Page last updated: 2024-09-27

Post-Dural Puncture Headache

A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.

Synonyms(3)

Synonym
Postdural Puncture Headache
Post-Dural Puncture Headache
Post-Lumbar Puncture Headache

Research Excerpts

Overview

ExcerptReference
"Postdural puncture headache is a common complication associated with neuraxial anesthesia and unintentional dural puncture."( Kent, S; Mehaffey, G, 2016)
"Postdural puncture headache is a challenging complication of diagnostic, therapeutic, and unintentional lumbar puncture."( Eisdorfer, S; Gralla, J; Tong, S; Zapapas, MK, 2020)

Treatment

ExcerptReference
"To demonstrate a possible alternative treatment for postdural puncture headache (PDPH)."( Kent, S; Mehaffey, G, 2016)

Research

Studies (129)

TimeframeStudies, This Condition (%)All Conditions %
pre-19909 (6.98)23.3326
1990's0 (0.00)12.5806
2000's27 (20.93)18.1394
2010's70 (54.26)28.8240
2020's23 (17.83)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0medium83
histamine0low10
acetaminophen0medium92
theophylline0medium82
baclofen0low10
bupivacaine0medium104
caffeine0medium181
diclofenac0medium11
fentanyl0medium51
gabapentin0medium72
lidocaine0low60
indomethacin0low10
ketamine0low10
ketorolac0low10
labetalol0low10
meperidine0medium11
metoclopramide0low10
mianserin0low10
mirtazapine0low10
neostigmine0medium72
ondansetron0medium41
oxybutynin0low10
procaine0low10
propofol0low30
sumatriptan0low20
prednisolone0low10
prednisone0low10
desoxycorticosterone acetate0low20
uridine diphosphate0low40
desoxycorticosterone0low20
phencyclidine0low10
methylprednisolone0low10
thiophenes0low10
ergotamine0medium11
chloroprocaine0low10
ephedrine0low10
pirinitramide0low10
aminophylline0medium62
betamethasone0low10
dihydroergotamine0low10
gadolinium0low10
magnesium sulfate0low30
tramadol0low10
sufentanil0low10
duloxetine hydrochloride0low10
frovatriptan0medium11
ketorolac tromethamine0low10
methotrexate0low10
atropine0medium72
ropivacaine0low20
cortisone0low10
oxytocin0low10
ergonovine0low10
retinol0low10
vitamin k semiquinone radical0low10
hydrocodone0low10
hydromorphone0low10
oxycodone0low20
morphine0medium93
dexmedetomidine0medium32
heroin0low10
pregabalin0medium11
td-51080low10
cosyntropin0medium72
ziconotide0low10
cardiovascular agents0low10
warfarin0low10
sildenafil citrate0low10

Protein Targets (858)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma130013
ATAD5 protein, partial7007
GLS protein120012
Microtubule-associated protein tau8008
Smad32002
aldehyde dehydrogenase 1 family, member A1120012
thyroid stimulating hormone receptor100010
nuclear receptor subfamily 1, group I, member 3130013
progesterone receptor150015
EWS/FLI fusion protein130013
retinoic acid nuclear receptor alpha variant 1170017
retinoid X nuclear receptor alpha130013
estrogen-related nuclear receptor alpha210021
estrogen nuclear receptor alpha260026
peroxisome proliferator activated receptor gamma100010
aryl hydrocarbon receptor6006
chromobox protein homolog 1110011
thyroid hormone receptor beta isoform 2160016
peripheral myelin protein 22100010
cytochrome P450 3A4 isoform 18008
Gamma-aminobutyric acid receptor subunit pi86115
ATP-binding cassette sub-family C member 3024024
Multidrug resistance-associated protein 4024025
Solute carrier family 22 member 60303
Carbonic anhydrase 120318
UDP-glucuronosyltransferase 1A90104
Bile salt export pump0202
Voltage-dependent calcium channel gamma-2 subunit9009
Bile salt export pump037037
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 106113
Carbonic anhydrase 206214
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20102
Prostaglandin G/H synthase 10405
Carbonic anhydrase 30318
Cytochrome P450 3A40718
Cytochrome P450 2D60606
Cytochrome P450 2C9 0506
Polyunsaturated fatty acid lipoxygenase ALOX150202
Gamma-aminobutyric acid receptor subunit beta-186115
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta86115
Gamma-aminobutyric acid receptor subunit gamma-286317
UDP-glucuronosyltransferase 1-60203
Glutamate receptor 29009
Gamma-aminobutyric acid receptor subunit alpha-586115
Gamma-aminobutyric acid receptor subunit alpha-386115
Arachidonate 5-lipoxygenase-activating protein0202
UDP-glucuronosyltransferase 1A1 0203
Carbonic anhydrase 40317
Prostaglandin G/H synthase 10505
Carbonic anhydrase 60317
Gamma-aminobutyric acid receptor subunit gamma-186115
Gamma-aminobutyric acid receptor subunit alpha-286115
Gamma-aminobutyric acid receptor subunit alpha-486115
Gamma-aminobutyric acid receptor subunit gamma-386115
Gamma-aminobutyric acid receptor subunit alpha-686115
Carbonic anhydrase 5A, mitochondrial0318
Prostaglandin G/H synthase 20618
Carbonic anhydrase 70317
Nuclear receptor ROR-gamma5005
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-186317
Gamma-aminobutyric acid receptor subunit beta-386115
Gamma-aminobutyric acid receptor subunit beta-286317
Carbonic anhydrase 90419
GABA theta subunit86115
Canalicular multispecific organic anion transporter 1024024
Carbonic anhydrase 150204
Carbonic anhydrase 130306
Gamma-aminobutyric acid receptor subunit epsilon86115
Carbonic anhydrase 140318
Carbonic anhydrase 5B, mitochondrial0318
toxin B0001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase6006
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase150015
GALC protein3003
GLI family zinc finger 3180018
cytochrome P450 family 3 subfamily A polypeptide 4150015
glucocorticoid receptor [Homo sapiens]240024
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A5005
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 2220022
Bloom syndrome protein isoform 17007
thyroid hormone receptor beta isoform a6006
nuclear factor erythroid 2-related factor 2 isoform 1120012
geminin180018
survival motor neuron protein isoform d6006
muscleblind-like protein 1 isoform 13003
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Glycogen phosphorylase, muscle form0202
Renin0404
Carbonic anhydrase 20202
Cathepsin B0101
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0809
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80101
Cytochrome P450 2A60101
5-hydroxytryptamine receptor 2A0808
Androgen receptor0404
Translocator protein0112
Cannabinoid receptor 10101
Cytochrome P450 2B60202
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10609
Serum paraoxonase/arylesterase 10202
Dipeptidyl peptidase 40001
Endochitinase0101
Adenosine receptor A2a05010
5-hydroxytryptamine receptor 2B0505
Sodium-dependent serotonin transporter0606
Delta-type opioid receptor0507
Cytochrome P450 2C190202
Delta-type opioid receptor09111
Mu-type opioid receptor011216
Carbonic anhydrase0102
Kappa-type opioid receptor0606
Carbonic anhydrase0101
D(1A) dopamine receptor0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0103
D(2) dopamine receptor0808
Cholinesterase0303
Carbonic anhydrase 0101
Mu-type opioid receptor0606
Fatty-acid amide hydrolase 10202
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0506
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70202
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0103
Carbonic anhydrase 30101
Carbonic anhydrase0104
Carbonic anhydrase0104
Carbonic anhydrase 0101
Sigma intracellular receptor 20202
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10505
Renin0101
Carbonic anhydrase 0103
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130215
Carbonic anhydrase 40304
Acidic mammalian chitinase0101
Carbonic anhydrase 70101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
USP1 protein, partial110011
lamin isoform A-delta10160016
Chain A, 2-oxoglutarate Oxygenase4004
AR protein260026
pregnane X nuclear receptor190019
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta3003
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 011014
5-hydroxytryptamine receptor 4014115
Muscarinic acetylcholine receptor M206212
Muscarinic acetylcholine receptor M40619
Muscarinic acetylcholine receptor M10529
Muscarinic acetylcholine receptor M30529
Muscarinic acetylcholine receptor M40327
Muscarinic acetylcholine receptor M50428
Muscarinic acetylcholine receptor M50619
Muscarinic acetylcholine receptor M205210
Muscarinic acetylcholine receptor M106111
Muscarinic acetylcholine receptor M10013
Muscarinic acetylcholine receptor M30619
Alpha-1D adrenergic receptor011213
5-hydroxytryptamine receptor 2C017017
Muscarinic acetylcholine receptor M40113
Histamine H2 receptor3117
5-hydroxytryptamine receptor 70404
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0124
phosphopantetheinyl transferase9009
NFKB1 protein, partial1001
regulator of G-protein signaling 48008
67.9K protein4004
activating transcription factor 62002
D(1A) dopamine receptor7007
histone acetyltransferase KAT2A isoform 16006
Gamma-aminobutyric acid type B receptor subunit 20224
Gamma-aminobutyric acid type B receptor subunit 20303
Gamma-aminobutyric acid type B receptor subunit 10224
Gamma-aminobutyric acid type B receptor subunit 10202
ATP-dependent phosphofructokinase7007
pregnane X receptor4004
farnesoid X nuclear receptor7007
vitamin D (1,25- dihydroxyvitamin D3) receptor120012
IDH18008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a100010
nuclear receptor subfamily 1, group I, member 26006
nuclear factor erythroid 2-related factor 2 isoform 27007
galanin receptor type 30101
Glucocorticoid receptor010217
Glycine receptor subunit alpha-1010010
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
ORF730011
Potassium channel subfamily K member 30303
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20134
Potassium channel subfamily K member 90101
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
thyroid stimulating hormone receptor4004
v-jun sarcoma virus 17 oncogene homolog (avian)9009
atrial natriuretic peptide receptor 1 precursor2002
nuclear receptor ROR-gamma isoform 15005
DNA polymerase kappa isoform 13003
muscarinic acetylcholine receptor M18008
lethal factor (plasmid)2002
Cholinesterase0303
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0303
Adenosine receptor A30202
Replicase polyprotein 1ab0303
Amine oxidase [flavin-containing] A0202
Acetylcholinesterase0404
Amine oxidase [flavin-containing] B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0303
Adenosine receptor A30202
Adenosine receptor A2a0439
Adenosine receptor A2b0204
Adenosine receptor A2b0305
Adenosine receptor A10329
Vasopressin V2 receptor0002
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0202
Adenosine receptor A10202
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0202
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10002
Chitotriosidase-10202
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0103
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0134
Endochitinase B10202
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20102
Guanine deaminase0101
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
endonuclease IV1001
dopamine D1 receptor3003
TDP1 protein170017
peroxisome proliferator-activated receptor delta7007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
peripheral myelin protein 22 isoform 12002
heat shock protein beta-15005
flap endonuclease 14004
M-phase phosphoprotein 83003
Sex hormone-binding globulin0022
Corticosteroid-binding globulin0303
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 436006
Multidrug and toxin extrusion protein 10707
SMAD family member 25005
SMAD family member 35005
mitogen-activated protein kinase 13003
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Solute carrier family 22 member 30101
Interferon beta100010
Solute carrier family 22 member 20203
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE8008
glp-1 receptor, partial4004
thioredoxin glutathione reductase4004
estrogen receptor 2 (ER beta)8008
G6006
vitamin D3 receptor isoform VDRA7007
HLA class I histocompatibility antigen, B alpha chain 6006
Spike glycoprotein9009
Inositol hexakisphosphate kinase 16006
cytochrome P450 2C9, partial6006
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 16006
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor3003
Alpha-2A adrenergic receptor013215
Alpha-1B adrenergic receptor08210
Alpha-1A adrenergic receptor0011
Alpha-2C adrenergic receptor09110
Alpha-2B adrenergic receptor0437
Alpha-2C adrenergic receptor0437
Alpha-2A adrenergic receptor0538
Alpha-1D adrenergic receptor08210
Alpha-1A adrenergic receptor08210
Aldo-keto reductase family 1 member B100101
Prostaglandin G/H synthase 1 0203
Transient receptor potential cation channel subfamily A member 10011
Dihydrofolate reductase0304
Cytochrome c oxidase subunit 20202
Fatty acid-binding protein, liver0303
Transthyretin0013
Albumin0336
Interleukin-80202
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Fatty acid-binding protein, intestinal0213
Aldo-keto reductase family 1 member B10202
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1A40101
Sodium- and chloride-dependent GABA transporter 10404
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20404
Sodium- and chloride-dependent GABA transporter 30404
Prostaglandin G/H synthase 2 0202
UDP-glucuronosyltransferase 1A30002
UDP-glucuronosyltransferase 2B10 0101
Sodium- and chloride-dependent betaine transporter0404
Prostaglandin G/H synthase 20303
Prostaglandin G/H synthase 20203
Solute carrier family 22 member 60203
Prostaglandin G/H synthase 1 0202
P2Y purinoceptor 120202
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
acetylcholinesterase6006
caspase 7, apoptosis-related cysteine protease3003
caspase-33003
Histone H2A.x3003
Caspase-71001
caspase-31001
Solute carrier family 22 member 20203
Cellular tumor antigen p53130013
ATP-dependent translocase ABCB10404
ATP-dependent translocase ABCB10707
D(2) dopamine receptor014014
Alpha-2B adrenergic receptor0909
5-hydroxytryptamine receptor 1A014115
ATP-dependent translocase ABCB10404
D(1A) dopamine receptor0808
5-hydroxytryptamine receptor 2A015015
5-hydroxytryptamine receptor 1B014014
Alpha-1A adrenergic receptor0325
Alpha-1B adrenergic receptor0022
D(3) dopamine receptor014014
5-hydroxytryptamine receptor 2B019019
5-hydroxytryptamine receptor 608010
Multidrug and toxin extrusion protein 20202
ATPase family AAA domain-containing protein 55005
Ataxin-28008
Fumarate hydratase3003
cytochrome P450 2D67007
polyprotein3003
potassium voltage-gated channel subfamily H member 2 isoform d6006
importin subunit beta-1 isoform 13003
snurportin-13003
GTP-binding nuclear protein Ran isoform 12002
Alpha-synuclein1102
Adenylate cyclase 0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Beta-2 adrenergic receptor0415
Beta-1 adrenergic receptor0415
Sodium-dependent dopamine transporter0404
Thromboxane-A synthase 0202
5-hydroxytryptamine receptor 1D0619
5-hydroxytryptamine receptor 1B0415
5-hydroxytryptamine receptor 5A0202
Luciferase4004
Nuclear receptor subfamily 1 group I member 20022
D(4) dopamine receptor0303
Kappa-type opioid receptor0719
Histamine H1 receptor0628
Mu-type opioid receptor09717
Delta-type opioid receptor07210
Kappa-type opioid receptor08312
Mu-type opioid receptor0429
Potassium voltage-gated channel subfamily H member 20909
Sigma non-opioid intracellular receptor 10909
Sigma non-opioid intracellular receptor 10404
5-hydroxytryptamine receptor 1A08311
POU domain, class 2, transcription factor 10001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Chain A, Ferritin light chain4004
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B5005
transcriptional regulator ERG isoform 33003
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid receptor subunit alpha-10224
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10123
Gamma-aminobutyric acid receptor subunit gamma-20224
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30224
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50123
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30123
Gamma-aminobutyric acid receptor subunit alpha-20123
Gamma-aminobutyric acid receptor subunit beta-20123
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40123
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60123
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Liver carboxylesterase 10002
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
apical membrane antigen 1, AMA11001
transforming acidic coiled-coil-containing protein 30001
DNA polymerase iota isoform a (long)6006
Solute carrier family 22 member 30204
Plasma kallikrein0001
Macrophage migration inhibitory factor0202
Histamine H2 receptor0325
Histamine H1 receptor0134
Histamine H1 receptor0415
Metabotropic glutamate receptor 50112
Glutamate receptor ionotropic, NMDA 1 0405
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0405
Glutamate receptor ionotropic, NMDA 2C0507
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, NMDA 2D0405
Solute carrier family 22 member 10102
Equilibrative nucleoside transporter 40001
Glutamate receptor ionotropic, NMDA 3B0405
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Glutamate receptor ionotropic, NMDA 3A0405
Histamine H3 receptor0123
Mas-related G-protein coupled receptor member X20022
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, Cruzipain2002
interleukin 82002
hypoxia-inducible factor 1 alpha subunit3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
glucocerebrosidase1001
Parkin2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
ras-related protein Rab-9A3003
serine/threonine-protein kinase mTOR isoform 11001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Procathepsin L0101
Neuronal acetylcholine receptor subunit alpha-40202
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10102
Nitric oxide synthase, inducible0101
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0102
Bifunctional epoxide hydrolase 20101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G2002
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30102
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80102
Dehydrogenase/reductase SDR family member 90101
Solute carrier organic anion transporter family member 1B30203
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
Glutamate receptor ionotropic, NMDA 2D0202
Acetylcholinesterase0404
Glutamate receptor ionotropic, NMDA 3B0202
Rap guanine nucleotide exchange factor 32002
Sodium channel protein type 4 subunit alpha0202
Glutamate receptor ionotropic, NMDA 10404
Glutamate receptor ionotropic, NMDA 2A0404
Glutamate receptor ionotropic, NMDA 2B0404
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 3A0202
NPC intracellular cholesterol transporter 1 precursor1001
Caspase-30101
Caspase-40101
Caspase-50101
Caspase-90101
Cell division control protein 42 homolog0101
Ras-related C3 botulinum toxin substrate 10101
Serine/threonine-protein kinase PAK 10101
histone deacetylase 9 isoform 31001
huntingtin isoform 22002
Beta-1 adrenergic receptor 0011
Aldo-keto reductase family 1 member B10808
Beta-3 adrenergic receptor0011
Sodium-dependent noradrenaline transporter 010010
Sodium-dependent dopamine transporter 0404
Beta-2 adrenergic receptor0112
Heparanase0011
Inositol monophosphatase 13003
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0101
Kappa-type opioid receptor0327
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
ClpP1001
15-lipoxygenase, partial2002
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Integrin beta-31102
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0112
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0202
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
PPM1D protein2002
nonstructural protein 11001
Nuclear receptor subfamily 1 group I member 20011
5-hydroxytryptamine receptor 3E0326
5-hydroxytryptamine receptor 3B0326
Albumin0022
Myeloperoxidase0101
D0404
D(3) dopamine receptor0404
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 3A0404
D(1B) dopamine receptor0202
5-hydroxytryptamine receptor 1D0516
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 1F0404
5-hydroxytryptamine receptor 3A0718
5-hydroxytryptamine receptor 3A0528
Lactoperoxidase0101
5-hydroxytryptamine receptor 4 0304
5-hydroxytryptamine receptor 3D0326
5-hydroxytryptamine receptor 3C0326
5-hydroxytryptamine receptor 3B0404
5-hydroxytryptamine receptor 3B0718
Endothelin receptor type B0101
Endothelin receptor type B0101
Endothelin-1 receptor0101
5-hydroxytryptamine receptor 60202
Sodium-dependent serotonin transporter0202
5-hydroxytryptamine receptor 7 0303
5-hydroxytryptamine receptor 70606
Type-2 angiotensin II receptor0303
5-hydroxytryptamine receptor 5A0202
5-hydroxytryptamine receptor 5B0202
Angiotensin-converting enzyme0202
G-protein coupled receptor 0101
Transporter0404
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Proteinase-activated receptor 10112
Nociceptin receptor0101
Mu-type opioid receptor0101
Mu-type opioid receptor0101
5-hydroxytryptamine receptor 3A0011
Beta-2 adrenergic receptor0101
Neuronal acetylcholine receptor subunit beta-20202
Beta-1 adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Interleukin-6 receptor subunit alpha0101
Beta-3 adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-40202
Neuronal acetylcholine receptor subunit alpha-70101
Thyrotropin-releasing hormone receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Glycine receptor subunit alpha-40101
Histamine H3 receptor0101
Leukotriene B4 receptor 10101
Nischarin0101
Amyloid-beta precursor protein0202
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Lysosomal Pro-X carboxypeptidase0101
Cholinesterase0101
Muscarinic acetylcholine receptor M50012
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Nociceptin receptor0011
Estrogen receptor beta0202
Voltage-dependent calcium channel subunit alpha-2/delta-10102
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
UDP-glucuronosyltransferase 1A80001
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Retinol-binding protein 40011
Beta-lactoglobulin0011
Disintegrin and metalloproteinase domain-containing protein 171001
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Voltage-dependent L-type calcium channel subunit alpha-1F0011
Carboxypeptidase M0101
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0011
Voltage-dependent L-type calcium channel subunit alpha-1S0011
Voltage-dependent L-type calcium channel subunit alpha-1C0011
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 40112
Chain A, Pyridoxal kinase0101
Chain A, Pyridoxal Kinase0101
Phosphodiesterase 0202
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Thyroid hormone receptor beta0101
Adenosine receptor A10202
Adenosine receptor A10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Phospholipase A-2-activating protein0101
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit0101
Seminal ribonuclease0101
Ribonucleoside-diphosphate reductase large subunit0001
Ribonucleoside-diphosphate reductase subunit M20001
P2Y purinoceptor 20011
P2Y purinoceptor 10011
P2Y purinoceptor 40011
Ribonuclease pancreatic0101
UDP-galactopyranose mutase0011
P2Y purinoceptor 60011
P2Y purinoceptor 140011
UDP-galactopyranose mutase0011
P2Y purinoceptor 60011
Ribonucleoside-diphosphate reductase subunit M2 B0001
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
Voltage-dependent N-type calcium channel subunit alpha-1B0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]