Adenoma, alpha-Cell

An almost always malignant GLUCAGON-secreting tumor derived from the PANCREATIC ALPHA CELLS. It is characterized by a distinctive migratory ERYTHEMA; WEIGHT LOSS; STOMATITIS; GLOSSITIS; DIABETES MELLITUS; hypoaminoacidemia; and normochromic normocytic ANEMIA.

Synonym
Adenoma, alpha-Cell
alpha-Cell Tumor
Glucagonoma
Glucagonoma Syndrome

Excerpt	Reference
"The glucagonoma syndrome is characterized by elevated serum glucagon, a pancreatic alpha-cell tumor, anemia, hypoaminoacidemia, and necrolytic migratory erythema."	( Raimer, SS; Shepherd, ME; Smith, EB; Tyring, SK, 1991)
"The glucagonoma syndrome is characterized by a necrolytic migratory erythematous rash, angular stomatitis, painful glossitis, a normochromic normocytic anemia, mild diabetes mellitus, weight loss, a tendency to thrombosis, and neuropsychiatric disturbances."	( Bloom, SR; Polak, JM, 1987)
"The glucagonoma syndrome is caused by excess glucagon secretion from such a tumour."	( Catling, SJ; Nicoll, JM, 1985)
"The glucagonoma syndrome is an uncommon but well-known entity associating erythema necroticans migrans (ENM) with glucagonoma."	( Blanchi, A; Celerier, P; Forest, JL; Maillard, H; Maisonneuve, C; Pasquiou, C, 1995)
"Glucagonoma is a rare pancreatic tumor of islet alpha 2 cells."	( Aichelmann, E; Dienes, HP; Hölscher, AH; Neuhaus, H; Wickenhauser, C, 2000)
"Isolated glucagonomas are very difficult to find out and often diagnosed already presenting metastasis."	( Aichelmann, E; Dienes, HP; Hölscher, AH; Neuhaus, H; Wickenhauser, C, 2000)
"Glucagonoma syndrome is a paraneoplastic phenomenon characterized by an islet alpha-cell pancreatic tumor, necrolytic migratory erythema, diabetes mellitus, weight loss, anemia, stomatitis, thromboembolism, and gastrointestinal and neuropsychiatric disturbances."	( Chastain, MA, 2001)
"Glucagonomas are relatively rare, and can be difficult to differentiate from other pancreatic tumors."	( Habu, D; Ishizu, H; Iwata, Y; Kawabe, J; Kurooka, H; Minamitani, S; Nishiguchi, S; Ochi, H; Shiomi, S, 2001)
"Glucagonoma is a rare pancreatic endocrine tumor that is often both well developed and malignant at detection."	( Eigentler, TK; Mueller-Horvart, C; Overkamp, D; Raab, HR; Radny, P; Rassner, G; Soennichsen, K; Sotlar, K; Viebahn, R, 2006)
"The glucagonoma syndrome is a rare disease in which a typical skin lesion, necrolytic migratory erythema, is often one of the presenting symptoms."	( Mensing, CH; Sander, CA; Stark, I, 2008)
"Malignant glucagonoma is an exceptional pancreatic endocrine tumour, with frequent dermatologic symptoms, diabetes and degradation of the general health status."	( de Mestier, L; Dove, P; Hammel, P; Hentic, O; Lévy, P; Ruszniewski, P, 2010)
"The glucagonoma syndrome is a rare disorder, characterized by necrolytic migratory erythema, elevated serum glucagon levels, abnormal glucose tolerance, weight loss, and anemia in association with a glucagon-secreting alpha-cell tumor of the pancreas."	( Amaral, C; Carvalho, A; Carvalho, R; Lobo, I; Machado, S, 2010)
"Glucagonoma is an extremely rare, glucagon-secreting neuroendocrine tumor of the pancreas."	( Caplin, M; Mandair, D; Navalkissoor, S; Papantoniou, D; Rottenburger, C, 2018)
"Glucagonoma is an extremely rare neuroendocrine tumor that arises from pancreatic islet alpha cells."	( Deng, Y; Dong, S; Han, L; Jiang, Y; Li, E; Li, W; Ma, Q; Ma, Z; Ren, J; Wang, Z; Wu, Y; Wu, Z; Xu, G; Yang, X, 2022)

Excerpt	Reference
"This glucagonoma has been investigated by several approaches including electron microscopy, immunocytochemistry and radioimmunological techniques."	( Gorguet, B; Hollande, E; Pradayrol, L; Vinel, JP; Voigt, JJ, 1981)

Excerpt	Reference
"One patient with a glucagonoma was treated for two years and had no evidence of disease at laparotomy 7 years later."	( Altimari, AF; Badrinath, K; Prinz, RA; Reisel, HJ, 1987)
"A 41-year-old woman with metastatic glucagonoma and the characteristic disabling rash, necrolytic migratory erythema, was treated with a synthetic somatostatin analog while waiting to undergo curative surgical resection."	( Dueno, MI; Krejs, GJ; Orci, L; Popma, JJ; Santangelo, WC; Unger, RH, 1986)
"In summary, the glucagonomas provide an interesting tool with which to study the nature of severe anorexia as well as adipsia, and the identification of the active substance(s) may provide novel therapeutics for the treatment of obesity-related disorders such as NIDDM."	( Blume, N; Holst, JJ; Jensen, HI; Karlsen, C; Larsson, LI; Madsen, OD, 1995)
"A 52-year-old female with metastatic glucagonoma secreting glucagon and chromogranin A was treated with the somatostatin analogue octreotide for 2 years without any additional tumor-reducing interventions."	( Jockenhövel, F; Krenning, EP; Lamberts, SW; Lederbogen, S; Olbricht, T; Reinwein, D; Schmidt-Gayk, H, 1994)
"In addition to glucagonoma treatments, the administration of corticoids, aminoacids, zinc or essential fatty acids can be helpful."	( Dandrifosse, AC; Dandrifosse, G; Dandrifosse, JF; Piérard, G; Scheen, AJ, 1998)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	92 (37.25)	23.3326
1990's	74 (29.96)	12.5806
2000's	38 (15.38)	18.1394
2010's	39 (15.79)	28.8240
2020's	4 (1.62)	9.53

Drug	Relationship Strength	Studies	Trials
acetone	low	1	0
histamine	low	1	0
niacinamide	low	2	0
urea	low	2	0
hydroxyindoleacetic acid	medium	4	2
ciprofloxacin	low	1	0
dapsone	low	1	0
diazoxide	low	1	0
pentetic acid	medium	5	1
fluorouracil	low	8	0
glyburide	low	1	0
iodoquinol	low	1	0
1-methyl-3-isobutylxanthine	low	1	0
lomustine	low	1	0
temozolomide	low	1	0
tolbutamide	medium	4	1
prednisolone	low	1	0
thymidine	low	1	0
carbachol	low	2	0
aldosterone	low	2	0
prednisone	low	1	0
alanine	low	2	0
glutamine	low	2	0
levodopa	low	1	0
tyrosine	low	1	0
leucine	low	1	0
phenylalanine	low	1	0
egtazic acid	low	1	0
tubercidin	low	1	0
arginine	low	8	0
pyrroles	low	1	0
calcium gluconate	low	2	0
hematoxylin	low	1	0
hydroxyethyl methacrylate	low	1	0
deoxycytidine	low	1	0
barium sulfate	low	1	0
deuterium	low	1	0
levamisole	low	1	0
danazol	low	1	0
etoposide	low	1	0
substance p	low	1	0
1-carboxyglutamic acid	low	1	0
gemcitabine	low	1	0
relcovaptan	low	1	0
capecitabine	low	1	0
vanadates	low	1	0
cephalosporin c	low	1	0
fluorodeoxyglucose f18	low	3	0
fibrinogen	low	1	0
u 73122	low	1	0
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole	low	1	0
u 73343	low	1	0
3-tyr-octreotide	low	1	0
glicentin	low	3	0
wortmannin	low	1	0
carboplatin	low	1	0
bradykinin	low	1	0
oxytocin	low	1	0
thapsigargin	low	1	0
melphalan	low	1	0
arginine vasopressin	low	1	0
1,2-bis(2-aminophenoxy)ethane n,n,n',n'-tetraacetic acid acetoxymethyl ester	low	1	0
alpha-chymotrypsin	low	1	0
vitamin k semiquinone radical	low	1	0
su 11248	low	1	0
everolimus	low	1	0
pituitrin	low	1	0
cholecystokinin	low	3	0
atrial natriuretic factor	low	1	0
(dtpa-phe(1))-octreotide	low	4	0
glucagon-like peptide 1 (7-36)amide	low	1	0
gastrins	low	11	0
glucagon	medium	161	1
neuropeptide y	low	1	0
pancreastatin	low	1	0
glucagon-like peptide 1	low	12	0
c-peptide	low	8	0
exendin (9-39)	low	1	0
prednylidene	low	1	0
chiniofon	low	1	0
neurotensin	low	3	0
l 366948	low	1	0
vasoactive intestinal peptide	low	12	0
epidermal growth factor	low	1	0
glucagon-like peptide 2	low	3	0
oxyntomodulin	low	6	0
cyclosporine	low	1	0
gallium ga 68 dotatate	low	3	0
lutetium lu 177 dotatate	low	1	0
68ga-dotanoc	low	1	0
dacarbazine	low	18	0
eye	low	1	0

Protein Targets (1,181)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
Chain A, Ferritin light chain	3	0	0	3
TDP1 protein	21	0	0	21
Microtubule-associated protein tau	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
regulator of G-protein signaling 4	7	0	0	7
glucocerebrosidase	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
vitamin D3 receptor isoform VDRA	10	0	0	10
survival motor neuron protein isoform d	7	0	0	7
Cytochrome P450 3A4	0	3	0	5
Cytochrome P450 2C9	0	8	0	9
Short transient receptor potential channel 6	0	1	0	1
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, Phosphodiesterase 9A	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, Class I phosphodiesterase PDEB1	0	1	0	1
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera	0	1	0	1
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
glp-1 receptor, partial	6	0	0	6
thyroid stimulating hormone receptor	12	0	0	12
estrogen-related nuclear receptor alpha	16	0	0	16
Phosphodiesterase	0	1	0	1
mitogen-activated protein kinase 1	4	0	0	4
geminin	21	0	0	21
cytochrome P450 3A4 isoform 1	7	0	0	7
histone acetyltransferase KAT2A isoform 1	9	0	0	9
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	7	1	0	8
Monocarboxylate transporter 4	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
Renin	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	7	1	0	8
Gamma-aminobutyric acid receptor subunit delta	7	1	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	7	1	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	7	2	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	7	1	0	8
Adenosine receptor A1	0	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	7	1	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	7	1	0	8
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	0	0	1
Adenosine receptor A2b	0	0	0	1
Adenosine receptor A2b	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	7	1	0	8
Adenosine receptor A1	0	0	1	3
Adenosine receptor A2a	0	2	0	6
Sodium-dependent serotonin transporter	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	1	0	8
Gamma-aminobutyric acid receptor subunit beta-3	7	1	0	8
Gamma-aminobutyric acid receptor subunit beta-2	7	1	0	8
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Phosphodiesterase	0	1	0	1
GABA theta subunit	7	1	0	8
Phosphodiesterase	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	1	0	8
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
glucocorticoid receptor [Homo sapiens]	17	0	0	17
thyroid hormone receptor beta isoform 2	12	0	0	12
lamin isoform A-delta10	14	0	0	14
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	15	0	0	15
Carbonic anhydrase 1	0	1	0	7
Carbonic anhydrase 2	0	1	0	8
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	6
Proton-coupled amino acid transporter 1	0	2	0	3
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
AR protein	20	0	0	20
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	3	3	6
Androgen receptor	0	4	0	4
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	12	0	0	12
phosphopantetheinyl transferase	9	0	0	9
NFKB1 protein, partial	2	0	0	2
GLS protein	11	0	0	11
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	12	0	0	12
flap endonuclease 1	8	0	0	8
DNA polymerase iota isoform a (long)	9	0	0	9
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	3	0	0	3
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	10	0	0	10
peripheral myelin protein 22	18	0	0	18
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	17
Bile salt export pump	0	23	0	23
Translocator protein	0	1	1	2
Vasopressin V2 receptor	0	4	2	7
Oxytocin receptor	0	3	3	6
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1a receptor	0	5	2	7
Vasopressin V1b receptor	0	2	2	4
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	2	1	4
Translocator protein	0	1	0	2
Oxytocin receptor	0	2	0	2
Vasopressin V2 receptor	0	3	1	4
Canalicular multispecific organic anion transporter 1	0	17	0	18
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
Angiotensin-converting enzyme	0	1	0	2
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
RAR-related orphan receptor gamma	18	0	0	18
estrogen nuclear receptor alpha	21	0	0	21
Liver carboxylesterase 1	0	0	0	1
Chain A, Beta-lactamase	5	0	0	5
acetylcholinesterase	4	0	0	4
GALC protein	3	0	0	3
peroxisome proliferator activated receptor gamma	11	0	0	11
IDH1	6	0	0	6
thyroid stimulating hormone receptor	5	0	0	5
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Bloom syndrome protein isoform 1	6	0	0	6
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	2	5
Muscarinic acetylcholine receptor M4	0	2	2	5
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	4
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	3
Muscarinic acetylcholine receptor M1	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Delta-type opioid receptor	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Muscarinic acetylcholine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
estrogen receptor 2 (ER beta)	7	0	0	7
G	7	0	0	7
cytochrome P450 2D6	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
DNA polymerase kappa isoform 1	7	0	0	7
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Inositol hexakisphosphate kinase 1	7	0	0	7
cytochrome P450 2C9, partial	7	0	0	7
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, Cruzipain	3	0	0	3
EWS/FLI fusion protein	6	0	0	6
cytochrome P450 2C9 precursor	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
Cytochrome P450 1A2	0	2	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
Cytochrome P450 2D6	0	1	0	1
DNA topoisomerase 2-alpha	0	2	3	13
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	1	0	1
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	7	0	1	8
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
interleukin 8	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	14	0	0	14
activating transcription factor 6	3	0	0	3
Matrix metalloproteinase-9	0	1	0	1
Inositol monophosphatase 1	4	0	0	4
Isocitrate lyase	0	1	0	1
pregnane X receptor	3	0	0	3
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
GLI family zinc finger 3	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
progesterone receptor	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
retinoid X nuclear receptor alpha	10	0	0	10
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	12	0	0	12
peroxisome proliferator-activated receptor delta	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Histone H2A.x	7	0	0	7
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
heat shock protein beta-1	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Rap guanine nucleotide exchange factor 3	4	0	0	4
Estrogen receptor	0	4	0	4
Glucocorticoid receptor	0	6	2	13
Cellular tumor antigen p53	11	0	0	11
Glycine receptor subunit alpha-1	0	6	0	6
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Adenosine receptor A3	0	4	0	4
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	4	0	4
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Glutamate receptor 2	7	0	0	9
Glycine receptor subunit beta	0	6	0	6
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	2	0	2
Glycine receptor subunit alpha-2	0	6	0	6
Sodium-dependent noradrenaline transporter	0	2	0	2
Glycine receptor subunit alpha-3	0	6	0	6
5-hydroxytryptamine receptor 2A	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	4	0	4
Cytochrome P450 2J2	0	3	0	3
Spike glycoprotein	5	0	1	6
Sodium-dependent dopamine transporter	0	2	0	2
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	9	0	0	9
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Smad3	5	0	0	5
67.9K protein	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
muscleblind-like protein 1 isoform 1	4	0	0	4
Bile salt export pump	0	4	0	4
Myeloperoxidase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	2	4
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	0	1	1
ATAD5 protein, partial	3	0	0	3
cytochrome P450 2D6 isoform 1	2	0	0	2
D(1A) dopamine receptor	3	0	0	3
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	8	0	0	8
Coagulation factor VII	0	2	0	2
Tissue factor	0	2	0	2
Glutamate receptor 1	0	0	0	2
Glutamate receptor 3	0	0	0	2
Glutamate receptor 4	0	0	0	2
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	2	1	3
ATP-sensitive inward rectifier potassium channel 11	0	2	1	3
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Amyloid-beta precursor protein	1	1	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
endonuclease IV	4	0	0	4
arylsulfatase A	6	0	0	6
peripheral myelin protein 22 isoform 1	6	0	0	6
caspase 7, apoptosis-related cysteine protease	3	0	0	3
caspase-3	3	0	0	3
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	3
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	5
Glutamate receptor ionotropic, NMDA 2B	0	0	0	5
Glutamate receptor ionotropic, NMDA 2C	0	0	0	5
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	3	10
Glutamate receptor ionotropic, NMDA 2D	0	0	0	5
Tubulin beta-2B chain	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	5
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	5
USP1 protein, partial	11	0	0	11
Bone morphogenetic protein receptor type-1B	0	0	2	2
Cell division cycle 7-related protein kinase	0	0	2	2
Serine/threonine-protein kinase PLK4	0	2	2	4
ATP-dependent RNA helicase DDX3X	0	0	2	2
Pyridoxal kinase	0	0	2	2
Citron Rho-interacting kinase	0	0	2	2
Serine/threonine-protein kinase Chk1	0	1	2	3
Aurora kinase A	0	1	2	3
Cyclin-G-associated kinase	0	0	2	2
Ephrin type-B receptor 6	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 3	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 2	0	0	2	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	2	2
Dynamin-like 120 kDa protein, mitochondrial	0	0	2	2
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	2	2
Ribosomal protein S6 kinase alpha-5	0	0	2	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	2	2
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	0	2	2
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	2	2	4
Tyrosine-protein kinase ABL1	0	2	3	5
Epidermal growth factor receptor	0	4	2	6
High affinity nerve growth factor receptor	0	0	2	2
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	2	2
ADP/ATP translocase 2	0	0	2	2
Protein kinase C beta type	0	0	2	2
Insulin receptor	0	1	2	3
Tyrosine-protein kinase Lck	0	3	2	5
Tyrosine-protein kinase Fyn	0	2	2	4
Cyclin-dependent kinase 1	0	0	2	2
Glycogen phosphorylase, liver form	0	0	2	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	0	2	2
Tyrosine-protein kinase Lyn	0	0	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	2	3
Insulin-like growth factor 1 receptor	0	0	2	2
Signal recognition particle receptor subunit alpha	0	0	2	2
Cytochrome c1, heme protein, mitochondrial	0	0	2	2
Hepatocyte growth factor receptor	0	1	2	3
Tyrosine-protein kinase HCK	0	1	2	3
Platelet-derived growth factor receptor beta	0	3	2	5
Tyrosine-protein kinase Fgr	0	0	2	2
Serine/threonine-protein kinase A-Raf	0	0	2	2
Glycogen phosphorylase, brain form	0	0	2	2
Breakpoint cluster region protein	0	0	3	3
Serine/threonine-protein kinase pim-1	0	0	2	2
Fibroblast growth factor receptor 1	0	1	2	3
Cyclin-dependent kinase 4	0	0	2	2
ADP/ATP translocase 3	0	0	2	2
Inosine-5'-monophosphate dehydrogenase 2	0	0	2	2
Proto-oncogene tyrosine-protein kinase Src	0	1	2	3
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Serine/threonine-protein kinase B-raf	0	0	2	2
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	2	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	2	2
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	0	2	2
cAMP-dependent protein kinase catalytic subunit alpha	0	0	2	2
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	2	2
Casein kinase II subunit alpha'	0	0	2	2
Ras-related protein Rab-6A	0	0	2	2
Ephrin type-A receptor 1	0	0	2	2
Multifunctional protein ADE2	0	0	2	2
cAMP-dependent protein kinase catalytic subunit gamma	0	0	2	2
cAMP-dependent protein kinase catalytic subunit beta	0	0	2	2
Ferrochelatase, mitochondrial	0	0	2	2
Ribosomal protein S6 kinase beta-1	0	0	2	2
Tyrosine-protein kinase JAK1	0	0	2	2
Cyclin-dependent kinase 2	0	1	2	3
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	2	2
Mitogen-activated protein kinase 3	0	1	2	3
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Mitogen-activated protein kinase 1	0	1	2	3
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-B receptor 2	0	0	2	2
Non-receptor tyrosine-protein kinase TYK2	0	0	2	2
UMP-CMP kinase	0	0	2	2
Phosphatidylethanolamine-binding protein 1	0	0	2	2
Wee1-like protein kinase	0	0	2	2
Heme oxygenase 2	0	0	2	2
S-adenosylmethionine synthase isoform type-2	0	0	2	2
DnaJ homolog subfamily A member 1	0	0	2	2
RAC-alpha serine/threonine-protein kinase	0	1	2	3
RAC-beta serine/threonine-protein kinase	0	0	2	2
Dual specificity protein kinase TTK	0	0	2	2
DNA replication licensing factor MCM4	0	0	2	2
Myosin-10	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 2	0	0	2	2
Receptor-type tyrosine-protein kinase FLT3	0	1	2	4
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	0	2	2
TGF-beta receptor type-2	0	0	2	2
Electron transfer flavoprotein subunit beta	0	0	2	2
Tyrosine-protein kinase CSK	0	0	2	2
Glycine--tRNA ligase	0	0	2	2
Protein kinase C iota type	0	0	2	2
Exosome RNA helicase MTR4	0	0	2	2
Serine/threonine-protein kinase mTOR	0	3	3	6
Tyrosine-protein kinase Tec	0	0	2	2
Tyrosine-protein kinase ABL2	0	1	2	3
Tyrosine-protein kinase FRK	0	0	2	2
G protein-coupled receptor kinase 6	0	0	2	2
Tyrosine-protein kinase SYK	0	0	2	2
26S proteasome regulatory subunit 6B	0	0	2	2
Mitogen-activated protein kinase 8	0	0	2	2
Mitogen-activated protein kinase 9	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Casein kinase I isoform alpha	0	1	2	3
Casein kinase I isoform delta	0	0	2	2
MAP kinase-activated protein kinase 2	0	0	2	2
Elongation factor Tu, mitochondrial	0	0	2	2
Choline-phosphate cytidylyltransferase A	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	2	2
Casein kinase I isoform epsilon	0	0	2	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	2	2
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	2	2
Dual specificity protein kinase CLK3	0	0	2	2
Glycogen synthase kinase-3 alpha	0	0	2	2
Glycogen synthase kinase-3 beta	0	0	2	2
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Ras-related protein Rab-27A	0	0	2	2
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Ribosomal protein S6 kinase alpha-3	0	1	2	3
Serine/threonine-protein kinase Nek2	0	1	2	3
Serine/threonine-protein kinase Nek3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase PLK1	0	4	2	6
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Mitogen-activated protein kinase 10	0	0	2	2
Tyrosine--tRNA ligase, cytoplasmic	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	1	2	3
Ephrin type-A receptor 4	0	0	2	2
Adenylate kinase 2, mitochondrial	0	0	2	2
Adenosine kinase	0	1	2	3
Ras-related protein Rab-10	0	0	2	2
Actin-related protein 3	0	0	2	2
Actin-related protein 2	0	0	2	2
GTP-binding nuclear protein Ran	0	0	2	2
Casein kinase I isoform gamma-2	0	0	2	2
Cyclin-dependent kinase 3	0	0	2	2
Cyclin-dependent kinase 6	0	0	2	2
Cyclin-dependent-like kinase 5	0	0	2	2
Cyclin-dependent kinase 16	0	0	2	2
Cyclin-dependent kinase 17	0	0	2	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 1	0	0	2	2
Protein kinase C theta type	0	0	2	2
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	0	2	2
Focal adhesion kinase 1	0	1	2	3
Protein kinase C delta type	0	0	2	2
Tyrosine-protein kinase BTK	0	0	2	2
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Serine/threonine-protein kinase 4	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	1	2	3
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
Integrin-linked protein kinase	0	0	2	2
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
cGMP-dependent protein kinase 1	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Maternal embryonic leucine zipper kinase	0	0	2	2
Structural maintenance of chromosomes protein 1A	0	0	2	2
Chromodomain-helicase-DNA-binding protein 4	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 1	0	0	2	2
Ephrin type-A receptor 7	0	0	2	2
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	1	2	3
Dual specificity testis-specific protein kinase 1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	1	2	3
Mitogen-activated protein kinase 11	0	0	2	2
Serine/threonine-protein kinase STK11	0	0	2	2
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Mitogen-activated protein kinase 14	0	1	2	3
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
Discoidin domain-containing receptor 2	0	0	2	2
AP2-associated protein kinase 1	0	1	2	3
Myosin light chain kinase 3	0	0	2	2
Putative heat shock protein HSP 90-beta 2	0	0	2	2
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	2	2
Uncharacterized protein FLJ45252	0	0	2	2
Acyl-CoA dehydrogenase family member 11	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	2	2
Serine/threonine-protein kinase MARK2	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	2	2
Serine/threonine-protein kinase TAO1	0	0	2	2
STE20-related kinase adapter protein alpha	0	0	2	2
Myosin-14	0	0	2	2
AarF domain-containing protein kinase 1	0	0	2	2
ATP-dependent RNA helicase DDX42	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
Serine/threonine-protein kinase Nek7	0	0	2	2
ATP-dependent RNA helicase DDX1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
Aurora kinase B	0	1	2	3
MAP/microtubule affinity-regulating kinase 4	0	0	2	2
Serine/threonine-protein kinase Nek1	0	0	2	2
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	2	2
EKC/KEOPS complex subunit TP53RK	0	0	2	2
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	2	2
Serine/threonine-protein kinase D2	0	0	2	2
NUAK family SNF1-like kinase 2	0	0	2	2
RNA cytidine acetyltransferase	0	0	2	2
Serine/threonine-protein kinase SIK2	0	0	2	2
STE20-like serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO3	0	0	2	2
dCTP pyrophosphatase 1	0	0	2	2
Dual specificity protein kinase CLK4	0	0	2	2
Casein kinase I isoform gamma-1	0	0	2	2
Phenylalanine--tRNA ligase beta subunit	0	0	2	2
BMP-2-inducible protein kinase	0	0	2	2
Obg-like ATPase 1	0	0	2	2
Midasin	0	0	2	2
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Cyclin-dependent kinase 12	0	0	2	2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	2	2
Serine/threonine-protein kinase 26	0	0	2	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	2	2
Serine/threonine-protein kinase NLK	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	2
Serine/threonine-protein kinase TBK1	0	1	2	3
Septin-9	0	0	2	2
Potassium voltage-gated channel subfamily D member 3	0	2	0	2
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO2	0	0	2	2
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Thyroid hormone receptor-associated protein 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 3	0	0	2	2
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	6	0	0	6
Skn7p	0	0	0	1
Thrombopoietin	1	0	0	1
nonstructural protein 1	4	0	0	4
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Vpr	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	1	0	2
Aromatase	0	2	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Glucagon-like peptide 1 receptor	0	0	1	1
Glucagon-like peptide 1 receptor	0	1	1	2
Glucagon receptor	0	0	1	1
Glucagon receptor	0	0	1	1
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	7	0	0	7
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	5
Amino acid transporter	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
Parkin	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
Solute carrier family 22 member 6	0	2	0	2
ATP-binding cassette sub-family C member 9	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Potassium channel subfamily K member 2	0	0	2	2
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
ATP synthase subunit beta, mitochondrial	0	1	0	1
ATP synthase subunit delta, mitochondrial	0	1	0	1
ATP synthase subunit gamma, mitochondrial	0	1	0	1
ATP synthase subunit epsilon, mitochondrial	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
WRN	3	0	0	3
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
PPM1D protein	3	0	0	3
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	5	0	0	5
apical membrane antigen 1, AMA1	4	0	0	4
hypothetical protein, conserved	2	0	0	2
luciferase	1	0	0	1
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
cellular tumor antigen p53 isoform a	2	0	0	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
DNA polymerase beta	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	2	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
phosphoglycerate kinase	2	0	0	2
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase 12	0	1	0	5
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	4
Carbonic anhydrase 3	0	0	0	4
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	0	0	4
Carbonic anhydrase 6	0	0	0	4
Histamine H2 receptor	0	1	2	3
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	4
Histamine H1 receptor	0	2	2	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase 7	0	0	0	4
Carbonic anhydrase	0	0	0	5
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	5
Carbonic anhydrase	0	0	0	5
Carbonic anhydrase	0	0	0	5
Carbonic anhydrase	0	0	0	5
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase	0	0	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	2
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 15	0	0	0	4
Carbonic anhydrase 13	0	0	0	3
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Carbonic anhydrase 14	0	0	0	4
Carbonic anhydrase 5B, mitochondrial	0	0	0	4
Histamine H3 receptor	0	1	2	3
Fumarate hydratase	3	0	0	3
polyprotein	3	0	0	3
M-phase phosphoprotein 8	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
citrate synthase 2, partial	0	0	1	1
PAX8	0	0	0	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
LAP4	0	0	1	1
MEP2	0	0	1	1
aryl hydrocarbon receptor	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	1	2
Catechol O-methyltransferase	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
TAR DNA-binding protein 43	3	0	0	3
heat shock protein 90, putative	0	0	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	4	0	4
Intestinal-type alkaline phosphatase	0	3	0	3
Large neutral amino acids transporter small subunit 1	0	4	0	5
Phospholipase A-2-activating protein	0	3	0	3
dopamine D1 receptor	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	2	0	2
5'-nucleotidase	0	2	0	2
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Polyphenol oxidase 2	0	0	0	2
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Neurotensin receptor type 1	0	0	1	1
Neurotensin receptor type 2	0	1	1	3
Myelin basic protein	0	0	1	1
Neurotensin receptor type 1	0	1	1	2
Neurotensin receptor type 1	0	2	2	5
Neurotensin receptor type 2	0	2	1	3
Sortilin	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	2	0	2
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Oxytocin receptor	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Prostaglandin G/H synthase 2	0	1	1	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
tyrosine-protein kinase Yes	1	0	0	1
Membrane-associated progesterone receptor component 1	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	2	2	4
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Mitogen-activated protein kinase 13	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
NUAK family SNF1-like kinase 1	0	1	1	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	1	1	2
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	1	2
Mast/stem cell growth factor receptor Kit	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	1	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	3	1	4
Myosin light chain kinase, smooth muscle	0	1	1	2
Insulin receptor-related protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	2	1	3
Vascular endothelial growth factor receptor 1	0	2	1	3
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Acetylcholinesterase	0	1	0	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
Protein kinase C eta type	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	0	1
Activin receptor type-2A	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	1	1	2
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Bifunctional epoxide hydrolase 2	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	2	1	3
Vascular endothelial growth factor receptor 2	0	3	1	4
Serine/threonine-protein kinase receptor R3	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	3	2	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	2	2	4
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	2	4
Cyclin-dependent kinase 8	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 12	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	1	1	2
Ephrin type-B receptor 1	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Protein delta homolog 1	0	1	1	2
Mu-type opioid receptor	0	1	0	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Protein kinase C epsilon type	0	0	1	1
Angiopoietin-1 receptor	0	1	1	2
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Serine/threonine-protein kinase ATR	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Cyclin-dependent kinase 10	0	0	1	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Rab-like protein 3	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	1	1	2
Serine/threonine-protein kinase Nek5	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Poly [ADP-ribose] polymerase tankyrase-2	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	3	1	4
Bromodomain-containing protein 9	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	1	1	2
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	2	1	3
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	1	1	2
eIF-2-alpha kinase GCN2	0	0	1	1
Phosphatidylinositol 4-kinase beta	0	1	1	2
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
ALK tyrosine kinase receptor	0	1	1	2
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-P receptor	0	1	0	1
Substance-K receptor	0	1	0	1
D(2) dopamine receptor	0	0	1	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
polyadenylate-binding protein 1	0	1	0	1
DNA polymerase III, partial	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	1	2
D(1A) dopamine receptor	1	0	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Albumin	0	1	1	2
Albumin	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Chain A, Purine nucleoside phosphorylase	0	1	0	1
Chain A, Purine nucleoside phosphorylase DeoD-type	0	1	0	1
NS5	0	0	1	1
MSH	0	0	0	1
Hsf1 protein	0	0	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Programmed cell death protein 4	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Telomerase reverse transcriptase	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Receptor-type tyrosine-protein phosphatase F	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Nrf2	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Alpha-synuclein	1	0	0	1
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (247)

Protein Targets (1,181)

Adenoma, alpha-Cell

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (247)

Drugs Studied (109)

Protein Targets (1,181)