Page last updated: 2024-12-06
mesudipine
Description
Mesudipine is a dihydropyridine calcium channel blocker with potential therapeutic applications in the treatment of cardiovascular diseases. It exhibits potent vasodilatory effects, leading to a decrease in blood pressure and improved blood flow. Research indicates that mesudipine selectively inhibits calcium influx through L-type calcium channels, primarily found in vascular smooth muscle cells, resulting in smooth muscle relaxation and vasodilation. Studies have explored its efficacy in managing hypertension, angina pectoris, and other cardiovascular disorders. Mesudipine's importance lies in its potential to provide alternative treatment options for these conditions, particularly for patients who may not respond well to existing therapies. The compound is being studied to further understand its pharmacological profile, optimize its therapeutic efficacy, and explore potential new applications in cardiovascular medicine.'
mesudipine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
PubMed CID | 68817 |
CHEMBL ID | 2106863 |
SCHEMBL ID | 1900480 |
MeSH ID | M0111456 |
Synonyms (17)
Synonym |
mesudipine |
62658-88-2 |
diethyl 2,6-dimethyl-4-(2-methylsulfanylpyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate |
SCHEMBL1900480 |
CHEMBL2106863 |
mesudipinum [inn-latin] |
einecs 263-677-3 |
mesudipinum |
mesudipino [inn-spanish] |
dt27w93dff , |
mesudipino |
unii-dt27w93dff |
diethyl 1',4'-dihydro-2',6'-dimethyl-2-(methylthio)(3,4'-bipyridine)-3',5'-dicarboxylate |
mesudipine [inn] |
diethyl 2',6'-dimethyl-2-(methylsulfanyl)-1',4'-dihydro[3,4'-bipyridine]-3',5'-dicarboxylate |
DTXSID00978230 |
Q27276586 |
Research
Studies (5)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 4 (80.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.36
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 12.36 (24.57) | Research Supply Index | 1.95 (2.92) | Research Growth Index | 4.31 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |