histamine has been researched along with Down Syndrome in 6 studies
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to study whether Alzheimer-like neuropathological changes involve the central histaminergic system we measured the concentration of histamine, its precursor histidine as well as the activity of histidine decarboxylase (HDC) and histamine-N-methyl-transferase (HMT) in frontal cortex of aging Down syndrome (DS) patients, Alzheimer patients and control individuals." | 7.69 | Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease. ( Cairns, N; Kirchner, L; Kitzmüller, E; Lubec, G; Prast, H; Risser, D; Schneider, C; Singewald, N, 1997) |
| "In order to study whether Alzheimer-like neuropathological changes involve the central histaminergic system we measured the concentration of histamine, its precursor histidine as well as the activity of histidine decarboxylase (HDC) and histamine-N-methyl-transferase (HMT) in frontal cortex of aging Down syndrome (DS) patients, Alzheimer patients and control individuals." | 3.69 | Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease. ( Cairns, N; Kirchner, L; Kitzmüller, E; Lubec, G; Prast, H; Risser, D; Schneider, C; Singewald, N, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| COGHLAN, MK | 1 |
| EVANS, PR | 1 |
| Schneider, C | 1 |
| Risser, D | 1 |
| Kirchner, L | 1 |
| Kitzmüller, E | 1 |
| Cairns, N | 2 |
| Prast, H | 1 |
| Singewald, N | 1 |
| Lubec, G | 4 |
| Seidl, R | 1 |
| Hauser, E | 1 |
| Bernert, G | 1 |
| Marx, M | 1 |
| Freilinger, M | 1 |
| Kim, SH | 2 |
| Fountoulakisc, M | 1 |
| Krapfenbauer, K | 1 |
| Cheon, MS | 1 |
| Fountoulakis, M | 1 |
| Cairns, NJ | 1 |
| Perry, TL | 1 |
| Hestrin, M | 1 |
| MacDougall, L | 1 |
| Hansen, S | 1 |
1 trial available for histamine and Down Syndrome
| Article | Year |
|---|---|
Auditory evoked potentials in young patients with Down syndrome. Event-related potentials (P3) and histaminergic system.
Topics: Adolescent; Adult; Child; Down Syndrome; Evoked Potentials, Auditory; Evoked Potentials, Auditory, B | 1997 |
5 other studies available for histamine and Down Syndrome
| Article | Year |
|---|---|
INFANTILE ECZEMA, ASTHMA AND HAY FEVER IN MONGOLISM.
Topics: Adolescent; Asthma; Child; Dermatitis, Atopic; Down Syndrome; Eczema; Histamine; Humans; Infant; Rhi | 1964 |
Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease.
Topics: Aged; Aging; Alzheimer Disease; Brain; Case-Control Studies; Down Syndrome; Female; Frontal Lobe; Hi | 1997 |
Decreased brain histamine-releasing factor protein in patients with Down syndrome and Alzheimer's disease.
Topics: Alzheimer Disease; Biomarkers, Tumor; Brain Chemistry; Down Syndrome; Electrophoresis, Gel, Two-Dime | 2001 |
Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease.
Topics: Aged; Brain; Cerebellum; Cytosol; Down Syndrome; Down-Regulation; Female; Frontal Lobe; Histamine; H | 2002 |
Urinary amines of intestinal bacterial origin.
Topics: Adult; Amines; Down Syndrome; Female; Histamine; Humans; Intestines; Male; Neomycin; Octopamine; Phe | 1966 |