Hydrosyringomyelia

Longitudinal cavities in the spinal cord, most often in the cervical region, which may extend for multiple spinal levels. The cavities are lined by dense, gliogenous tissue and may be associated with SPINAL CORD NEOPLASMS; spinal cord traumatic injuries; and vascular malformations. Syringomyelia is marked clinically by pain and PARESTHESIA, muscular atrophy of the hands, and analgesia with thermoanesthesia of the hands and arms, but with the tactile sense preserved (sensory dissociation). Lower extremity spasticity and incontinence may also develop. (From Adams et al., Principles of Neurology, 6th ed, p1269)

Synonym
Syringomyelus
Hydrosyringomyelia
Syringomyelia
Morvan's Disease
Myelosyringosis
Morvan Disease

Excerpt	Reference
"Syringomyelia is a common cause of cutaneous trophic alterations that are often unilateral."	( Fine, E; Paroski, M; Soria, E, 1989)
"Syringomyelia is rare in children aged less than 10 years, and bladder dysfunction is an unlikely first manifestation."	( Bensman, A; Forin, V; Houang, M; Leroy, B; Sinnassamy, P, 1994)
"Syringomyelia is a clinically important condition in which a cystic cavity forms within the spinal cord."	( Brown, C; Cleland, L; Jones, NR; Lee, GY; Mayrhofer, G, 2005)
"Syringomyelia is characterized by slow progression."	( Arslan Cebeci, S; Cetinkaya, E; Erdem, HR; Karagoz, A; Nacir, B, 2010)
"Syringomyelia is a pathological cavitation of the spinal cord."	( Bal, E; Başak, AT; Bozkurt, G; Çetinkaya, DU; Hanalioğlu, Ş; Köprü, ÇZ; Korkusuz, P; Köse, S; Pehlivan, SB; Purali, N, 2022)

Excerpt	Reference
"Also divided out of the syringomyelia treated groups were those given human mesenchymal stem cells (hMSCs)."	( Bal, E; Başak, AT; Bozkurt, G; Çetinkaya, DU; Hanalioğlu, Ş; Köprü, ÇZ; Korkusuz, P; Köse, S; Pehlivan, SB; Purali, N, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	157 (53.22)	23.3326
1990's	41 (13.90)	12.5806
2000's	42 (14.24)	18.1394
2010's	45 (15.25)	28.8240
2020's	10 (3.39)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	8	1
benzene	low	1	0
betaine	low	1	0
bromide	low	1	0
chlorine	low	1	0
salicylic acid	low	2	0
hydrogen carbonate	low	1	0
histamine	low	3	0
iodine	low	1	0
niacinamide	low	1	0
niacin	low	1	0
pyrazinamide	low	1	0
thiamine	low	1	0
uracil	low	1	0
urea	low	1	0
homovanillic acid	low	1	0
phenytoin	low	1	0
hydroxyindoleacetic acid	low	1	0
acetazolamide	low	1	0
albendazole	low	2	0
baclofen	medium	3	2
bupivacaine	low	1	0
caffeine	low	1	0
carprofen	low	1	0
chlorpromazine	low	2	0
clonazepam	low	1	0
cyproheptadine	low	1	0
pentetic acid	low	7	0
erythrosine	low	1	0
fentanyl	low	1	0
furosemide	low	3	0
gabapentin	medium	4	1
lidocaine	low	2	0
iodixanol	low	1	0
iohexol	low	2	0
iothalamic acid	low	2	0
isoniazid	low	2	0
ketamine	low	1	0
lomustine	low	2	0
mechlorethamine	low	1	0
mexiletine	low	1	0
apnea	low	3	0
neostigmine	low	1	0
procaine	low	1	0
propofol	low	1	0
temozolomide	low	1	0
prednisolone	low	3	0
reserpine	low	1	0
thyroxine	low	1	0
prednisone	low	2	0
aspartic acid	low	1	0
glutamine	low	1	0
physostigmine	low	1	0
adenosine diphosphate	low	1	0
phenylephrine	low	1	0
levodopa	low	2	0
threonine	medium	1	1
methylprednisolone	low	6	0
furaldehyde	low	1	0
pentoxyl	low	2	0
thiamine pyrophosphate	low	1	0
ephedrine	low	1	0
evans blue	low	1	0
gentian violet	low	1	0
ethambutol	low	1	0
vancomycin	low	1	0
streptomycin	low	1	0
lanthanum	low	1	0
silver	low	1	0
tantalum	low	1	0
technetium	low	4	0
titanium	low	2	0
argon	low	1	0
gadolinium	low	6	0
xenon	low	1	0
barium sulfate	low	1	0
galactose	low	1	0
radon	low	1	0
chlormerodrin	low	1	0
trolamine salicylate	low	11	0
phenyl acetate	low	1	0
fludrocortisone	low	1	0
transferrin	low	1	0
glutamic acid	low	1	0
substance p	low	2	0
nimustine	low	1	0
quisqualic acid	low	6	0
fomesafen	medium	9	1
iopamidol	low	1	0
cephalosporin c	low	1	0
xenon radioisotopes	low	1	0
fluorodeoxyglucose f18	low	4	0
5-hydroxymethyluracil	low	1	0
tebuconazole	low	1	0
alliin	low	1	0
methotrexate	low	1	0
technetium tc 99m pentetate	low	2	0
atropine	low	3	0
lacosamide	low	1	0
cortisone	low	1	0
fibrin	low	1	0
metrizamide	low	40	0
chlorprothixene	medium	1	1
D-fructopyranose	medium	2	1
nadp	low	2	0
myelin basic protein	low	1	0
phenylephrine hydrochloride	low	1	0
topiramate	medium	1	1
morphine	low	2	0
aluminum	low	1	0
veratrine	low	1	0
beryllium	low	1	0
cysteine	low	1	0
silicon	low	1	0
phosphorus	low	1	0
cefepime	low	1	0
pregabalin	medium	4	2
gadolinium dtpa	low	8	0
sidnocarb	low	1	0
jaw	low	1	0
nad	low	2	0
cholecystokinin	low	1	0
sodium oxybate	low	1	0
sodium ethylxanthate	low	1	0
kaolinite	low	32	0
transforming growth factor beta	low	1	0
hyaluronoglucosaminidase	low	1	0
vitamin b 12	low	3	0
dacarbazine	low	1	0
eye	low	3	0
phosphorus radioisotopes	low	1	0

Protein Targets (1,120)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Carbonic anhydrase 1	0	17	1	29
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	14	0	0	14
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	10	0	0	10
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
thioredoxin reductase	25	0	0	25
GALC protein	6	0	0	6
GLI family zinc finger 3	29	0	0	29
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
cytochrome P450 family 3 subfamily A polypeptide 4	17	0	0	17
glucocorticoid receptor [Homo sapiens]	23	0	0	23
retinoic acid nuclear receptor alpha variant 1	26	0	0	26
retinoid X nuclear receptor alpha	21	0	0	21
estrogen-related nuclear receptor alpha	28	0	0	28
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	14	0	0	14
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	39	0	0	39
Bloom syndrome protein isoform 1	20	0	0	20
thyroid hormone receptor beta isoform a	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
geminin	29	0	0	29
peripheral myelin protein 22	14	0	0	14
survival motor neuron protein isoform d	10	0	0	10
muscleblind-like protein 1 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	11	6	1	18
ATP-binding cassette sub-family C member 3	0	28	0	28
Multidrug resistance-associated protein 4	0	28	0	29
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	7	1	14
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	3
Bile salt export pump	0	39	0	39
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	3	0	3
Carbonic anhydrase 2	0	16	3	30
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	1	3
Carbonic anhydrase 3	0	6	1	11
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	5	1	6
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	0	5
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2D6	0	4	1	5
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	8	1	9
5-hydroxytryptamine receptor 2A	0	5	0	5
Androgen receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	11	6	1	18
Translocator protein	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	11	6	1	18
Gamma-aminobutyric acid receptor subunit gamma-2	11	6	3	20
Gamma-aminobutyric acid receptor subunit alpha-5	11	6	1	18
Gamma-aminobutyric acid receptor subunit alpha-3	11	6	1	18
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Cytochrome P450 2B6	0	1	1	2
Carbonic anhydrase 4	0	10	1	16
Carbonic anhydrase 6	0	7	1	13
Gamma-aminobutyric acid receptor subunit gamma-1	11	6	1	18
Gamma-aminobutyric acid receptor subunit alpha-2	11	6	1	18
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	3	0	6
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	11	6	1	18
Gamma-aminobutyric acid receptor subunit gamma-3	11	6	1	18
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	11	6	1	18
Adenosine receptor A2a	0	3	0	7
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	3	0	3
Delta-type opioid receptor	0	6	0	7
Cytochrome P450 2C19	0	3	0	3
Delta-type opioid receptor	0	7	1	9
Mu-type opioid receptor	0	7	2	12
Carbonic anhydrase 5A, mitochondrial	0	6	2	14
Carbonic anhydrase	0	6	0	8
Kappa-type opioid receptor	0	5	0	6
Carbonic anhydrase 7	0	6	1	12
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	2	0	5
D(2) dopamine receptor	0	6	1	8
Gamma-aminobutyric acid receptor subunit alpha-1	11	6	3	20
Gamma-aminobutyric acid receptor subunit beta-3	11	6	1	18
Gamma-aminobutyric acid receptor subunit beta-2	11	6	3	20
Cholinesterase	0	5	0	6
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	6	0	6
Fatty-acid amide hydrolase 1	1	6	0	7
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	9	1	12
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	7	1	14
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	5
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	7
GABA theta subunit	11	6	1	18
Canalicular multispecific organic anion transporter 1	0	29	0	29
Carbonic anhydrase 4	0	4	0	6
Carbonic anhydrase 15	0	8	0	11
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	5	0	10
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	11	6	1	18
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	6	1	13
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	6	1	13
Telomerase reverse transcriptase	0	1	0	1
Amyloid-beta precursor protein	0	2	0	2
Reverse transcriptase/RNaseH	0	1	0	2
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	14	0	0	14
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	10	3	14
Delta-type opioid receptor	0	6	2	9
Kappa-type opioid receptor	0	8	2	11
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	5	0	0	5
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Luciferase	10	0	0	10
glp-1 receptor, partial	8	0	0	8
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
RAR-related orphan receptor gamma	29	0	0	29
ATAD5 protein, partial	13	0	0	13
Fumarate hydratase	8	0	0	8
TDP1 protein	27	0	0	27
AR protein	35	0	0	35
caspase 7, apoptosis-related cysteine protease	6	0	0	6
progesterone receptor	16	0	0	16
farnesoid X nuclear receptor	13	0	0	13
pregnane X nuclear receptor	24	0	0	24
estrogen nuclear receptor alpha	41	0	0	41
polyprotein	8	0	0	8
67.9K protein	8	0	0	8
peroxisome proliferator activated receptor gamma	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	17	0	0	17
caspase-3	6	0	0	6
IDH1	11	0	0	11
aryl hydrocarbon receptor	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	18	0	0	18
v-jun sarcoma virus 17 oncogene homolog (avian)	16	0	0	16
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
Histone H2A.x	9	0	0	9
cellular tumor antigen p53 isoform a	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
chromobox protein homolog 1	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
transcriptional regulator ERG isoform 3	4	0	0	4
thyroid hormone receptor beta isoform 2	21	0	0	21
histone deacetylase 9 isoform 3	5	0	0	5
heat shock protein beta-1	6	0	0	6
mitogen-activated protein kinase 1	7	0	0	7
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
Vif	0	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lamin isoform A-delta10	25	0	0	25
neuropeptide S receptor isoform A	5	0	0	5
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Interferon beta	13	0	0	13
Cellular tumor antigen p53	17	0	0	17
Integrin beta-3	5	0	1	6
Integrin alpha-IIb	5	0	1	6
Methionine aminopeptidase	0	1	0	1
Glutamate receptor 2	11	3	1	15
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	10	0	0	10
Microtubule-associated protein tau	10	0	0	11
D(1A) dopamine receptor	8	0	0	8
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Chain A, Ferritin light chain	5	0	0	5
phosphopantetheinyl transferase	14	0	0	14
aldehyde dehydrogenase 1 family, member A1	22	0	0	22
cytochrome P450 2C19 precursor	3	0	0	3
lethal factor (plasmid)	8	0	0	8
Metabotropic glutamate receptor 6	0	2	2	5
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	7	1	10
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	7	1	10
Glutamate receptor ionotropic, NMDA 2C	0	7	1	10
Metabotropic glutamate receptor 1	0	2	3	6
Metabotropic glutamate receptor 2	0	2	3	6
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	7	1	10
Glutamate receptor ionotropic, NMDA 3B	0	7	1	10
Glutamate receptor ionotropic, NMDA 3A	0	7	1	10
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	6	0	9
5-hydroxytryptamine receptor 4	0	8	0	8
Muscarinic acetylcholine receptor M2	0	8	1	12
Muscarinic acetylcholine receptor M4	0	8	1	11
Muscarinic acetylcholine receptor M1	0	5	1	8
Muscarinic acetylcholine receptor M3	0	5	1	8
Muscarinic acetylcholine receptor M4	0	5	1	8
Muscarinic acetylcholine receptor M5	0	5	1	8
Muscarinic acetylcholine receptor M5	0	8	1	11
Muscarinic acetylcholine receptor M2	0	6	1	10
Muscarinic acetylcholine receptor M1	0	8	1	12
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	8	1	11
Alpha-1D adrenergic receptor	0	8	0	8
5-hydroxytryptamine receptor 2C	0	8	0	8
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	6	0	1	8
5-hydroxytryptamine receptor 7	0	4	0	4
Muscarinic acetylcholine receptor	0	1	1	3
NFKB1 protein, partial	7	0	0	7
activating transcription factor 6	11	0	0	11
cytochrome P450 3A4 isoform 1	11	0	0	11
histone acetyltransferase KAT2A isoform 1	13	0	0	13
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
ATP-dependent phosphofructokinase	15	0	0	15
Chain A, Integrase	0	1	0	1
Chain A, Integrase	0	1	0	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, GCN4P1	0	0	1	1
Chain B, GCN4P1	0	0	1	1
Chain C, GCN4P1	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, Replicase polyprotein 1ab	0	1	0	1
Chain A, 3C-like proteinase	0	1	0	1
pregnane X receptor	5	0	0	5
thyroid stimulating hormone receptor	16	0	0	16
peroxisome proliferator-activated receptor delta	14	0	0	14
Endolysin	0	0	1	1
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Bile salt export pump	0	9	0	9
Proton-coupled amino acid transporter 1	0	2	0	2
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	3	2	5
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
GLS protein	16	0	0	16
thyroid stimulating hormone receptor	9	0	0	9
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
nuclear receptor ROR-gamma isoform 1	6	0	0	6
DNA polymerase kappa isoform 1	11	0	0	11
muscarinic acetylcholine receptor M1	15	0	0	15
Cholinesterase	0	5	0	5
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Adenosine receptor A3	0	3	0	3
Replicase polyprotein 1ab	0	2	1	3
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	6	0	7
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	4	1	6
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	5
Guanine deaminase	0	1	0	1
acetylcholinesterase	7	0	0	7
USP1 protein, partial	15	0	0	15
Vpr	2	0	0	2
Albumin	0	0	2	2
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	5	0	5
Sodium channel protein type 3 subunit alpha	0	4	0	4
UDP-glucuronosyltransferase 2B7	0	0	0	1
Sodium channel protein type 4 subunit alpha	0	6	0	8
Cytochrome P450 2J2	0	5	0	5
Potassium voltage-gated channel subfamily H member 2	0	11	0	11
Sodium channel protein type 9 subunit alpha	0	8	0	8
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
nonstructural protein 1	7	0	0	7
vitamin D3 receptor isoform VDRA	10	0	0	10
Complement C5	0	0	1	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	3
TAR DNA-binding protein 43	5	0	0	5
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Beta-lactamase TEM	0	0	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	2	0	0	2
Smad3	3	0	0	3
estrogen receptor 2 (ER beta)	10	0	0	10
NADPH oxidase 1	0	1	0	1
G	8	0	0	8
cytochrome P450 2D6	9	0	0	9
Snq2p	0	0	0	2
Adenylate cyclase type 1	0	2	0	2
Caspase-7	5	0	0	5
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
cytochrome P450 2D6 isoform 1	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	10	0	0	10
caspase-3	5	0	0	5
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
M-phase phosphoprotein 8	10	0	0	10
Proteasome subunit alpha type-7	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Transmembrane protease serine 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Epidermal growth factor receptor	0	3	0	3
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Albumin	0	2	3	5
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	3	0	3
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	6	0	6
ATP-dependent translocase ABCB1	0	5	0	6
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	8	2	10
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Angiotensin-converting enzyme	0	4	0	4
D(2) dopamine receptor	0	8	0	9
Alpha-1B adrenergic receptor	0	7	0	7
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	7	0	7
Alpha-2C adrenergic receptor	0	7	1	8
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	5	0	5
Alpha-2B adrenergic receptor	0	4	0	4
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	7	0	8
D(4) dopamine receptor	0	3	0	4
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	4	0	4
UDP-glucuronosyltransferase 1A4	0	0	0	2
Alpha-2A adrenergic receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	5	0	5
Sodium-dependent noradrenaline transporter	0	8	0	8
Sodium-dependent dopamine transporter	0	3	0	3
Histamine H2 receptor	0	7	2	9
D(1B) dopamine receptor	0	3	0	3
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	7	0	7
5-hydroxytryptamine receptor 1B	0	4	0	4
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	3	0	3
Histamine H1 receptor	0	2	3	5
Sodium-dependent serotonin transporter	0	3	0	3
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	3	0	3
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	2	0	2
Histamine H1 receptor	0	9	3	12
D(3) dopamine receptor	0	8	0	9
Sodium channel protein type 1 subunit alpha	0	3	0	3
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
5-hydroxytryptamine receptor 2B	0	8	0	8
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	7	0	7
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 6	0	5	0	5
Gastrin/cholecystokinin type B receptor	0	1	0	1
Spike glycoprotein	11	1	1	13
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Sodium-dependent dopamine transporter	0	4	0	4
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	5	0	5
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Inositol hexakisphosphate kinase 1	8	0	0	8
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Proteasome subunit beta type-7	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	5	0	5
Angiotensin-converting enzyme 2	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Histamine H3 receptor	0	3	2	5
Sodium channel protein type 10 subunit alpha	0	2	0	2
cytochrome P450 2C9, partial	8	0	0	8
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
DNA polymerase iota isoform a (long)	7	0	0	7
Guanine nucleotide-binding protein G	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-4	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	2
Neuronal acetylcholine receptor subunit beta-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-1	0	4	2	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	5	2	7
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	2	6
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	2	6
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
endonuclease IV	6	0	0	6
dopamine D1 receptor	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
peripheral myelin protein 22 isoform 1	7	0	0	7
flap endonuclease 1	8	0	0	8
Glucocorticoid receptor	0	8	2	15
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	4	0	4
PPM1D protein	3	0	0	3
EWS/FLI fusion protein	12	0	0	12
huntingtin isoform 2	2	0	0	2
chaperonin GroEL	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Glycogen phosphorylase, brain form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Endothelin receptor type B	0	1	0	1
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	2
D(2) dopamine receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	2	0	2
Transporter	0	2	0	2
interleukin 8	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
thioredoxin glutathione reductase	4	0	0	4
hypothetical protein, conserved	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
thyrotropin-releasing hormone receptor	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	5
Pantothenate synthetase	0	2	0	2
Luciferin 4-monooxygenase	0	1	0	1
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	3	0	3
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Nuclear factor NF-kappa-B p105 subunit	0	0	0	1
Tyrosine-protein phosphatase 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	3	0	3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Vesicular glutamate transporter 3	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	3	1	6
Sigma non-opioid intracellular receptor 1	0	1	0	1
Polyphenol oxidase 2	0	4	0	6
Nuclear receptor ROR-gamma	5	0	0	5
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Chain A, Cruzipain	1	0	0	1
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
alpha synuclein, partial	1	0	0	1
glucocerebrosidase	1	0	0	1
luciferase	1	0	0	1
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
Glutamate receptor ionotropic, kainate 1	1	4	1	6
Glutamate receptor ionotropic, kainate 2	1	4	1	6
Glutamate receptor ionotropic, kainate 3	1	4	0	5
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Glutamate receptor ionotropic, kainate 4	1	3	0	4
Leukotriene B4 receptor 1	1	0	0	1
Glutamate receptor ionotropic, kainate 5	1	3	0	4
Leukotriene B4 receptor 2	1	0	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	3	1	4
Glutamate receptor 3	0	3	1	4
Glutamate receptor 4	0	3	1	4
Metabotropic glutamate receptor 1	0	2	2	4
Metabotropic glutamate receptor 2	0	0	2	2
Metabotropic glutamate receptor 3	0	0	2	2
Metabotropic glutamate receptor 4	0	1	2	3
Metabotropic glutamate receptor 5	0	1	3	4
Metabotropic glutamate receptor 6	0	0	2	2
Metabotropic glutamate receptor 7	0	0	2	2
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	2	2	5
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Metabotropic glutamate receptor 8	0	0	2	2
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate carboxypeptidase 2	0	2	0	2
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	2	4
Metabotropic glutamate receptor 3	0	2	1	4
Metabotropic glutamate receptor 4	0	2	2	5
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	5	0	0	5
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	2
Macrophage migration inhibitory factor	0	3	0	3
Histamine H1 receptor	0	2	1	3
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	1	0	2
Solute carrier family 22 member 2	0	2	0	3
ClpP	2	0	0	2
lysosomal alpha-glucosidase preproprotein	4	0	0	4
Solute carrier family 22 member 8	0	0	0	1
alpha-galactosidase	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Acetylcholinesterase	0	6	0	7
Rap guanine nucleotide exchange factor 3	3	0	0	3
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
DNA polymerase eta isoform 1	4	0	0	4
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosinase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
phosphoglycerate kinase	1	0	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Caspase-7	2	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Acyl-CoA desaturase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	2	2
Mu-type opioid receptor	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	2	0	2
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
polyadenylate-binding protein 1	0	2	0	2
bcl-2-related protein A1	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
POU domain, class 2, transcription factor 1	0	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, Glutamate Receptor 2	0	1	0	1
Chain A, Glutamate Receptor 2	0	1	0	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
Glutamate receptor 4	0	1	0	1
Glutamate receptor 3	0	1	0	1
hemoglobin subunit beta	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Free fatty acid receptor 3	0	0	1	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-P receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Cytochrome P450 14alpha-demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Tyrosine-protein kinase ABL2	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Protein cereblon	0	2	0	2
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (295)

Protein Targets (1,120)

Hydrosyringomyelia

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (295)

Drugs Studied (155)

Protein Targets (1,120)