A cannabinoid receptor agonist that binds to and activates type 2 cannabinoid receptors.
ChEBI ID: 146246
| Member | Definition | Class |
|---|---|---|
| arachidonyl-2-chloroethylamide | A fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM). | arachidonyl-2'-chloroethylamide |
| hu 308 | A carbobicyclic compound that is bicyclo[3.1.1]hept-2-ene which is substituted by a hydroxymethyl group at position 2, a 2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl group at position 4, and two methyl groups at position 6 (the 1S,4S,5S stereoisomer). A highly selective and effective cannabinoid type-2 agonist and the enantiomer of HU-433. | HU-308 |
| jwh-133 | A dibenzopyran that is Delta(9)-tetrahydrocannabinol which is lacking the hydroxy group and in which the pentyl group at position 3 has been replaced by a 1,1-dimethylbutyl group. A potent and highly selective CB2 receptor agonist. | JWH-133 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (1.00) | 18.2507 |
| 2000's | 102 (25.44) | 29.6817 |
| 2010's | 228 (56.86) | 24.3611 |
| 2020's | 67 (16.71) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.23%) | 5.53% |
| Reviews | 12 (2.76%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 1 (0.23%) | 0.25% |
| Other | 421 (96.78%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 28.1838 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 31.6228 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0034 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 0.5163 | 14 | 14 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 4.2714 | 5 | 5 |
| Cannabinoid receptor 2 | Homo sapiens (human) | IC50 | 0.0818 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 0.0125 | 24 | 24 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 1.1557 | 1 | 2 |
| Cannabinoid receptor 2 | Homo sapiens (human) | EC50 | 0.1334 | 7 | 7 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.8190 | 2 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | EC50 | 0.8190 | 2 | 3 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | EC50 | 0.8190 | 2 | 3 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | EC50 | 0.8190 | 2 | 3 |