2-(2-methyl-4-chlorophenylamino)-2-imidazoline profile

2-(2-methyl-4-chlorophenylamino)-2-imidazoline, also known as **Mibefradil**, is a **calcium channel blocker** that was once used to treat **high blood pressure (hypertension)**.

**Why is Mibefradil important for research?**

Mibefradil is important for research due to its unique pharmacological profile and its **interaction with a wide range of drug metabolizing enzymes (CYP)**, making it a valuable tool in drug development and research.

**Here's a breakdown of its significance:**

* **Unique pharmacological profile:** Mibefradil is a **non-dihydropyridine calcium channel blocker** that exhibits high selectivity for **T-type calcium channels**. This unique profile makes it an intriguing molecule for exploring the role of T-type calcium channels in various physiological processes.
* **CYP interaction:** Mibefradil is a potent **inhibitor** of several cytochrome P450 enzymes (CYP), particularly **CYP3A4**. This property makes it crucial to understand its potential for drug-drug interactions. By studying Mibefradil's interactions with CYP enzymes, researchers can gain valuable insights into the metabolism of other drugs and develop strategies to minimize potential adverse effects.
* **Withdrawal from market:** Mibefradil was withdrawn from the market due to serious **drug-drug interactions** that led to adverse events like **heart rhythm problems and kidney damage**. Despite its withdrawal, its extensive research history provides a wealth of information about the complex interplay of drug metabolism, CYP interactions, and clinical outcomes.

**Research applications:**

* **Understanding T-type calcium channels:** Mibefradil is a valuable tool for studying the role of T-type calcium channels in various physiological processes like neuronal excitability, heart rhythm, and vascular smooth muscle contraction.
* **Drug-drug interaction studies:** Mibefradil's potent inhibition of CYP3A4 has contributed significantly to our understanding of drug-drug interactions and the development of strategies to predict and manage them.
* **Development of new drugs:** The research on Mibefradil has informed the design of newer calcium channel blockers with improved selectivity and reduced drug-drug interaction potential.

**In summary, Mibefradil is important for research because it provides a unique pharmacological profile, offers valuable insights into CYP interactions, and highlights the importance of understanding drug metabolism and drug-drug interactions in drug development.**

2-(2-methyl-4-chlorophenylamino)-2-imidazoline: RN given refers to parent cpd; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	77870
CHEMBL ID	62674
SCHEMBL ID	10689485
MeSH ID	M0104797

Synonym
cdmi
CHEMBL62674
4201-26-7
n-(4-chloro-2-methylphenyl)-4,5-dihydro-1h-imidazol-2-amine
1h-imidazol-2-amine, n-(4-chloro-2-methylphenyl)-4,5-dihydro-
2-(2-methyl-4-chlorophenylamino)-2-imidazoline
SCHEMBL10689485
DTXSID40194816
EN300-738510

Excerpt	Relevance	Reference
" The slopes of the individual dose-response curves were not significantly different which suggested a common mechanism of action."	( Central and peripheral anti-inflammatory actions by clonidine and a structurally related imidazoline analog. Holsapple, MP; Lowy, MT; Malave, A; Yim, GK, 1984)	0.27

Assay ID	Title	Year	Journal	Article
AID25092	Ionization constant (pKa)	1991	Journal of medicinal chemistry, Jul, Volume: 34, Issue:7	Direct prediction of dissociation constants (pKa's) of clonidine-like imidazolines, 2-substituted imidazoles, and 1-methyl-2-substituted-imidazoles from 3D structures using a comparative molecular field analysis (CoMFA) approach.
AID1150956	Octan-1-ol-aqueous buffer partition coefficient, log P of the compound at 10 to 20 mg at pH 7.4 by UV-spectroscopic analysis	1976	Journal of medicinal chemistry, Aug, Volume: 19, Issue:8	Clonidine and related analogues. Quantitative correlations.
AID26357	Dissociation constant (pKa)	1993	Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20	QSAR's from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods.
AID1150958	Hypotensive activity in rat assessed as change in mean blood pressure relative to control	1976	Journal of medicinal chemistry, Aug, Volume: 19, Issue:8	Clonidine and related analogues. Quantitative correlations.
AID1150955	Retardation factor, deltaRm of the compound at pH 13 by TLC analysis	1976	Journal of medicinal chemistry, Aug, Volume: 19, Issue:8	Clonidine and related analogues. Quantitative correlations.
AID1150959	Peripheral adrenergic activity in iv dosed pithed rat assessed as change in mean blood pressure	1976	Journal of medicinal chemistry, Aug, Volume: 19, Issue:8	Clonidine and related analogues. Quantitative correlations.
AID1150957	Dissociation constant, pKa of the compound in water-ethyl alcohol	1976	Journal of medicinal chemistry, Aug, Volume: 19, Issue:8	Clonidine and related analogues. Quantitative correlations.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (66.67)	18.7374
1990's	2 (33.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-hydroxybenzoic acid 4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.	1.98	1	monohydroxybenzoic acid	algal metabolite; plant metabolite
benzoic acid Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.. benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.. aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.	1.98	1	benzoic acids	algal metabolite; antimicrobial food preservative; drug allergen; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; human xenobiotic metabolite; plant metabolite
3-chlorobenzoic acid [no description available]	1.98	1	monochlorobenzoic acid	drug metabolite
histamine [no description available]	1.96	1	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
imidazole imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.	1.97	1	imidazole
4-aminobenzoic acid 4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.. 4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.. 4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.	1.98	1	aminobenzoic acid; aromatic amino-acid zwitterion	allergen; Escherichia coli metabolite; plant metabolite
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.	1.98	1	methylpyridines; phenylpyridine; tetrahydropyridine	neurotoxin
1-methylimidazole 1-methyl-1H-imidazole : A 1H-imidazole having a methyl substituent at the N-1 position.	1.97	1	imidazoles
aspirin Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.	2.36	2	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent
clonidine Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.. clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.	3.21	6	clonidine; imidazoline
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	1.96	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
corticosterone [no description available]	1.98	1	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite
etiocholanolone Etiocholanolone: The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.. 3alpha-hydroxy-5beta-androstan-17-one : An androstanoid that is 5beta-androstane substituted by an alpha-hydroxy group at position 3 and an oxo group at position 17. It is a metabolite of testosterone in mammals.	1.98	1	17-oxo steroid; 3alpha-hydroxy steroid; androstanoid	human metabolite; mouse metabolite
dehydroepiandrosterone Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.	1.98	1	17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid	androgen; human metabolite; mouse metabolite
4-nitrobenzoic acid 4-nitrobenzoic acid: RN given refers to parent cpd. 4-nitrobenzoic acid : A nitrobenzoic acid having the nitro group at the 4-position.	1.98	1	nitrobenzoic acid
androstenedione Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.. androst-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.	1.98	1	17-oxo steroid; 3-oxo-Delta(4) steroid; androstanoid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
desoxycorticosterone Desoxycorticosterone: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE	1.98	1	20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; mineralocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite
17-alpha-hydroxyprogesterone 17alpha-hydroxyprogesterone : A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.	1.98	1	17alpha-hydroxy-C21-steroid; 17alpha-hydroxy steroid; tertiary alpha-hydroxy ketone	human metabolite; metabolite; mouse metabolite; progestin
4-chlorobenzoic acid 4-chlorobenzoic acid: RN given refers to parent cpd. 4-chlorobenzoic acid : A monochlorobenzoic acid carrying a chloro substituent at position 4.	1.98	1	monochlorobenzoic acid	bacterial xenobiotic metabolite
4-tert-butylbenzoic acid 4-tert-butylbenzoic acid: RN given refers to parent cpd	1.98	1	alkylbenzene
3-toluic acid 3-toluic acid: RN given refers to parent cpd; structure	1.98	1	methylbenzoic acid	human xenobiotic metabolite
3-aminobenzoic acid 3-aminobenzoic acid: RN given refers to parent cpd. 3-aminobenzoic acid : An aminobenzoic acid carrying an amino group at position 3.	1.98	1	aminobenzoic acid
3-hydroxybenzoic acid 3-hydroxybenzoic acid: RN given refers to parent cpd. 3-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid substituted by a hydroxy group at position 3. It has been isolated from Taxus baccata. It is used as an intermediate in the synthesis of plasticisers, resins, pharmaceuticals, etc.	1.98	1	monohydroxybenzoic acid	bacterial metabolite; plant metabolite
4-toluic acid 4-toluic acid: RN given refers to parent cpd; structure. p-toluic acid : A methylbenzoic acid in which the methyl substituent is located at position 4.	1.98	1	methylbenzoic acid
4-anisic acid 4-methoxybenzoic acid: structure in first source. 4-methoxybenzoic acid : A methoxybenzoic acid substituted with a methoxy group at position C-4.	1.98	1	methoxybenzoic acid	plant metabolite
3-nitrobenzoic acid 3-nitrobenzoic acid: RN given refers to parent cpd	1.98	1
pregnenolone [no description available]	1.98	1	20-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; C21-steroid	human metabolite; mouse metabolite
4-(trifluoromethyl)benzoic acid 4-trifluoromethylbenzoic acid : A benzoic acid carrying a 4-trifluoromethyl substituent.	1.98	1	(trifluoromethyl)benzenes; benzoic acids
3-fluorobenzoic acid [no description available]	1.98	1	fluorobenzoic acid
4-fluorobenzoic acid [no description available]	1.98	1	fluorobenzoic acid	bacterial xenobiotic metabolite
dihydrotestosterone Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.	1.98	1	17beta-hydroxy steroid; 17beta-hydroxyandrostan-3-one; 3-oxo-5alpha-steroid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
azomycin azomycin: RN given refers to parent cpd with specified locant; structure	1.97	1	C-nitro compound; imidazoles	antitubercular agent
3-methoxybenzoic acid [no description available]	1.98	1	methoxybenzoic acid	flavouring agent; human urinary metabolite
4-bromobenzoic acid 4-bromobenzoic acid : A bromobenzoic acid carrying a single bromo subsituent at the 4-position.	1.98	1	bromobenzoic acid
3-iodobenzoate 3-iodobenzoic acid: RN given refers to unlabeled parent cpd. 3-iodobenzoic acid : An iodobenzoic acid with a single iodo substituent placed at the 3-position.	1.98	1	iodobenzoic acid
4-ethylbenzoic acid [no description available]	1.98	1	benzoic acids
4-cyanobenzoic acid [no description available]	1.98	1
2-methylimidazole [no description available]	1.97	1
1-methyl-2-nitroimidazole [no description available]	1.97	1
st 91 ST 91: RN given refers to parent cpd; structure	2.66	3	substituted aniline
norharman norharman: RN given refers to parent cpd. beta-carboline : The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.	1.98	1	beta-carbolines; mancude organic heterotricyclic parent	fungal metabolite; marine metabolite
2-ethylimidazole [no description available]	1.97	1
4-(fluorosulfonyl)benzoic acid [no description available]	1.98	1
2-phenylimidazole [no description available]	1.97	1
tiazuril [no description available]	1.98	1	aryl sulfide
xylonidine xylonidine: alpha adrenoreceptor stimulation by above cpd mainly inhibits the release of mediator and/or the bronchoconstriction caused by moderate activation of sensory nerves; forced molting agent; structure given in first source	2.66	3
1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine [no description available]	1.98	1
2-aminoimidazole 2-aminoimidazole: from catabolism of arginine	1.97	1
4-phenyl-1,2,3,6-tetrahydropyridine 4-phenyl-1,2,3,6-tetrahydropyridine: RN given refers to parent cpd	1.98	1
4-(methylthio)benzoic acid [no description available]	1.98	1
17-alpha-hydroxypregnenolone 17-alpha-Hydroxypregnenolone: A 21-carbon steroid that is converted from PREGNENOLONE by STEROID 17-ALPHA-HYDROXYLASE. It is an intermediate in the delta-5 pathway of biosynthesis of GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.. 17alpha-hydroxypregnenolone : A hydroxypregnenolone carrying an alpha-hydroxy group at position 17.	1.98	1	17alpha-hydroxy-C21-steroid; 17alpha-hydroxy steroid; 3beta-hydroxy-Delta(5)-steroid; hydroxypregnenolone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine: more potent dopaminergic neurotoxic compound than MPTP in mice	1.98	1
4-mercaptobenzoate 4-mercaptobenzoate: substrate for 4-hydroxybenzoate hydroxylase	1.98	1
2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one [no description available]	1.98	1
beta-carboline-3-carboxylic acid ethyl ester beta-carboline-3-carboxylic acid ethyl ester: isolated from brain tissue & urine; extremely potent displacer of diazepam from brain benzodiazepam receptors; structure in first source	1.98	1	beta-carbolines
beta-carboline-3-carboxylic acid methyl ester beta-carboline-3-carboxylic acid methyl ester: structure given in first source	1.98	1	beta-carbolines
2-methyltryptoline 2-methyltryptoline: enzymatic preparation from human brain converts methyltyptamine to methyltryptoline; structure	1.98	1	beta-carbolines
3-ethoxy-beta-carboline 3-ethoxy-beta-carboline: high affinity benzodiazepine receptor ligand with partial inverse agonist properties	1.98	1
tert-butyl beta-carboline-3-carboxylate tert-butyl beta-carboline-3-carboxylate: benzodiazepine receptor antagonist	1.98	1
1-methyl-4-cyclohexyl-1,2,3,6-tetrahydropyridine [no description available]	1.98	1
1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine [no description available]	1.98	1
1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine 1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine: structure given in first source	1.98	1
4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine 4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine: structure given in first source; RN given is for HCl	1.98	1
n-propyl-4-phenyl-1,2,3,6-tetrahydropyridine N-propyl-4-phenyl-1,2,3,6-tetrahydropyridine: structure given in first source	1.98	1
cortisone [no description available]	1.98	1	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
cortodoxone Cortodoxone: 17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.. 11-deoxycortisol : A deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen.	1.98	1	deoxycortisol; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
diclazuril [no description available]	1.98	1	nitrile
3-propoxy-beta-carboline 3-propoxy-beta-carboline: structure in first source	1.98	1
harman harman: a beta-carboline; RN given refers to parent cpd; structure. harman : An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.	1.98	1	harmala alkaloid; indole alkaloid fundamental parent; indole alkaloid	anti-HIV agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; plant metabolite
1-Ethyl-9H-pyrido[3,4-b]indole [no description available]	1.98	1	harmala alkaloid

Condition	Relationship Strength	Studies
Anasarca [description not available]	2.37	2
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.37	2
Gastric Ulcer [description not available]	2.36	2
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	2.36	2

2-(2-methyl-4-chlorophenylamino)-2-imidazoline

Description

Cross-References

Synonyms (9)

Research Excerpts

Dosage Studied

Bioassays (7)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.41

Study Types