Page last updated: 2024-09-28

Chorioadenoma

A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.

Synonyms(3)

Synonym
Invasive Mole
Hydatidiform Mole, Invasive
Chorioadenoma

Research Excerpts

Overview

ExcerptReference
"Invasive mole is a distinct subgroup of GTN, which if not diagnosed and treated early, can result in serious complications like uterine perforation and haemoperitoneum."( Al-Khawari, H; Nair, K, 2014)
"An invasive mole is a potentially life-threatening complication of gestational trophoblastic disease [1]."( Anteby, E; Gemer, O; Grin, L; Lavie, O; Namazov, A; Volodarsky, M, 2017)

Research

Studies (132)

TimeframeStudies, This Condition (%)All Conditions %
pre-199092 (69.70)23.3326
1990's19 (14.39)12.5806
2000's8 (6.06)18.1394
2010's10 (7.58)28.8240
2020's3 (2.27)9.53
DrugIndicatedRelationship StrengthStudiesTrials
hydrochloric acid0low10
hydrogen carbonate0low10
histamine0low10
pk 111950low10
3-methylcholanthrene0low10
chlorambucil0low70
cyclofenil0low10
pentetic acid0low20
diphenhydramine0low20
fluorouracil0low100
mechlorethamine0low10
floxuridine0low10
estrone0low10
tyrosine0low10
desoxycorticosterone0low10
thiazoles0low10
ephedrine0low10
nandrolone0medium11
levonorgestrel0low10
carbonates0low10
gadolinium0low10
carbimazole0low10
phenyl acetate0low10
pregnanolone0low10
etoposide0low60
thiazolyl blue0low10
metaperiodate0low10
fluorodeoxyglucose f180low10
fibrinogen0low10
at 12580low20
methotrexate0medium731
17-hydroxypregnanolone0low10
aminopterin0low10
cortisone0low10
trimethoprim, sulfamethoxazole drug combination0low10
glycogen0low20
bradykinin0low10
inositol 3-phosphate0low10
dactinomycin0low420
bromochloroacetic acid0low10
stilbenes0low10
mercaptopurine0low70
dimethylstilbestrol0low10
17-ketosteroids0low20
oxymetholone0medium11
lutein0low10
misoprostol0low10
radium0low10
pregnanediol0low20
gadolinium dtpa0low20
clove0low10
acid phosphatase0low10
cellulose0low10
methylcellulose0low10
chondroitin0low10
epidermal growth factor0low30
kiss1 protein, human0low10
lewis x antigen0low10
norgestrel0low10
thromboplastin0low10
levoleucovorin0low60
cyclic gmp0low10
folic acid0low10
concanavalin a0low10

Protein Targets (484)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Luciferase5005
pregnane X receptor3003
phosphopantetheinyl transferase7007
RAR-related orphan receptor gamma170017
SMAD family member 27007
SMAD family member 37007
TDP1 protein210021
Microtubule-associated protein tau8008
AR protein260026
caspase 7, apoptosis-related cysteine protease5005
aldehyde dehydrogenase 1 family, member A1140014
nuclear receptor subfamily 1, group I, member 3180018
retinoic acid nuclear receptor alpha variant 1170017
estrogen-related nuclear receptor alpha190019
farnesoid X nuclear receptor100010
pregnane X nuclear receptor160016
estrogen nuclear receptor alpha280028
peroxisome proliferator-activated receptor delta160016
peroxisome proliferator activated receptor gamma150015
caspase-35005
euchromatic histone-lysine N-methyltransferase 2170017
aryl hydrocarbon receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
activating transcription factor 68008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a100010
thyroid hormone receptor beta isoform a5005
heat shock protein beta-17007
nuclear factor erythroid 2-related factor 2 isoform 1210021
Voltage-dependent calcium channel gamma-2 subunit100010
Cellular tumor antigen p53190019
Cytochrome P450 1A20101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Aldo-keto reductase family 1 member B10404
Adenosine receptor A30202
Alpha-1B adrenergic receptor0202
Glutamate receptor 2100010
Acetylcholinesterase0101
Sodium-dependent noradrenaline transporter 0404
Aryl hydrocarbon receptor0011
Alpha-1A adrenergic receptor0202
hypoxia-inducible factor 1 alpha subunit6006
glucocorticoid receptor [Homo sapiens]180018
retinoid X nuclear receptor alpha140014
vitamin D (1,25- dihydroxyvitamin D3) receptor130013
Histone H2A.x110011
thyroid hormone receptor beta isoform 2190019
Dihydrofolate reductase0405
Dihydrofolate reductase0406
Dihydrofolate reductase0305
5-hydroxytryptamine receptor 2C0103
Dihydrofolate reductase0336
Folylpolyglutamate synthase, mitochondrial0206
Solute carrier organic anion transporter family member 1A30204
Folylpolyglutamate synthase, mitochondrial0106
histone acetyltransferase KAT2A isoform 13003
Angiotensin-converting enzyme 0001
B2 bradykinin receptor0101
B2 bradykinin receptor0215
B1 bradykinin receptor0101
Olfactory receptor 51E20011
thyroid stimulating hormone receptor5005
Nuclear receptor ROR-gamma4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
USP1 protein, partial110011
geminin150015
lamin isoform A-delta10130013
Bile salt export pump015015
Lactoperoxidase0101
Carbonic anhydrase 10507
Carbonic anhydrase 20519
Carbonic anhydrase 40406
Carbonic anhydrase0305
Carbonic anhydrase 150204
interleukin 83003
thioredoxin reductase7007
NFKB1 protein, partial2002
GALC protein5005
GLS protein4004
GLI family zinc finger 3140014
Thrombopoietin3003
thioredoxin glutathione reductase4004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
thyroid stimulating hormone receptor6006
EWS/FLI fusion protein9009
bromodomain adjacent to zinc finger domain 2B3003
v-jun sarcoma virus 17 oncogene homolog (avian)100010
Bloom syndrome protein isoform 16006
peripheral myelin protein 22 isoform 16006
vitamin D3 receptor isoform VDRA6006
chromobox protein homolog 18008
potassium voltage-gated channel subfamily H member 2 isoform d5005
FAD-linked sulfhydryl oxidase ALR0001
urokinase-type plasminogen activator precursor7007
plasminogen precursor7007
urokinase plasminogen activator surface receptor precursor7007
peripheral myelin protein 229009
survival motor neuron protein isoform d9009
muscleblind-like protein 1 isoform 13003
muscarinic acetylcholine receptor M13003
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40609
Carbonic anhydrase 120103
Cytochrome P450 2D60101
Spike glycoprotein5005
Carbonic anhydrase 90305
Canalicular multispecific organic anion transporter 10708
ATPase family AAA domain-containing protein 59009
Ataxin-2100010
Solute carrier organic anion transporter family member 1B30405
ATP-dependent phosphofructokinase5005
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
endonuclease IV5005
dopamine D1 receptor2002
progesterone receptor120012
regulator of G-protein signaling 44004
atrial natriuretic peptide receptor 1 precursor1001
flap endonuclease 14004
cytochrome P450 3A4 isoform 14004
M-phase phosphoprotein 83003
Gamma-aminobutyric acid receptor subunit pi4318
Glucocorticoid receptor0202
Sex hormone-binding globulin0044
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0404
Gamma-aminobutyric acid receptor subunit beta-14318
Gamma-aminobutyric acid receptor subunit delta4318
Gamma-aminobutyric acid receptor subunit gamma-24318
Gamma-aminobutyric acid receptor subunit alpha-54318
Gamma-aminobutyric acid receptor subunit alpha-34318
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit gamma-14318
Gamma-aminobutyric acid receptor subunit alpha-24318
Glycine receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-44318
Gamma-aminobutyric acid receptor subunit gamma-34318
Gamma-aminobutyric acid receptor subunit alpha-64318
Gamma-aminobutyric acid receptor subunit alpha-14318
Gamma-aminobutyric acid receptor subunit beta-34318
Gamma-aminobutyric acid receptor subunit beta-24318
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 435005
GABA theta subunit4318
Multidrug and toxin extrusion protein 10101
Gamma-aminobutyric acid receptor subunit epsilon4318
Phosphodiesterase 0101
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Chain A, Ferritin light chain5005
estrogen receptor 2 (ER beta)100010
cytochrome P450 family 3 subfamily A polypeptide 48008
G7007
cytochrome P450 2D65005
Interferon beta110011
HLA class I histocompatibility antigen, B alpha chain 7007
Estrogen receptor0326
Inositol hexakisphosphate kinase 17007
cytochrome P450 2C9, partial7007
Chain A, Putative fructose-1,6-bisphosphate aldolase5005
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain2002
15-lipoxygenase, partial3003
RAD510101
Caspase-72002
caspase-32002
huntingtin isoform 23003
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 14004
caspase-1 isoform alpha precursor2002
ATP-dependent translocase ABCB10204
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-72002
Growth factor receptor-bound protein 20101
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
IDH16006
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 28008
mitogen-activated protein kinase 11001
Solute carrier family 22 member 30101
Solute carrier family 22 member 20304
Androgen receptor0707
cytochrome P450 2D6 isoform 11001
5-hydroxytryptamine receptor 40202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M10202
Cytochrome P450 2C9 0202
Angiotensin-converting enzyme0202
Muscarinic acetylcholine receptor M30202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Histamine H1 receptor0124
Histamine H1 receptor0426
5-hydroxytryptamine receptor 2B0404
Histamine H2 receptor1013
Histamine N-methyltransferase0001
Cytochrome P450 2J20101
Potassium voltage-gated channel subfamily H member 20202
Sodium channel protein type 5 subunit alpha0101
Solute carrier family 22 member 10203
Nuclear receptor subfamily 3 group C member 3 0202
Calcium release-activated calcium channel protein 10101
Protein orai-20101
Protein orai-30101
Histamine H4 receptor0224
Histamine H3 receptor0102
67.9K protein5005
ATAD5 protein, partial5005
nonstructural protein 13003
arylsulfatase A3003
hexokinase-4 isoform 11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
glucokinase regulatory protein1001
DNA polymerase iota isoform a (long)6006
Rap guanine nucleotide exchange factor 33003
Steryl-sulfatase0101
Aromatase0202
Polyunsaturated fatty acid lipoxygenase ALOX150202
17-beta-hydroxysteroid dehydrogenase type 10203
Sodium-dependent serotonin transporter0202
Mu-type opioid receptor0112
Alpha-synuclein1102
Solute carrier organic anion transporter family member 1A10101
Mu-type opioid receptor0011
Inositol monophosphatase 11001
Cytochrome P450 1B10101
Estrogen receptor beta0113
Ghrelin O-acyltransferase0101
Broad substrate specificity ATP-binding cassette transporter ABCG20102
glp-1 receptor, partial3003
LMP1 [Human herpesvirus 4]0001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
transactivating tegument protein VP16 [Human herpesvirus 1]0202
nuclear receptor coactivator 3 isoform a0202
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40202
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0102
Serum paraoxonase/arylesterase 10101
Glutamate receptor ionotropic, NMDA 1 0003
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0003
Glutamate receptor ionotropic, NMDA 2B0003
Glutamate receptor ionotropic, NMDA 2C0003
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0003
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0003
Glutamate receptor ionotropic, NMDA 3A0003
interferon gamma precursor0001
streptokinase A precursor0011
Sodium/nucleoside cotransporter 20101
Thymidylate synthase0505
Thymidine phosphorylase0001
Solute carrier family 15 member 10101
Thymidine kinase0001
Chain A, Uracil Phosphoribosyltransferase0101
acetylcholinesterase1001
Skn7p0001
hemoglobin subunit beta2002
serine/threonine-protein kinase mTOR isoform 11001
Vpr1001
Solute carrier family 22 member 80002
Epidermal growth factor receptor0101
Amyloid-beta precursor protein1001
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Dihydrofolate reductase0011
Chain A, 2-oxoglutarate Oxygenase4004
acid sphingomyelinase2002
glucocerebrosidase2002
alpha-galactosidase2002
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase beta4004
Thymidylate synthase0404
Aldo-keto reductase family 1 member B10101
Multidrug resistance associated protein0103
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
Chain A, Beta-lactamase4004
aryl hydrocarbon receptor nuclear translocator0001
apical membrane antigen 1, AMA13003
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0102
Solute carrier family 22 member 30102
Plasma kallikrein0002
Carbonic anhydrase 30002
Macrophage migration inhibitory factor0202
Carbonic anhydrase 60103
Histamine H2 receptor0123
Adenosine receptor A10002
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0002
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0204
Carbonic anhydrase 70103
Carbonic anhydrase0003
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 0003
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0104
Carbonic anhydrase0003
Carbonic anhydrase 0003
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 130102
Carboxylic ester hydrolase 0001
Carbonic anhydrase 140002
Carbonic anhydrase 5B, mitochondrial0103
Histamine H3 receptor0123
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
transcriptional regulator ERG isoform 33003
Progesterone receptor0011
retinoic acid receptor alpha isoform 10101
retinoic acid receptor RXR-alpha isoform a0101
Fumarate hydratase3003
PPM1D protein1001
polyprotein3003
Chain A, JmjC domain-containing histone demethylation protein 3A1001
cellular tumor antigen p53 isoform a3003
UDP-glucose 6-dehydrogenase0101
Hypoxanthine-guanine phosphoribosyltransferase0001
Integrin beta-32002
Integrin alpha-IIb2002
UDP-glucose 6-dehydrogenase0101
Prostaglandin G/H synthase 10101
Purine nucleoside phosphorylase0011
UDP-glucuronosyltransferase 1A1 0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
ClpP1001
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
importin subunit beta-1 isoform 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
DNA polymerase kappa isoform 12002
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Bifunctional dihydrofolate reductase-thymidylate synthase0101
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
6-phosphogluconate dehydrogenase, decarboxylating0101
Dihydrofolate reductase0101
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
neuropeptide S receptor isoform A2002
5-hydroxytryptamine receptor 70101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial0101
lethal factor (plasmid)1001
cytochrome P450 2C19 precursor1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Parkin1001
prostaglandin E2 receptor EP2 subtype0001
Translocator protein0213
5-hydroxytryptamine receptor 1A0011
Translocator protein0214
Nuclear receptor subfamily 1 group I member 3 0101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit theta0011
Gamma-aminobutyric acid receptor subunit gamma-10011
histone deacetylase 9 isoform 31001
Tyrosinase0101
NAD(P)H dehydrogenase [quinone] 10001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Polyphenol oxidase 20001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Tubulin--tyrosine ligase0101
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]