ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate profile

ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate: has antidiabetic activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	2737412
CHEMBL ID	455456
SCHEMBL ID	7690389
MeSH ID	M000602356

Synonym
EU-0067311
AKOS002169557
6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydro -pyrimidine-5-carboxylic acid ethyl ester
BB 0240292
OPREA1_330764
UPCMLD0ENAT0504-0766:001
5118-36-5
NCI60_014903
NSC643910 ,
nsc-643910
5-pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-thioxo-, ethyl ester
ethyl 6-methyl-4-phenyl-2-thioxo-3,4-dihydro-1h-pyrimidine-5-carboxylate
STK096198
ethyl 4-methyl-6-phenyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate
MAYBRIDGE1_006365
STK394294
ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
AKOS000295404
AKOS000273256
HMS559J07
CHEMBL455456
33458-26-3
AKOS016295285
ethyl 6-methyl-4-phenyl-2-sulfanylidene-3,4-dihydro-1h-pyrimidine-5-carboxylate
ethyl 6-methyl-4-phenyl-2-sulfanyl-1,4-dihydropyrimidine-5-carboxylate
STK973249
EN300-60723
SCHEMBL7690389
ethyl 6-methyl-4-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate
ethyl 2-mercapto-4-methyl-6-phenyl-1,6-dihydropyrimidine-5-carboxylate
F0126-0205
FT-0626149
S11646
BBL028942
AKOS016040515
AKOS016037974
10R-0368
AC-31097
QMFBVGUFEGVPNG-UHFFFAOYSA-N
pyrimidine-5-carboxilyc acid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-thioxo-, ethyl ester
ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate #
2-mercapto-4-methyl-6-phenyl-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester
bdbm175352
ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (7)
sr-01000392939
SR-01000392939-1
mfcd00188414
6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester
ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
ethyl 2-mercapto-6-methyl-4-phenyl-1,4-dihydro-5-pyrimidinecarboxylate
BCP10706
6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester
(r)-ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
DTXSID30965456
mfcd00778457
A923899
SB58138
SB60204
CS-0216794
PD011489
Z47738890
nsc823777
nsc-823777

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Urease	Canavalia ensiformis (jack bean)	Ki	15.7600	0.4070	0.4070	0.4070	AID1801532
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (116)

Assay ID	Title	Year	Journal	Article
AID410837	Antifungal activity against Aspergillus niger assessed as radial growth at 5% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410857	Growth promotion of Aspergillus niger assessed as radial growth at 1% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410850	Antifungal activity against Aspergillus niger assessed as radial growth at 1% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410668	Antifungal activity against Aspergillus niger assessed as radial growth at 1% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410637	Antifungal activity against Trichoderma koningii assessed as radial growth at 0.5% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410832	Antifungal activity against Aspergillus niger assessed as radial growth at 5% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410828	Antifungal activity against Aspergillus niger assessed as radial growth at 7% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410657	Antifungal activity against Trichoderma koningii assessed as radial growth at 0.5% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID1377668	Modulation of [3H]NCS-382 binding to alpha4betadelta GABAA receptor in rat cortical membranes after 1 hr by TopCount scintillation counting method	2017	European journal of medicinal chemistry, Sep-29, Volume: 138	Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α
AID654126	Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay	2012	Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8	Free radical scavenging and antiproliferative properties of Biginelli adducts.
AID654124	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay	2012	Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8	Free radical scavenging and antiproliferative properties of Biginelli adducts.
AID410625	Antifungal activity against Trichoderma hamatum assessed as radial growth at 5% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410610	Antifungal activity against Trichoderma hamatum assessed as radial growth at 5% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410627	Antifungal activity against Trichoderma hamatum assessed as radial growth at 0.5% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410646	Antifungal activity against Trichoderma koningii assessed as radial growth at 7% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410629	Antifungal activity against Trichoderma hamatum assessed as radial growth at 3% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410834	Antifungal activity against Aspergillus niger assessed as radial growth at 0.5% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID1377669	Modulation of [3H]NCS-382 binding to alpha4betadelta GABAA receptor in rat cortical membranes assessed as [3H]NCS-382 binding at 100 uM after 1 hr by TopCount scintillation counting method relative to control	2017	European journal of medicinal chemistry, Sep-29, Volume: 138	Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α
AID410660	Antifungal activity against Trichoderma koningii assessed as radial growth at 5% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410611	Antifungal activity against Trichoderma hamatum assessed as radial growth at 7% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410616	Antifungal activity against Trichoderma hamatum assessed as radial growth at 7% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410859	Growth promotion of Trichoderma koningii assessed as radial growth at 1% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410659	Antifungal activity against Trichoderma koningii assessed as radial growth at 3% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410658	Antifungal activity against Trichoderma koningii assessed as radial growth at 1% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410619	Antifungal activity against Trichoderma hamatum assessed as radial growth at 3% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410640	Antifungal activity against Trichoderma koningii assessed as radial growth at 5% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410633	Antifungal activity against Trichoderma hamatum assessed as radial growth at 1% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410631	Antifungal activity against Trichoderma hamatum assessed as radial growth at 7% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410618	Antifungal activity against Trichoderma hamatum assessed as radial growth at 1% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410664	Antifungal activity against Trichoderma koningii assessed as radial growth at 3% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410647	Antifungal activity against Trichoderma koningii assessed as radial growth at 0.5% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410846	Antifungal activity against Aspergillus niger assessed as radial growth at 3% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410848	Antifungal activity against Aspergillus niger assessed as radial growth at 7% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410623	Antifungal activity against Trichoderma hamatum assessed as radial growth at 1% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410644	Antifungal activity against Trichoderma koningii assessed as radial growth at 3% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410841	Antifungal activity against Aspergillus niger assessed as radial growth at 3% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410642	Antifungal activity against Trichoderma koningii assessed as radial growth at 0.5% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410620	Antifungal activity against Trichoderma hamatum assessed as radial growth at 5% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410835	Antifungal activity against Aspergillus niger assessed as radial growth at 1% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410871	Growth promotion of Aspergillus niger assessed as radial growth at 0.5% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410847	Antifungal activity against Aspergillus niger assessed as radial growth at 5% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID654129	Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay	2012	Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8	Free radical scavenging and antiproliferative properties of Biginelli adducts.
AID410836	Antifungal activity against Aspergillus niger assessed as radial growth at 3% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410614	Antifungal activity against Trichoderma hamatum assessed as radial growth at 3% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410869	Growth promotion of Trichoderma koningii assessed as radial growth at 0.5% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410612	Antifungal activity against Trichoderma hamatum assessed as radial growth at 0.5% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410843	Antifungal activity against Aspergillus niger assessed as radial growth at 7% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410860	Growth promotion of Trichoderma koningii assessed as radial growth at 1% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410654	Antifungal activity against Trichoderma koningii assessed as radial growth at 3% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410661	Antifungal activity against Trichoderma koningii assessed as radial growth at 7% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410655	Antifungal activity against Trichoderma koningii assessed as radial growth at 5% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410861	Growth promotion of Trichoderma koningii assessed as radial growth at 1% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410872	Growth promotion of Aspergillus niger assessed as radial growth at 0.5% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410666	Antifungal activity against Trichoderma koningii assessed as radial growth at 7% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID1153369	Inhibition pig alpha-amylase at 300 ug/ml pretreated for 30 mins followed by addition of 1% starch for 10 mins by spectrometer	2014	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13	Graphite catalyzed solvent free synthesis of dihydropyrimidin-2(1H)-ones/thiones and their antidiabetic activity.
AID410829	Antifungal activity against Aspergillus niger assessed as radial growth at 0.5% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410842	Antifungal activity against Aspergillus niger assessed as radial growth at 5% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410868	Growth promotion of Trichoderma koningii assessed as radial growth at 0.5% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410643	Antifungal activity against Trichoderma koningii assessed as radial growth at 1% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410667	Antifungal activity against Aspergillus niger assessed as radial growth at 0.5% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410826	Antifungal activity against Aspergillus niger assessed as radial growth at 3% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410873	Growth promotion of Aspergillus niger assessed as radial growth at 0.5% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410853	Antifungal activity against Aspergillus niger assessed as radial growth at 7% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410651	Antifungal activity against Trichoderma koningii assessed as radial growth at 7% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410656	Antifungal activity against Trichoderma koningii assessed as radial growth at 7% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410855	Antifungal activity against Trichoderma koningii	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410827	Antifungal activity against Aspergillus niger assessed as radial growth at 5% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410636	Antifungal activity against Trichoderma hamatum assessed as radial growth at 7% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410630	Antifungal activity against Trichoderma hamatum assessed as radial growth at 5% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410851	Antifungal activity against Aspergillus niger assessed as radial growth at 3% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410852	Antifungal activity against Aspergillus niger assessed as radial growth at 5% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410609	Antifungal activity against Trichoderma hamatum assessed as radial growth at 3% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410839	Antifungal activity against Aspergillus niger assessed as radial growth at 0.5% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID654128	Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay	2012	Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8	Free radical scavenging and antiproliferative properties of Biginelli adducts.
AID410652	Antifungal activity against Trichoderma koningii assessed as radial growth at 0.5% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410624	Antifungal activity against Trichoderma hamatum assessed as radial growth at 3% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID654130	Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay	2012	Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8	Free radical scavenging and antiproliferative properties of Biginelli adducts.
AID410665	Antifungal activity against Trichoderma koningii assessed as radial growth at 5% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410622	Antifungal activity against Trichoderma hamatum assessed as radial growth at 0.5% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410844	Antifungal activity against Aspergillus niger assessed as radial growth at 0.5% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410662	Antifungal activity against Trichoderma koningii assessed as radial growth at 0.5% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410632	Antifungal activity against Trichoderma hamatum assessed as radial growth at 0.5% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410833	Antifungal activity against Aspergillus niger assessed as radial growth at 7% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410648	Antifungal activity against Trichoderma koningii assessed as radial growth at 1% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410831	Antifungal activity against Aspergillus niger assessed as radial growth at 3% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410615	Antifungal activity against Trichoderma hamatum assessed as radial growth at 5% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID654127	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	2012	Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8	Free radical scavenging and antiproliferative properties of Biginelli adducts.
AID410635	Antifungal activity against Trichoderma hamatum assessed as radial growth at 5% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410608	Antifungal activity against Trichoderma hamatum assessed as radial growth at 1% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410621	Antifungal activity against Trichoderma hamatum assessed as radial growth at 7% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410641	Antifungal activity against Trichoderma koningii assessed as radial growth at 7% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410858	Growth promotion of Aspergillus niger assessed as radial growth at 1% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410849	Antifungal activity against Aspergillus niger assessed as radial growth at 0.5% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID654115	Antioxidant activity assessed as scavenging of DPPH at 160 uM after 30 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8	Free radical scavenging and antiproliferative properties of Biginelli adducts.
AID410845	Antifungal activity against Aspergillus niger assessed as radial growth at 1% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410617	Antifungal activity against Trichoderma hamatum assessed as radial growth at 0.5% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410607	Antifungal activity against Trichoderma hamatum assessed as radial growth at 0.5% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410638	Antifungal activity against Trichoderma koningii assessed as radial growth at 1% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410645	Antifungal activity against Trichoderma koningii assessed as radial growth at 5% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410663	Antifungal activity against Trichoderma koningii assessed as radial growth at 1% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410639	Antifungal activity against Trichoderma koningii assessed as radial growth at 3% after 24 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410613	Antifungal activity against Trichoderma hamatum assessed as radial growth at 1% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410838	Antifungal activity against Aspergillus niger assessed as radial growth at 7% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410830	Antifungal activity against Aspergillus niger assessed as radial growth at 1% after 48 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410634	Antifungal activity against Trichoderma hamatum assessed as radial growth at 3% after 72 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410856	Antifungal activity against Aspergillus niger	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410867	Growth promotion of Trichoderma koningii assessed as radial growth at 0.5% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410840	Antifungal activity against Aspergillus niger assessed as radial growth at 1% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410628	Antifungal activity against Trichoderma hamatum assessed as radial growth at 1% after 48 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410653	Antifungal activity against Trichoderma koningii assessed as radial growth at 1% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410649	Antifungal activity against Trichoderma koningii assessed as radial growth at 3% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410626	Antifungal activity against Trichoderma hamatum assessed as radial growth at 7% after 24 hrs by poison food technique of Flack relative to control	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID410854	Antifungal activity against Trichoderma hamatum	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID654125	Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay	2012	Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8	Free radical scavenging and antiproliferative properties of Biginelli adducts.
AID410650	Antifungal activity against Trichoderma koningii assessed as radial growth at 5% after 72 hrs by poison food technique of Flack	2008	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24	Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
AID1801532	Urease Inhibition Assay from Article 10.1016/j.bioorg.2015.12.007: \\Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors.\\	2016	Bioorganic chemistry, Feb, Volume: 64	Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	4 (80.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acarbose [no description available]	2.1	1	amino cyclitol; glycoside
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.07	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
4-(1,3-benzodioxol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester [no description available]	2.49	2	benzodioxoles
(S)-monastrol [no description available]	2.79	3	ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	2.13	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore
monastrol monastrol: stops mitosis by fostering formation of monopolar spindles; structure in first source. (S)-monastrol : An ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate that has S configuration.. monastrol : A racemate comprising equimolar amounts of R- and S-monastrol.. ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate : A member of the class of thioureas that is 3,4-dihydropyrimidine-2(1)-thione substituted by a 3-hydroxyphenyl group at position 4, an ethoxycarbonyl group at position 5, and a methyl group at position 6.	2.54	2	enoate ester; ethyl ester; phenols; racemate; thioureas	antileishmanial agent; antimitotic; antineoplastic agent; EC 3.5.1.5 (urease) inhibitor

Condition	Indicated	Relationship Strength	Studies	Trials
Diabetes Mellitus, Adult-Onset [description not available]	0	2.1	1	0
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	0	2.1	1	0

ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Description

Cross-References

Synonyms (63)

Protein Targets (1)

Inhibition Measurements

Bioassays (116)

Research

Studies (5)

Market Indicators

Research Demand Index: 13.28

Study Types

ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Description

Cross-References

Synonyms (63)

Protein Targets (1)

Inhibition Measurements

Bioassays (116)

Research

Studies (5)

Market Indicators

Research Demand Index: 13.28

Study Types

Related Drugs (6)

Related Conditions (2)