Gangliocytoma

A benign neoplasm that usually arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. The tumor may present clinically with HORNER SYNDROME or diarrhea due to ectopic production of vasoactive intestinal peptide. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p966)

Synonym
Gangliocytoma
Ganglioneuroma

Excerpt	Reference
"Ganglioneuromas are usually considered not to be functionally active."	( Castello, MA; Ciofetta, G; Clerico, A; Codini, M; Jenkner, A; Lucarelli, C, 1991)
"Retroperitoneal ganglioneuroma is rare and only 82 cases including our case have been reported in Japan, in recent years, adult cases are increasing in number."	( Fujiwara, Y; Kusama, H; Namiki, K; Shiozawa, H; Tsuchiya, A, 1994)
"Five GHRH secreting gangliocytomas are reported."	( Losa, M; Lüdecke, DK; Saeger, W, 1997)
"Ganglioneuromas are benign and slow-growing tumors that most commonly originate from the sympathetic trunk."	( Codsi, MJ; Masso, PD; Meyer, BC; Moral, LA; Roberts, JM; Skaggs, DL, 2000)
"Ganglioneuroma is a benign neurogenic tumor."	( Ertel, W; Heyde, CE; Perez-Canto, A; Przkora, R, 2006)
"Ganglioneuroma is a rare, benign, well-differentiated, slow-growing tumor composed of sympathetic ganglion cells and mature stroma with a good prognosis."	( Bandorski, D; Brueck, M; Kramer, W; Rauber, K, 2006)
"Adrenal ganglioneuromas are rare tumors originating from the neural crest tissue of the sympathetic nervous system."	( Cinel, A; Erem, C; Erso, HO; Kocak, M; Reis, A, 2008)
"Ganglioneuromas are benign tumors originating from the neural crest and are composed of mature ganglion cells."	( Aponte, LF; Camelo, M; Lugo-Vicente, H, 2012)
"Ganglioneuroma is a rare tumor in the posterior mediastinum; fat-containing ganglioneuromas are rarely reported."	( Ayabe, T; Fukushima, T; Kataoka, H; Nakada, H; Nakashima, K; Yonei, A; Yorita, K, 2014)
"Adrenal ganglioneuroma is a rare tumor constituting 20-30% of all ganglioneuromas."	( Ahallat, M; Elaloui, M; Elmouhadi, S; Hrora, A; Majbar, AM; Raiss, M; Sabbah, F, 2014)
"Imaging of adrenal ganglioneuromas is diagnostically challenging."	( Ahallat, M; Elaloui, M; Elmouhadi, S; Hrora, A; Majbar, AM; Raiss, M; Sabbah, F, 2014)

Excerpt	Reference
"Ciliochoroidal ganglioneuromas have not been previously reported in patients with this syndrome."	( Abdulkader, MM; Bonnin, JM; Dalesandro, MF; Mendenhall, SK; Shah, MV, 2016)

Excerpt	Reference
"With rare exception, ganglioneuroma (GN) is a benign lesion which presents as a localized mass without metastatic potential and which is chemotherapy resistant."	( Blatt, J; Gula, MJ; Knisely, AS; Lucas, K; Virgi, MA; Wollman, M, 1994)
"Although transformation to ganglioneuroma in an adrenal neuroblastoma is common, an olfactory neuroblastoma showing ganglioneuronal maturation after chemoradiotherapy has not been reported."	( Mineta, H; Miura, K; Tsutsui, Y; Yokota, N, 2001)
"Herein, we describe our experience in treating a mixed gangliocytoma and prolactinoma of the pituitary gland."	( Hide, T; Honda, Y; Kuratsu, JI; Mikami, Y; Uekawa, K; Yano, S, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	209 (58.22)	23.3326
1990's	69 (19.22)	12.5806
2000's	46 (12.81)	18.1394
2010's	32 (8.91)	28.8240
2020's	3 (0.84)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
5-hydroxytryptophan	low	1	0
choline	low	3	0
chlorine	low	1	0
creatine	low	2	0
cytosine	low	1	0
formaldehyde	low	1	0
histamine	low	3	0
dihydroxyphenylalanine	low	12	0
inositol	low	1	0
pyridoxine	low	1	0
thymine	low	1	0
vanillin	low	1	0
8-hydroxy-2-(di-n-propylamino)tetralin	low	2	0
normetanephrine	low	6	0
vanilmandelic acid	low	41	0
mandelic acid	low	8	0
3-methoxytyramine	low	1	0
3-methylcholanthrene	low	1	0
homovanillic acid	low	13	0
phenytoin	low	2	0
hydroxyindoleacetic acid	low	1	0
diatrizoic acid	low	1	0
caffeine	low	1	0
carbamazepine	low	1	0
chlorambucil	low	1	0
dicyclomine	low	1	0
pentetic acid	low	5	0
valproic acid	low	1	0
doxylamine	low	1	0
etilefrine	low	1	0
gabapentin	low	1	0
lidocaine	low	1	0
ifosfamide	low	1	0
iohexol	low	1	0
iomeprol	low	1	0
2-propanol	low	2	0
ketoconazole	low	1	0
mechlorethamine	low	4	0
apnea	low	1	0
phenoxybenzamine	low	4	0
streptonigrin	low	1	0
sulfasalazine	low	1	0
temozolomide	low	1	0
tyramine	low	2	0
phentolamine	low	1	0
sorbitol	low	1	0
thymidine	low	1	0
aldosterone	low	4	0
prednisone	low	2	0
dehydroepiandrosterone	low	2	0
triiodothyronine	low	1	0
aspartic acid	low	2	0
bromodeoxyuridine	low	2	0
p-dimethylaminoazobenzene	low	1	0
tyrosine	low	3	0
androstenedione	low	1	0
methionine	low	1	0
cytarabine	low	1	0
arginine	low	1	0
meglumine	low	2	0
azacitidine	low	2	0
hematoxylin	low	2	0
methoxyhydroxyphenylglycol	low	1	0
eosine yellowish-(ys)	low	2	0
methylnitrosourea	low	1	0
ethylnitrosourea	low	3	0
azo rubin s	low	1	0
metanephrine	low	2	0
silver	low	1	0
technetium	low	4	0
gadolinium	low	7	0
acetylglucosamine	low	1	0
barium sulfate	low	4	0
bromocriptine	low	1	0
triamcinolone	low	1	0
fludrocortisone	low	1	0
etoposide	low	4	0
substance p	low	3	0
enkephalin, methionine	low	1	0
propiconazole	low	4	0
fomesafen	low	1	0
cabergoline	low	1	0
3-iodobenzylguanidine	medium	24	1
n-acetylaspartic acid	low	2	0
iopamidol	low	1	0
delphinidin	low	1	0
fluorodeoxyglucose f18	low	6	0
adosterol	low	1	0
arginyl-glycyl-aspartic acid	low	1	0
selenonorcholesterol	low	1	0
technetium tc 99m hydroxymethylene diphosphonate	low	1	0
methotrexate	low	2	0
carboplatin	low	2	0
glycogen	low	5	0
inositol 3-phosphate	low	2	0
metrizamide	low	2	0
trichostatin a	low	1	0
tretinoin	low	5	0
tacrolimus	low	1	0
fosfomycin	low	1	0
dactinomycin	low	2	0
enkephalin, leucine	low	4	0
bromochloroacetic acid	low	7	0
isomethyleugenol	low	1	0
mercaptopurine	low	3	0
pica	low	1	0
17-ketosteroids	low	2	0
rhodamine 123	low	1	0
myelin basic protein	low	1	0
phenylephrine hydrochloride	low	2	0
barium	low	1	0
aluminum	low	1	0
bismuth	low	1	0
sulfur	low	1	0
cysteine	low	1	0
gadolinium dtpa	low	6	0
ergoline	low	1	0
phosphocreatine	low	1	0
cystathionine	low	2	0
losartan potassium	low	1	0
pituitrin	low	2	0
acid phosphatase	low	1	0
gastrins	low	2	0
glucagon	low	1	0
neuropeptide y	low	8	0
peptide phi	low	3	0
pancreastatin	low	1	0
gastrin 17	low	1	0
phosphatidylcholines	low	1	0
19-iodocholesterol	low	3	0
6-iodomethylcholesterol	low	2	0
technetium tc 99m sestamibi	medium	1	1
vasoactive intestinal peptide	low	63	0
epidermal growth factor	low	1	0
transforming growth factor beta	low	1	0
cyclin d1	low	1	0
hyaluronoglucosaminidase	low	1	0
vitamin b 12	low	5	0
cyclosporine	low	1	0
technetium tc 99m medronate	low	6	0
chondroitin sulfates	low	1	0
exudates	low	1	0
angiogenin	low	1	0
dacarbazine	low	1	0
olanzapine	low	1	0
eye	low	2	0
technetium tc 99m bicisate	low	1	0

Protein Targets (986)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
RAR-related orphan receptor gamma	29	0	0	29
GLI family zinc finger 3	24	0	0	24
AR protein	39	0	0	39
aldehyde dehydrogenase 1 family, member A1	28	0	0	28
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	17	0	0	17
estrogen nuclear receptor alpha	38	0	0	38
peroxisome proliferator-activated receptor delta	14	0	0	14
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	22	0	0	22
activating transcription factor 6	13	0	0	13
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	14	0	0	14
thyroid hormone receptor beta isoform a	14	0	0	14
heat shock protein beta-1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	29	0	0	29
lamin isoform A-delta10	29	0	0	29
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Glutamate receptor 2	13	0	0	13
dopamine D1 receptor	5	0	0	5
thioredoxin reductase	21	0	0	21
GLS protein	20	0	0	20
Thrombopoietin	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C19 precursor	5	0	0	5
ras-related protein Rab-9A	3	0	0	3
histone acetyltransferase KAT2A isoform 1	11	0	0	11
lethal factor (plasmid)	5	0	0	5
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	17	0	0	17
ATP-dependent phosphofructokinase	20	0	0	20
thyroid stimulating hormone receptor	15	0	0	15
mitogen-activated protein kinase 1	10	0	0	10
muscarinic acetylcholine receptor M1	13	0	0	13
D(2) dopamine receptor	0	6	3	9
Trace amine-associated receptor 1	0	0	2	2
Luciferase	9	0	0	9
pregnane X receptor	9	0	0	9
phosphopantetheinyl transferase	16	0	0	16
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
TDP1 protein	36	0	0	36
Microtubule-associated protein tau	16	0	0	16
caspase 7, apoptosis-related cysteine protease	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	22	0	0	22
estrogen-related nuclear receptor alpha	29	0	0	29
farnesoid X nuclear receptor	14	0	0	14
pregnane X nuclear receptor	23	0	0	23
peroxisome proliferator activated receptor gamma	18	0	0	18
caspase-3	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	39	0	0	39
aryl hydrocarbon receptor	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
Cellular tumor antigen p53	25	0	0	25
Cytochrome P450 1A2	0	2	1	3
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	5	0	5
Adenosine receptor A3	0	6	0	6
Alpha-1B adrenergic receptor	0	10	2	12
Acetylcholinesterase	0	3	0	3
Sodium-dependent noradrenaline transporter	0	5	0	5
Aryl hydrocarbon receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	10	2	12
5-hydroxytryptamine receptor 2C	0	6	2	9
5-hydroxytryptamine receptor 2A	0	7	2	10
5-hydroxytryptamine receptor 1A	0	8	3	13
5-hydroxytryptamine receptor 1B	0	4	2	7
5-hydroxytryptamine receptor 1D	0	2	2	5
5-hydroxytryptamine receptor 1F	0	2	2	5
5-hydroxytryptamine receptor 2B	0	5	2	7
5-hydroxytryptamine receptor 6	0	0	2	2
Sodium-dependent serotonin transporter	0	4	1	5
Sodium-dependent serotonin transporter	0	3	0	3
5-hydroxytryptamine receptor 7	0	1	2	3
5-hydroxytryptamine receptor 5A	0	0	2	2
5-hydroxytryptamine receptor 5B	0	0	2	2
5-hydroxytryptamine receptor 3A	0	1	2	3
5-hydroxytryptamine receptor 4	0	0	2	2
5-hydroxytryptamine receptor 3B	0	1	2	3
mu-type opioid receptor isoform MOR-1	0	0	2	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
5-hydroxytryptamine receptor 2A	0	0	2	2
Gamma-aminobutyric acid receptor subunit pi	6	4	1	11
Cytochrome P450 3A4	0	10	1	13
5-hydroxytryptamine receptor 1A	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Cytochrome P450 2C9	0	7	1	8
Neuronal acetylcholine receptor subunit beta-2	1	2	0	3
D(2) dopamine receptor	0	7	1	8
Gamma-aminobutyric acid receptor subunit beta-1	6	4	1	11
Translocator protein	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	6	4	1	11
Gamma-aminobutyric acid receptor subunit gamma-2	6	4	2	12
D	0	4	0	4
D(3) dopamine receptor	0	4	0	4
Alpha-2B adrenergic receptor	0	6	2	9
Gamma-aminobutyric acid receptor subunit alpha-5	6	4	1	11
Gamma-aminobutyric acid receptor subunit alpha-3	6	4	1	11
D(2) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	6	2	9
Alpha-2A adrenergic receptor	0	6	2	9
Gamma-aminobutyric acid receptor subunit gamma-1	6	4	1	11
Gamma-aminobutyric acid receptor subunit alpha-2	6	4	1	11
Alpha-1D adrenergic receptor	0	7	2	11
Sodium-dependent dopamine transporter	0	2	0	2
Alpha-1D adrenergic receptor	0	7	1	9
5-hydroxytryptamine receptor 1D	0	1	0	3
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 2C	0	9	1	10
Gamma-aminobutyric acid receptor subunit alpha-4	6	4	1	11
Gamma-aminobutyric acid receptor subunit gamma-3	6	4	1	11
Gamma-aminobutyric acid receptor subunit alpha-6	6	4	1	11
5-hydroxytryptamine receptor 7	0	2	0	2
Alpha-1A adrenergic receptor	0	4	1	6
Alpha-1B adrenergic receptor	0	4	1	6
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 6	0	7	0	7
5-hydroxytryptamine receptor 7	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	6	4	2	12
Gamma-aminobutyric acid receptor subunit beta-3	6	4	1	11
Gamma-aminobutyric acid receptor subunit beta-2	6	4	2	12
D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
GABA theta subunit	6	4	1	11
Sigma non-opioid intracellular receptor 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	6	4	1	11
Lysosomal alpha-glucosidase	0	1	0	1
Transporter	0	2	0	2
Putative glycosyltransferase WbgO	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
glucocorticoid receptor [Homo sapiens]	30	0	0	30
nuclear factor erythroid 2-related factor 2 isoform 2	12	0	0	12
geminin	32	0	0	32
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	3	0	3
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	7	0	7
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
interleukin 8	7	0	0	7
acetylcholinesterase	5	0	0	5
Smad3	6	0	0	6
estrogen receptor 2 (ER beta)	11	0	0	11
progesterone receptor	17	0	0	17
regulator of G-protein signaling 4	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	14	0	0	14
nonstructural protein 1	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
Caspase-7	4	0	0	4
Bloom syndrome protein isoform 1	17	0	0	17
peripheral myelin protein 22 isoform 1	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
caspase-3	4	0	0	4
thyroid hormone receptor beta isoform 2	25	0	0	25
importin subunit beta-1 isoform 1	4	0	0	4
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	11	0	0	11
nuclear receptor ROR-gamma isoform 1	12	0	0	12
peripheral myelin protein 22	16	0	0	16
survival motor neuron protein isoform d	13	0	0	13
muscleblind-like protein 1 isoform 1	7	0	0	7
neuropeptide S receptor isoform A	6	0	0	6
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	2	0	2
Aromatase	0	4	0	6
Gastrin/cholecystokinin type B receptor	0	0	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Alpha-synuclein	1	4	0	5
Nuclear receptor ROR-gamma	9	1	1	11
TAR DNA-binding protein 43	7	0	0	7
ATAD5 protein, partial	14	0	0	14
arylsulfatase A	15	0	0	15
D(1A) dopamine receptor	7	0	0	7
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	7	0	0	7
alpha-galactosidase	3	0	0	3
chromobox protein homolog 1	26	0	0	26
flap endonuclease 1	12	0	0	12
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
DNA polymerase kappa isoform 1	14	0	0	14
Integrin beta-3	5	2	0	7
Integrin beta-1	0	1	0	1
Integrin alpha-V	0	1	0	1
Integrin alpha-IIb	5	2	0	7
Integrin alpha-5	0	1	0	1
Integrin beta-5	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
Chain A, Ferritin light chain	8	0	0	8
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	6	0	9
Carbonic anhydrase 2	0	6	1	11
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	4
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	4
Glutamate receptor ionotropic, NMDA 2B	0	1	0	4
Glutamate receptor ionotropic, NMDA 2C	0	1	0	4
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	4
Glutamate receptor ionotropic, NMDA 3B	0	1	0	4
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	4
Chain A, Beta-lactamase	11	0	0	11
glp-1 receptor, partial	8	0	0	8
Fumarate hydratase	6	0	0	6
PPM1D protein	4	0	0	4
polyprotein	6	0	0	6
67.9K protein	8	0	0	8
Parkin	2	0	0	2
IDH1	11	0	0	11
thyroid stimulating hormone receptor	15	0	0	15
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	6	0	0	6
huntingtin isoform 2	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
Interferon beta	16	0	0	16
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Adenosine receptor A2a	0	3	1	5
Adenosine receptor A1	0	4	1	7
D(1A) dopamine receptor	2	0	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	15	0	0	15
Ataxin-2	19	0	0	19
Genome polyprotein	0	1	1	2
G	10	0	0	10
vitamin D3 receptor isoform VDRA	14	0	0	14
5-hydroxytryptamine receptor 4	0	8	0	8
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
ATP-dependent translocase ABCB1	0	4	0	4
ATP-dependent translocase ABCB1	0	5	1	9
Beta-1 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	8	1	10
Alpha-2B adrenergic receptor	0	8	1	10
Alpha-2C adrenergic receptor	0	6	1	8
ATP-dependent translocase ABCB1	0	4	0	4
D(1A) dopamine receptor	0	5	0	6
D(1B) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	8	1	9
D(4) dopamine receptor	0	3	0	3
D(3) dopamine receptor	0	6	0	6
5-hydroxytryptamine receptor 2B	0	11	1	12
Inositol hexakisphosphate kinase 1	10	0	0	10
cytochrome P450 2C9, partial	10	0	0	10
bromodomain adjacent to zinc finger domain 2B	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Nuclear hormone receptor family member daf-12	0	0	1	1
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine kinase, cytosolic	0	4	0	6
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
cytochrome P450 2D6	9	0	0	9
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	19	0	20
Bile salt export pump	0	30	0	30
Canalicular multispecific organic anion transporter 1	0	18	0	19
Histamine H3 receptor	0	2	2	4
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
DNA polymerase beta	4	0	0	4
Potassium channel subfamily K member 2	0	1	1	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	3
Adenosine receptor A1	1	3	0	7
Amine oxidase [flavin-containing] B	0	3	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A2a	0	2	1	7
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
Guanine deaminase	0	1	0	1
USP1 protein, partial	16	0	0	16
Vpr	2	0	0	2
Bile salt export pump	0	5	0	5
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	4
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	3	0	5
Cytochrome P450 2J2	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Sodium channel protein type 9 subunit alpha	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
GALC protein	6	0	0	6
thioredoxin glutathione reductase	8	0	0	8
EWS/FLI fusion protein	10	0	0	10
FAD-linked sulfhydryl oxidase ALR	0	0	0	2
Carbonic anhydrase 12	0	2	0	4
Cytochrome P450 2D6	0	3	1	4
Carbonic anhydrase 9	0	2	0	4
Solute carrier organic anion transporter family member 1B3	0	6	0	8
Carbonic anhydrase 4	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase 15	0	1	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 1	0	2	0	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	2	0	4
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	2	0	4
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
endonuclease IV	5	0	0	5
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	2	0	4
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Matrix metalloproteinase-9	0	1	0	1
Inositol monophosphatase 1	7	0	0	7
Isocitrate lyase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Cruzipain	3	0	0	3
15-lipoxygenase, partial	6	0	0	6
RAD51	0	1	0	1
cytochrome P450 3A4 isoform 1	6	0	0	6
caspase-1 isoform alpha precursor	2	0	0	2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	3	0	0	3
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	5	0	5
G-protein coupled bile acid receptor 1	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Epidermal growth factor receptor	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	0	1	0	1
M-phase phosphoprotein 8	6	0	0	6
phosphoglycerate kinase	3	0	0	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
cytochrome P450 2C9 precursor	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M5	0	4	0	4
Muscarinic acetylcholine receptor M1	0	3	1	4
Angiotensin-converting enzyme	0	5	0	5
Muscarinic acetylcholine receptor M3	0	4	0	4
Histamine H2 receptor	0	5	2	7
Histamine H2 receptor	7	1	1	9
Nuclear receptor subfamily 3 group C member 3	0	5	0	5
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Proenkephalin-B	0	0	1	1
Delta-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	4	1	5
Kappa-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	1	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
galanin receptor type 3	0	1	0	1
D(3) dopamine receptor isoform e	2	0	0	2
Prothrombin	0	0	1	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	2
transcriptional regulator ERG isoform 3	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Histone deacetylase 3	0	5	0	7
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Histone deacetylase 4	0	5	1	9
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Histone deacetylase 1	0	5	2	9
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Histone deacetylase 7	0	5	0	7
Histone deacetylase 2	0	5	1	8
Polyamine deacetylase HDAC10	0	5	0	7
Histone deacetylase 11	0	5	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Histone deacetylase 8	0	5	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Histone deacetylase 6	0	5	1	8
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	5	0	7
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Histone deacetylase 5	0	5	0	7
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Cholecystokinin receptor type A	0	1	1	2
Gastrin/cholecystokinin type B receptor	0	1	1	2
Chain E, Fibrin beta chain	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
WRN	2	0	0	2
Mcl-1	0	1	0	1
MPI protein	0	2	0	2
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
apical membrane antigen 1, AMA1	5	0	0	5
hypothetical protein, conserved	2	0	0	2
glucocerebrosidase	3	0	0	3
luciferase	1	0	0	1
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
lysosomal alpha-glucosidase preproprotein	4	0	0	4
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
DNA polymerase eta isoform 1	3	0	0	3
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
Vif	0	2	0	2
Tat	0	2	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	2	0	2
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	2	0	3
Plasma kallikrein	0	1	0	3
Carbonic anhydrase 3	0	0	0	2
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 6	0	0	0	2
Histamine H1 receptor	0	2	2	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	2
Histamine H1 receptor	0	5	3	8
Carbonic anhydrase 7	0	0	0	2
Carbonic anhydrase	0	0	0	3
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
ClpP	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Amyloid-beta precursor protein	0	2	0	2
Sodium/myo-inositol cotransporter 2	0	1	0	1
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Estrogen receptor	0	1	0	1
Substance-K receptor	0	4	0	4
Thromboxane-A synthase	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	1	3
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
heat shock 70kDa protein 1A	0	1	0	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	0	1	0	1
heat shock cognate 71 kDa protein isoform 1	0	1	0	1
dual specificity protein phosphatase 6	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
heat shock cognate 71 kDa protein isoform 2	0	1	0	1
Glutathione S-transferase Mu 1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Neurotensin receptor type 1	0	0	1	1
Neurotensin receptor type 2	0	1	1	3
Myelin basic protein	0	0	1	1
Neurotensin receptor type 1	0	1	1	2
Neurotensin receptor type 1	0	2	2	5
Neurotensin receptor type 2	0	2	1	3
Sortilin	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	2
5-hydroxytryptamine receptor 3A	0	1	1	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Sigma non-opioid intracellular receptor 1	0	2	1	3
Transporter	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
BRCA1	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
C-terminal-binding protein 1	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
estrogen receptor beta isoform 1	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Nischarin	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Pyridoxal kinase	0	0	0	1
galactokinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
protein-arginine deiminase type-4	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA repair and recombination protein RAD54-like	0	0	1	1
Sentrin-specific protease 6	0	1	0	1
Sentrin-specific protease 2	0	1	0	1
Sentrin-specific protease 1	0	1	0	1
Protein-arginine deiminase type-1	0	1	0	1
Protein-arginine deiminase type-3	0	1	0	1
Protein-arginine deiminase type-2	0	1	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-P receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Chain A, Glutathione S-transferase	0	1	0	1
Replicase polyprotein 1ab	0	0	1	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Mitogen-activated protein kinase 1	0	2	0	2
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Cystine/glutamate transporter	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Cytochrome P450 3A5	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	2	0	2
polyadenylate-binding protein 1	0	1	0	1
Tyrosine-protein kinase ABL2	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2C19	0	1	1	2
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	0	1	0	1
Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	0	1	0	1
Chain A, Histone deacetylase 7a	0	1	0	1
Chain A, Histone deacetylase 7a	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
unnamed protein product	0	0	0	1
Histone deacetylase 1	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Histone deacetylase 3	0	1	0	1
Coagulation factor VII	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Vitamin D3 receptor	0	1	0	1
Tissue factor	0	2	0	2
Adenosine receptor A1	0	1	0	1
Histone deacetylase 2	0	1	0	1
Histone deacetylase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Histone deacetylase	0	1	0	1
Histone deacetylase 4	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	0	2
Histone deacetylase 7	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	1	2
Histone deacetylase 8	0	1	0	1
Histone deacetylase 11	0	1	0	1
HD2 type histone deacetylase HDA106	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Histone deacetylase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	0	0	1
Androgen receptor	0	1	0	1
Thyroid hormone receptor alpha	0	2	2	4
Thyroid hormone receptor beta	0	2	2	4
Proliferating cell nuclear antigen	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
guanine nucleotide-binding protein subunit alpha-15	0	1	1	2
trace amine-associated receptor 1	0	1	1	2
Polyphenol oxidase 2	0	1	0	3
Phenylethanolamine N-methyltransferase	0	1	0	1
Dopamine beta-hydroxylase	0	0	0	1
Beta-secretase 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Histamine H3 receptor	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
SLC16A10 protein	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Cytochrome P450 2A6	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Transcription intermediary factor 1-alpha	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
Secreted chorismate mutase	0	1	0	1
E3 ubiquitin-protein ligase TRIM33	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (359)

Protein Targets (986)

Gangliocytoma

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (359)

Drugs Studied (173)

Protein Targets (986)