Gastrinoma

A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).

Synonym
Gastrinoma

Excerpt	Reference
"Gastrinomas are now being detected at an earlier stage than was formerly the case."	( Eckhauser, FE; Thompson, NW; Vinik, AI, 1989)
"Metastatic gastrinoma is becoming increasingly recognized in patients with Zollinger-Ellison Syndrome."	( Benya, RV; Doppman, JL; Fishbeyn, VA; Fraker, DL; Metz, DC; Norton, JA; Orbuch, M; Pisegna, JR; Slimak, GG; Strader, DB, 1993)
"Sporadic gastrinoma is a pancreatic endocrine tumor whose ontogeny is unknown."	( Bhagavan, BS; Cummings, OW; Howard, TJ; Lewin, KJ; Passaro, E; Sawicki, M; Steel, B, 1995)
"Gastrinoma is a kind of neuroendocrine tumor very rare in children."	( Barca Rodriguez, P; Eire, PF; Rodriguez Pereira, C; Varela Cives, R, 1996)
"Gastrinoma is a rare endocrine tumor that is frequently associated with liver metastasis."	( Hayashida, Y; Iwanuma, Y; Kamano, T; Kobayashi, S; Okuzawa, A; Ono, K; Sakamoto, K; Seki, E; Suzuki, Y; Tomiki, Y; Tsurumaru, M; Uchida, Y, 2000)
"Gastrinomas are uncommon tumors which are difficult to locate."	( Bello Arques, P; Hervás Benito, I; Mateo Navarro, A, 2001)
"Gastrinomas are located more frequently in the pancreas, which normally has no cells that can produce gastrin."	( Bulgakov, G; Egorov, A; Gurevich, L; Isakov, VA; Kazantseva, I; Korsakova, N; Kubishkin, V, 2003)
"Gastrinoma is difficult to detect even in the general population, and hence symptoms such as recurrent idiopathic peptic ulcer and diarrhea in neurofibromatosis type 1 patients should be accounted for as possibly contributing to Zollinger-Ellison syndrome."	( Cho, CK; Choi, SK; Joo, YE; Kim, HS; Kim, JC; Kim, SJ; Koh, YS; Lee, WS; Park, CH; Rew, JS, 2005)
"Patients with a gastrinoma are treated with proton pump inhibitors (PPI) and histamine type-2 receptor antagonists (H2)."	( Dhillo, WS; Jayasena, CN; Lewis, CJ; Martin, NM; Meeran, K; Tang, KC; Todd, JF, 2006)
"Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES)."	( Anlauf, M; Dralle, H; Eisenberger, CF; Garbrecht, N; Gimm, O; Heitz, PU; Henopp, T; Klöppel, G; Knoefel, WT; Komminoth, P; Krausch, M; Perren, A; Raffel, A; Schlenger, R; Schmitt, A, 2006)
"Gastrinomas are defined as gastrin producing tumors that are associated with an elevated fasting gastrin serum level, a positive gastrin secretin stimulation test and certain clinical symptoms, e."	( Anlauf, M; Klöppel, G, 2007)
"Gastrinoma is the most frequent functional pancreaticoduodenal endocrine tumor in patients with multiple endocrine neoplasia type 1 (MEN1) and one major determinant of mortality in this syndrome."	( Bartsch, DK; Langer, P; Rothmund, M, 2007)
"Gastrinomas are functional neuroendocrine tumors of the gastroenteropancreatic system."	( Auernhammer, CJ; Göke, B, 2007)
"Primary lymph node gastrinomas are relatively rare in children and, to the best of our knowledge, have not previously been reported at this location."	( Nazir, Z, 2011)
"Gastrinomas are neuroendocrine tumors, some of which become malignant."	( Bardram, L; Goetze, JP; Hilsted, L; Poitras, P; Rehfeld, JF, 2012)
"Gastrinoma is a rare disease that predominantly affects young adults, but it must be considered in the pediatric group when clinical and laboratorial features of this disease are observed."	( Arcanjo, TL; Barreto, JH; Fernandes, GE; Mendonça, N, 2012)
"Because gastrinoma is the most common pancreatic endocrine tumor seen in multiple endocrine neoplasia type I (MEN 1), the possibility of gastrinoma should be investigated carefully when patients exhibit symptoms associated with hormonal changes."	( Cho, JW; Kim, JK; Kim, JW; Lee, JU; Lee, NE; Lee, YJ; Park, MS; Yun, SH, 2013)
"Diagnosis of gastrinoma is complex, difficult, and controversial."	( Brandi, ML; Cioppi, F; Fossi, C; Giusti, F; Marini, F; Masi, L; Tonelli, F, 2022)
"Gastrinomas are gastrin-secreting pancreatic tumours rarely diagnosed in cats."	( Mazepa, ASW; Myers-Nodes, J, 2022)
"Gastrinomas are neuroendocrine neoplasms that overproduce the hormone gastrin and can arise sporadically or as part of the MEN1 syndrome, in which mutations in the MEN1 gene lead to loss or inactivation of MENIN protein."	( Duan, S; Elvis-Offiah, UB; Merchant, JL, 2023)

Excerpt	Reference
"Gastrinomas have been reported to either manifest sporadically or to occur in conjunction with the genetic background of the MEN-I syndrome."	( Banasch, M; Schmitz, F, 2007)
"Primary lymph node gastrinoma has been defined as gastrin-producing tumor present in lymph nodes and predominantly found in well-defined anatomical region known as gastrinoma triangle."	( Gupta, R; Kumar, R; Lal, SB; Mittal, BR; Singh, D; Sood, A; Vashishta, RK, 2019)

Excerpt	Reference
"The role of surgery in the treatment of gastrinoma is unclear."	( Howard, TJ; Passaro, E; Stabile, BE; Zinner, MJ, 1990)
"The primary aim of treating gastrinoma is to control gastric acid hypersecretion by means of high doses of a proton pump inhibitor."	( Fliers, E; Hart, W; Koopmans, RP; van den Born, BJ, 2002)
"Surgery is first line treatment in gastrinomas, however often fails to be curative."	( Auernhammer, CJ; Göke, B, 2007)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	24 (8.05)	23.3326
1990's	118 (39.60)	12.5806
2000's	97 (32.55)	18.1394
2010's	49 (16.44)	28.8240
2020's	10 (3.36)	9.53

Drug	Relationship Strength	Studies	Trials
5-hydroxytryptophan	low	1	0
butyric acid	low	1	0
glycine	low	1	0
histamine	low	3	0
hydroxyindoleacetic acid	medium	8	3
cimetidine	medium	3	1
diazoxide	low	1	0
pentetic acid	medium	10	3
famotidine	medium	4	1
fluorouracil	low	5	0
hexamethylene bisacetamide	low	1	0
lansoprazole	low	2	0
metoclopramide	low	1	0
nifedipine	low	1	0
carbachol	low	1	0
levodopa	low	1	0
methylene blue	low	1	0
pyrroles	low	1	0
calcium gluconate	low	5	0
gluconic acid	low	1	0
copper gluconate	low	1	0
enbucrilate	low	1	0
lutetium	low	1	0
gadolinium	low	1	0
xenon	medium	1	1
bromocriptine	low	1	0
triamcinolone	low	1	0
paclitaxel	low	1	0
etoposide	low	2	0
fura-2	low	1	0
fluorodeoxyglucose f18	low	1	0
methylimidazoleacetic acid	low	1	0
yttrium radioisotopes	low	3	0
gadolinium 1,4,7,10-tetraazacyclododecane-n,n',n'',n'''-tetraacetate	low	1	0
3-tyr-octreotide	low	3	0
edotreotide	low	1	0
ranitidine	medium	5	1
indium	low	1	0
everolimus	low	1	0
gadolinium dtpa	low	1	0
s 1743	low	1	0
pasireotide	low	1	0
calcimycin	low	1	0
indocyanine green	low	1	0
cholecystokinin	low	2	0
(dtpa-phe(1))-octreotide	medium	9	2
xenin 25	low	1	0
gastrins	medium	210	5
glucagon	low	5	0
big gastrin	low	14	0
neuropeptide y	low	2	0
pancreastatin	low	2	0
gastrin 17	low	5	0
calpain	low	1	0
bucladesine	low	1	0
sodium pertechnetate tc 99m	low	1	0
neurotensin	low	1	0
vasoactive intestinal peptide	low	3	0
transforming growth factor beta	low	1	0
transforming growth factor alpha	low	1	0
peptide yy	low	1	0
gallium ga 68 dotatate	low	1	0
lutetium lu 177 dotatate	low	1	0
68ga-dotanoc	low	2	0
dacarbazine	low	2	0

Protein Targets (930)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Genome polyprotein	0	1	1	2
dopamine D1 receptor	2	0	0	2
thioredoxin reductase	10	0	0	10
ATAD5 protein, partial	10	0	0	10
Fumarate hydratase	5	0	0	5
GLS protein	9	0	0	9
TDP1 protein	13	0	0	13
AR protein	22	0	0	22
regulator of G-protein signaling 4	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	12	0	0	12
pregnane X nuclear receptor	11	0	0	11
estrogen nuclear receptor alpha	22	0	0	22
G	6	0	0	6
polyprotein	5	0	0	5
peroxisome proliferator activated receptor gamma	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	18	0	0	18
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
D(1A) dopamine receptor	5	0	0	5
vitamin D3 receptor isoform VDRA	7	0	0	7
chromobox protein homolog 1	14	0	0	14
thyroid hormone receptor beta isoform 2	10	0	0	10
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
5-hydroxytryptamine receptor 4	0	6	0	6
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Cellular tumor antigen p53	12	0	0	12
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	8	0	11
Beta-1 adrenergic receptor	0	2	0	2
Cytochrome P450 3A4	0	5	0	5
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	4	0	4
D(2) dopamine receptor	0	4	1	5
Androgen receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	3	0	3
Alpha-2B adrenergic receptor	0	2	0	2
ATP-dependent translocase ABCB1	0	4	0	4
D(1A) dopamine receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	6	1	7
5-hydroxytryptamine receptor 1B	0	3	0	3
D(4) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	4	0	4
Alpha-synuclein	3	1	0	4
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	2	0	2
D(2) dopamine receptor	0	3	1	4
Inositol hexakisphosphate kinase 1	6	0	0	6
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	10	0	0	10
cytochrome P450 2C9, partial	6	0	0	6
ATP-dependent phosphofructokinase	11	0	0	11
glp-1 receptor, partial	6	0	0	6
vasopressin V1b receptor	1	0	0	1
cAMP-dependent protein kinase type I-alpha regulatory subunit	0	0	1	1
cAMP-dependent protein kinase type II-beta regulatory subunit	0	0	1	1
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
cAMP-dependent protein kinase catalytic subunit beta isoform 1	0	0	1	1
urokinase plasminogen activator surface receptor precursor	7	0	0	7
geminin	20	0	0	20
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
neuropeptide S receptor isoform A	4	0	0	4
cAMP-dependent protein kinase catalytic subunit beta isoform 3	0	0	1	1
Chain A, Nitrile Hydratase alpha subunit	0	1	0	1
Chain B, Nitrile Hydratase beta subunit	0	1	0	1
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
estrogen-related nuclear receptor alpha	13	0	0	13
Lysine-specific demethylase 4E	0	1	0	1
thyroid stimulating hormone receptor	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
Free fatty acid receptor 3	0	0	1	1
Histone deacetylase 3	0	2	0	2
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	3	0	0	3
Chain A, Cruzipain	1	0	0	1
acid sphingomyelinase	1	0	0	1
endonuclease IV	4	0	0	4
ClpP	3	0	0	3
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
USP1 protein, partial	10	0	0	10
Microtubule-associated protein tau	6	0	0	6
TSHR protein	2	0	0	2
Smad3	5	0	0	5
apical membrane antigen 1, AMA1	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
thyroid stimulating hormone receptor	11	0	0	11
nonstructural protein 1	4	0	0	4
67.9K protein	5	0	0	5
glucocerebrosidase	1	0	0	1
Parkin	3	0	0	3
arylsulfatase A	6	0	0	6
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
IDH1	8	0	0	8
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
serine-protein kinase ATM isoform a	2	0	0	2
Bloom syndrome protein isoform 1	8	0	0	8
lysosomal alpha-glucosidase preproprotein	2	0	0	2
hexokinase-4 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
peripheral myelin protein 22 isoform 1	8	0	0	8
type-1 angiotensin II receptor	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
glucokinase regulatory protein	2	0	0	2
huntingtin isoform 2	4	0	0	4
mitogen-activated protein kinase 1	4	0	0	4
flap endonuclease 1	5	0	0	5
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase PLK1	4	0	0	4
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA polymerase iota isoform a (long)	8	0	0	8
DNA damage-inducible transcript 3 protein	0	1	0	1
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Vpr	3	0	0	3
survival motor neuron protein isoform d	8	0	0	8
histone acetyltransferase KAT2A isoform 1	5	0	0	5
streptokinase A precursor	0	0	1	1
lamin isoform A-delta10	16	0	0	16
Rap guanine nucleotide exchange factor 3	1	0	0	1
Amyloid-beta precursor protein	3	2	0	5
D(1A) dopamine receptor	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
TAR DNA-binding protein 43	2	0	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
heat shock protein 90, putative	0	0	0	1
Chain A, Beta-lactamase	7	0	0	7
acetylcholinesterase	6	0	0	6
GALC protein	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	2	6
Muscarinic acetylcholine receptor M4	0	2	2	6
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	4
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	2	6
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Muscarinic acetylcholine receptor M2	0	2	0	3
Muscarinic acetylcholine receptor M1	0	2	2	6
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	2	2	6
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Delta-type opioid receptor	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Muscarinic acetylcholine receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
interleukin 8	4	0	0	4
phosphopantetheinyl transferase	9	0	0	9
progesterone receptor	10	0	0	10
cytochrome P450 2D6	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	6	0	0	6
DNA polymerase kappa isoform 1	2	0	0	2
peripheral myelin protein 22	12	0	0	12
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	7	0	0	7
muscarinic acetylcholine receptor M1	7	0	0	7
Solute carrier family 22 member 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	7	0	0	7
Solute carrier family 22 member 2	0	2	0	4
Solute carrier family 22 member 1	0	3	0	4
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	13
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Bile salt export pump	0	16	0	16
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C9	0	7	0	7
Gamma-aminobutyric acid receptor subunit beta-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit delta	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	7	0	0	7
Potassium-transporting ATPase alpha chain 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	7	0	0	7
Histamine H2 receptor	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	7	0	0	7
Histamine H1 receptor	0	1	3	4
Histamine H2 receptor	6	2	2	10
Potassium-transporting ATPase subunit beta	0	2	0	2
Cytochrome P450 2J2	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-2	7	0	0	7
Aldehyde oxidase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
Multidrug and toxin extrusion protein 2	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
GABA theta subunit	7	0	0	7
Canalicular multispecific organic anion transporter 1	0	14	0	15
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	0	0	7
Histamine H4 receptor	0	3	2	5
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
RAR-related orphan receptor gamma	13	0	0	13
activating transcription factor 6	4	0	0	4
Matrix metalloproteinase-9	0	1	0	1
Inositol monophosphatase 1	3	0	0	3
Isocitrate lyase	0	1	0	1
cytochrome P450 2D6 isoform 1	5	0	0	5
thyroid hormone receptor beta isoform a	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Glutamate receptor 1	0	0	0	2
Glutamate receptor 2	8	0	0	10
Glutamate receptor 3	0	0	0	2
Glutamate receptor 4	0	0	0	2
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
Histone H2A.x	4	0	0	4
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Somatostatin receptor type 1	0	2	0	2
Somatostatin receptor type 2	0	2	0	2
Somatostatin receptor type 4	0	2	0	2
Somatostatin receptor type 3	0	2	0	2
Somatostatin receptor type 5	0	2	0	2
GLI family zinc finger 3	9	0	0	9
caspase 7, apoptosis-related cysteine protease	3	0	0	3
retinoid X nuclear receptor alpha	7	0	0	7
peroxisome proliferator-activated receptor delta	7	0	0	7
caspase-3	3	0	0	3
LMP1 [Human herpesvirus 4]	0	0	0	1
heat shock protein beta-1	6	0	0	6
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	2	8
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
Serum paraoxonase/arylesterase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	1	6
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	6
Glutamate receptor ionotropic, NMDA 2B	0	2	1	6
Glutamate receptor ionotropic, NMDA 2C	0	2	1	6
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	2	9
Glutamate receptor ionotropic, NMDA 2D	0	2	1	6
Tubulin beta-2B chain	0	1	1	4
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	0	3
Glutamate receptor ionotropic, NMDA 3B	0	2	1	6
Solute carrier organic anion transporter family member 1B3	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	2	1	6
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	1	1	2
Epidermal growth factor receptor	0	3	1	4
High affinity nerve growth factor receptor	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	2	1	3
Cyclin-dependent kinase 1	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	1	1	2
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	1	2
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	1	1	2
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
ATP-dependent RNA helicase DDX42	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
EWS/FLI fusion protein	7	0	0	7
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	8	0	0	8
Skn7p	0	0	0	1
pregnane X receptor	3	0	0	3
Thrombopoietin	2	0	0	2
estrogen receptor 2 (ER beta)	6	0	0	6
farnesoid X nuclear receptor	4	0	0	4
hemoglobin subunit beta	1	0	0	1
muscleblind-like protein 1 isoform 1	4	0	0	4
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	1	0	1
Aromatase	0	2	0	2
Cholecystokinin receptor type A	0	3	1	4
Gastrin/cholecystokinin type B receptor	0	1	1	2
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	0	0	2
Solute carrier family 22 member 3	0	1	0	2
Carbonic anhydrase 1	0	1	0	3
Carbonic anhydrase 2	0	1	0	4
Plasma kallikrein	0	0	0	2
Carbonic anhydrase 3	0	0	0	2
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	0	0	2
Carbonic anhydrase 6	0	0	0	2
Adenosine receptor A1	0	0	0	2
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	1	0	3
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	2
Histamine H1 receptor	0	2	2	4
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase 7	0	0	0	2
Carbonic anhydrase	0	0	0	3
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	2
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	0	0	2
Carbonic anhydrase 13	0	0	0	2
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
Histamine H3 receptor	0	2	2	4
NFKB1 protein, partial	4	0	0	4
hypothetical protein, conserved	3	0	0	3
cytochrome P450 2C9 precursor	3	0	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Spike glycoprotein	5	0	0	5
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
15-lipoxygenase, partial	3	0	0	3
aryl hydrocarbon receptor	5	0	0	5
Replicase polyprotein 1ab	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Replicase polyprotein 1ab	0	1	0	1
Microtubule-associated protein tau	0	2	1	3
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Cytochrome P450 2C19	0	2	0	3
Fatty acid synthase	0	4	0	4
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
WD repeat-containing protein 5	0	2	0	2
Histone-lysine N-methyltransferase 2A	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Cytosolic endo-beta-N-acetylglucosaminidase	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
WRN	1	0	0	1
integrase, partial	0	2	0	2
lens epithelium-derived growth factor p75	0	2	0	2
pyruvate kinase	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
Polyphenol oxidase 2	0	0	0	1
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
phosphoglycerate kinase	2	0	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Cholinesterase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Acetylcholinesterase	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	5	0	5
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear receptor ROR-gamma	2	0	0	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
PPM1D protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
pyruvate kinase PKM isoform a	2	0	0	2
DNA polymerase beta	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Alpha-1B adrenergic receptor	0	4	0	4
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	0	1	1
Cruzipain	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
5-hydroxytryptamine receptor 3E	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Albumin	0	0	1	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 7	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	2
5-hydroxytryptamine receptor 3D	0	0	1	1
5-hydroxytryptamine receptor 3C	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Neurotensin receptor type 1	0	0	1	1
Neurotensin receptor type 2	0	1	1	3
Myelin basic protein	0	0	1	1
Neurotensin receptor type 1	0	1	1	2
Neurotensin receptor type 1	0	2	2	5
Neurotensin receptor type 2	0	2	1	3
Sortilin	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Bile salt export pump	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Integrin beta-3	1	1	0	2
Integrin alpha-IIb	1	0	0	1
Adenosine receptor A3	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Leukotriene B4 receptor 1	0	0	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Mcl-1	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	2	0	2
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	2	0	2
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Glutathione S-transferase omega-1	0	1	0	1
Genome polyprotein	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Substance-K receptor	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Delta-type opioid receptor	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	1	0	1
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
interferon gamma precursor	0	0	0	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (298)

Protein Targets (930)

Gastrinoma

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (298)

Drugs Studied (82)

Protein Targets (930)