate receptor ionotropic, NMDA 2D	0	6	3	12
Glutamate receptor ionotropic, NMDA 3B	0	6	3	12
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	6	3	12
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, Cruzipain	3	0	0	3
USP1 protein, partial	6	0	0	6
Microtubule-associated protein tau	5	0	0	5
vitamin D3 receptor isoform VDRA	4	0	0	4
DNA polymerase kappa isoform 1	5	0	0	5
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Solute carrier organic anion transporter family member 1B1	0	2	0	4
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
RAR-related orphan receptor gamma	9	0	0	9
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	0	1	0	1
estrogen nuclear receptor alpha	14	0	0	14
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, Beta-lactamase	2	0	0	2
acetylcholinesterase	2	0	0	2
GALC protein	2	0	0	2
TDP1 protein	12	0	0	12
AR protein	14	0	0	14
peroxisome proliferator activated receptor gamma	10	0	0	10
IDH1	6	0	0	6
thyroid stimulating hormone receptor	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
geminin	12	0	0	12
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Muscarinic acetylcholine receptor M2	0	4	2	7
Muscarinic acetylcholine receptor M4	0	6	2	9
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	4
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	3	0	4
Muscarinic acetylcholine receptor M5	0	8	2	11
Neuronal acetylcholine receptor subunit alpha-4	0	3	0	3
Muscarinic acetylcholine receptor M2	0	2	0	3
Muscarinic acetylcholine receptor M1	0	8	2	11
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	3	0	3
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	8	2	11
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Delta-type opioid receptor	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-9	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	2	3
Muscarinic acetylcholine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	0	2
Luciferase	6	0	0	6
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	11	0	0	11
farnesoid X nuclear receptor	5	0	0	5
peroxisome proliferator-activated receptor delta	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
caspase-3	3	0	0	3
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
Bile salt export pump	0	5	0	6
Cellular tumor antigen p53	9	0	0	9
Alpha-2A adrenergic receptor	0	1	2	3
Vitamin D3 receptor	0	3	3	6
Alpha-2B adrenergic receptor	0	2	2	4
Alpha-2C adrenergic receptor	0	0	2	2
Retinoic acid receptor RXR-alpha	0	0	1	1
Guanine nucleotide-binding protein G	1	0	0	1
Ileal sodium/bile acid cotransporter	0	4	0	5
TAR DNA-binding protein 43	6	0	0	6
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	1	5	6
Bile acid receptor	0	0	3	3
Carbonic anhydrase 4	0	3	0	6
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase 15	0	2	0	5
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Phospholipase A2	0	0	1	1
G-protein coupled bile acid receptor 1	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Acetylcholinesterase	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Solute carrier family 22 member 1	0	2	0	3
High affinity choline transporter 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
glp-1 receptor, partial	5	0	0	5
pregnane X receptor	3	0	0	3
GLI family zinc finger 3	10	0	0	10
estrogen receptor 2 (ER beta)	7	0	0	7
progesterone receptor	6	0	0	6
pregnane X nuclear receptor	4	0	0	4
G	5	0	0	5
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
thyroid hormone receptor beta isoform 2	6	0	0	6
steroidogenic factor 1	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
peripheral myelin protein 22	5	0	0	5
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Rap guanine nucleotide exchange factor 3	2	0	0	2
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
ATP-dependent translocase ABCB1	0	3	0	4
5-hydroxytryptamine receptor 1A	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 1	0	2	1	3
Glutamate receptor 2	6	2	1	9
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
Inositol hexakisphosphate kinase 1	5	0	0	5
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	6	0	0	6
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
cytochrome P450 2C9, partial	5	0	0	5
interleukin 8	1	0	0	1
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	2	0	0	2
PPM1D protein	3	0	0	3
Smad3	2	0	0	2
EWS/FLI fusion protein	6	0	0	6
polyprotein	2	0	0	2
67.9K protein	3	0	0	3
P53	2	0	0	2
RPL19A	0	0	1	1
activating transcription factor 6	5	0	0	5
Histone H2A.x	4	0	0	4
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
cellular tumor antigen p53 isoform a	2	0	0	2
thyroid hormone receptor beta isoform a	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	1	2
ras-related protein Rab-9A	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	3	0	0	3
COUP transcription factor 2 isoform a	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	3	2	0	5
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	3	2	0	5
Gamma-aminobutyric acid receptor subunit delta	3	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	3	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	3	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	3	2	0	5
Alpha-synuclein	1	1	0	2
Nuclear receptor ROR-gamma	2	0	0	2
Eukaryotic initiation factor 4A-I	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	2	1	6
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	3	2	0	5
Gamma-aminobutyric acid receptor subunit beta-2	3	2	1	6
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
GABA theta subunit	3	2	0	5
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	3	2	0	5
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	1
thioredoxin glutathione reductase	2	0	0	2
PINK1	1	0	0	1
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
neutrophil cytosol factor 1	0	1	0	1
mitogen-activated protein kinase 1	2	0	0	2
Solute carrier family 2, facilitated glucose transporter member 3	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	0	1	0	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Steroid Delta-isomerase	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
regulator of G-protein signaling 4	7	0	0	7
cytochrome P450 2D6	4	0	0	4
D(1A) dopamine receptor	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
huntingtin isoform 2	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	4	0	4
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	7	0	7
5-hydroxytryptamine receptor 2C	0	4	0	4
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C9	0	3	0	3
Angiotensin-converting enzyme	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Alpha-2B adrenergic receptor	0	4	0	4
Acetylcholinesterase	0	1	0	1
Alpha-2C adrenergic receptor	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent noradrenaline transporter	0	8	2	10
Sodium-dependent dopamine transporter	0	5	0	5
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
5-hydroxytryptamine receptor 2B	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Sodium-dependent serotonin transporter	0	4	2	6
Sodium-dependent serotonin transporter	0	4	0	4
Cytochrome P450 2C19	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	3	0	3
Cytochrome P450 2J2	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	3	1	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Cytochrome P450 1B1	0	3	0	3
Sigma intracellular receptor 2	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	4	0	4
Histamine H3 receptor	0	1	0	1
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Beta-galactosidase	0	4	0	4
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
transcriptional regulator ERG isoform 3	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Glycogen phosphorylase, muscle form	0	2	0	2
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	1	0	1	2
Integrin alpha-IIb	1	0	1	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	1	2	0	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	6	0	7
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, Probable hydrogenase nickel incorporation protein hypB	0	0	1	1
Chain B, Probable hydrogenase nickel incorporation protein hypB	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	2	0	5
Plasma kallikrein	0	1	0	4
Carbonic anhydrase 3	0	1	0	4
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 6	0	1	0	4
Adenosine receptor A1	0	0	0	2
Adenosine receptor A2a	0	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	5
Carbonic anhydrase 7	0	1	0	4
Carbonic anhydrase	0	0	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	3	0	6
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 13	0	0	0	3
Carbonic anhydrase 14	0	1	0	4
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
cytochrome P450 2C9 precursor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
heat shock protein beta-1	2	0	0	2
Acetylcholinesterase	0	3	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Genome polyprotein	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Histamine H2 receptor	3	1	0	4
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Cholinesterase	0	3	0	3
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Oleandomycin glycosyltransferase	0	0	0	1
Snq2p	0	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	1	0	2
Prostaglandin G/H synthase 1	0	2	1	3
D(2) dopamine receptor	0	2	0	2
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	2	0	2
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Histamine H1 receptor	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Envelope glycoprotein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Translocator protein	0	1	0	1
Beta-galactosidase	0	1	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
Cathepsin B	0	1	0	1
Prothrombin	0	1	0	1
Plasminogen	0	1	0	1
Cationic trypsin	0	1	0	1
Trypsin	0	1	0	1
Papain	0	1	0	1
Serine protease hepsin	0	1	0	1
Plasminogen	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Cathepsin B	0	1	0	1
Cathepsin B	0	3	0	3
Pro-cathepsin H	0	2	0	2
Trypsin-3	0	1	0	1
Calpain-1 catalytic subunit	0	1	0	1
Cathepsin K	0	1	0	1
Hepatocyte growth factor activator	0	1	0	1
Transmembrane protease serine 6	0	1	0	1
Cysteine protease	0	2	0	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine protease falcipain-3	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Alpha-mannosidase 2C1	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
15-lipoxygenase, partial	1	0	0	1
Beta-galactosidase	0	1	0	1
Alpha-galactosidase	0	2	0	2
Beta-galactosidase	0	1	0	1
Beta-galactosidase	0	1	0	1
Alpha-galactosidase C	0	1	0	1
Sucrase-isomaltase	0	1	0	1
Ceramide glucosyltransferase	0	1	0	1
Beta-galactosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	2	0	2
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, Beta-n-acetylhexosaminidase	0	1	0	1
Chain A, N-acetyl-beta-D-glucosaminidase	0	1	0	1
Chain A, ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D	0	0	1	1
Protein O-GlcNAcase	0	1	0	1
Beta-N-acetylhexosaminidase	0	1	0	1
Beta-hexosaminidase subunit alpha	0	1	0	1
Beta-hexosaminidase subunit beta	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
nonstructural protein 1	1	0	0	1
Chain A, CATHEPSIN D	0	1	0	1
Chain B, CATHEPSIN D	0	1	0	1
Chain A, PLASMEPSIN II	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain E, ENDOTHIAPEPSIN	0	1	0	1
Chain E, RHIZOPUSPEPSIN	0	1	0	1
Chain E, ENDOTHIAPEPSIN	0	1	0	1
Chain E, ENDOTHIAPEPSIN	0	1	0	1
Chain E, RHIZOPUSPEPSIN	0	1	0	1
Chain E, RHIZOPUSPEPSIN	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Pepsin A	0	2	0	2
Renin	0	2	0	2
Cathepsin D	0	3	0	4
Candidapepsin-2	0	1	0	1
Pepsin A-5	0	1	0	1
Gag-Pro polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cathepsin E	0	1	0	1
Plasmepsin-1	0	1	0	1
Plasmepsin-2	0	1	0	1
Cathepsin D	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 9	0	1	0	1
Plasmepsin 4	0	1	0	1
Protease	0	1	0	1
Chymotrypsin-C	0	1	0	1
Protease	0	2	0	2
Tyrosine-protein kinase Fyn	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	1	4
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Neutrophil elastase	0	1	0	1
Myeloblastin	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Proto-oncogene vav	0	0	1	1
Protein kinase C alpha type	0	1	2	4
Protein kinase C eta type	0	1	1	2
Protein kinase C delta type	0	1	1	2
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	1	1	2
Protein kinase C delta type	0	1	1	2
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Fatty acid-binding protein, liver	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Pyridoxal kinase	0	0	0	1
Bile salt export pump	0	1	0	2
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
BRCA1	1	0	0	1
ClpP	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
pyruvate kinase	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
histone deacetylase 9 isoform 3	2	0	0	2
glucokinase regulatory protein	1	0	0	1
DNA polymerase beta	2	0	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Vif	0	1	0	1
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
POsterior Segregation	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	1
Polyphenol oxidase 2	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Tyrosine-protein kinase ABL1	0	1	0	2
Myc proto-oncogene protein	0	1	0	2
Transthyretin	0	0	1	1
Estrogen receptor	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Amyloid-beta precursor protein	0	1	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Cholinesterase	0	1	0	1
Luciferin 4-monooxygenase	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Breakpoint cluster region protein	0	1	0	2
Tyrosinase	0	3	0	3
Aromatase	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Tyrosinase	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Estrogen receptor	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Dipeptidyl peptidase 4	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Squalene synthase	0	1	0	1
Transcription factor p65	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	3
Tubulin beta-2B chain	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	0	1	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
NAD-dependent protein deacetylase sirtuin-1	0	0	1	3
Prenyltransferase homolog	0	0	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Zinc finger protein mex-5	0	0	1	1
large T antigen	0	1	0	1
Glucocorticoid receptor	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Carbonic anhydrase	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Sodium/bile acid cotransporter	0	1	0	3
Solute carrier organic anion transporter family member 1A1	0	1	0	3
acid sphingomyelinase	1	0	0	1
endonuclease IV	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
DNA polymerase eta isoform 1	1	0	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Solute carrier family 22 member 6	0	1	0	1
ATP-binding cassette sub-family C member 3	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Myeloperoxidase	0	1	0	1
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (296)

Protein Targets (973)

Gangliosidoses

Synonyms(1)

Research Excerpts

Overview

Research

Studies (296)

Drugs Studied (137)

Protein Targets (973)