Compounds > 3-dimethylaminopropylamine
Page last updated: 2024-11-05

3-dimethylaminopropylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-Dimethylaminopropylamine, also known as N,N-dimethyl-1,3-propanediamine, is a colorless liquid with a strong, ammonia-like odor. It is a versatile chemical intermediate used in the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a curing agent for epoxy resins and as a catalyst in organic reactions. 3-Dimethylaminopropylamine has been reported to have anticancer activity in preclinical studies. The compound acts as a potent inhibitor of histone deacetylase (HDAC) enzymes, which are known to play a role in the development and progression of cancer. 3-Dimethylaminopropylamine is also used as a precursor to the synthesis of other bioactive compounds, such as N-methyl-3-dimethylaminopropylamine, which has been shown to have antidepressant effects. The compound is also used in the synthesis of pesticides and herbicides. 3-Dimethylaminopropylamine is studied because of its potential applications in various fields, including medicine, agriculture, and industry. Research on 3-Dimethylaminopropylamine is ongoing to further understand its properties and potential applications. It is also being studied for its environmental impact and potential toxicity.'

3-dimethylaminopropylamine: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7993
CHEMBL ID1232234
SCHEMBL ID30161
SCHEMBL ID7633005
MeSH IDM0060296

Synonyms (127)

Synonym
AC-363
CHEMBL1232234
1,3-propanediamine, n,n-dimethyl-
n,n-dimethylpropane-1,3-diamine
propane,1-amino,3-dimethylamino
inchi=1/c5h14n2/c1-7(2)5-3-4-6/h3-6h2,1-2h
1-amino-3-dimethylaminopropane
ccris 4799
brn 0605293
1-amino-3-dimethylamino propane
n,n-dimethyl-1,3-diaminopropane
einecs 203-680-9
n,n-dimethyl-1,3-propylenediamine
propylamine, 3-(n,n-dimethylamino)-
nsc 1067
n,n-dimethyl-1,3-propanediamine
hsdb 5391
3-dimethylaminopropylamine
gamma-(dimethylamino)propylamine
ai3-25441
3-aminopropyldimethylamine
3-(dimethylamino)-1-propylamine
1-amino-3-(dimethylamino)propane
propylamine,n-dimethylamino)-
wln: z3n1&1
3-(dimethylamino)propylamine
n,n-dimethylpropylenediamine
nsc1067
109-55-7
1-(dimethylamino)-3-aminopropane
3-(dimethylamino)-1-propanamine
n,n-dimethyltrimethylenediamine
n,3-propylenediamine
3-amino-1-(dimethylamino)propane
n,n-dimethyl-n-(3-aminopropyl)amine
.gamma.-(dimethylamino)propylamine
nsc-1067
n-dimethyltrimethylenediamine
3-(dimethylamino)-1-propylamine, 99%
3-amino-(dimethylpropylamine)
DIB ,
D0790
n',n'-dimethylpropane-1,3-diamine
68497-58-5
FT-0667531
AKOS000119881
NCGC00249155-01
dimethylaminopropylamine
unii-i98i2uec03
i98i2uec03 ,
ec 203-680-9
1,3-propanediamine, n1,n1-dimethyl-
dtxcid505102
cas-109-55-7
NCGC00257003-01
tox21_303328
dtxsid5025102 ,
NCGC00259597-01
tox21_202048
STL168867
(3-aminopropyl)dimethylamine
FT-0629498
cyclohexyl aminen,n-dimethyl-1,3-propanediamine
SCHEMBL30161
n,n-dimethyl-1,3-propanediamine [hsdb]
dimethylaminopropylamine [inci]
3-dimethylamino-n-propylamine
n,n-dimethylpropylene-1,3-diamine
3-(dimethylamino)-n-propylamine
h2n(ch2)3n(ch3)2
3-(dimethylamino)-1-aminopropane
1-amino-3-dimethylamino-propane
n,n-dimethy-1,3-propanediamine
3-(dimethyl-amino)propylamine
3-(n,n-dimethylamino)propylamine
3-dimethylamino-propylamine
3-(n,n-dimethylamino)-1-propylamine
(3-dimethylaminopropyl)amine
n, n-dimethyl-1,3-propanediamine
n',n'-dimethyl-1,3-propanediamine
3-(n,n-dimethyl amino)propylamine
n1,n1-dimethyl-1,3-propanediamine
n(1),n(1)-dimethyl-propane-1,3-diamine
dimethylaminopropyl-amine
3-(dimethyamino)propylamine
n1,n1-dimethylpropan-1,3-diamine
dimethylammo propylamme
n, n-dimethyl-1,3-diaminopropane
3-dimethylamino-1propylamine
n,n-dimethyl-propane-1,3-diamine
n',n'-dimethyl-propane-1,3-diamine
h2nc3h6n(ch3)2
n,n-dimethyl-1, 3-propanediamine
3-(n,n-dimethylamino)-propylamine
3-dimethylamino-propyl amine
dimethyl aminopropylamine
3-dimethylaminopropyl amine
dimethylaminopropyl amine
3-dimethylamino-1-propylamine
n,n-dimethyl-1,3-propane diamine
n,n-di-methyl-3-amino-propyl-amine
3-(dimethylamino)propyl amine
3-(dimethylamino)-propylamine
n,n-dimethyl-1,3-propane-diamine
n(1), n(1)-dimethyl-propane-1,3-diamine
nh2ch2ch2ch2nme2
3-dimethylamino propylamine
3-(dimethylamino) propylamine
[3-(dimethylamino)propyl]amine
n1,n1-dimethylpropane-1,3-diamine
n,n-dimethyl-1.3-propanediamine
n,n-dimethyltrimethylendiamin
SCHEMBL7633005
mfcd00008216
J-520165
J-002305
F2187-2249
3-(dimethylamino)-1-propylamine, analytical standard
n',n'-dimethyl propane-1,3-diamine
3-(dimethylamino)-1-propylamine, purum, >=98.0% (gc)
3-dimethylaminopropylamine (dmapa)
Q5277328
3-(dimethyl-d6-amino)-1-propylamine
STR00957
EN300-19758
gamma-(dimethyl-d6)aminopropylamine
BP-31209
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency48.55770.000657.913322,387.1992AID1259377
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency30.94970.003041.611522,387.1992AID1159555
estrogen nuclear receptor alphaHomo sapiens (human)Potency7.84140.000229.305416,493.5996AID743069
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (32)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (12.50)18.7374
1990's9 (28.13)18.2507
2000's7 (21.88)29.6817
2010's10 (31.25)24.3611
2020's2 (6.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 45.32

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index45.32 (24.57)
Research Supply Index3.58 (2.92)
Research Growth Index4.81 (4.65)
Search Engine Demand Index64.21 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (45.32)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (2.94%)5.53%
Reviews0 (0.00%)6.00%
Case Studies6 (17.65%)4.05%
Observational0 (0.00%)0.25%
Other27 (79.41%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
betaine
glycine betaine : The amino acid betaine derived from glycine.		5.1101amino-acid betaine;
glycine derivative		fundamental metabolite
chloroacetic acid
chloroacetic acid: urinary metabolite of vinyl chloride; RN given refers to parent cpd; structure. chloroacetic acid : A chlorocarboxylic acid that is acetic acid carrying a 2-chloro substituent.		1.9910chlorocarboxylic acid;
haloacetic acid		alkylating agent;
herbicide
glycolic acid
glycolic acid: RN given refers to parent cpd. glycolic acid : A 2-hydroxy monocarboxylic acid that is acetic acid where the methyl group has been hydroxylated.		2.31102-hydroxy monocarboxylic acid;
primary alcohol		keratolytic drug;
metabolite
histamine
[no description available]		1.9610aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
ethylenediamine
ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.		2.0610alkane-alpha,omega-diamineGABA agonist
ficusin
Ficusin: A naturally occurring furocoumarin, found in PSORALEA. After photoactivation with UV radiation, it binds DNA via single and double-stranded cross-linking.. psoralen : The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.		210psoralensplant metabolite
ethylamine
ethylamine : A two-carbon primary aliphatic amine.		1.9610primary aliphatic aminehuman metabolite
4-toluenesulfonyl chloride
[no description available]		2.1110
benzoyl chloride
benzoyl chloride: potential carcinogens in manufacturing process. benzoyl chloride : An acyl chloride consisting of benzene in which a hydrogen is replaced by an acyl chloride group. It is an important chemical intermediate for the manufacture of other chemicals, dyes, perfumes, herbicides and pharmaceuticals.		2.1110acyl chloride;
benzenes		carcinogenic agent
maleic anhydride
Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.. maleic anhydride : A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.		2.1710cyclic dicarboxylic anhydride;
furans		allergen
1-pentene
1-pentene: structure in first source		2.1710
luminol
Luminol: 5-Amino-2,3-dihydro-1,4-phthalazinedione. Substance that emits light on oxidation. It is used in chemical determinations.		1.9810
deoxycytidine
[no description available]		2.2110pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cocamidopropyl betaine
cocamidopropyl betaine: structure given in first source; Genagen CAB, Tego Betain, Rewoteric AMB 14 usually contain 30% cocamidopropyl betaine (CAPB). cocamidopropyl betaine : A mixture of carboxamidopropyl betaines derived from fatty acids of varying chain lengths. The principal component is lauramidopropyl betaine.. lauramidopropyl betaine : An ammonium betaine in which the the ammonium nitrogen is substituted by two methyl groups and a lauramidopropyl group. It is the major (>50%) component of cocamidopropyl betaine.		10.0191ammonium betainesurfactant
deuterium oxide
Deuterium Oxide: The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.		2.0410deuterated compound;
water		NMR solvent
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		1.9910benzenes;
phenyl acetates
alkenes
[no description available]		2.1710
gemcitabine
gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.		2.2110organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic
trichloroacetamide
[no description available]		2.1510
perfluoropropionic acid
perfluoropropionic acid: ion pairing reagent; RN given refers to parent cpd		2.0710
1-methylhistidine
1-methylhistidine: found in muscle proteins; RN given refers to (L)-isomer. 1-methylhistidine : A methylhistidine in which the methyl group is located at N-1.. N(tele)-methyl-L-histidine : A L-histidine derivative in which the methyl group is at N(tele)-position.		2.0610L-histidine derivative;
non-proteinogenic L-alpha-amino acid;
zwitterion		human metabolite
glycogen
glycogen : A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.		2.110
pyrantel
Pyrantel: A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920). pyrantel : A carboxamidine that is 1,4,5,6-tetrahydropyrimidine that is substituted at position 1 by a methyl group and at position 2 by an (E)-2-(2-thienyl)vinyl group. It is used, particularly as the embonate [4,4'-methylenebis(3-hydroxy-2-naphthoate)] salt, as an anthelmintic that is effective against intestinal nematodes including threadworms, roundworms and hookworms, and is included in the WHO 'Model List of Essential Medicines'.		2.07101,4,5,6-tetrahydropyrimidines;
carboxamidine;
thiophenes		antinematodal drug
triethyloxonium tetrafluoroborate
triethyloxonium tetrafluoroborate: a trialkyloxonium salt (Meerweins' reagents)		1.9810
morantel
Morantel: Antinematodal agent used mainly for livestock.		2.0710
n-(3-(dimethylamino)propyl)oleamide
N-(3-(dimethylamino)propyl)oleamide: RN given refers to (Z)-isomer; structure given in first source		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Allergic Contact Dermatitis
[description not available]		03.88120
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		03.88120
Cancer of Pancreas
[description not available]		02.2110
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.2110
Diseases, Occupational
[description not available]		02.0310
Dermatitis, Irritant
A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.		03.3711
Contact Dermatitis
[description not available]		03.7821
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		03.7821
Erythema
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.		03.3711
Dermatitis, Occupational
A recurrent contact dermatitis caused by substances found in the work place.		02.6830
Hand Dermatosis
[description not available]		01.9910
Hand Dermatoses
Skin diseases involving the HANDS.		01.9910
Aortic Diseases
Pathological processes involving any part of the AORTA.		01.9510
Arteriosclerosis
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.		01.9510