Chorioadenoma

A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.

Synonyms(3)

Synonym
Invasive Mole
Hydatidiform Mole, Invasive
Chorioadenoma

Research Excerpts

Overview

Excerpt	Reference
"Invasive mole is a distinct subgroup of GTN, which if not diagnosed and treated early, can result in serious complications like uterine perforation and haemoperitoneum."	( Al-Khawari, H; Nair, K, 2014)
"An invasive mole is a potentially life-threatening complication of gestational trophoblastic disease [1]."	( Anteby, E; Gemer, O; Grin, L; Lavie, O; Namazov, A; Volodarsky, M, 2017)

Research

Studies (132)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	92 (69.70)	23.3326
1990's	19 (14.39)	12.5806
2000's	8 (6.06)	18.1394
2010's	10 (7.58)	28.8240
2020's	3 (2.27)	9.53

Drug	Relationship Strength	Studies	Trials
hydrochloric acid	low	1	0
hydrogen carbonate	low	1	0
histamine	low	1	0
pk 11195	low	1	0
3-methylcholanthrene	low	1	0
chlorambucil	low	7	0
cyclofenil	low	1	0
pentetic acid	low	2	0
diphenhydramine	low	2	0
fluorouracil	low	10	0
mechlorethamine	low	1	0
floxuridine	low	1	0
estrone	low	1	0
tyrosine	low	1	0
desoxycorticosterone	low	1	0
thiazoles	low	1	0
ephedrine	low	1	0
nandrolone	medium	1	1
levonorgestrel	low	1	0
carbonates	low	1	0
gadolinium	low	1	0
carbimazole	low	1	0
phenyl acetate	low	1	0
pregnanolone	low	1	0
etoposide	low	6	0
thiazolyl blue	low	1	0
metaperiodate	low	1	0
fluorodeoxyglucose f18	low	1	0
fibrinogen	low	1	0
at 1258	low	2	0
methotrexate	medium	73	1
17-hydroxypregnanolone	low	1	0
aminopterin	low	1	0
cortisone	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
glycogen	low	2	0
bradykinin	low	1	0
inositol 3-phosphate	low	1	0
dactinomycin	low	42	0
bromochloroacetic acid	low	1	0
stilbenes	low	1	0
mercaptopurine	low	7	0
dimethylstilbestrol	low	1	0
17-ketosteroids	low	2	0
oxymetholone	medium	1	1
lutein	low	1	0
misoprostol	low	1	0
radium	low	1	0
pregnanediol	low	2	0
gadolinium dtpa	low	2	0
clove	low	1	0
acid phosphatase	low	1	0
cellulose	low	1	0
methylcellulose	low	1	0
chondroitin	low	1	0
epidermal growth factor	low	3	0
kiss1 protein, human	low	1	0
lewis x antigen	low	1	0
norgestrel	low	1	0
thromboplastin	low	1	0
levoleucovorin	low	6	0
cyclic gmp	low	1	0
folic acid	low	1	0
concanavalin a	low	1	0

Protein Targets (484)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	5	0	0	5
pregnane X receptor	3	0	0	3
phosphopantetheinyl transferase	7	0	0	7
RAR-related orphan receptor gamma	17	0	0	17
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
TDP1 protein	21	0	0	21
Microtubule-associated protein tau	8	0	0	8
AR protein	26	0	0	26
caspase 7, apoptosis-related cysteine protease	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
retinoic acid nuclear receptor alpha variant 1	17	0	0	17
estrogen-related nuclear receptor alpha	19	0	0	19
farnesoid X nuclear receptor	10	0	0	10
pregnane X nuclear receptor	16	0	0	16
estrogen nuclear receptor alpha	28	0	0	28
peroxisome proliferator-activated receptor delta	16	0	0	16
peroxisome proliferator activated receptor gamma	15	0	0	15
caspase-3	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	17	0	0	17
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
activating transcription factor 6	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
thyroid hormone receptor beta isoform a	5	0	0	5
heat shock protein beta-1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
Cellular tumor antigen p53	19	0	0	19
Cytochrome P450 1A2	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Adenosine receptor A3	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Glutamate receptor 2	10	0	0	10
Acetylcholinesterase	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	0	4
Aryl hydrocarbon receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	2	0	2
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
glucocorticoid receptor [Homo sapiens]	18	0	0	18
retinoid X nuclear receptor alpha	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
Histone H2A.x	11	0	0	11
thyroid hormone receptor beta isoform 2	19	0	0	19
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	4	0	6
Dihydrofolate reductase	0	3	0	5
5-hydroxytryptamine receptor 2C	0	1	0	3
Dihydrofolate reductase	0	3	3	6
Folylpolyglutamate synthase, mitochondrial	0	2	0	6
Solute carrier organic anion transporter family member 1A3	0	2	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	6
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
thyroid stimulating hormone receptor	5	0	0	5
Nuclear receptor ROR-gamma	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
USP1 protein, partial	11	0	0	11
geminin	15	0	0	15
lamin isoform A-delta10	13	0	0	13
Bile salt export pump	0	15	0	15
Lactoperoxidase	0	1	0	1
Carbonic anhydrase 1	0	5	0	7
Carbonic anhydrase 2	0	5	1	9
Carbonic anhydrase 4	0	4	0	6
Carbonic anhydrase	0	3	0	5
Carbonic anhydrase 15	0	2	0	4
interleukin 8	3	0	0	3
thioredoxin reductase	7	0	0	7
NFKB1 protein, partial	2	0	0	2
GALC protein	5	0	0	5
GLS protein	4	0	0	4
GLI family zinc finger 3	14	0	0	14
Thrombopoietin	3	0	0	3
thioredoxin glutathione reductase	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
thyroid stimulating hormone receptor	6	0	0	6
EWS/FLI fusion protein	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
Bloom syndrome protein isoform 1	6	0	0	6
peripheral myelin protein 22 isoform 1	6	0	0	6
vitamin D3 receptor isoform VDRA	6	0	0	6
chromobox protein homolog 1	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	9	0	0	9
muscleblind-like protein 1 isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	9
Carbonic anhydrase 12	0	1	0	3
Cytochrome P450 2D6	0	1	0	1
Spike glycoprotein	5	0	0	5
Carbonic anhydrase 9	0	3	0	5
Canalicular multispecific organic anion transporter 1	0	7	0	8
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	10	0	0	10
Solute carrier organic anion transporter family member 1B3	0	4	0	5
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
endonuclease IV	5	0	0	5
dopamine D1 receptor	2	0	0	2
progesterone receptor	12	0	0	12
regulator of G-protein signaling 4	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
flap endonuclease 1	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	4	3	1	8
Glucocorticoid receptor	0	2	0	2
Sex hormone-binding globulin	0	0	4	4
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	4	3	1	8
Gamma-aminobutyric acid receptor subunit delta	4	3	1	8
Gamma-aminobutyric acid receptor subunit gamma-2	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-5	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-3	4	3	1	8
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-2	4	3	1	8
Glycine receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	4	3	1	8
Gamma-aminobutyric acid receptor subunit gamma-3	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-6	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-1	4	3	1	8
Gamma-aminobutyric acid receptor subunit beta-3	4	3	1	8
Gamma-aminobutyric acid receptor subunit beta-2	4	3	1	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
GABA theta subunit	4	3	1	8
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	3	1	8
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Chain A, Ferritin light chain	5	0	0	5
estrogen receptor 2 (ER beta)	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
G	7	0	0	7
cytochrome P450 2D6	5	0	0	5
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Estrogen receptor	0	3	2	6
Inositol hexakisphosphate kinase 1	7	0	0	7
cytochrome P450 2C9, partial	7	0	0	7
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	2	0	0	2
15-lipoxygenase, partial	3	0	0	3
RAD51	0	1	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
huntingtin isoform 2	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	2	0	0	2
ATP-dependent translocase ABCB1	0	2	0	4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	2	0	0	2
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
IDH1	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
mitogen-activated protein kinase 1	1	0	0	1
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
Androgen receptor	0	7	0	7
cytochrome P450 2D6 isoform 1	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Cytochrome P450 2C9	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Histamine H1 receptor	0	1	2	4
Histamine H1 receptor	0	4	2	6
5-hydroxytryptamine receptor 2B	0	4	0	4
Histamine H2 receptor	1	0	1	3
Histamine N-methyltransferase	0	0	0	1
Cytochrome P450 2J2	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	2	2	4
Histamine H3 receptor	0	1	0	2
67.9K protein	5	0	0	5
ATAD5 protein, partial	5	0	0	5
nonstructural protein 1	3	0	0	3
arylsulfatase A	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
glucokinase regulatory protein	1	0	0	1
DNA polymerase iota isoform a (long)	6	0	0	6
Rap guanine nucleotide exchange factor 3	3	0	0	3
Steryl-sulfatase	0	1	0	1
Aromatase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Sodium-dependent serotonin transporter	0	2	0	2
Mu-type opioid receptor	0	1	1	2
Alpha-synuclein	1	1	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
Cytochrome P450 1B1	0	1	0	1
Estrogen receptor beta	0	1	1	3
Ghrelin O-acyltransferase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
glp-1 receptor, partial	3	0	0	3
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	3
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	3
Glutamate receptor ionotropic, NMDA 2B	0	0	0	3
Glutamate receptor ionotropic, NMDA 2C	0	0	0	3
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	0	0	3
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	3
Glutamate receptor ionotropic, NMDA 3A	0	0	0	3
interferon gamma precursor	0	0	0	1
streptokinase A precursor	0	0	1	1
Sodium/nucleoside cotransporter 2	0	1	0	1
Thymidylate synthase	0	5	0	5
Thymidine phosphorylase	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Thymidine kinase	0	0	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
acetylcholinesterase	1	0	0	1
Skn7p	0	0	0	1
hemoglobin subunit beta	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	2
Epidermal growth factor receptor	0	1	0	1
Amyloid-beta precursor protein	1	0	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
acid sphingomyelinase	2	0	0	2
glucocerebrosidase	2	0	0	2
alpha-galactosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase beta	4	0	0	4
Thymidylate synthase	0	4	0	4
Aldo-keto reductase family 1 member B1	0	1	0	1
Multidrug resistance associated protein	0	1	0	3
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
Chain A, Beta-lactamase	4	0	0	4
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	2
Carbonic anhydrase 3	0	0	0	2
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 6	0	1	0	3
Histamine H2 receptor	0	1	2	3
Adenosine receptor A1	0	0	0	2
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	0	0	2
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	4
Carbonic anhydrase 7	0	1	0	3
Carbonic anhydrase	0	0	0	3
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	3
Histamine H3 receptor	0	1	2	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
Progesterone receptor	0	0	1	1
retinoic acid receptor alpha isoform 1	0	1	0	1
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
Fumarate hydratase	3	0	0	3
PPM1D protein	1	0	0	1
polyprotein	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
UDP-glucose 6-dehydrogenase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
UDP-glucose 6-dehydrogenase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Bile salt export pump	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
neuropeptide S receptor isoform A	2	0	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
lethal factor (plasmid)	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Parkin	1	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
Translocator protein	0	2	1	3
5-hydroxytryptamine receptor 1A	0	0	1	1
Translocator protein	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
histone deacetylase 9 isoform 3	1	0	0	1
Tyrosinase	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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