An antagonist at the bradykinin receptor.
ChEBI ID: 68557
| Member | Definition | Class |
|---|---|---|
| arg-3-hyp-7-phe-bradykinin | A ten-membered oligopeptide comprising D-arginyl, L-arginyl, L-prolyl, (4R)-4-hydroxy-L-prolyl, glycyl, L-phenylalanyl, L-seryl, D-phenylalanyl, L-phenylalanyl and L-arginine residues joined in sequence. | NPC-567 |
| icatibant | A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acute attacks of hereditary angioedema in adult patients. | icatibant |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (8.20) | 18.7374 |
| 1990's | 43 (70.49) | 18.2507 |
| 2000's | 9 (14.75) | 29.6817 |
| 2010's | 4 (6.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (3.17%) | 5.53% |
| Reviews | 1 (1.59%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 60 (95.24%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| B2 bradykinin receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0025 | 2 | 3 |
| B2 bradykinin receptor | Homo sapiens (human) | IC50 | 0.0066 | 8 | 8 |
| B2 bradykinin receptor | Homo sapiens (human) | Ki | 0.0001 | 4 | 4 |
| B2 bradykinin receptor | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| B2 bradykinin receptor | Homo sapiens (human) | Kd | 0.0003 | 1 | 1 |