Page last updated: 2024-11-13
alpha-tocotrienol quinone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
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Protein Interactions
Research Growth
Market Indicators
Description
alpha-tocotrienol quinone: reverses visual loss due to retinal ganglion degeneration [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 46184405 |
CHEMBL ID | 1812161 |
SCHEMBL ID | 503125 |
SCHEMBL ID | 14639355 |
MeSH ID | M0577028 |
Synonyms (40)
Synonym |
---|
vatiquinone , |
epi-743 |
CHEMBL1812161 |
(r)-alpha-tocotrienol quinone |
alpha tocotrienol quinone |
alpha-tocotrienol quinone |
.alpha.-tocotrienol quinone |
6o85fk9i0x , |
2,5-cyclohexadiene-1,4-dione, 2-((3r,6e,10e)-3-hydroxy-3,7,11,15-tetramethyl-6,10,14-hexadecatrien-1-yl)-3,5,6-trimethyl- |
vatiquinone [usan:inn] |
epi 743 |
1213269-98-7 |
unii-6o85fk9i0x |
vatiquinone (jan/usan) |
D10407 |
ptc-743 |
vatiquinone [inn] |
2-[(3r,6e,10e)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trien-1-yl]-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione |
vatiquinone [jan] |
vatiquinone [usan] |
ptc743 |
SCHEMBL503125 |
SCHEMBL14639355 |
DTXSID90153231 |
CS-0012384 |
HY-16772 |
DB11917 |
epi 743;epi743; vatiquinone; alpha-tocotrienol quinone |
BCP21072 |
2-((r,6e,10e)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trien-1-yl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione |
LNOVHERIIMJMDG-XZXLULOTSA-N |
Q27265220 |
2-[(3r,6e,10e)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl]-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione |
MS-27922 |
EX-A5566 |
2-[(3r,6e,10e)-3-hydroxy-3,7,11,15-tetramethyl-6,10,14-hexadecatrien-1-yl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dion |
A937320 |
bdbm594069 |
us11584728, compound vatiquinone |
AKOS040754343 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (62)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID611206 | Volume of infusion in rat plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611408 | Ratio of compound EC50 to co-enzyme Q10 EC50 for cytoprotectant activity in Friedreich ataxia patient fibroblasts | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611310 | Cmax in mouse brain at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611323 | Drug level in dog cornea at 300 mg/kg/day, po qd for 7 days | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611215 | AUCt in rat plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611205 | Clearance in rat plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611333 | Prolongation of prothrombin time in rat at 100 mg/kg/day, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611314 | Terminal half life in mouse brain at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611212 | Bioavailability in fasted rat plasma at 25 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611228 | AUCt in dog plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611321 | Drug level in mouse heart at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611227 | Tmax in dog plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611231 | Cmax in mouse plasma at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611313 | AUC (infinity) in mouse brain at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611319 | Drug level in mouse serum at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611230 | Terminal half life in dog plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611332 | Toxicity in rat administered orally once daily for 28 days | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611322 | Drug level in dog retina at 300 mg/kg/day, po qd for 7 days | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611334 | Prolongation of activated partial thromboplastin time in rat at 100 mg/kg/day, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611217 | Terminal half life in rat plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611316 | Tmax in human plasma at 2 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611225 | Apparent volume of distribution in dog plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611210 | Tmax in rat plasma at 25 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611309 | Terminal half life in mouse plasma at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611219 | AUCt in dog plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611220 | AUC (infinity) in dog plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611202 | AUCt in rat plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611308 | AUC (infinity) in mouse plasma at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611221 | Terminal half life in dog plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611312 | AUCt in mouse brain at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611404 | Cytoprotectant activity against L-buthionine-(S,R)-sulfoximine-induced cell death in Friedreich ataxia patient fibroblasts assessed as increase of cell viability | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611209 | Cmax in rat plasma at 25 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611336 | Prolongation of activated partial thromboplastin time in dog at 100 mg/kg/day, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611223 | Volume of infusion in dog plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611226 | Cmax in dog plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611315 | Cmax in human plasma at 2 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611233 | AUCt in mouse plasma at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611213 | Cmax in rat plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611232 | Tmax in mouse plasma at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611214 | Tmax in rat plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611204 | Terminal half life in rat plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611406 | Cytoprotectant activity against L-buthionine-(S,R)-sulfoximine-induced cell death in Leigh syndrome patient fibroblasts assessed as increase of cell viability | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611330 | Genotoxicity in CHO cells assessed as induction of micronucleus | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611311 | Tmax in mouse brain at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611324 | Plasma concentration in dog at 300 mg/kg/day, po qd for 7 days | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611329 | Mutagenic activity in Salmonella Typhimurium by Ames test | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611224 | Volume of distribution at steady state in dog plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611203 | AUC (infinity) in rat plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611211 | AUCt in rat plasma at 25 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611207 | Volume of distribution at steady state in rat plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611218 | Bioavailability in fed rat plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611222 | Clearance in dog plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611410 | Ratio of compound EC50 to resveratrol EC50 for cytoprotectant activity in Friedreich ataxia patient fibroblasts | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611317 | Bioavailability in dog plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611335 | Prolongation of prothrombin time in dog at 100 mg/kg/day, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611229 | AUC (infinity) in dog plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611216 | AUC (infinity) in rat plasma at 10 mg/kg, po | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611320 | Ratio of drug level in mouse heart to serum at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611318 | Ratio of drug level in mouse brain to serum at 25 mg/kg, ip | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611331 | Toxicity in dog administered orally once daily for 28 days | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611208 | Apparent volume of distribution in rat plasma at 2 mg/kg, iv | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
AID611409 | Ratio of compound EC50 to idebenone EC50 for cytoprotectant activity in Friedreich ataxia patient fibroblasts | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (14)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 14 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 16.75
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (16.75) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 3 (20.00%) | 5.53% |
Reviews | 4 (26.67%) | 6.00% |
Case Studies | 2 (13.33%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (40.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |