| AID141205 | Compound was evaluated for its antagonist affinity towards Muscarinic acetylcholine receptor M3 of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86268 | Antagonist effects was studied on contraction of guinea-pig ileum preparation; value ranges from 3 to 30; f means observed by Kaumann-Marano plot | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID28749 | Concentration of the compound | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86580 | The compound was evaluated for intrinsic activity i.e. maximum histamine controls relative to contraction evoked by 10 uM PGF2-alpha; termed: intrinsic activity | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86433 | Intrinsic activity was reported in guinea pig ileum whole segment | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87387 | Maximum response (E max) against H1 receptor in rat aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID86575 | Maximum response (E max) against histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87543 | Effective concentration against histamine H1 receptor in rat aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID5600 | Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 2A receptor of rat | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87386 | Intrinsic activity of the histamine as reported in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID28748 | Mepyramine concentration required to antagonise histaprodifens compound induced effects in guinea pig or rat assays | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87544 | Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87083 | Relative potency in guinea pig ileum whole segment; value ranges from 99 to 124 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86269 | Concentration required for agonistic activity against histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87540 | Maximum response (E max) against Histamine H1 receptor in rat aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID86579 | The compound was evaluated for intrinsic activity i.e. maximum histamine controls relative to contraction evoked by 10 uM PGF2-alpha | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86763 | Relative potency determined against histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID28754 | concentration was determined; value ranges from 3 to 30. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87393 | maximum relaxation evoked by carbachol in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87212 | Relative potency was recorded in Endothelium-Denuded guinea pig aortic segment; value ranges from 81 to 126 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87549 | Relative potency was recorded in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619; value ranges from 330 to 847 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87536 | Relative potency against Histamine H1 receptor in rat aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87071 | Equilibrium dissociation constant (pKp) against histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87372 | Inhibitory activity against human Histamine H1 receptor | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists. |
| AID6248 | Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 4 receptor of rat | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87362 | Inhibitory activity against human Histamine H1 receptor | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists. |
| AID86923 | Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID42212 | Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86285 | Compound was evaluated for its antagonist affinity towards Histamine H3 receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87227 | Intrinsic activity was determined | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists. |
| AID4489 | Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 1B receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID79479 | Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87074 | Negative logarithm of receptor dissociation constant Kp was reported guinea pig ileal whole segment | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID35610 | Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87381 | Compound was evaluated for mepyramine antagonism effects in rat aorta (relaxation) at a mepyramine concentration of 100 nM | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86762 | Relative potency against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87217 | Relative potency was recorded in endothelium-denuded guinea pig aortic segment; value ranges from 105 to 126 at 10 uM | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86895 | Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86922 | Effective concentration against histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID5965 | Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 3 receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86921 | Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID86898 | Antagonism of guinea pig ileum contraction at 100 nM mepyramine | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86273 | concentration of mepyramine was determined; value ranges from 1 to 30 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID88149 | Compound was evaluated for its antagonist affinity towards Histamine H2 receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86925 | Effective concentration for agonist activity in guinea pig ileum whole segment | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID1798265 | H4R Radioligand Binding Assay from Article 10.1124/jpet.105.087965: \\Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.\\ | 2005 | The Journal of pharmacology and experimental therapeutics, Sep, Volume: 314, Issue:3
| Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. |
| AID1346037 | Human H1 receptor (Histamine receptors) | 2005 | The Journal of pharmacology and experimental therapeutics, Sep, Volume: 314, Issue:3
| Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |