Androgen Insensitivity Syndrome

A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY.

Synonym
Androgen Receptor Deficiency
Testicular Feminization Syndrome
Androgen Resistance Syndrome
Androgen-Insensitivity Syndrome, Complete
Reifenstein Syndrome
Reifenstein's Syndrome
Androgen-Insensitivity Syndrome
Testicular Feminization
Dihydrotestosterone Receptor Deficiency
AR Deficiency
Androgen-Insensitivity Syndrome, Partial
Male Pseudohermaphroditism Due to Androgen Insensitivity
Androgen Insensitivity, Partial
DHTR Deficiency
Androgen Insensitivity Syndrome

Excerpt	Reference
"Testicular feminization is a classic form of complete male pseudohermaphroditism."	( Faucher, G; Kaufman, M; Lambert, B; Pinsky, L; Rosenfeld, R, 1977)
"The androgen resistance syndromes are generally felt to be due to quantitative or qualitative abnormalities of the androgen receptor."	( Eil, C, 1983)
"Complete androgen insensitivity syndrome is caused by X chromosome linked disorder resulting in a target organ insensitivity to androgen."	( Isojima, S; Kasumi, H; Komori, S; Shima, H; Yamasaki, N, 1993)
"The androgen insensitivity syndrome is a disorder caused by deficient function of the androgen receptor, characterized by varying degrees of undermasculinization in karyotypic males."	( Alm, J; Byström, B; Knudtzon, J; Lindsten, K; Lundberg Giwercman, Y; Nikoshkov, A; Pousette, A; Wedell, A, 2000)
"Androgen insensitivity syndrome is an X-linked disorder of male sexual differentiation caused by mutations in the androgen receptor gene and resulting in a wide range of phenotypes."	( Argente Oliver, J; González Medeiro, I; Martín Sobrino, MA; Martinez Pérez, J; Muñoz Calvo, MT; Pozo Román, J; Soriano Guillén, L, 2002)

Excerpt	Reference
"Some patients with testicular feminization have no demonstrable fibroblast cytosol androgen binding, whereas others have androgen binding in cultured fibrobalsts that is thermolabile or fails to be stabilized by sodium molybdate."	( Eil, C, 1983)

Excerpt	Reference
"In two patients with testicular feminization syndrome, one Yq12-positive and the other Yq12-negative, we compared phenotype, gonadal histology and ultrastructure, in vivo steroid response of the testes to the administration of exogenous gonadotropin during adrenal suppression, and of the adrenal gland to ACTH."	( Barbarino, A; Bova, R; de Marinis, L; Menini, E; Moneta, E; Pasargiklian, E; Pizzolato, G; Serra, A, 1978)
"In a newborn patient with partial androgen insensitivity syndrome caused by an AR gene point mutation, the functional analysis of the mutated AR offers a possible treatment modality."	( Bartsch, G; Corvin, S; Culig, Z; Hobisch, A; Klocker, H; Radmayr, C, 1998)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	414 (63.30)	23.3326
1990's	74 (11.31)	12.5806
2000's	75 (11.47)	18.1394
2010's	71 (10.86)	28.8240
2020's	20 (3.06)	9.53

Drug	Relationship Strength	Studies	Trials
acetone	low	1	0
quinacrine	low	2	0
salicylic acid	low	1	0
creatine	low	1	0
cytosine	low	1	0
glycine	low	1	0
glycerol	low	2	0
histamine	low	1	0
methanol	low	1	0
thymine	low	1	0
ddt	low	1	0
pentetic acid	low	1	0
flutamide	low	8	0
guanidine	low	1	0
hexestrol	low	1	0
hexobarbital	low	2	0
ketoconazole	low	1	0
metformin	low	1	0
metyrapone	low	1	0
minoxidil	low	1	0
activins	low	1	0
risperidone	low	1	0
corticosterone	low	8	0
estriol	low	3	0
thymidine	low	2	0
thyroxine	low	4	0
norethindrone acetate	low	1	0
spironolactone	low	1	0
aldosterone	low	4	0
norethandrolone	low	1	0
prednisone	low	1	0
estrone	low	15	0
androsterone	medium	19	1
etiocholanolone	medium	5	1
dehydroepiandrosterone	low	27	0
triiodothyronine	low	5	0
diethylnitrosamine	low	2	0
alanine	low	1	0
serine	low	2	0
glutamine	low	3	0
lysine	low	1	0
ethinyl estradiol	low	9	0
testosterone propionate	low	1	0
methyltestosterone	low	3	0
phenylephrine	low	1	0
tyrosine	low	1	0
androstenedione	low	23	0
phenylalanine	low	1	0
desoxycorticosterone	low	2	0
cycloheximide	low	1	0
norethindrone	low	2	0
17-alpha-hydroxyprogesterone	low	2	0
histidine	low	1	0
medroxyprogesterone acetate	low	2	0
threonine	low	1	0
mestranol	low	1	0
arginine	low	11	0
fluoxymesterone	low	3	0
pregnenolone	low	15	0
chlormadinone acetate	low	1	0
testosterone enanthate	low	2	0
cyproterone acetate	low	5	0
nandrolone	low	6	0
medroxyprogesterone	low	5	0
dihydrotestosterone	low	140	0
ethyl n-alpha-acetyl-tyrosinate	low	1	0
boldenone	low	2	0
manganese	low	1	0
molybdenum	low	1	0
technetium	low	1	0
stanozolol	low	4	0
danazol	low	4	0
phenyl acetate	medium	7	1
pregnanolone	low	1	0
androstane-3,17-diol	low	4	0
glutamic acid	low	1	0
etoposide	low	1	0
vecuronium bromide	low	1	0
ng-nitroarginine methyl ester	low	1	0
colforsin	low	1	0
sertindole	low	1	0
sodium molybdate(vi)	low	1	0
testosterone undecanoate	low	1	0
ovosiston	low	1	0
fluorodeoxyglucose f18	low	3	0
17-alpha-hydroxypregnenolone	low	3	0
pregnanetriol	low	4	0
rc 3095	low	1	0
piperaquine	medium	1	1
benzoylarginine ethyl ester	low	1	0
proline	low	1	0
technetium tc 99m pentetate	low	1	0
cortisone	low	2	0
androstane-3,17-dione, (5alpha)-isomer	low	1	0
norethindrone enanthate	low	1	0
mibolerone	low	5	0
metribolone	low	15	0
carboplatin	low	1	0
glycogen	low	2	0
tretinoin	low	1	0
retinol	low	1	0
diethylstilbestrol	low	12	0
isomethyleugenol	low	1	0
retinaldehyde	low	1	0
arginine vasopressin	low	1	0
leuprolide	low	1	0
enclomiphene	low	6	0
tamoxifen	low	5	0
androstane-3,17-diol glucuronide	low	1	0
cystine	low	1	0
alpha-chymotrypsin	low	1	0
17-ketosteroids	medium	57	2
calcitriol	low	1	0
cyproterone	low	7	0
naloxone	low	1	0
naltrexone	low	1	0
cysteine	low	2	0
phosphorus	low	4	0
pregnanediol	low	7	0
sincalide	low	1	0
artenimol	medium	1	1
pituitrin	low	1	0
nad	low	1	0
glucagon	low	1	0
beta-endorphin	low	1	0
oligonucleotides	low	2	0
19-iodocholesterol	low	1	0
menotropins	low	1	0
bucladesine	low	1	0
sodium pertechnetate tc 99m	low	2	0
sodium ethylxanthate	low	5	0
glycolipids	low	1	0
epidermal growth factor	low	2	0
gastrin-releasing peptide	low	2	0
guanine	low	1	0
eye	low	1	0

Protein Targets (942)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Cruzipain	7	0	0	7
IDH1	13	0	0	13
DNA polymerase iota isoform a (long)	11	0	0	11
geminin	43	0	0	43
Sex hormone-binding globulin	0	1	20	21
acetylcholinesterase	13	0	0	13
pregnane X receptor	19	0	0	19
SMAD family member 2	20	0	0	20
SMAD family member 3	20	0	0	20
TDP1 protein	45	0	0	45
GLI family zinc finger 3	43	0	0	43
Microtubule-associated protein tau	10	0	0	10
AR protein	53	0	0	53
progesterone receptor	38	0	0	38
glucocorticoid receptor [Homo sapiens]	47	0	0	47
retinoic acid nuclear receptor alpha variant 1	39	0	0	39
retinoid X nuclear receptor alpha	36	0	0	36
estrogen-related nuclear receptor alpha	45	0	0	45
farnesoid X nuclear receptor	23	0	0	23
pregnane X nuclear receptor	38	0	0	38
estrogen nuclear receptor alpha	56	0	0	56
G	21	0	0	21
vitamin D (1,25- dihydroxyvitamin D3) receptor	32	0	0	32
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	23	0	0	23
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	34	0	0	34
activating transcription factor 6	18	0	0	18
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
chromobox protein homolog 1	23	0	0	23
nuclear factor erythroid 2-related factor 2 isoform 1	46	0	0	46
survival motor neuron protein isoform d	13	0	0	13
histone acetyltransferase KAT2A isoform 1	12	0	0	12
lamin isoform A-delta10	23	0	0	23
Voltage-dependent calcium channel gamma-2 subunit	24	0	0	24
Interferon beta	26	0	0	26
HLA class I histocompatibility antigen, B alpha chain	21	0	0	21
Glucocorticoid receptor	0	32	3	36
Glycine receptor subunit alpha-1	0	30	0	30
Corticosteroid-binding globulin	0	14	0	14
Adenosine receptor A3	0	16	0	16
Replicase polyprotein 1ab	0	2	2	4
Androgen receptor	0	48	1	50
Alpha-1B adrenergic receptor	0	20	0	20
Glutamate receptor 2	24	2	1	27
Glycine receptor subunit beta	0	30	0	30
Glycine receptor subunit alpha-2	0	30	0	30
Glycine receptor subunit alpha-3	0	30	0	30
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	20	0	20
Sodium-dependent dopamine transporter	0	14	0	14
TAR DNA-binding protein 43	14	0	0	14
Inositol hexakisphosphate kinase 1	21	0	0	21
cytochrome P450 2C9, partial	21	0	0	21
ATP-dependent phosphofructokinase	9	0	0	9
thyroid hormone receptor beta isoform 2	43	0	0	43
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	15	0	0	15
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Carbonic anhydrase 1	0	3	0	11
Carbonic anhydrase 2	0	3	0	12
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	6	2	13
Proton-coupled amino acid transporter 1	0	6	0	7
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	3
thyroid hormone receptor beta isoform a	17	0	0	17
nuclear factor erythroid 2-related factor 2 isoform 2	12	0	0	12
Mineralocorticoid receptor	0	6	3	10
Mineralocorticoid receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	4	0	5
Guanine nucleotide-binding protein G	4	0	0	4
Olfactory receptor 51E2	0	0	3	3
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
interleukin 8	10	0	0	10
RAR-related orphan receptor gamma	41	0	0	41
Smad3	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	19	0	0	19
estrogen receptor 2 (ER beta)	32	0	0	32
regulator of G-protein signaling 4	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	22	0	0	22
nonstructural protein 1	7	0	0	7
peroxisome proliferator-activated receptor delta	32	0	0	32
peroxisome proliferator activated receptor gamma	29	0	0	29
Histone H2A.x	16	0	0	16
Caspase-7	7	0	0	7
Bloom syndrome protein isoform 1	5	0	0	5
peripheral myelin protein 22 isoform 1	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	10	0	0	10
caspase-3	7	0	0	7
importin subunit beta-1 isoform 1	3	0	0	3
mitogen-activated protein kinase 1	9	0	0	9
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	15	0	0	15
peripheral myelin protein 22	21	0	0	21
muscleblind-like protein 1 isoform 1	3	0	0	3
neuropeptide S receptor isoform A	6	0	0	6
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	2	0	2
Aromatase	0	8	0	11
Gastrin/cholecystokinin type B receptor	0	1	1	3
Testosterone 17-beta-dehydrogenase 3	0	3	0	3
Alpha-synuclein	8	6	0	14
Nuclear receptor ROR-gamma	16	1	1	18
Chain A, retinol dehydratase	0	1	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	23	0	0	23
Gamma-aminobutyric acid receptor subunit pi	18	2	1	21
Glucose-6-phosphate 1-dehydrogenase	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	18	2	1	21
Gamma-aminobutyric acid receptor subunit delta	18	2	1	21
Gamma-aminobutyric acid receptor subunit gamma-2	18	2	1	21
Gamma-aminobutyric acid receptor subunit alpha-5	18	2	1	21
Gamma-aminobutyric acid receptor subunit alpha-3	18	2	1	21
Gamma-aminobutyric acid receptor subunit gamma-1	18	2	1	21
Gamma-aminobutyric acid receptor subunit alpha-2	18	2	1	21
Gamma-aminobutyric acid receptor subunit alpha-4	18	2	1	21
Gamma-aminobutyric acid receptor subunit gamma-3	18	2	1	21
Gamma-aminobutyric acid receptor subunit alpha-6	18	2	1	21
Gamma-aminobutyric acid receptor subunit alpha-1	18	2	1	21
Gamma-aminobutyric acid receptor subunit beta-3	18	2	1	21
Gamma-aminobutyric acid receptor subunit beta-2	18	2	1	21
G-protein coupled bile acid receptor 1	0	0	4	4
GABA theta subunit	18	2	1	21
Gamma-aminobutyric acid receptor subunit epsilon	18	2	1	21
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	19	0	0	19
phosphopantetheinyl transferase	12	0	0	12
NFKB1 protein, partial	4	0	0	4
GLS protein	9	0	0	9
thyroid stimulating hormone receptor	15	0	0	15
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	5	0	0	5
flap endonuclease 1	7	0	0	7
muscarinic acetylcholine receptor M1	6	0	0	6
lethal factor (plasmid)	11	0	0	11
Cytochrome P450 3A4	0	12	1	16
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	2	0	2
vitamin D3 receptor isoform VDRA	12	0	0	12
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	17
Bile salt export pump	0	28	0	28
Translocator protein	0	1	1	2
Vasopressin V2 receptor	0	2	1	4
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	3	1	4
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	18	0	19
Cytochrome P450 2B6	0	3	0	3
Protein-arginine deiminase type-4	0	0	0	1
glp-1 receptor, partial	13	0	0	13
ATAD5 protein, partial	10	0	0	10
vasopressin V1b receptor	1	0	0	1
cAMP-dependent protein kinase type I-alpha regulatory subunit	0	0	1	1
cAMP-dependent protein kinase type II-beta regulatory subunit	0	0	1	1
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
cAMP-dependent protein kinase catalytic subunit beta isoform 1	0	0	1	1
urokinase plasminogen activator surface receptor precursor	7	0	0	7
relaxin receptor 1 isoform 1	2	0	0	2
relaxin receptor 2 isoform 1	2	0	0	2
cAMP-dependent protein kinase catalytic subunit beta isoform 3	0	0	1	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	12	0	0	12
Chain A, Ferritin light chain	10	0	0	10
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	18	0	0	18
PPM1D protein	4	0	0	4
thioredoxin glutathione reductase	4	0	0	4
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	2	1	4
Androgen receptor	0	17	8	28
Cytochrome P450 2D6	0	9	1	11
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	5	1	7
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	5	7
Cytochrome P450 2C19	0	7	1	8
Kappa-type opioid receptor	0	4	2	7
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	1	3
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
cytochrome P450 2D6	16	0	0	16
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
DNA polymerase kappa isoform 1	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	28	0	0	28
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
thyroid stimulating hormone receptor	21	0	0	21
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	23	0	0	23
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	9	0	0	9
transcriptional regulator ERG isoform 3	8	0	0	8
Cellular tumor antigen p53	26	0	0	26
Spike glycoprotein	15	0	2	17
aryl hydrocarbon receptor	10	0	0	10
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	1	2	3
Rap guanine nucleotide exchange factor 3	5	0	0	5
ATP-dependent translocase ABCB1	0	9	2	13
5-hydroxytryptamine receptor 1A	0	3	2	5
Solute carrier family 2, facilitated glucose transporter member 1	0	1	1	2
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
ATPase family AAA domain-containing protein 5	14	0	0	14
Ataxin-2	15	0	0	15
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
GALC protein	7	0	0	7
Thrombopoietin	1	0	0	1
heat shock protein beta-1	17	0	0	17
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
cytochrome P450 3A4 isoform 1	18	0	0	18
Solute carrier family 22 member 2	0	5	0	6
Solute carrier family 22 member 1	0	7	0	8
Solute carrier family 22 member 3	0	4	0	5
Solute carrier family 22 member 3	0	2	0	2
C-8 sterol isomerase	0	3	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	1	5
Solute carrier family 22 member 1	0	5	0	8
Sigma non-opioid intracellular receptor 1	0	6	0	6
Solute carrier family 22 member 2	0	6	0	8
endonuclease IV	4	0	0	4
dopamine D1 receptor	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
M-phase phosphoprotein 8	6	0	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	6	0	6
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Fumarate hydratase	5	0	0	5
EWS/FLI fusion protein	9	0	0	9
polyprotein	5	0	0	5
67.9K protein	9	0	0	9
P53	1	0	0	1
RPL19A	0	0	1	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
cellular tumor antigen p53 isoform a	5	0	0	5
ras-related protein Rab-9A	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	2	2
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	2	2
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	4
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	3	1	4
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	1
D(1A) dopamine receptor	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Progesterone receptor	0	10	5	15
Adenosine receptor A1	0	2	0	6
Adenosine receptor A2b	0	1	0	1
Adenosine receptor A2a	0	1	0	5
Mu-type opioid receptor	0	14	3	20
ORF73	0	0	1	1
Deoxycytidine kinase	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	13	0	0	13
Estrogen receptor	0	23	6	31
Aldo-keto reductase family 1 member B1	0	16	0	16
Alpha-2A adrenergic receptor	0	18	1	19
Beta-3 adrenergic receptor	0	6	1	7
Alpha-2B adrenergic receptor	0	16	0	16
Alpha-2C adrenergic receptor	0	12	1	13
Muscarinic acetylcholine receptor M3	0	13	0	13
Substance-K receptor	0	10	0	10
D(1A) dopamine receptor	0	9	0	9
Sodium-dependent noradrenaline transporter	0	16	0	16
5-hydroxytryptamine receptor 2A	0	15	0	15
Sodium-dependent serotonin transporter	0	21	0	21
D(3) dopamine receptor	0	15	0	15
Kappa-type opioid receptor	0	12	3	19
Cytochrome P450 2J2	0	3	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Luciferase	6	0	0	6
15-lipoxygenase, partial	7	0	0	7
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
serine/threonine-protein kinase PLK1	2	0	0	2
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
5-hydroxytryptamine receptor 4	0	10	0	10
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Integrin beta-3	3	0	1	4
Tyrosine-protein kinase Fyn	0	3	0	3
Integrin alpha-IIb	3	0	1	4
Beta-1 adrenergic receptor	0	4	1	5
Muscarinic acetylcholine receptor M1	0	10	0	10
Polyunsaturated fatty acid lipoxygenase ALOX15	0	6	0	6
D(2) dopamine receptor	0	9	0	9
Acetylcholinesterase	0	4	0	4
Prostaglandin G/H synthase 1	0	4	0	4
Thromboxane-A synthase	0	3	0	3
Alpha-1D adrenergic receptor	0	9	0	10
5-hydroxytryptamine receptor 2C	0	11	0	11
Adenosine receptor A2a	0	6	0	6
Adenosine receptor A1	0	7	0	7
Delta-type opioid receptor	0	10	4	17
5-hydroxytryptamine receptor 2B	0	14	0	14
Histamine H2 receptor	6	0	1	7
5-hydroxytryptamine receptor 6	0	10	0	10
Estrogen-related receptor gamma	0	1	1	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Inositol monophosphatase 1	3	0	0	3
Aldehyde oxidase	0	3	0	3
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Estrogen receptor beta	0	8	6	15
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Cysteinyl leukotriene receptor 1	0	2	0	2
Chain A, Sex Hormone-Binding Globulin	0	0	1	1
thyrotropin-releasing hormone receptor	3	0	0	3
Plasma kallikrein	0	1	0	5
Progesterone receptor	0	1	0	1
Glucocorticoid receptor	0	1	0	1
Sex hormone-binding globulin	0	2	0	2
Androgen receptor	0	1	3	4
Angiotensin-converting enzyme	0	0	1	1
Cannabinoid receptor 2	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Neuropeptide FF receptor 2	0	0	0	2
ALK tyrosine kinase receptor	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	2	0	2
protein AF-9 isoform a	0	0	0	1
Epidermal growth factor receptor	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Muscarinic acetylcholine receptor M2	0	10	0	10
Muscarinic acetylcholine receptor M4	0	8	0	8
Muscarinic acetylcholine receptor M5	0	8	0	8
UDP-glucuronosyltransferase 2B7	0	0	0	1
Lanosterol 14-alpha demethylase	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Steryl-sulfatase	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Mu-type opioid receptor	0	4	5	9
Mu-type opioid receptor	0	4	3	8
Cytochrome P450 1B1	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
caspase 7, apoptosis-related cysteine protease	6	0	0	6
caspase-3	6	0	0	6
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Vpr	2	0	0	2
Cytochrome P450 2B1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
UDP-glucuronosyltransferase 1A1	0	3	0	6
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	3	0	3
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
ClpP	1	0	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	2	3
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	3	0	3
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	2	11
Glutamate receptor ionotropic, NMDA 2B	0	4	2	11
Glutamate receptor ionotropic, NMDA 2C	0	4	2	11
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	4	2	11
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	4	2	11
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Glutamate receptor ionotropic, NMDA 3A	0	4	2	11
cytochrome P450 2C9 precursor	2	0	0	2
huntingtin isoform 2	1	0	0	1
Cocaine esterase	0	1	0	2
Bile salt export pump	0	3	0	3
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	5	0	5
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	6
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	3	0	3
Amino acid transporter	0	3	0	3
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	5	0	6
Serine racemase	0	1	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	4	0	0	4
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	1	0	5
Carbonic anhydrase 3	0	1	0	5
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	1	0	5
Carbonic anhydrase 6	0	1	0	5
Histamine H2 receptor	0	11	2	13
Histamine H1 receptor	0	2	2	4
Histamine H1 receptor	0	2	1	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	5
Histamine H1 receptor	0	5	2	7
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase 7	0	1	0	5
Carbonic anhydrase	0	0	0	5
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Carbonic anhydrase 9	0	1	0	5
Carbonic anhydrase	0	0	0	5
Carbonic anhydrase	0	0	0	5
Carbonic anhydrase	0	0	0	5
Carbonic anhydrase	0	0	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 15	0	1	0	5
Carbonic anhydrase 13	0	1	0	4
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase 14	0	1	0	5
Carbonic anhydrase 5B, mitochondrial	0	1	0	5
Histamine H3 receptor	0	2	2	4
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Estrogen receptor beta	0	1	0	2
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	4	0	4
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2A	0	5	1	6
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Estrogen receptor	0	1	0	2
Gonadotropin-releasing hormone receptor	0	3	1	4
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Sodium/bile acid cotransporter	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	1	4
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
PINK1	2	0	0	2
Parkin	3	0	0	3
5-hydroxytryptamine receptor 1B	0	6	0	6
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
glucocerebrosidase	4	0	0	4
5-hydroxytryptamine receptor 3E	0	1	1	2
cytochrome P450 2D6 isoform 1	3	0	0	3
5-hydroxytryptamine receptor 3B	0	1	1	2
Albumin	0	0	2	2
Myeloperoxidase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	5	0	5
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	6	0	6
Alpha-2B adrenergic receptor	0	3	0	3
D(2) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
D(2) dopamine receptor	0	5	0	5
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	2
5-hydroxytryptamine receptor 3D	0	1	1	2
5-hydroxytryptamine receptor 3C	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Chain A, androgen receptor	0	0	1	1
Chain A, androgen receptor	0	0	1	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Histidine decarboxylase	0	0	2	2
Delta-type opioid receptor	0	4	2	8
Delta-type opioid receptor	0	4	3	7
Kappa-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	3	3	6
Mu-type opioid receptor	0	3	1	6
Sigma non-opioid intracellular receptor 1	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Nociceptin receptor	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
Estrogen receptor	0	0	2	3
Estrogen receptor beta	0	0	2	3
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Alpha-1B adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
POU domain, class 2, transcription factor 1	0	0	0	1
Beta-1 adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	3	1	4
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	4	1	6
Alpha-1B adrenergic receptor	0	3	1	5
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
N	0	1	0	1
NPYLR7B	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	0	1	1
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Trypanothione reductase	0	2	0	2
D(1A) dopamine receptor	2	0	0	2
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	2	0	2
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
Aldo-keto reductase family 1 member B10	0	0	0	2
Amyloid-beta precursor protein	0	3	0	3
Aldo-keto reductase family 1 member B1	0	1	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Angiotensin-converting enzyme	0	5	0	5
D(4) dopamine receptor	0	4	0	4
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Transporter	0	1	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	3
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Cholecystokinin receptor type A	0	2	2	4
Gastrin/cholecystokinin type B receptor	0	2	2	4
Gastrin/cholecystokinin type B receptor	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
interferon gamma precursor	0	0	0	1
streptokinase A precursor	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Protein kinase C alpha type	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	2
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Androgen Insensitivity Syndrome

Synonyms(15)

Research Excerpts

Overview

Context

Treatment

Research

Studies (654)

Protein Targets (942)

Androgen Insensitivity Syndrome

Synonyms(15)

Research Excerpts

Overview

Context

Treatment

Research

Studies (654)

Drugs Studied (161)

Protein Targets (942)