Compounds > lichexanthone
Page last updated: 2024-12-11

lichexanthone

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Description

lichexanthone: a dihydropyranexanthone derived from the natural xanthone; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

lichexanthone : A member of the class of xanthones that is 9H-xanthen-9-one substituted by a hydroxy group at position 1, a methyl group at position 8 and methoxy groups at positions 3 and 6. It has been isolated from the bark of Cupania cinerea. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Cupaniagenus[no description available]SapindaceaeThe soapberry plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida. Some members contain SAPONINS.[MeSH]

Cross-References

ID SourceID
PubMed CID5358904
CHEMBL ID470650
CHEBI ID67821
SCHEMBL ID4272316
MeSH IDM0593094

Synonyms (29)

Synonym
DIVK1C_006167
KBIO1_001111
SPECTRUM5_001811
nsc288657
lichexanthone
9h-xanthen-9-one,6-dimethoxy-8-methyl-
nsc-288657
15222-53-4
lichexanthone b804322k045
xanthen-9-one,6-dimethoxy-8-methyl-
SPECPLUS_000071
chebi:67821 ,
CHEMBL470650
1-hydroxy-3,6-dimethoxy-8-methylxanthen-9-one
nsc 288657
9h-xanthen-9-one, 1-hydroxy-3,6-dimethoxy-8-methyl-
unii-92o5d9z07w
92o5d9z07w ,
xanthen-9-one, 1-hydroxy-3,6-dimethoxy-8-methyl-
1-hydroxy-3,6-dimethoxy-8-methyl-9h-xanthen-9-one
1-hydroxy-3,6-dimethoxy-8-methyl-xanthen-9-one
SCHEMBL4272316
1-hydroxy-3,6-dimethoxy-8-methylxanthone
QDLAGTHXVHQKRE-UHFFFAOYSA-N
1-hydroxy-3,6-dimethoxy-8-methyl-9h-xanthen-9-one #
DTXSID80164977
9h-xanthen-9-one, 1-hydroxy-3,6-dimethoxy-8-methyl- (9ci)
Q27136297
lichenxanthone
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
xanthonesAny member of the class of xanthenes based on a xanthone skeleton.
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (51)

Assay IDTitleYearJournalArticle
AID377855Phytogrowth-inhibitory activity against Amaranthus hypochondriacus assessed as inhibition of seedling germination2000Journal of natural products, Oct, Volume: 63, Issue:10
Effect of lichen metabolites on thylakoid electron transport and photophosphorylation in isolated spinach chloroplasts.
AID1081977Antifungal activity against Rhizoctonia solani assessed as growth inhibition at 125 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081972Antifungal activity against Rhizoctonia bataticola assessed as growth inhibition at 62.5 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID356226Antimicrobial activity against Candida albicans up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID402590Cytotoxicity against human BxPC3 cells2004Journal of natural products, Jun, Volume: 67, Issue:6
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
AID356218Antimicrobial activity against Streptococcus pneumoniae up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID402595Cytotoxicity against human DU145 cells2004Journal of natural products, Jun, Volume: 67, Issue:6
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
AID402592Cytotoxicity against human SF268 cells2004Journal of natural products, Jun, Volume: 67, Issue:6
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
AID402593Cytotoxicity against human NCI-H460 cells2004Journal of natural products, Jun, Volume: 67, Issue:6
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
AID1081960Antifungal activity against Pythium debaryanum assessed as growth inhibition at 62.5 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081980Antifungal activity against Athelia rolfsii assessed as growth inhibition at 62.5 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID356220Antimicrobial activity against Micrococcus luteus up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID1081970Antifungal activity against Fusarium udum assessed as growth inhibition at 250 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1607896Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 25.0 mg/ml after 24 hrs by Griess reagent based assay relative to control2019European journal of medicinal chemistry, Oct-01, Volume: 179Human disorders associated with inflammation and the evolving role of natural products to overcome.
AID356224Antimicrobial activity against Neisseria gonorrhoeae up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID1081981Antifungal activity against Athelia rolfsii assessed as growth inhibition at 125 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID377853Phytogrowth-inhibitory activity against Amaranthus hypochondriacus assessed as inhibition of seedling growth2000Journal of natural products, Oct, Volume: 63, Issue:10
Effect of lichen metabolites on thylakoid electron transport and photophosphorylation in isolated spinach chloroplasts.
AID1081959Antifungal activity against Pythium debaryanum assessed as growth inhibition by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081966Antifungal activity against Pythium aphanidermatum assessed as growth inhibition at 250 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081965Antifungal activity against Pythium aphanidermatum assessed as growth inhibition at 125 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID356217Antimicrobial activity against Staphylococcus aureus up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID1081962Antifungal activity against Pythium debaryanum assessed as growth inhibition at 250 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID402589Cytotoxicity against mouse P388 cells2004Journal of natural products, Jun, Volume: 67, Issue:6
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
AID377856Phytogrowth-inhibitory activity against Echinochloa crusgalli assessed as inhibition of seedling growth2000Journal of natural products, Oct, Volume: 63, Issue:10
Effect of lichen metabolites on thylakoid electron transport and photophosphorylation in isolated spinach chloroplasts.
AID356222Antimicrobial activity against Escherichia coli up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID1081963Antifungal activity against Pythium aphanidermatum assessed as growth inhibition by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID597077Antiparasitic activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream form after 72 hrs by microplate fluorimetry2011Journal of natural products, Apr-25, Volume: 74, Issue:4
Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.
AID1081978Antifungal activity against Rhizoctonia solani assessed as growth inhibition at 250 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081982Antifungal activity against Athelia rolfsii assessed as growth inhibition at 250 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081976Antifungal activity against Rhizoctonia solani assessed as growth inhibition at 62.5 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID597076Antiplasmodial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting2011Journal of natural products, Apr-25, Volume: 74, Issue:4
Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.
AID1081973Antifungal activity against Rhizoctonia bataticola assessed as growth inhibition at 125 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID356216Cytotoxicity against mouse P388 cells2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID1081968Antifungal activity against Fusarium udum assessed as growth inhibition at 62.5 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID356219Antimicrobial activity against Enterococcus faecalis up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID1081961Antifungal activity against Pythium debaryanum assessed as growth inhibition at 125 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID356221Antimicrobial activity against Enterobacter cloacae up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID1081971Antifungal activity against Rhizoctonia bataticola assessed as growth inhibition by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID402591Cytotoxicity against human MCF7 cells2004Journal of natural products, Jun, Volume: 67, Issue:6
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
AID1081964Antifungal activity against Pythium aphanidermatum assessed as growth inhibition at 62.5 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID377854Phytogrowth-inhibitory activity against Echinochloa crusgalli assessed as inhibition of seedling germination2000Journal of natural products, Oct, Volume: 63, Issue:10
Effect of lichen metabolites on thylakoid electron transport and photophosphorylation in isolated spinach chloroplasts.
AID1081967Antifungal activity against Fusarium udum assessed as growth inhibition by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID402594Cytotoxicity against human KM20L2 cells2004Journal of natural products, Jun, Volume: 67, Issue:6
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
AID356223Antimicrobial activity against Stenotrophomonas maltophilia up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID1081979Antifungal activity against Athelia rolfsii assessed as growth inhibition by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1825215Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay2022Journal of natural products, 01-28, Volume: 85, Issue:1
Anti-inflammatory Dimeric Benzophenones from an Endophytic Pleosporales Species.
AID1081974Antifungal activity against Rhizoctonia bataticola assessed as growth inhibition at 250 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081969Antifungal activity against Fusarium udum assessed as growth inhibition at 125 ug/ml by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID356225Antimicrobial activity against Cryptococcus neoformans up to 64 ug/mL by broth microdilution susceptibility assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
AID1081975Antifungal activity against Rhizoctonia solani assessed as growth inhibition by poisoned food technique2011Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6
Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID597078Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry2011Journal of natural products, Apr-25, Volume: 74, Issue:4
Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
[no description available]		3.3110catechin
2,4-dichlorophenoxyacetic acid
2,4-Dichlorophenoxyacetic Acid: An herbicide with irritant effects on the eye and the gastrointestinal system.. 2,4-D : A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.		210chlorophenoxyacetic acid;
dichlorobenzene		agrochemical;
defoliant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
environmental contaminant;
phenoxy herbicide;
synthetic auxin
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		3.3110benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
celecoxib
[no description available]		3.3110organofluorine compound;
pyrazoles;
sulfonamide;
toluenes		cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0610aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
diuron
Diuron: A pre-emergent herbicide.. diuron : A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.		2103-(3,4-substituted-phenyl)-1,1-dimethylurea;
dichlorobenzene		environmental contaminant;
mitochondrial respiratory-chain inhibitor;
photosystem-II inhibitor;
urea herbicide;
xenobiotic
melarsoprol
Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.		2.0610triazines
orcinol
orcinol: used as reagent for pentoses, lignin, beet sugar, saccharoses, arabinose & diastase; RN given refers to parent cpd; structure. orcinol : A 5-alkylresorcinol in which the alkyl group is specified as methyl.		2105-alkylresorcinol;
dihydroxytoluene		Aspergillus metabolite
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.0610furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
betulinic acid
[no description available]		3.5720hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
xanthyletine
xanthyletine: structure		2.0210coumarins
hexaconazole
2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol : A member of the class of triazoles that is 1-hexyl-1H-1,2,4-triazole in which the hydrogens at position 2 of the hexyl chain are replaced by hydroxy and 2,4-dichlorophenyl groups.. hexaconazole : A racemate comprising equimolar amounts of (R)- and (S)-hexaconazole. An agricultural fungicide introduced in the 1980s, it is not approved for use within the European Union.		2.0610dichlorobenzene;
tertiary alcohol;
triazoles		chelator
atranorin
atranorin: RN given refers to parent cpd; structure given in first source		2.0610carbonyl compound
zaluzanin C
zaluzanin C: from Ainsliaea yunnanensis and Zaluzania robinsonii; structure in first source. zaluzanin C : A sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and a hydroxy group at position 8.		3.3110gamma-lactone;
guaiane sesquiterpenoid;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite
2,4-dihydroxy-6-methylbenzoic acid ethyl ester
[no description available]		2.06104-hydroxybenzoate ester
methyl orsellinate
methyl orsellinate: orcinol derivative from the lichen Peltigera leucophlebia (Peltigeraceae); structure in first source		210hydroxybenzoic acidmetabolite
methyl 2,4-dihydroxy-3,6-dimethyl benzoate
atraric acid: structure in first source; from the stem barks of Newbouldia laevis		2.43204-hydroxybenzoate ester
taraxerol
taraxerol: structure. taraxerol : A pentacyclic triterpenoid that is oleanan-3-ol lacking the methyl group at position 14, with an alpha-methyl substituent at position 13 and a double bond between positions 14 and 15.		2.0610pentacyclic triterpenoid;
secondary alcohol		metabolite
lupenone
lupenone: structure in first source		2.0610triterpenoidmetabolite
taraxerone
taraxerone: structure		2.0610scalarane sesterterpenoidmetabolite
syringaresinol
[no description available]		3.3110aromatic ether;
furofuran;
lignan;
polyether;
polyphenol		plant metabolite
gyrophoric acid
gyrophoric acid: a tridepside isolated from Parmelia nepalensis		210carbonyl compound
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		3.3110resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
Methyl Haematommate
[no description available]		2.43204-hydroxybenzoate ester
isoliquiritigenin
[no description available]		3.3110chalconesantineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.3110aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
scopoletin
[no description available]		2.0610hydroxycoumarinplant growth regulator;
plant metabolite
quercetin 3-o-methyl ether
quercetin 3-O-methyl ether: from Rhamnus species; structure in first source. 3',4',5,7-tetrahydroxy-3-methoxyflavone : A tetrahydroxyflavone having the 4-hydroxy groups located at the 3'- 4'- 5- and 7-positions as well as a methoxy group at the 2-position.		3.3110monomethoxyflavone;
tetrahydroxyflavone		antimicrobial agent;
metabolite
stigmasterol
stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.		2.01103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol		plant metabolite
isobavachalcone
isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.		3.3110chalcones;
polyphenol		antibacterial agent;
metabolite;
platelet aggregation inhibitor
norathyriol
norathyriol: from Gentinanaceae; has vasorelaxing action on rat thoracic aorta; structure given in first source. norathyriol : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.		3.3110polyphenol;
xanthones		antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite
norlichexanthone
norlichexanthone: isolated from fungus P16; structure in first source. norlichexanthone : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3 and 6 and a methyl group at position 8. It has been isolated from Wardomyces anomalus.		2.4110polyphenol;
xanthones		antimalarial;
fungal metabolite
myricitrin
myricitrin: isolated from root bark of Myrica cerifera L.; structure. myricitrin : A glycosyloxyflavone that consists of myricetin attached to a alpha-L-rhamnopyranosyl residue at position 3 via a glycosidic linkage. Isolated from Myrica cerifera, it exhibits anti-allergic activity.		3.3110alpha-L-rhamnoside;
glycosyloxyflavone;
monosaccharide derivative;
pentahydroxyflavone		anti-allergic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite
acteoside
acteoside: a protein kinase C inhibitor with hepatoprotective, anti-asthmatic, and analgesic activities; a phenylethanoid glycoside related to isoacteoside; from leaves of Lippia multiflora (Verbenaceae). acteoside : A glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid.		3.3110catechols;
cinnamate ester;
disaccharide derivative;
glycoside;
polyphenol		anti-inflammatory agent;
antibacterial agent;
antileishmanial agent;
neuroprotective agent;
plant metabolite
muromonab-cd3
cudraflavone B: antiproliferative from Cudrania tricuspidata. cudraflavone B : An extended flavonoid that consists of a pyranochromane skeleton that is 2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, a 2,4-dihydroxyphenyl group at position 8, a hydroxy group at position 5 and a prenyl group at position 7. Isolated from Morus alba and Morus species it exhibits anti-inflammatory activity.		3.3110extended flavonoid;
pyranochromane;
trihydroxyflavone		anti-inflammatory agent;
plant metabolite
salazinic acid
salazinic acid: lichen metabolite; structure in first source		2.0610
baeomycesic acid
baeomycesic acid: structure in first source		2.0610carbonyl compound
ergosterol-5,8-peroxide
ergosterol-5,8-peroxide: also inhibits sulfatase; isolated from fungus Cercospora kikuchii; structure given in first source. ergosterol peroxide : An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.		3.31103beta-sterol;
ergostanoid;
organic peroxide;
phytosterols		antimycobacterial drug;
antineoplastic agent;
metabolite;
trypanocidal drug
guttiferone e
guttiferone E: isolated from the fruits of Garcinia pyrifera collected in Malaysia; structure in first source		3.3110
alternariol
alternariol: structure. alternariol : A benzochromenone that is 6H-benzo[c]chromen-6-one which is substituted by a methyl group at position 1 and by hydroxy groups at positions 3, 7, and 9. It is the most important mycotoxin produced by the black mould Alternaria species, which are the most common mycoflora infecting small grain cereals worldwide.		2.4110benzochromenone;
phenols		EC 3.1.1.8 (cholinesterase) inhibitor;
metabolite;
mycotoxin
1,3,5,6-tetrahydroxyxanthone
1,3,5,6-tetrahydroxyxanthone: from roots of Cudrania cochinchinensis		3.3110
Norartocarpetin
[no description available]		3.3110flavones
24-ethyl-4-cholesten-3-one
stigmast-4-en-3-one: from the bark of Anacardium occidentale (cashew); structure in first source		3.3110C29-steroid;
steroid		metabolite
lyoniside
daucosterol : A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa.		3.3110beta-D-glucoside;
monosaccharide derivative;
steroid saponin		plant metabolite
13-oxo-9,11-octadecadienoic acid
13-oxo-9Z,11E-ODE : An oxooctadecadienoic acid that consists of 9Z,11E-octadecadienoic acid bearing an additional 13-keto substituent. In addtion it has been found as a natural product found in Carthamus oxyacantha.		3.311013-oxo-9,11-octadecadienoic acidmetabolite;
mouse metabolite
cajanine
cajanine: isolated from Cajanus cajan L.; structure in first source		3.3110stilbenoid
2,4,2',4'-Tetrahydroxychalcone
[no description available]		3.3110chalcones
betulone
[no description available]		2.0610triterpenoidmetabolite
chikusetsu saponin iva
chikusetsu saponin IVa: from the tubers of Hemsleya pengxianensis (Cucurbitaceae)		3.3110triterpenoid saponinmetabolite
Norartocarpanone
[no description available]		3.3110flavanones
(E)-1,7-Bis(4-hydroxyphenyl)hept-4-en-3-one
[no description available]		3.3110diarylheptanoid
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.4220
Rheumatoid Arthritis
[description not available]		03.1210
Innate Inflammatory Response
[description not available]		03.1210
Benign Neoplasms
[description not available]		03.1210
Dermatoses
[description not available]		03.1210
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		03.1210
Cardiovascular Diseases
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.		03.1210
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		03.1210
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.1210
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		03.1210