Page last updated: 2024-09-28

Favus

A disease of the scalp that may affect the glabrous skin and the nails and is recognized by the concave sulfur-yellow crusts that form around loose, wiry hairs. Atrophy ensues, leaving a smooth, glossy, thin, paper-white patch. This type of disease is rare in the United States and more frequently seen in the Middle East, Africa, Southeastern Europe, and other countries bordering the Mediterranean Sea. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p319)

Synonyms(2)

Synonym
Tinea Favosa
Favus

Research Excerpts

Overview

ExcerptReference
"Favus is typically a childhood disease, yet adult cases are not uncommon."( Ilkit, M, 2010)
"Favus is common in Iran, Nigeria, and China, however it has been reported rarely in the last two decades in Turkey."( Acar, A; Erkan, D; İlkit, M; Kandemir, H; Kolukırık, İ, 2015)

Actions

ExcerptReference
"We report a case of favus affecting the temporal region of the scalp in a 22-month-old boy."( García-Sánchez, MS; Pereiro, M; Pereiro, MM; Toribio, J, 1997)

Research

Studies (78)

TimeframeStudies, This Condition (%)All Conditions %
pre-199065 (83.33)23.3326
1990's4 (5.13)12.5806
2000's4 (5.13)18.1394
2010's4 (5.13)28.8240
2020's1 (1.28)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low200
histamine0low10
thiamine0low10
ciclopirox0low10
dequalinium0low10
diphenhydramine0low10
isoconazole0low10
ketoconazole0low30
miconazole0low20
prednisolone0low10
emetine0low10
dehydroemetine0low10
floxacillin0low10
mercury0low10
permethrin0low10
bisdequalinium0low10
prednisolone 21-3-sulfobenzoate0low10
griseofulvin0medium471
bromochloroacetic acid0low20
terbinafine0low40
oxiconazole0low10
acebutolol0low10
dextrothyroxine0low10
agar0low20

Protein Targets (442)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma8008
AR protein9009
aldehyde dehydrogenase 1 family, member A14004
nuclear receptor subfamily 1, group I, member 36006
retinoic acid nuclear receptor alpha variant 17007
thyroid stimulating hormone receptor3003
nuclear factor erythroid 2-related factor 2 isoform 17007
Cellular tumor antigen p53100010
Nuclear receptor ROR-gamma2002
Fumarate hydratase4004
PPM1D protein3003
EWS/FLI fusion protein5005
polyprotein4004
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Isocitrate dehydrogenase [NADP] cytoplasmic0101
Lysine-specific demethylase 4B0101
Bile salt export pump0909
Interferon beta6006
Hypoxia-inducible factor 1-alpha0203
Multidrug and toxin extrusion protein 10101
Deoxyhypusine hydroxylase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain3003
thioredoxin reductase5005
15-lipoxygenase, partial1001
phosphopantetheinyl transferase3003
ATAD5 protein, partial3003
USP1 protein, partial5005
TDP1 protein7007
Microtubule-associated protein tau2002
Thrombopoietin2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor4004
regulator of G-protein signaling 44004
arylsulfatase A1001
euchromatic histone-lysine N-methyltransferase 27007
cytochrome P450 2D6 isoform 13003
NPC intracellular cholesterol transporter 1 precursor2002
cellular tumor antigen p53 isoform a1001
D(1A) dopamine receptor1001
chromobox protein homolog 12002
huntingtin isoform 22002
flap endonuclease 12002
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 12002
nuclear receptor ROR-gamma isoform 13003
DNA polymerase kappa isoform 11001
peripheral myelin protein 224004
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M12002
lamin isoform A-delta108008
Gamma-aminobutyric acid receptor subunit pi3003
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Amyloid-beta precursor protein1001
Integrin beta-31001
Integrin alpha-IIb1001
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Alpha-synuclein2002
Histamine H2 receptor3015
D(1A) dopamine receptor1001
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Inositol monophosphatase 11001
GABA theta subunit3003
Ataxin-25005
Gamma-aminobutyric acid receptor subunit epsilon3003
Single-stranded DNA cytosine deaminase1001
ATP-dependent phosphofructokinase1001
Chain A, Ferritin light chain1001
endonuclease IV1001
nonstructural protein 11001
estrogen-related nuclear receptor alpha6006
glucocerebrosidase2002
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d7007
DNA polymerase beta1001
mitogen-activated protein kinase 11001
DNA polymerase iota isoform a (long)3003
geminin7007
neuropeptide S receptor isoform A1001
Spike glycoprotein4015
Luciferase2002
GLS protein2002
glucocorticoid receptor [Homo sapiens]9009
estrogen nuclear receptor alpha8008
cytochrome P450 2D64004
v-jun sarcoma virus 17 oncogene homolog (avian)4004
vitamin D3 receptor isoform VDRA2002
thyroid hormone receptor beta isoform 28008
5-hydroxytryptamine receptor 40404
Aldo-keto reductase family 1 member B1010010
Muscarinic acetylcholine receptor M20606
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M10606
Cytochrome P450 2C9 0415
Angiotensin-converting enzyme0202
Muscarinic acetylcholine receptor M30606
Sodium-dependent noradrenaline transporter 010010
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 2C0404
Histamine H1 receptor0135
Histamine H1 receptor0426
5-hydroxytryptamine receptor 2B0606
Histamine N-methyltransferase0001
Cytochrome P450 2J20202
Potassium voltage-gated channel subfamily H member 20303
Sodium channel protein type 5 subunit alpha0101
Solute carrier family 22 member 10304
Nuclear receptor subfamily 3 group C member 3 0202
Calcium release-activated calcium channel protein 10202
Protein orai-20101
Protein orai-30101
Histamine H4 receptor0224
Histamine H3 receptor0102
Solute carrier family 22 member 20304
NS5 0011
hypoxia-inducible factor 1 alpha subunit3003
GLI family zinc finger 34004
estrogen receptor 2 (ER beta)3003
progesterone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 47007
farnesoid X nuclear receptor6006
pregnane X nuclear receptor7007
Parkin1001
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
activating transcription factor 64004
nuclear receptor subfamily 1, group I, member 25005
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Glucose transporter0101
Serine hydrolase RBBP90101
Voltage-dependent calcium channel gamma-2 subunit2002
Hexose transporter 1 0101
Procathepsin L0011
ATP-dependent translocase ABCB10506
Alpha-2A adrenergic receptor010010
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Solute carrier family 2, facilitated glucose transporter member 10101
Alpha-2C adrenergic receptor0404
Glutamate receptor 22002
Dihydroorotate dehydrogenase 0101
Canalicular multispecific organic anion transporter 10303
ATPase family AAA domain-containing protein 53003
Endothelial PAS domain-containing protein 10102
Angiotensin-converting enzyme 2 0011
Bile salt export pump0303
Solute carrier family 15 member 10101
pregnane X receptor2002
SMAD family member 21001
SMAD family member 31001
caspase 7, apoptosis-related cysteine protease1001
retinoid X nuclear receptor alpha5005
caspase-31001
IDH13003
aryl hydrocarbon receptor5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 23003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Solute carrier family 22 member 1 0305
Heme oxygenase 1 0303
Heme oxygenase 20303
Lanosterol 14-alpha demethylase0415
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
Chain A, Beta-lactamase1001
aryl hydrocarbon receptor nuclear translocator0001
GALC protein1001
apical membrane antigen 1, AMA12002
bromodomain adjacent to zinc finger domain 2B3003
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20001
Carbonic anhydrase 120102
Solute carrier family 22 member 30102
Carbonic anhydrase 10304
Carbonic anhydrase 20305
Plasma kallikrein0001
Carbonic anhydrase 30102
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40102
Carbonic anhydrase 60203
Histamine H2 receptor0527
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0001
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0102
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70102
Carbonic anhydrase0002
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90102
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0002
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 150102
Carbonic anhydrase 130102
Carboxylic ester hydrolase 0001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
Histamine H3 receptor0123
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, BCL-2-RELATED PROTEIN A10011
acetylcholinesterase1001
glp-1 receptor, partial2002
Smad32002
isocitrate dehydrogenase 1, partial1001
G3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
Histone H2A.x2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
heat shock protein beta-12002
Vpr2002
bcl-2-like protein 11 isoform 10011
HLA class I histocompatibility antigen, B alpha chain 3003
Steroid 17-alpha-hydroxylase/17,20 lyase0404
Indoleamine 2,3-dioxygenase 10404
TAR DNA-binding protein 431001
Rap guanine nucleotide exchange factor 42002
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Estrogen receptor beta0102
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Chymotrypsinogen A0202
Beta-lactamase0202
ATP-dependent translocase ABCB10404
Epoxide hydrolase 10002
Cytochrome P450 2C11 0101
Cytochrome P450 3A40405
Steroid 21-hydroxylase0101
Cytochrome P450 2C80101
Aromatase0303
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0101
Cytochrome P450 11B1, mitochondrial0101
Translocator protein0101
Alpha-2B adrenergic receptor0606
Cytochrome P450 7A1 0101
Cytochrome P450 11B2, mitochondrial0101
Estrogen receptor0102
ATP-dependent translocase ABCB10404
Substance-K receptor0606
UDP-glucuronosyltransferase 1A1 0101
Thromboxane-A synthase 0303
Gonadotropin-releasing hormone receptor0112
Sodium-dependent serotonin transporter0606
Type-1 angiotensin II receptor0101
Malate dehydrogenase, cytoplasmic0202
Delta-type opioid receptor0606
Cytochrome P450 4F20101
Sodium-dependent dopamine transporter 0606
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0101
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
serine/threonine-protein kinase PLK11001
heat shock protein HSP 90-alpha isoform 20001
Metabotropic glutamate receptor 60101
Acetylcholinesterase0202
Cytochrome P450 1A20101
Epidermal growth factor receptor0101
Receptor tyrosine-protein kinase erbB-20101
Cytochrome P450 1A2 0101
Cytochrome P450 1A20101
Tyrosine-protein kinase Fyn0101
Beta-1 adrenergic receptor0202
Adenosine receptor A30404
Cytochrome P450 2D60303
Beta-3 adrenergic receptor0404
D(2) dopamine receptor0202
Androgen receptor0303
Alpha-1B adrenergic receptor0404
5-hydroxytryptamine receptor 1A0404
Cannabinoid receptor 10202
D(1A) dopamine receptor0404
D(4) dopamine receptor0202
Acetylcholinesterase0303
Aromatase0011
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 1B0404
Indoleamine 2,3-dioxygenase 10101
Adenosine receptor A2a0202
Adenosine receptor A10202
Melanocortin receptor 40202
Melanocortin receptor 50202
Cytochrome P450 2C190202
Prostaglandin G/H synthase 20303
Mu-type opioid receptor0202
D(3) dopamine receptor0404
Kappa-type opioid receptor0202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0404
Type-2 angiotensin II receptor0202
5-hydroxytryptamine receptor 60202
Beta-lactamase TEM0101
Cholinesterase0202
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Indoleamine 2,3-dioxygenase 20101
heat shock protein 90, putative0001
methionyl-tRNA synthetase, putative0101
serine-protein kinase ATM isoform a1001
thyroid hormone receptor beta isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nociceptin receptor0011
Estrogen receptor beta0202
chaperonin-containing TCP-1 beta subunit homolog1001
histone acetyltransferase KAT2A isoform 11001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20203
5'-AMP-activated protein kinase subunit beta-20001
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Prostaglandin G/H synthase 10101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
cystic fibrosis transmembrane conductance regulator0101
C-8 sterol isomerase0101
Squalene monooxygenase 0101
Squalene monooxygenase0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sigma non-opioid intracellular receptor 10202
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain B, Odorant-binding Protein0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Transient receptor potential cation channel subfamily A member 10011
Secreted chorismate mutase0101
Heat sensitive channel TRPV30011
Transient receptor potential cation channel subfamily A member 10112
Transient receptor potential cation channel subfamily M member 80112
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]