Anthracosilicosis

A form of pneumoconiosis caused by inhalation of dust that contains both CARBON and crystalline SILICON DIOXIDE. These foreign matters induce fibrous nodule formation in the lung.

Synonym
Anthracosilicosis

Excerpt	Reference
"Premorbid stage of anthracosilicosis is characterized by activated lipids peroxidation, high levels of neuromediators (acetylcholine, catecholamines), tissue hormones (histamine, serotonine) and lower contents of adaptive hormones (cortisol, triiodothyronine, thyroxine)."	( Dzhangozina, DM; Kulkybaev, GA; Salimbaeva, BM, 1999)
"In miners anthracosilicosis is caused by chronic exposure to coal dust and is characterized by progressive development of the inflammatory process, the expressed disorders of lipid metabolism, and immunodeficiency."	( Bondarev, OI; Fomenko, DV; Gorokhova, LG; Kazitskaia, AS; Panev, NI, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	92 (69.17)	23.3326
1990's	25 (18.80)	12.5806
2000's	8 (6.02)	18.1394
2010's	7 (5.26)	28.8240
2020's	1 (0.75)	9.53

Drug	Relationship Strength	Studies	Trials
carbon monoxide	low	3	0
hydrochloric acid	low	1	0
histamine	low	1	0
pyridoxine	low	1	0
thiamine	low	1	0
uracil	low	1	0
albuterol	low	1	0
benzo(a)pyrene	low	1	0
isoniazid	low	2	0
isoproterenol	low	1	0
metaproterenol	low	1	0
apnea	low	1	0
sulfamethoxazole	medium	2	1
trimethoprim	medium	2	1
oxyphenonium	low	1	0
prednisolone	low	1	0
hydroxyproline	low	5	0
thyroxine	low	1	0
triiodothyronine	low	1	0
edetic acid	low	1	0
methionine	low	1	0
ampicillin	medium	2	1
phencyclidine	low	72	0
anthracene	low	1	0
ephedrine	low	1	0
limestone	low	1	0
6-methyluracil	low	1	0
ethambutol	low	1	0
cadmium sulfide	low	1	0
thorium dioxide	low	1	0
lead sulfide	low	1	0
d-alpha tocopherol	low	1	0
diazoline	low	1	0
cadmium	low	2	0
zirconium	low	1	0
trolamine salicylate	low	2	0
fluorides	low	2	0
cephalosporin c	low	1	0
methotrexate	low	1	0
glycogen	low	2	0
cocaine	low	2	0
lead	low	3	0
antimony	low	1	0
aluminum	low	3	0
beryllium	low	1	0
silicon	low	1	0
acid phosphatase	low	2	0
(9R)-9-chloro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one	low	1	0
salicylates	low	1	0
gastrin-releasing peptide	low	1	0
rome	low	1	0
hyaluronoglucosaminidase	low	1	0
muramidase	low	1	0
rifampin	low	1	0

Protein Targets (632)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
IDH1	3	0	0	3
chromobox protein homolog 1	9	0	0	9
geminin	12	0	0	12
estrogen-related nuclear receptor alpha	14	0	0	14
Carbonic anhydrase 1	0	5	0	7
glp-1 receptor, partial	6	0	0	6
thioredoxin reductase	9	0	0	9
GLS protein	7	0	0	7
regulator of G-protein signaling 4	5	0	0	5
estrogen nuclear receptor alpha	16	0	0	16
NPYLR7B	0	0	2	2
arylsulfatase A	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
thyroid stimulating hormone receptor	3	0	0	3
flap endonuclease 1	4	0	0	4
peripheral myelin protein 22	5	0	0	5
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	8
Bile salt export pump	0	13	0	13
Beta-2 adrenergic receptor	0	4	5	10
Beta-1 adrenergic receptor	0	2	3	5
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-3 adrenergic receptor	0	1	2	3
Delta-type opioid receptor	0	1	1	2
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
Beta-2 adrenergic receptor	0	1	3	6
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Beta-2 adrenergic receptor	0	1	4	5
Canalicular multispecific organic anion transporter 1	0	7	0	7
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	2	0	0	2
Beta-lactamase	0	0	0	1
acid sphingomyelinase	3	0	0	3
GLI family zinc finger 3	10	0	0	10
apical membrane antigen 1, AMA1	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
farnesoid X nuclear receptor	6	0	0	6
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
thyroid hormone receptor beta isoform 2	10	0	0	10
DNA polymerase beta	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	4	0	0	4
DNA polymerase kappa isoform 1	4	0	0	4
Carbonic anhydrase 2	0	4	1	8
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	3	0	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	2
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	1	0	2
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	1	0	2
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	10	0	0	10
AR protein	13	0	0	13
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
pregnane X nuclear receptor	7	0	0	7
peroxisome proliferator-activated receptor delta	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
Histone H2A.x	4	0	0	4
histone deacetylase 9 isoform 3	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Glutamate receptor 2	6	0	0	6
5-lipoxygenase	0	1	0	1
ATAD5 protein, partial	3	0	0	3
TDP1 protein	8	0	0	8
Microtubule-associated protein tau	6	0	0	6
Bloom syndrome protein isoform 1	4	0	0	4
D(1A) dopamine receptor	1	0	0	1
lamin isoform A-delta10	8	0	0	8
neuropeptide S receptor isoform A	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Luciferase	3	0	0	3
acetylcholinesterase	2	0	0	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
Smad3	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
progesterone receptor	6	0	0	6
glucocorticoid receptor [Homo sapiens]	6	0	0	6
retinoid X nuclear receptor alpha	5	0	0	5
peroxisome proliferator activated receptor gamma	6	0	0	6
caspase-3	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
heat shock protein beta-1	2	0	0	2
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cellular tumor antigen p53	10	0	0	10
Cytochrome P450 1A2	0	2	0	2
Tyrosine-protein kinase Fyn	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
Aryl hydrocarbon receptor	0	0	1	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Amyloid-beta precursor protein	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
5-hydroxytryptamine receptor 2C	0	3	0	4
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	3	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	6
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	3	1	6
Glutamate receptor ionotropic, NMDA 2B	0	3	1	6
Glutamate receptor ionotropic, NMDA 2C	0	3	1	7
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	1	6
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	3	1	6
Sigma non-opioid intracellular receptor 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	1	6
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	2	0	2
USP1 protein, partial	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
dopamine D1 receptor	3	0	0	3
hexokinase-4 isoform 1	2	0	0	2
vitamin D3 receptor isoform VDRA	4	0	0	4
glucokinase regulatory protein	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Angiotensin-converting enzyme	0	1	0	1
Histamine H2 receptor	2	0	2	4
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
67.9K protein	4	0	0	4
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	4
Pantothenate synthetase	0	2	0	2
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 15	0	1	0	3
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
phosphopantetheinyl transferase	4	0	0	4
GALC protein	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
EWS/FLI fusion protein	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	2	0	4
Carbonic anhydrase 12	0	0	0	2
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	2
Carbonic anhydrase 3	0	0	0	2
Macrophage migration inhibitory factor	0	3	0	3
Carbonic anhydrase 6	0	2	0	4
Histamine H2 receptor	0	1	2	3
Adenosine receptor A1	0	0	0	2
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	0	0	2
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	2	1	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	3
Histamine H1 receptor	0	2	2	4
Carbonic anhydrase 7	0	1	0	3
Carbonic anhydrase	0	0	0	3
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	0	0	3
Solute carrier family 22 member 1	0	2	0	3
Carbonic anhydrase	0	0	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	2	0	3
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	3
Histamine H3 receptor	0	1	2	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	1	3
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Bile salt export pump	0	6	0	6
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 3A4	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	1	3
Gamma-aminobutyric acid receptor subunit delta	2	0	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	1	3
Cytochrome P450 2C19	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	1	3
Gamma-aminobutyric acid receptor subunit beta-3	2	0	1	3
Gamma-aminobutyric acid receptor subunit beta-2	2	0	1	3
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
GABA theta subunit	2	0	1	3
Endonuclease 8-like 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	1	3
cytochrome P450 2D6	1	0	0	1
Beta-1 adrenergic receptor	0	0	1	2
beta-2 adrenergic receptor	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Beta-2 adrenergic receptor	0	2	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	1	4
Beta-2 adrenergic receptor	0	0	1	1
D(1A) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Beta-adrenergic receptor kinase 1	0	0	2	2
Alpha-1D adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
D(3) dopamine receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Taste receptor type 2 member 42	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	2
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, Ferritin light chain	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
survival motor neuron protein isoform d	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	3	0	3
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Thymidylate synthase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	4	2	6
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	5	0	6
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	3
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
TAR DNA-binding protein 43	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	5
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	1	2
Muscarinic acetylcholine receptor M4	0	0	1	2
Delta-type opioid receptor	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Mu-type opioid receptor	0	0	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
luciferase	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Interferon beta	2	0	0	2
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	3	0	3
Cytochrome P450 2C9	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	2	0	2
Estrogen receptor beta	0	2	0	2
Pyridoxal kinase	0	0	0	1
interleukin 8	3	0	0	3
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Albumin	0	0	1	1
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	3
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	5
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protease	0	1	1	2
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
G	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
glucocerebrosidase	1	0	0	1
Prothrombin	0	0	1	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
endonuclease IV	1	0	0	1
NFKB1 protein, partial	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
SLC16A10 protein	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Protein cereblon	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (133)

Protein Targets (632)

Anthracosilicosis

Synonyms(1)

Research Excerpts

Overview

Research

Studies (133)

Drugs Studied (64)

Protein Targets (632)