Page last updated: 2024-09-27

Pick Disease of the Brain

A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)

Synonyms(1)

Synonym
Pick Disease of the Brain

Research

Studies (68)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (5.88)23.3326
1990's1 (1.47)12.5806
2000's37 (54.41)18.1394
2010's10 (14.71)28.8240
2020's16 (23.53)9.53
DrugIndicatedRelationship StrengthStudiesTrials
choline0low20
creatine0low30
histamine0low10
inositol0low10
nitrates0low20
sarcosine0low10
1,3-dipropyl-8-cyclopentylxanthine0low10
hydroxyindoleacetic acid0low20
methenamine0low10
moclobemide0low10
propentofylline0low10
propidium0low10
risperidone0low10
mitomycin0low10
serine0low40
aspartic acid0low40
lysine0low20
tyrosine0low20
leucine0low20
methionine0low10
asparagine0low20
histidine0low10
valine0low10
threonine0low10
thiazoles0low70
s,n,n'-tripropylthiocarbamate0low10
thioflavin t0low30
carbonates0low20
silver0low10
silver iodide0low10
iodine0low10
glutamic acid0low20
colforsin0low10
adenosine0low10
n-acetylaspartic acid0low30
fluorodeoxyglucose f180low30
proline0low10
cortisone0low10
tretinoin0low10
arachidonic acid0low10
curcumin0low10
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole0low40
dinoprost0low10
anandamide0low10
4-hydroxy-2-nonenal0low10
casein kinase ii0low10
i(3)so3-galactosylceramide0low10
n(6)-cyclohexyladenosine0low10
alpha-synuclein0low140
acid phosphatase0low10
silver carbonate0low20
calpain0low10
sarkosyl0low10
metallothionein0low10

Protein Targets (801)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
thioredoxin reductase110011
ATAD5 protein, partial7007
TDP1 protein120012
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
thyroid stimulating hormone receptor5005
estrogen-related nuclear receptor alpha100010
67.9K protein3003
euchromatic histone-lysine N-methyltransferase 2150015
peripheral myelin protein 22 isoform 17007
chromobox protein homolog 17007
nuclear factor erythroid 2-related factor 2 isoform 24004
DNA polymerase iota isoform a (long)8008
nuclear receptor ROR-gamma isoform 16006
geminin140014
muscarinic acetylcholine receptor M15005
lamin isoform A-delta10110011
5-hydroxytryptamine receptor 1A0336
Adenosine receptor A30528
Adenosine receptor A105312
Adenosine receptor A10101
Adenosine receptor A30505
Adenosine receptor A2a0339
Adenosine receptor A2b0226
Adenosine receptor A2b0418
Adenosine receptor A104410
Adenosine receptor A2a04111
Vasopressin V2 receptor0001
Mu-type opioid receptor0101
Adenosine receptor A10112
Adenylate cyclase type 50001
Adenylate cyclase type 10113
Sigma non-opioid intracellular receptor 10101
Amyloid-beta precursor protein0506
Microtubule-associated protein tau7007
vitamin D3 receptor isoform VDRA8008
Transient receptor potential cation channel subfamily A member 10011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
AR protein130013
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 47007
glucocorticoid receptor [Homo sapiens]100010
retinoid X nuclear receptor alpha6006
estrogen nuclear receptor alpha150015
NPYLR7B0011
arylsulfatase A7007
IDH13003
Histone H2A.x3003
glycogen synthase kinase-3 beta isoform 10011
mitogen-activated protein kinase 13003
flap endonuclease 14004
peripheral myelin protein 227007
survival motor neuron protein isoform d5005
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Voltage-dependent calcium channel gamma-2 subunit6006
Rap guanine nucleotide exchange factor 32002
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0101
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20101
Insulin receptor0001
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0112
Platelet-derived growth factor receptor beta0001
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10001
Inosine-5'-monophosphate dehydrogenase 20101
Endoplasmin0112
Glutamate receptor 262210
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenylate kinase 2, mitochondrial0101
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine kinase0001
Adenosine deaminase 0001
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10202
Phosphatidylinositol 4-kinase type 2-alpha0203
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
Chain A, Ferritin light chain5005
phosphopantetheinyl transferase9009
aldehyde dehydrogenase 1 family, member A19009
Bloom syndrome protein isoform 18008
DNA polymerase kappa isoform 17007
Fatty-acid amide hydrolase 10303
Fatty-acid amide hydrolase 10001
Potassium channel subfamily K member 30101
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Fatty acid-binding protein, liver0101
Glutamate receptor 10224
Glutamate receptor 30224
Glutamate receptor 40224
Cannabinoid receptor 10112
Cannabinoid receptor 10102
Cannabinoid receptor 2 0102
Alpha-1A adrenergic receptor0505
Cannabinoid receptor 10101
Histamine H2 receptor5016
Cannabinoid receptor 20101
Fatty-acid amide hydrolase 10304
Fatty acid-binding protein 50022
Corticotropin-releasing factor receptor 20101
Lanosterol 14-alpha demethylase0202
Potassium channel subfamily K member 2 0101
Transient receptor potential cation channel subfamily V member 10012
Cannabinoid receptor 20101
Transient receptor potential cation channel subfamily V member 20202
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN0011
Chain A, SERUM ALBUMIN0011
Chain A, SERUM ALBUMIN0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Beta-lactamase4004
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase5005
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Chain A, Cruzipain3003
15-lipoxygenase, partial2002
USP1 protein, partial7007
thioredoxin glutathione reductase3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
cellular tumor antigen p53 isoform a2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
cytochrome P450 3A4 isoform 17007
histone acetyltransferase KAT2A isoform 14004
DNA dC->dU-editing enzyme APOBEC-3G isoform 12002
caspase-1 isoform alpha precursor3003
Gamma-aminobutyric acid receptor subunit pi7007
Prostaglandin G/H synthase 1 0102
Trypsin0101
Coagulation factor VII0101
60 kDa chaperonin0303
60 kDa heat shock protein, mitochondrial0303
Aromatase0101
Tissue factor0202
Fatty acid-binding protein, adipocyte0112
Gamma-aminobutyric acid receptor subunit beta-17007
Gamma-aminobutyric acid receptor subunit delta7007
Gamma-aminobutyric acid receptor subunit gamma-27007
Gamma-aminobutyric acid receptor subunit alpha-57007
Gamma-aminobutyric acid receptor subunit alpha-37007
Gamma-aminobutyric acid receptor subunit gamma-17007
Gamma-aminobutyric acid receptor subunit alpha-27007
Gamma-aminobutyric acid receptor subunit alpha-47007
Gamma-aminobutyric acid receptor subunit gamma-37007
Gamma-aminobutyric acid receptor subunit alpha-67007
Prostaglandin G/H synthase 20214
Nuclear receptor subfamily 4 group A member 20011
10 kDa heat shock protein, mitochondrial0303
Calmodulin 0001
Gamma-aminobutyric acid receptor subunit alpha-17007
Gamma-aminobutyric acid receptor subunit beta-37007
Gamma-aminobutyric acid receptor subunit beta-27007
Disintegrin and metalloproteinase domain-containing protein 171001
Prostaglandin G/H synthase 20001
Solute carrier organic anion transporter family member 2A10103
Fatty acid-binding protein 50101
Thiosulfate sulfurtransferase0303
60 kDa chaperonin 0303
10 kDa chaperonin 0303
GABA theta subunit7007
Gamma-aminobutyric acid receptor subunit epsilon7007
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Solute carrier organic anion transporter family member 1B10202
Carbonic anhydrase 103010
Carbonic anhydrase 203011
Neutral amino acid transporter A0303
Neutral amino acid transporter B(0)0303
Carbonic anhydrase-like protein, putative0006
Amino acid transporter0303
cytochrome P450 2C19 precursor3003
lethal factor (plasmid)5005
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0003
Glutamate receptor ionotropic, NMDA 1 0418
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 0317
Glutamate receptor ionotropic, NMDA 2B0317
Glutamate receptor ionotropic, NMDA 2C0317
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Glutamate receptor ionotropic, NMDA 2D0317
Glutamate receptor ionotropic, NMDA 3B0317
Carbonic anhydrase 40003
Glutamate receptor ionotropic, NMDA 3A0317
Carbonic anhydrase 40306
Carbonic anhydrase0306
Carbonic anhydrase 150306
Chain A, Protein kinase CK2, alpha Subunit0101
Chain A, PROTEIN KINASE CK2, alpha SUBUNIT0101
Chain A, Protein Kinase Ck2, Alpha Subunit0101
endonuclease IV4004
dopamine D1 receptor3003
NFKB1 protein, partial3003
Thrombopoietin1001
Parkin3003
NPC intracellular cholesterol transporter 1 precursor1001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
Serine/threonine-protein kinase Sgk10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0112
Casein kinase II subunit alpha 0101
Casein kinase II subunit alpha'0202
Cyclin-A20101
Cyclin-dependent kinase 20101
D(1A) dopamine receptor1001
Casein kinase II subunit beta0202
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0202
Cyclin-A10101
Dual specificity mitogen-activated protein kinase kinase 10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Ribosomal protein S6 kinase alpha-10101
Casein kinase II subunit alpha 30202
Single-stranded DNA cytosine deaminase1001
interleukin 82002
GLI family zinc finger 38008
EWS/FLI fusion protein4005
retinoic acid nuclear receptor alpha variant 19009
farnesoid X nuclear receptor5005
pregnane X nuclear receptor5005
G4004
cytochrome P450 2D64004
peroxisome proliferator activated receptor gamma8008
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
aryl hydrocarbon receptor5005
activating transcription factor 64004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
thyroid hormone receptor beta isoform 26006
heat shock protein beta-14004
nuclear factor erythroid 2-related factor 2 isoform 17007
streptokinase A precursor0011
Dihydroxyacetone phosphate acyltransferase0001
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0707
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 4004
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Cellular tumor antigen p537007
Cytochrome P450 3A40213
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Inositol hexakisphosphate kinase 14004
Methionine--tRNA ligase, mitochondrial0011
cytochrome P450 2C9, partial4004
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20104
Solute carrier family 22 member 1 0003
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0606
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Solute carrier family 22 member 10204
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20204
ATP-dependent phosphofructokinase3003
glp-1 receptor, partial2002
pregnane X receptor4004
RAR-related orphan receptor gamma7007
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor4004
cytochrome P450 family 3 subfamily A polypeptide 44004
peroxisome proliferator-activated receptor delta6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
thyroid stimulating hormone receptor5005
nuclear receptor subfamily 1, group I, member 22002
nuclear receptor subfamily 0 group B member 10101
steroidogenic factor 10101
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
relaxin receptor 1 isoform 11001
relaxin receptor 2 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent translocase ABCB10102
Solute carrier family 2, facilitated glucose transporter member 10011
Adenylate cyclase type 20011
Adenylate cyclase type 80011
ATPase family AAA domain-containing protein 54004
Ataxin-25005
Relaxin receptor 10011
Nuclear receptor subfamily 1 group I member 20011
GLS protein7007
v-jun sarcoma virus 17 oncogene homolog (avian)2002
atrial natriuretic peptide receptor 1 precursor1001
M-phase phosphoprotein 83003
Glucocorticoid receptor0202
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 434004
Multidrug and toxin extrusion protein 10202
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10506
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Luciferase2002
acetylcholinesterase2002
Nrf21001
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 21001
SMAD family member 31001
alkaline phosphatase, intestinal0101
Smad33003
apical membrane antigen 1, AMA12002
caspase 7, apoptosis-related cysteine protease2002
PINK11001
glucocerebrosidase1001
bromodomain adjacent to zinc finger domain 2B3003
toll-like receptor 90101
caspase-32002
TPA: protein transporter TIM100101
thyrotropin-releasing hormone receptor2002
lysosomal alpha-glucosidase preproprotein1001
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
hemoglobin subunit beta1001
polyunsaturated fatty acid lipoxygenase ALOX121001
perilipin-50101
intestinal alkaline phosphatase precursor0101
thyroid hormone receptor beta isoform a4004
perilipin-10101
potassium voltage-gated channel subfamily H member 2 isoform d4004
transcriptional regulator ERG isoform 34004
huntingtin isoform 21001
importin subunit beta-1 isoform 11001
pyruvate kinase PKM isoform a1001
DNA polymerase beta1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
muscleblind-like protein 1 isoform 11001
alkaline phosphatase, germ cell type preproprotein0101
hypothetical protein SA14220101
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
neuropeptide S receptor isoform A2002
Prostaglandin E synthase0101
Histone deacetylase 30101
Acetylcholinesterase0303
Lysine-specific histone demethylase 1A0101
D-amino-acid oxidase0101
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Integrin beta-31012
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Prostaglandin G/H synthase 10101
Cholinesterase0606
Heme oxygenase 1 0101
Integrin alpha-IIb1012
Glutathione S-transferase P0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Microtubule-associated protein tau0102
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tyrosinase0101
Aminopeptidase N0101
Aminopeptidase N0101
Alpha-1B adrenergic receptor0404
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0101
Amine oxidase [flavin-containing] A0404
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Heme oxygenase 20101
Alpha-1D adrenergic receptor0303
Amine oxidase [flavin-containing] B0404
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Proteasome subunit beta type-50101
17-beta-hydroxysteroid dehydrogenase type 20101
Alpha-synuclein2215
Glycogen synthase kinase-3 beta0101
Nuclear receptor ROR-gamma1113
Caspase-72002
Histone deacetylase 40101
Beta-secretase 10202
Guanine nucleotide-binding protein G1001
Cholinesterase0314
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
Serine/threonine-protein kinase PAK 10101
Histone deacetylase 10202
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0011
Nuclear factor erythroid 2-related factor 20011
Thioredoxin reductase 1, cytoplasmic0101
Thioredoxin reductase 30101
Sortase A0101
Histone deacetylase 70101
Histone deacetylase 20202
CREB-binding protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
NACHT, LRR and PYD domains-containing protein 3 0101
Histone deacetylase 80202
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10202
Histone deacetylase 60101
Histone deacetylase 90101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Histone deacetylase 50101
Lymphocyte antigen 960011
Beta lactamase (plasmid)0101
Prostaglandin G/H synthase 2 0101
Thromboxane A2 receptor 0112
Prostaglandin G/H synthase 10101
Prostaglandin E2 receptor EP1 subtype0112
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin F2-alpha receptor0202
Prostaglandin F2-alpha receptor0213
Prostaglandin E2 receptor EP3 subtype0112
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin F2-alpha receptor0011
Prostacyclin receptor0101
Prostaglandin D2 receptor0101
Solute carrier family 22 member 60001
Solute carrier family 22 member 70001
Solute carrier family 22 member 80001
Solute carrier organic anion transporter family member 2A10102
Solute carrier organic anion transporter family member 2A10101
Solute carrier organic anion transporter family member 2B10101
Solute carrier family 22 member 110001
Solute carrier family 22 member 70001
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0404
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
ATP-citrate synthase 0101
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50123
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
GALC protein1001
transforming acidic coiled-coil-containing protein 30001
Carbonic anhydrase 120003
Solute carrier family 22 member 30102
Plasma kallikrein0003
Carbonic anhydrase 30003
Macrophage migration inhibitory factor0202
Carbonic anhydrase 60003
Histamine H2 receptor0325
Histamine H1 receptor0224
Histamine H1 receptor0213
Carbonic anhydrase 5A, mitochondrial0003
Histamine H1 receptor0426
Carbonic anhydrase 70003
Carbonic anhydrase0004
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0202
Carbonic anhydrase 90003
Carbonic anhydrase 0004
Carbonic anhydrase0004
Carbonic anhydrase0004
Carbonic anhydrase 0004
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130002
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 130002
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0102
Carbonic anhydrase 140003
Carbonic anhydrase 5B, mitochondrial0003
Histamine H3 receptor0224
Chain A, HISTIDINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Histidine-binding periplasmic protein0011
Large neutral amino acids transporter small subunit 10505
Fumarate hydratase2002
hypothetical protein, conserved1001
polyprotein2002
alpha-galactosidase1001
cytochrome P450 2C9 precursor2002
Uracil nucleotide/cysteinyl leukotriene receptor0101
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Sodium/myo-inositol cotransporter 20101
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Phospholipase A-2-activating protein0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Cationic amino acid transporter 30101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Indoleamine 2,3-dioxygenase 10101
Spike glycoprotein2002
Amine oxidase [flavin-containing] B0202
Amine oxidase [flavin-containing] A 0303
Amine oxidase [flavin-containing] A 0202
Amine oxidase [flavin-containing] B0202
Potassium voltage-gated channel subfamily H member 20303
Sigma intracellular receptor 20101
Sigma intracellular receptor 20101
Canalicular multispecific organic anion transporter 10303
Sigma non-opioid intracellular receptor 10101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Rap guanine nucleotide exchange factor 41001
Adenosine receptor A10101
Sodium/iodide cotransporter0101
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
cytochrome P450 2D6 isoform 12002
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Acetylcholinesterase0303
Acetylcholinesterase 0202
Inositol monophosphatase 11001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Albumin0011
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40303
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0202
Cytochrome P450 2D60112
Muscarinic acetylcholine receptor M10303
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0202
Alpha-2B adrenergic receptor0202
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0202
D0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0303
Alpha-2B adrenergic receptor0101
Muscarinic acetylcholine receptor M30404
D(1A) dopamine receptor0202
D(4) dopamine receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Glycine receptor subunit alpha-10011
Sodium-dependent dopamine transporter0101
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 2B0202
Sodium-dependent serotonin transporter0202
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 60101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
D(2) dopamine receptor0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Transporter0101
5-hydroxytryptamine receptor 1A0101
Nuclear receptor subfamily 3 group C member 3 0202
Multidrug and toxin extrusion protein 20101
Transporter0101
Acetylcholinesterase0101
Acyl-CoA desaturase 10101
Acetylcholine receptor subunit epsilon0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Cholinesterase0101
Acetylcholinesterase0101
Tyrosine-protein kinase SYK0101
Cholinesterase0101
Carboxylic ester hydrolase 0101
Sodium- and chloride-dependent glycine transporter 10101
Peroxisome proliferator-activated receptor alpha1001
Pyruvate kinase PKM0011
Chain A, Nuclear Receptor ROR-beta0101
nonstructural protein 11001
Caspase-71001
caspase-31001
Ornithine decarboxylase0001
Cytochrome P450 1A20011
Ornithine decarboxylase0001
Retinoic acid receptor alpha0227
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Cytochrome P450 2C9 0112
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190112
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Polyphenol oxidase 20001
SLC16A10 protein0001
Tubulin--tyrosine ligase0101
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
Chain A, Arginase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]