Page last updated: 2024-12-06

2-phenoxybenzoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-phenoxybenzoic acid, also known as o-phenoxybenzoic acid, is a white crystalline solid with a melting point of 143-144 °C. It is synthesized through various methods, including the reaction of 2-chlorobenzoic acid with phenol in the presence of a base. 2-phenoxybenzoic acid exhibits a range of biological activities, including antifungal and antibacterial properties. It has also been reported to act as a ligand for certain proteins, suggesting potential applications in drug discovery. The compound's unique structure and biological activities make it a subject of interest for researchers studying potential new therapeutic agents. Its antifungal and antibacterial properties are particularly intriguing, leading to investigations into its potential use in the treatment of fungal and bacterial infections.'

phenoxybenzoic acid : An aromatic ether that is diphenyl ether in which one of the hydrogens is replaced by a carboxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

2-phenoxybenzoic acid : A phenoxybenzoic acid in which the phenoxy group is ortho to the carboxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID75237
CHEMBL ID2219842
CHEBI ID72636
SCHEMBL ID1798

Synonyms (64)

Synonym
EU-0067008
UNM000011073601
ortho-phenoxybenzoic acid
CHEBI:72636 ,
diphenyl ether 2-carboxylic acid
2-phoc6h4cooh
o-phenoxybenzoic aci
o-carboxydiphenyl ether
2-phoc6h4co2h
2-carboxybiphenyl ether
nsc39656
nsc-39656
benzoic acid, 2-phenoxy-
o-phenoxybenzoic acid
2243-42-7
2-phenoxybenzoic acid
benzoic acid, o-phenoxy-
einecs 218-811-5
nsc 39656
ai3-03453
OPREA1_816007
STK358768
2-phenoxybenzoic acid, 98%
UNM-0000305915
HMS1607P11
2-(phenoxy)benzoic acid
pkrsyepbqpfnrb-uhfffaoysa-
inchi=1/c13h10o3/c14-13(15)11-8-4-5-9-12(11)16-10-6-2-1-3-7-10/h1-9h,(h,14,15)
P1252
AKOS000119525
2-carboxydiphenyl ether
einecs 252-989-5
phenoxybenzoic acid
36349-67-4
2-phenoxy-benzoic acid
902c93kxk0 ,
unii-902c93kxk0
FT-0613275
AR1175
AB01141509-03
2-phenoxyphenyl carboxylic acid
2-phenoxy benzoic acid
2-phenoxyphenylcarboxylic acid
AM83133
SCHEMBL1798
DTXSID8062286
2-phenoxybenzoicacid
CHEMBL2219842 ,
benzoic acid,2-phenoxy-
F0347-1640
sr-01000391096
SR-01000391096-1
mfcd00002429
GS-6049
Z57127879
J-014714
Q27140035
2-(phenyloxy)benzoic acid
2-pba
EN300-17942
NCGC00326072-01
SY048275
bdbm50538221
CS-0073045
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenoxybenzoic acidAn aromatic ether that is diphenyl ether in which one of the hydrogens is replaced by a carboxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Fatty acid-binding protein, adipocyteHomo sapiens (human)Ki500.00000.00200.92916.8000AID1648406
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (11)

Processvia Protein(s)Taxonomy
response to bacteriumFatty acid-binding protein, adipocyteHomo sapiens (human)
long-chain fatty acid transportFatty acid-binding protein, adipocyteHomo sapiens (human)
cholesterol homeostasisFatty acid-binding protein, adipocyteHomo sapiens (human)
negative regulation of DNA-templated transcriptionFatty acid-binding protein, adipocyteHomo sapiens (human)
positive regulation of inflammatory responseFatty acid-binding protein, adipocyteHomo sapiens (human)
white fat cell differentiationFatty acid-binding protein, adipocyteHomo sapiens (human)
brown fat cell differentiationFatty acid-binding protein, adipocyteHomo sapiens (human)
cellular response to lithium ionFatty acid-binding protein, adipocyteHomo sapiens (human)
cellular response to tumor necrosis factorFatty acid-binding protein, adipocyteHomo sapiens (human)
positive regulation of cold-induced thermogenesisFatty acid-binding protein, adipocyteHomo sapiens (human)
fatty acid transportFatty acid-binding protein, adipocyteHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
long-chain fatty acid transmembrane transporter activityFatty acid-binding protein, adipocyteHomo sapiens (human)
long-chain fatty acid bindingFatty acid-binding protein, adipocyteHomo sapiens (human)
hormone receptor bindingFatty acid-binding protein, adipocyteHomo sapiens (human)
fatty acid bindingFatty acid-binding protein, adipocyteHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
nucleusFatty acid-binding protein, adipocyteHomo sapiens (human)
cytoplasmFatty acid-binding protein, adipocyteHomo sapiens (human)
lipid dropletFatty acid-binding protein, adipocyteHomo sapiens (human)
cytosolFatty acid-binding protein, adipocyteHomo sapiens (human)
extracellular exosomeFatty acid-binding protein, adipocyteHomo sapiens (human)
cytosolFatty acid-binding protein, adipocyteHomo sapiens (human)
nucleusFatty acid-binding protein, adipocyteHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1486518Inhibition of acid-induced wild type transthyretin (unknown origin) aggregation expressed in Escherichia coli pre-incubated for 30 mins before acid addition and further incubated for 72 hrs at 37 degC under dark conditions by UV-Vis spectrophotometry2017Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.
AID1648406Displacement of 1,8-ANS from recombinant human 6His-tagged FABP4 expressed in Escherichia coli BL21 DE3 incubated for 15 mins followed by 1,8-ANS addition and measured after 3 mins by fluorescence based assay2020Journal of medicinal chemistry, 04-23, Volume: 63, Issue:8
Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation.
AID1850549Thermal stabilization of wildtype beta catenin ARD (148 to 662 residues) (unknown origin) assessed as change in melting temperature at 125 uM by DSF method2022Journal of medicinal chemistry, 05-26, Volume: 65, Issue:10
Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.
AID1486519Binding affinity to transthyretin in human blood plasma assessed as plasma binding selectivity by measuring stoichiometry of small molecule bound to TTR incubated for 24 hrs at 37 degC by RP-HPLC2017Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.38 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]