Endolymphatic Hydrops

An accumulation of ENDOLYMPH in the inner ear (LABYRINTH) leading to buildup of pressure and distortion of intralabyrinthine structures, such as COCHLEA and SEMICIRCULAR CANALS. It is characterized by SENSORINEURAL HEARING LOSS; TINNITUS; and sometimes VERTIGO.

Synonym
Endolymphatic Hydrops

Excerpt	Reference
"Endolymphatic hydrops is usually diagnosed on the basis of clinical symptoms although objective parameters for this disease can be difficult to differentiate from other disorders of the inner ear."	( Höhmann, D, 1993)
"Two-phase endolymphatic hydrops is a subtle experimental model for Meniere's disease."	( Albers, FW; Blaauw, EH; Dunnebier, EA; Segenhout, JM; Verheul, J; Wit, HP, 1999)
"Endolymphatic hydrops is the hystopathological substrate characteristic of Ménière's disease."	( Casani, A; De Iaco, G; Donati, C; Fattori, B; Nacci, A, 2001)
"Endolymphatic hydrops is believed to be associated with a number of ear diseases, including Ménière's disease."	( Andrews, JC; Lufkin, R; Niyazov, DM; Sinha, S; Strelioff, D, 2001)
"Endolymphatic hydrops is also thought to occur in Ménière's disease patients."	( Azuma, H; Kakigi, A; Kitano, H; Sawada, S; Takeda, T; Takeuchi, S, 2002)
"Endolymphatic hydrops is the pathologic feature associated with Meniere's disease."	( Djalilian, HR; Paparella, MM, 2002)
"Evaluation of endolymphatic hydrops is feasible using the newly proposed 10-min protocol."	( Ikeda, M; Kawai, H; Naganawa, S; Nakashima, T; Sone, M, 2015)
"Endolymphatic hydrops is closely related to hearing loss but does not necessarily result in Ménière's symptoms."	( Jia, H; Li, Y; Liu, Y; Shi, J; Wu, H; Yang, J; Zheng, H, 2015)
"Endolymphatic hydrops is not a pathognomic phenomenon, and detecting hydrops should not directly indicate a diagnosis of Menière's disease."	( Bruintjes, TD; Kimenai, DM; Lambin, P; Postma, AA; Vaidyanathan, A; van de Berg, R; van der Lubbe, MFJA; van Hoof, M; Van Rompaey, V, 2020)

Excerpt	Reference
"Visualization of endolymphatic hydrops has been performed using magnetic resonance imaging (MRI) after intratympanic or intravenous gadolinium (Gd) injection."	( Kondo, M; Naganawa, S; Nagatani, T; Nakashima, T; Sone, M; Teranishi, M; Terasaki, H; Wakabayashi, T; Yasuma, T; Yoshida, T, 2012)
"Visulization of endolymphatic hydrops has been reported using magnetic resonance imaging (MRI) in patients with Meniere's disease."	( Choi, JY; Kim, J; Lee, WS; Seo, YJ, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (0.63)	23.3326
1990's	55 (17.41)	12.5806
2000's	81 (25.63)	18.1394
2010's	118 (37.34)	28.8240
2020's	60 (18.99)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	1	0
dimethyl sulfoxide	low	2	0
glycerol	medium	30	2
histamine	low	1	0
taurine	low	1	0
urea	low	1	0
acetazolamide	low	5	0
pimagedine	low	2	0
antipyrine	low	1	0
betahistine	low	4	0
bumetanide	low	1	0
caffeine	low	1	0
chlorothiazide	low	1	0
cilostamide	low	1	0
flufenamic acid	low	1	0
furosemide	medium	20	1
gentamicin	medium	19	1
glutaral	low	1	0
edaravone	low	1	0
nimodipine	low	1	0
pentoxifylline	low	1	0
ono 1078	low	1	0
riluzole	low	2	0
rolipram	low	1	0
thalidomide	low	1	0
tolazoline	low	1	0
mitomycin	low	1	0
prednisolone	low	1	0
spironolactone	low	2	0
aldosterone	low	8	0
prednisone	low	1	0
carbostyril	low	1	0
edetic acid	low	1	0
tyrosine	low	1	0
mannitol	medium	2	1
arginine	low	1	0
phencyclidine	low	1	0
meglumine	low	3	0
cyanogen bromide	low	1	0
isosorbide	medium	8	1
amiloride	low	1	0
streptomycin	low	4	0
carbonates	low	1	0
gadolinium	medium	73	4
mercuric chloride	low	1	0
glutamic acid	low	2	0
ng-nitroarginine methyl ester	low	1	0
colforsin	low	2	0
fomesafen	low	1	0
pemirolast	low	1	0
cephalosporin c	low	1	0
fluorodeoxyglucose f18	low	1	0
tadalafil	low	1	0
mozavaptan	low	3	0
gadolinium 1,4,7,10-tetraazacyclododecane-n,n',n'',n'''-tetraacetate	low	2	0
tolvaptan	low	1	0
erythritol	low	1	0
3-nitrotyrosine	low	1	0
ouabain	low	2	0
pectins	low	1	0
sodium bicarbonate	low	1	0
arginine vasopressin	low	11	0
capsaicin	low	2	0
lithium	low	1	0
dinoprost	low	1	0
8-epi-prostaglandin f2alpha	low	1	0
olopatadine hydrochloride	low	1	0
deamino arginine vasopressin	low	2	0
arsenic	low	1	0
bafilomycin a	low	1	0
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid	low	1	0
gadolinium dtpa	medium	68	2
org 2766	low	1	0
mocetinostat	low	1	0
empagliflozin	low	1	0
sepharose	low	1	0
pituitrin	low	19	0
endothelin-1	low	1	0
cortisol succinate, sodium salt	low	1	0
sildenafil citrate	low	2	0
eye	low	2	0
pyrimidinones	low	1	0

Protein Targets (868)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
phosphopantetheinyl transferase	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	25	0	0	25
pyruvate kinase PKM isoform a	1	0	0	1
geminin	23	0	0	23
Glycoprotein hormones alpha chain	1	0	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Tubulin--tyrosine ligase	0	2	0	2
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	8	0	0	8
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	3	0	3
thioredoxin reductase	15	0	0	15
GALC protein	3	0	0	3
GLI family zinc finger 3	27	0	0	27
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
cytochrome P450 family 3 subfamily A polypeptide 4	17	0	0	17
glucocorticoid receptor [Homo sapiens]	30	0	0	30
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	16	0	0	16
estrogen-related nuclear receptor alpha	27	0	0	27
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
arylsulfatase A	11	0	0	11
Carbonic anhydrase	0	1	0	1
Bloom syndrome protein isoform 1	11	0	0	11
thyroid hormone receptor beta isoform a	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	25	0	0	25
peripheral myelin protein 22	11	0	0	11
survival motor neuron protein isoform d	9	0	0	9
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	7	3	1	11
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	18
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	4	0	4
Carbonic anhydrase 12	0	6	1	14
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	25	0	25
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	4	0	4
Carbonic anhydrase 1	0	10	1	21
Carbonic anhydrase 2	0	11	1	22
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	3	0	4
Carbonic anhydrase 3	0	6	1	12
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	5	0	7
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	4	0	4
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	9	0	10
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	5	0	6
Gamma-aminobutyric acid receptor subunit beta-1	7	3	1	11
Translocator protein	0	2	2	5
Gamma-aminobutyric acid receptor subunit delta	7	3	1	11
Gamma-aminobutyric acid receptor subunit gamma-2	7	3	1	11
Gamma-aminobutyric acid receptor subunit alpha-5	7	3	1	11
Gamma-aminobutyric acid receptor subunit alpha-3	7	3	1	11
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Carbonic anhydrase 4	0	9	1	16
Carbonic anhydrase 6	0	6	1	13
Gamma-aminobutyric acid receptor subunit gamma-1	7	3	1	11
Gamma-aminobutyric acid receptor subunit alpha-2	7	3	1	11
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	0	7
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	7	3	1	11
Gamma-aminobutyric acid receptor subunit gamma-3	7	3	1	11
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	7	3	1	11
Adenosine receptor A2a	0	5	0	9
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Delta-type opioid receptor	0	3	0	4
Cytochrome P450 2C19	0	6	0	6
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	7	1	15
Carbonic anhydrase	0	4	0	6
Kappa-type opioid receptor	0	1	1	2
Carbonic anhydrase 7	0	6	1	13
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	1	0	4
D(2) dopamine receptor	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	7	3	1	11
Gamma-aminobutyric acid receptor subunit beta-3	7	3	1	11
Gamma-aminobutyric acid receptor subunit beta-2	7	3	1	11
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	5	1	8
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	7	1	15
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	6
GABA theta subunit	7	3	1	11
Canalicular multispecific organic anion transporter 1	0	16	0	16
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 15	0	3	0	6
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	5	0	10
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	3	1	11
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 14	0	6	1	14
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	7	1	15
AR protein	32	0	0	32
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	5	3	9
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	2
interleukin 8	2	0	0	2
TDP1 protein	18	0	0	18
thyroid stimulating hormone receptor	12	0	0	12
estrogen receptor 2 (ER beta)	12	0	0	12
progesterone receptor	16	0	0	16
estrogen nuclear receptor alpha	39	0	0	39
IDH1	8	0	0	8
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	17	0	0	17
ras-related protein Rab-9A	3	0	0	3
lamin isoform A-delta10	18	0	0	18
Polyphenol oxidase 2	0	1	0	2
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	18	0	0	18
Glutamate receptor 2	13	2	1	16
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	3	2	6
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
acid sphingomyelinase	1	0	0	1
acetylcholinesterase	7	0	0	7
regulator of G-protein signaling 4	9	0	0	9
glucocerebrosidase	5	0	0	5
alpha-galactosidase	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
huntingtin isoform 2	1	0	0	1
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	3
Prothrombin	0	1	1	2
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Cationic trypsin	0	1	0	1
Coagulation factor XI	0	1	0	1
Plasma kallikrein	0	1	0	3
Vitamin K-dependent protein C	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Sodium/hydrogen exchanger 1	0	2	0	2
Sodium/hydrogen exchanger 3	0	2	0	2
Trypsin-3	0	1	0	1
Amiloride-sensitive sodium channel subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Sodium/hydrogen exchanger 2	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium/hydrogen exchanger 5	0	2	0	2
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	2	0	3
Acid-sensing ion channel 3	0	1	0	1
Sodium/hydrogen exchanger	0	1	0	1
ATAD5 protein, partial	8	0	0	8
USP1 protein, partial	10	0	0	10
67.9K protein	5	0	0	5
peroxisome proliferator-activated receptor delta	13	0	0	13
chromobox protein homolog 1	13	0	0	13
Cytochrome P450 2J2	0	5	0	5
Nicotinate phosphoribosyltransferase	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	5	0	0	5
GLS protein	8	0	0	8
flap endonuclease 1	6	0	0	6
DNA polymerase iota isoform a (long)	9	0	0	9
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	3	0	4
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	3
Nitric oxide synthase, inducible	0	2	1	5
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	7	0	0	7
vitamin D3 receptor isoform VDRA	6	0	0	6
Vasopressin V2 receptor	0	7	2	10
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	2	3
Vasopressin V1a receptor	0	6	2	8
Vasopressin V1b receptor	0	3	2	5
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	2	1	4
Translocator protein	0	2	0	3
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	3	2	5
Histamine H3 receptor	0	1	0	1
Chain A, Ferritin light chain	4	0	0	4
Luciferase	8	0	0	8
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
histone acetyltransferase KAT2A isoform 1	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 12 member 2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
RAR-related orphan receptor gamma	20	0	0	20
farnesoid X nuclear receptor	10	0	0	10
pregnane X nuclear receptor	19	0	0	19
thyroid stimulating hormone receptor	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
DNA polymerase beta	1	0	0	1
nuclear receptor ROR-gamma isoform 1	10	0	0	10
DNA polymerase kappa isoform 1	3	0	0	3
Potassium channel subfamily K member 2	0	0	3	3
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	2	0	2
Acetylcholinesterase	0	3	0	3
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	6	1	8
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A2b	0	3	0	4
Adenosine receptor A1	0	1	1	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Adenylate cyclase type 1	0	1	1	3
Chitotriosidase-1	0	3	1	4
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	3	1	4
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Guanine deaminase	0	1	0	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	3	0	0	3
Microtubule-associated protein tau	4	0	0	4
thioredoxin glutathione reductase	3	0	0	3
mitogen-activated protein kinase 1	4	0	0	4
Interferon beta	16	0	0	16
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	6	2	8
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
15-lipoxygenase, partial	2	0	0	2
peroxisome proliferator activated receptor gamma	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
cytochrome P450 3A4 isoform 1	7	0	0	7
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	1	3
Lysine-specific histone demethylase 1A	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
Cannabinoid receptor 1	0	3	0	3
Prostaglandin G/H synthase 1	0	4	0	4
Cannabinoid receptor 2	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Spike glycoprotein	8	0	0	8
Inositol monophosphatase 1	2	0	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	1	4
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	0	1	1
Chain A, serum paraoxonase	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
EWS/FLI fusion protein	10	0	0	10
nonstructural protein 1	4	0	0	4
ORF73	0	0	1	1
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
G	12	0	0	12
peripheral myelin protein 22 isoform 1	6	0	0	6
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	5	0	5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	4	0	4
cGMP-specific 3',5'-cyclic phosphodiesterase	0	7	1	9
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	5
Platelet-activating factor receptor	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	4	0	5
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	3	0	3
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	4	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	7	1	9
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	5	0	6
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	5	0	6
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	6	0	7
Inositol hexakisphosphate kinase 1	12	0	0	12
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	8	0	0	8
cytochrome P450 2C9, partial	12	0	0	12
glp-1 receptor, partial	6	0	0	6
pregnane X receptor	4	0	0	4
aryl hydrocarbon receptor	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
relaxin receptor 1 isoform 1	2	0	0	2
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
ATP-dependent translocase ABCB1	0	2	0	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
activating transcription factor 6	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
Gamma-aminobutyric acid	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	2	1	4
Albumin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
5-hydroxytryptamine receptor 1A	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Cereblon isoform 4	0	4	0	4
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	6	1	8
Solute carrier family 22 member 2	0	0	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin G/H synthase 2	0	3	0	3
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	2	0	3
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
cytochrome P450 2D6	8	0	0	8
caspase-3	4	0	0	4
Histone H2A.x	7	0	0	7
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
UDP-glucuronosyltransferase 2B17	0	0	0	1
Amyloid-beta precursor protein	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Angiotensin-converting enzyme	0	1	0	1
Histamine H2 receptor	4	0	1	5
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Sodium/glucose cotransporter 1	0	0	1	1
Sodium/glucose cotransporter 2	0	1	1	2
Endothelin-1 receptor	0	1	0	1
Alpha-synuclein	3	0	0	3
Chain A, PROTEIN (TRANSTHYRETIN)	0	0	1	1
Chain B, PROTEIN (TRANSTHYRETIN)	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cytochrome P450 2C9 precursor	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
Aldo-keto reductase family 1 member B10	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Transthyretin	0	1	1	2
Prostaglandin G/H synthase 1	0	2	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Transcription factor SOX-18	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Transcriptional enhancer factor TEF-3	0	1	1	2
Potassium channel subfamily K member 18	0	0	1	1
Acid-sensing ion channel 5	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
Bile salt export pump	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Integrin beta-3	1	0	1	2
Integrin alpha-IIb	1	0	1	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	4	1	7
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, NMDA 2A	0	4	1	7
Glutamate receptor ionotropic, NMDA 2C	0	4	1	8
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	4	1	7
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	4	1	7
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	4	1	7
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Macrophage migration inhibitory factor	0	2	0	2
Histamine H2 receptor	0	1	2	3
5-hydroxytryptamine receptor 1D	0	1	0	2
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Histamine H1 receptor	0	2	2	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Histamine H3 receptor	0	1	2	3
Hsf1 protein	0	0	1	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Fumarate hydratase	2	0	0	2
polyprotein	2	0	0	2
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Neutrophil elastase	0	2	0	2
Nitric oxide synthase, endothelial	0	2	0	2
Collagenase 3	0	2	0	2
Chain A, Cruzipain	3	0	0	3
endonuclease IV	2	0	0	2
Parkin	2	0	0	2
M-phase phosphoprotein 8	1	0	0	1
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Bile acid receptor	0	1	1	2
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
Cruzipain	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
Cysteinyl leukotriene receptor 2	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
STAT3, partial	0	1	0	1
Kruppel-like factor 5	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
G protein-coupled receptor GPR35	0	0	1	1
dopamine D1 receptor	1	0	0	1
vasopressin V1b receptor	1	0	0	1
Tumor necrosis factor	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	5	1	6
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M4	0	0	1	2
Kappa-type opioid receptor	0	0	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Mu-type opioid receptor	0	0	0	1
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Albumin	0	0	1	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Complement C1s subcomponent	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	4	1	5
Glucocorticoid receptor	0	6	3	14
Progesterone receptor	0	4	1	6
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	1	4
pyruvate kinase	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
pyruvate kinase PKM isoform b	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Sodium-dependent noradrenaline transporter	0	3	0	3
Pteridine reductase 1	0	2	0	2
Retina-specific copper amine oxidase	0	1	0	1
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	4	0	4
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Endothelin-1 receptor	0	1	0	1
Phosphodiesterase	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Smad3	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Vpr	1	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Protein-arginine deiminase type-4	0	2	0	2
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphodiesterase	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2A adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Trace amine-associated receptor 1	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

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Overview

Context

Research

Studies (316)

Protein Targets (868)

Endolymphatic Hydrops

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (316)

Drugs Studied (97)

Protein Targets (868)