Page last updated: 2024-09-27

Ventricular Flutter

A potentially lethal cardiac arrhythmia characterized by an extremely rapid, hemodynamically unstable ventricular tachycardia (150-300 beats/min) with a large oscillating sine-wave appearance. If untreated, ventricular flutter typically progresses to VENTRICULAR FIBRILLATION.

Synonyms(1)

Synonym
Ventricular Flutter

Research

Studies (17)

TimeframeStudies, This Condition (%)All Conditions %
pre-199011 (64.71)23.3326
1990's0 (0.00)12.5806
2000's2 (11.76)18.1394
2010's4 (23.53)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
niacin0low10
amiodarone0low10
cefixime0low10
ciprofloxacin0low10
lidocaine0low10
khellin0low10
neostigmine0low10
procainamide0low40
sotalol0low10
penicillin g0low10
4-methoxyamphetamine0low10
levofloxacin0low10
moxifloxacin0low10
quinidine0low20
digitoxin0low20
resveratrol0low10
stilbenes0low10
antimony0low10
natriuretic peptide, brain0low10
antimony potassium tartrate0low10

Protein Targets (551)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0112
5-hydroxytryptamine receptor 2A0112
5-hydroxytryptamine receptor 1A0113
5-hydroxytryptamine receptor 1B0112
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0112
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0213
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
acetylcholinesterase2002
phosphopantetheinyl transferase1001
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma5005
SMAD family member 24004
ATAD5 protein, partial3003
Fumarate hydratase1001
USP1 protein, partial2002
NFKB1 protein, partial1001
PPM1D protein1001
SMAD family member 34004
TDP1 protein9009
Thrombopoietin1001
AR protein100010
caspase 7, apoptosis-related cysteine protease2002
aldehyde dehydrogenase 1 family, member A18008
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
thyroid stimulating hormone receptor3003
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor3003
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha6006
farnesoid X nuclear receptor3003
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha7007
G3003
cytochrome P450 2D64004
polyprotein1001
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma4004
caspase-32002
euchromatic histone-lysine N-methyltransferase 26006
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x3003
cytochrome P450 2D6 isoform 12002
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C9 precursor2002
D(1A) dopamine receptor1001
chromobox protein homolog 13003
thyroid hormone receptor beta isoform a3003
potassium voltage-gated channel subfamily H member 2 isoform d4004
thyroid hormone receptor beta isoform 24004
heat shock protein beta-11001
huntingtin isoform 22002
mitogen-activated protein kinase 14004
flap endonuclease 13003
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 15005
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
nuclear receptor ROR-gamma isoform 13003
geminin6006
peripheral myelin protein 222002
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 15005
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)1001
lamin isoform A-delta108008
Gamma-aminobutyric acid receptor subunit pi5106
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010010
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Solute carrier organic anion transporter family member 1A40202
Voltage-dependent L-type calcium channel subunit alpha-1F0505
5-hydroxytryptamine receptor 40404
Lysine-specific demethylase PHF20101
Bile salt export pump012012
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 3003
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p534004
Integrin beta-32002
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10202
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20418
Muscarinic acetylcholine receptor M40417
ATP-dependent translocase ABCB10519
Integrin alpha-IIb2002
Beta-1 adrenergic receptor0415
Muscarinic acetylcholine receptor M50417
Alpha-2A adrenergic receptor0202
Adenosine receptor A30202
Cytochrome P450 2C80101
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M10418
Beta-3 adrenergic receptor0314
D(2) dopamine receptor0202
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-15106
Alpha-1B adrenergic receptor0202
Lethal factor0101
Alpha-2B adrenergic receptor0202
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit delta5106
Gamma-aminobutyric acid receptor subunit gamma-25106
Gamma-aminobutyric acid receptor subunit alpha-55106
Gamma-aminobutyric acid receptor subunit alpha-35106
Muscarinic acetylcholine receptor M30417
ATP-dependent translocase ABCB10202
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit gamma-15106
Gamma-aminobutyric acid receptor subunit alpha-25106
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0415
Histamine H2 receptor0202
Endothelin-1 receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0404
Gamma-aminobutyric acid receptor subunit alpha-45106
Gamma-aminobutyric acid receptor subunit gamma-35106
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-65106
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0202
Squalene synthase0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
Histamine H2 receptor3004
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60202
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein4004
Gamma-aminobutyric acid receptor subunit alpha-15106
Gamma-aminobutyric acid receptor subunit beta-35106
Gamma-aminobutyric acid receptor subunit beta-25106
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0505
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 209011
Voltage-dependent L-type calcium channel subunit alpha-1S0505
Voltage-dependent L-type calcium channel subunit alpha-1C0505
Sodium channel protein type 5 subunit alpha0404
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0202
Lysine-specific demethylase 7A0101
GABA theta subunit5106
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 13003
Canalicular multispecific organic anion transporter 1010010
Sodium channel protein type 2 subunit alpha0101
Ataxin-23003
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit epsilon5106
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0022
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial3003
ATP-dependent phosphofructokinase4004
Chain A, 2-oxoglutarate Oxygenase4004
GLI family zinc finger 36006
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta3003
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0406
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30215
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M10001
Alpha-1D adrenergic receptor0202
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 70202
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, Cruzipain2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
Cytochrome P450 1A20404
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Cytochrome P450 3A40606
DNA gyrase subunit B0203
DNA gyrase subunit A0205
DNA gyrase subunit B0205
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0203
Cytochrome P450 2D60404
DNA topoisomerase 2-alpha0105
Cytochrome P450 2C9 0516
DNA gyrase subunit A0203
Cytochrome P450 2C190303
Multidrug resistance protein MdtK0011
DNA gyrase subunit B0203
DNA gyrase subunit A0304
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
Chain A, Beta-lactamase4004
Microtubule-associated protein tau3003
STAT3, partial0101
Smad31001
67.9K protein2002
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
IDH13003
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
nuclear receptor subfamily 1, group I, member 21001
NPC intracellular cholesterol transporter 1 precursor2002
nuclear factor erythroid 2-related factor 2 isoform 21001
ras-related protein Rab-9A2002
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Voltage-dependent calcium channel gamma-2 subunit3003
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit beta-10101
Replicase polyprotein 1ab0202
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Glutamate receptor 23003
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10101
ATPase family AAA domain-containing protein 52002
glp-1 receptor, partial4004
GALC protein1001
cytochrome P450 family 3 subfamily A polypeptide 42002
aryl hydrocarbon receptor4004
cytochrome P450 2C19 precursor2002
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
histone acetyltransferase KAT2A isoform 12002
Cytochrome P450 1A10303
Cytochrome P450 1B10303
Chain A, JmjC domain-containing histone demethylation protein 3A2002
thioredoxin reductase3003
Replicase polyprotein 1ab0101
CAAX prenyl protease 2 isoform 20001
streptokinase A precursor0022
Bile salt export pump0101
Tubulin beta-4A chain0101
Tubulin beta chain0101
Tubulin alpha-3C chain0101
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
Fatty-acid amide hydrolase 10101
DNA primase0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Multidrug and toxin extrusion protein 10404
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
GLS protein4004
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50202
Potassium voltage-gated channel subfamily D member 20202
Potassium channel subfamily K member 180101
DNA gyrase subunit B0101
Replicase polyprotein 1ab0101
Potassium voltage-gated channel subfamily E member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Potassium voltage-gated channel subfamily KQT member 10101
Atrial natriuretic peptide receptor 10101
regulator of G-protein signaling 43003
arylsulfatase A3003
Acetylcholinesterase0202
Cholinesterase0404
Acetylcholinesterase0505
Cholinesterase0303
bromodomain adjacent to zinc finger domain 2B1001
thyrotropin-releasing hormone receptor1001
lysosomal alpha-glucosidase preproprotein2002
Polyphenol oxidase 20202
Amyloid-beta precursor protein0213
Neuronal acetylcholine receptor subunit alpha-41102
Cholesteryl ester transfer protein0101
Neuronal acetylcholine receptor subunit beta-21102
D-amino-acid oxidase0101
Xanthine dehydrogenase/oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 22 member 60101
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10101
Beta-lactamase TEM0102
Guanine nucleotide-binding protein G1001
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80101
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase VIM-1 0001
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Sterol O-acyltransferase 10101
Solute carrier family 22 member 20101
Solute carrier family 22 member 30101
Acetylcholinesterase 0101
DNA (cytosine-5)-methyltransferase 10101
Sterol O-acyltransferase 10101
Solute carrier family 22 member 10405
Solute carrier family 22 member 20404
Solute carrier family 22 member 40101
DNA (cytosine-5)-methyltransferase 3-like0101
DNA (cytosine-5)-methyltransferase 3A0101
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
Histidine-rich protein PFHRP-II0101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
UDP-glucuronosyltransferase 2B10 0101
Solute carrier organic anion transporter family member 1A10101
Cytochrome P450 2D40101
Multidrug resistance protein 1a0001
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Luciferase2002
BRCA11001
ClpP1001
Parkin1001
P531001
pyruvate kinase1001
M18 aspartyl aminopeptidase0101
cathepsin L10101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Bloom syndrome protein isoform 11001
hexokinase-4 isoform 11001
peripheral myelin protein 22 isoform 11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
histone deacetylase 9 isoform 32002
glucokinase regulatory protein1001
atrial natriuretic peptide receptor 2 precursor1001
nuclear factor NF-kappa-B p105 subunit isoform 10011
FAD-linked sulfhydryl oxidase ALR0001
DNA polymerase iota isoform a (long)1001
DNA polymerase kappa isoform 11001
Vif0101
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
POsterior Segregation0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0011
Carbonic anhydrase 120101
Lysine-specific histone demethylase 1A0101
Transient receptor potential cation channel subfamily A member 10112
Tyrosine-protein kinase ABL10102
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Myc proto-oncogene protein0102
Transthyretin0011
Estrogen receptor0101
Prostaglandin G/H synthase 10112
Tyrosine-protein kinase Lck0101
Cathepsin D0101
Carbonic anhydrase 30101
Luciferin 4-monooxygenase0101
DNA polymerase alpha catalytic subunit0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Leukotriene A-4 hydrolase0101
Breakpoint cluster region protein0102
Tyrosinase0303
Aromatase0202
Ornithine decarboxylase0101
Tyrosinase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0213
Protein kinase C alpha type0011
Tyrosine-protein phosphatase non-receptor type 10101
Estrogen receptor0011
Nuclear factor NF-kappa-B p105 subunit0101
Amine oxidase [flavin-containing] A0101
Endothelin receptor type B1001
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Sucrase-isomaltase, intestinal0101
Endothelin-1 receptor1001
Amine oxidase [flavin-containing] B0101
Dipeptidyl peptidase 40101
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
Cannabinoid receptor 10101
Nuclear receptor ROR-gamma1001
Alpha-glucosidase MAL120101
Prostaglandin G/H synthase 20101
Inositol monophosphatase 11001
Nuclear factor NF-kappa-B p100 subunit 0101
Squalene synthase0101
Transcription factor p650101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0001
Bcl-2-like protein 10101
Serine/threonine-protein kinase PAK 10101
Nuclear factor erythroid 2-related factor 20012
Carbonic anhydrase 90101
N1L 0101
NAD(P)H dehydrogenase [quinone] 10003
Tubulin beta-2B chain0101
Lysosomal alpha-glucosidase0101
Transient receptor potential cation channel subfamily A member 10101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
NAD-dependent protein deacetylase sirtuin-20011
Carbonic anhydrase 130101
Rap guanine nucleotide exchange factor 41001
NAD-dependent protein deacetylase sirtuin-10013
Carbonic anhydrase 150101
Prenyltransferase homolog0001
Carbonic anhydrase 140101
Zinc finger protein mex-50011
Carbonic anhydrase 5B, mitochondrial0101
large T antigen0101
Albumin0101
Beta-2 adrenergic receptor0213
POU domain, class 2, transcription factor 10001
Beta-2 adrenergic receptor0101
Beta-2 adrenergic receptor 0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]