Crystal Arthritis

Joint disorders that are characterized by accumulation of microcrystals in and around the joint including in the SYNOVIAL FLUID. They are classified according to the chemical nature of the crystals such as CALCIUM PYROPHOSPHATE; basic CALCIUM PHOSPHATES; and monosodium urate (see URIC ACID).

Synonym
Crystal Arthritis
Crystal Arthropathies
Crystalline Arthritis
Crystalline Arthropathies

Excerpt	Reference
"Crystal arthritis is the most common type of inflammatory arthritis, and fractures contribute to significant morbidity and mortality, therefore, the relationship between the two is of clinical importance."	( Chang, I; Gazeley, D, 2018)
"Crystal arthropathies are a group of joint disorders due to deposition of crystals in and around joints that lead to joint destruction and soft tissue masses."	( Klauser, A; Reijnierse, M; Schwabl, C, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	21 (60.00)	28.8240
2020's	14 (40.00)	9.53

Drug	Relationship Strength	Studies	Trials
uric acid	low	11	0
diclofenac	low	1	0
prednisone	medium	2	1
edetic acid	low	1	0
gentian violet	low	2	0
durapatite	low	5	0
gold	low	1	0
tricalcium phosphate	low	5	0
calcium pyrophosphate	medium	18	1
trolamine salicylate	medium	11	1
aceclofenac	low	1	0
resveratrol	low	1	0
alizarin red s	low	1	0
chitosan	low	1	0
sodium morrhuate	low	1	0

Protein Targets (369)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
GLS protein	2	0	0	2
GLI family zinc finger 3	4	0	0	4
estrogen receptor 2 (ER beta)	4	0	0	4
progesterone receptor	5	0	0	5
retinoid X nuclear receptor alpha	4	0	0	4
G	3	0	0	3
peroxisome proliferator activated receptor gamma	3	0	0	3
cytochrome P450 2C9 precursor	1	0	0	1
chromobox protein homolog 1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
geminin	3	0	0	3
lamin isoform A-delta10	2	0	0	2
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	1
Bile salt export pump	0	2	0	2
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Transthyretin	0	0	3	5
Mitogen-activated protein kinase 1	0	1	0	1
Histamine H2 receptor	4	0	0	4
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Inositol hexakisphosphate kinase 1	3	0	0	3
cytochrome P450 2C9, partial	3	0	0	3
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	2
Phosphoglycerate mutase 1	0	1	0	1
Tyrosine-protein phosphatase 1	0	1	0	1
Pyruvate kinase PKLR	0	1	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	2	3
Dihydrofolate reductase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	1	1	2
Prostaglandin G/H synthase 1	0	2	1	3
Cytochrome P450 3A4	0	4	0	4
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	2	0	3
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 9	0	2	0	2
Solute carrier family 22 member 6	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	4	0	0	4
AR protein	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
estrogen-related nuclear receptor alpha	4	0	0	4
estrogen nuclear receptor alpha	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Cellular tumor antigen p53	4	0	0	4
Amyloid-beta precursor protein	0	2	1	3
Angiotensin-converting enzyme	0	1	0	1
Glutamate receptor 2	3	0	0	3
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Chain A, Cruzipain	1	0	0	1
Luciferase	2	0	0	2
acetylcholinesterase	1	0	0	1
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
pregnane X receptor	2	0	0	2
phosphopantetheinyl transferase	1	0	0	1
SMAD family member 2	2	0	0	2
USP1 protein, partial	1	0	0	1
SMAD family member 3	2	0	0	2
TDP1 protein	3	0	0	3
Microtubule-associated protein tau	2	0	0	3
caspase 7, apoptosis-related cysteine protease	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
alpha synuclein, partial	1	0	0	1
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
glucocorticoid receptor [Homo sapiens]	3	0	0	3
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	3	0	0	3
cytochrome P450 2D6	2	0	0	2
67.9K protein	2	0	0	2
glucocerebrosidase	1	0	0	1
luciferase	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
caspase-3	2	0	0	2
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Caspase-7	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
caspase-3	1	0	0	1
thyroid hormone receptor beta isoform 2	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
heat shock protein beta-1	1	0	0	1
huntingtin isoform 2	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	1	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
DNA polymerase kappa isoform 1	2	0	0	2
peripheral myelin protein 22	1	0	0	1
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
lethal factor (plasmid)	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Solute carrier family 22 member 1	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Integrin beta-3	2	0	0	2
Tyrosine-protein kinase Fyn	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Integrin alpha-IIb	2	0	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Adenosine receptor A2a	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Nuclear receptor ROR-gamma	3	0	0	3
Spike glycoprotein	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Fatty-acid amide hydrolase 1	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Leukotriene B4 receptor 1	1	0	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
10 kDa chaperonin	0	1	0	1
GABA theta subunit	2	0	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Leukotriene B4 receptor 2	1	0	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
thioredoxin glutathione reductase	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Chain A, Beta-lactamase	1	0	0	1
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
glp-1 receptor, partial	1	0	0	1
thioredoxin reductase	1	0	0	1
BRCA1	1	0	0	1
ClpP	1	0	0	1
ATAD5 protein, partial	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
Parkin	1	0	0	1
P53	1	0	0	1
arylsulfatase A	1	0	0	1
pyruvate kinase	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
IDH1	1	0	0	1
cathepsin L1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
DNA polymerase beta	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vif	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
POsterior Segregation	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	1
Acetylcholinesterase	0	1	0	1
Polyphenol oxidase 2	0	1	0	1
Carbonic anhydrase 12	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	2
Myc proto-oncogene protein	0	1	0	2
Estrogen receptor	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Cholinesterase	0	1	0	1
Cathepsin D	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	2
Luciferin 4-monooxygenase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Breakpoint cluster region protein	0	1	0	2
Tyrosinase	0	2	0	2
Aromatase	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Tyrosinase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
Protein kinase C alpha type	0	0	1	1
5-hydroxytryptamine receptor 1A	0	0	0	1
Estrogen receptor	0	0	1	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin receptor type B	1	0	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Sucrase-isomaltase, intestinal	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	1	3
Endothelin-1 receptor	1	0	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Alpha-glucosidase MAL12	0	1	0	1
Cholinesterase	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Squalene synthase	0	1	0	1
Transcription factor p65	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	0	0	1
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
Cytochrome P450 1B1	0	2	0	2
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	2
Tubulin beta-2B chain	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	0	1	1
Carbonic anhydrase 13	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
NAD-dependent protein deacetylase sirtuin-1	0	0	1	3
Carbonic anhydrase 15	0	1	0	1
Prenyltransferase homolog	0	0	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Carbonic anhydrase 14	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
large T antigen	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Research

Studies (35)

Protein Targets (369)

Crystal Arthritis

Synonyms(4)

Research Excerpts

Overview

Research

Studies (35)

Drugs Studied (16)

Protein Targets (369)