Cerebrospinal Fluid Hypovolemia

Reduction of CEREBROSPINAL FLUID pressure characterized clinically by ORTHOSTATIC HEADACHE and occasionally by an ABDUCENS NERVE PALSY; HEARING LOSS; NAUSEA; neck stiffness, and other symptoms. This condition may be spontaneous or secondary to CEREBROSPINAL FLUID LEAK; SPINAL PUNCTURE; NEUROSURGICAL PROCEDURES; DEHYDRATION; UREMIA; trauma (see also CRANIOCEREBRAL TRAUMA); and other processes. Chronic hypotension may be associated with subdural hematomas (see HEMATOMA, SUBDURAL) or hygromas. (From Semin Neurol 1996 Mar;16(1):5-10; Adams et al., Principles of Neurology, 6th ed, pp637-8)

Synonyms(6)

Synonym
CSF Hypovolemia
Cerebrospinal Fluid Hypovolemia
Intracranial Hypotension
Intracranial Hypotension, Essential
Intracranial Hypotension, Spontaneous
Intracranial Hypotension, Secondary

Research Excerpts

Overview

Excerpt	Reference
"Spontaneous intracranial hypotension is an increasingly recognized cause of postural headache."	( Binder, DK; Dillon, WP; Fishman, RA; Schmidt, MH, 2002)
"The syndrome of spontaneous intracranial hypotension is characterized by orthostatic headaches in conjunction with reduced cerebrospinal fluid (CSF) pressure or CSF volume, and characteristic magnetic resonance (MR) imaging findings."	( Guhlmann, A; Nowak, DA; Rodiek, SO; Topka, H; Zinner, J, 2003)
"Spontaneous intracranial hypotension is characterized by orthostatic headache, low CSF pressure, and MRI findings of diffuse pachymeningeal gadolinium enhancement without previous history of head trauma or lumbar puncture."	( Ferrante, E; Nappi, G; Sances, G; Savino, A, 2004)
"Spontaneous intracranial hypotension is a well defined entity, however it is characterised by a relevant clinical heterogeneity."	( Clerici, AM; Mazza, S; Merlo, P; Noce, M; Rebecchi, V; Stival, B, 2005)
"Spontaneous intracranial hypotension is an infrequent clinical entity characterized by orthostatic headache, low cerebrospinal fluid pressure, and magnetic resonance imaging findings of diffuse pachymeningeal gadolinium enhancement without previous history of head trauma or lumbar puncture."	( Cristiano, E; Doctorovich, D; Patrucco, L; Rojas, JI; Romano, M, 2006)
"Intracranial hypotension is a syndrome of low cerebrospinal fluid pressure with a variable clinical presentation ranging from postural headaches to coma."	( Henderson, JM; Lad, SP; Li, G; Lin, SC, 2008)
"Spontaneous intracranial hypotension is a rare complication of connective tissue disorders."	( Kollár, K; Kordas, M; Móser, J; Rosdy, B; Várallyay, G, 2009)
"Intracranial hypotension is a frequently misdiagnosed syndrome which is caused by reduced intracranial cerebrospinal fluid (CSF) pressure due to spontaneous spinal CSF leakage."	( Musahl, C; Papke, K; Schick, U, 2010)
"Spontaneous intracranial hypotension is a rare syndrome characterized by orthostatic headache not associated with trauma or dural puncture."	( Ayoub, C; Ayoub, S; El Khatib, M; Hujeily, E; Rizk, M; Skaf, G; Yamout, B, 2015)

Treatment

Excerpt	Reference
"Spontaneous intracranial hypotension (SIH) is a rare syndrome defined by postural headache, associated with a low cerebrospinal fluid pressure, without history of previous dural trauma or invasive treatment on rachis."	( Angrisani, L; Clarice, A; Proietta, M; Rocchietti March, M; Scorza, A; Trappolini, F; Trappolini, M, 2006)
"We report a case of spontaneous intracranial hypotension in a pregnant patient successfully treated by epidural injection of dextran-40 and paramethasone, with adjuvant oral steroid therapy."	( Bel, I; Gomar, C; Moreno, LA, 2006)
"We present our series of intracranial hypotension regarding especially the required diagnostic imaging and the treatment."	( Musahl, C; Papke, K; Schick, U, 2010)
"We report a case of spontaneous intracranial hypotension successfully treated with repetitive epidural blood patch after warfarin reversal."	( Hanaoka, M; Ishihara, M; Matsuda, T; Matsuzaki, K; Miyake, H; Niki, H; Satoh, K, 2019)
"Spontaneous intracranial hypotension (SIH) is a clinical syndrome that is increasingly recognized as an important and treatable secondary cause of headaches."	( Amrhein, TJ; Gray, L; Kranz, PG; Malinzak, MD, 2019)

Research

Studies (166)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.60)	23.3326
1990's	13 (7.83)	12.5806
2000's	80 (48.19)	18.1394
2010's	54 (32.53)	28.8240
2020's	18 (10.84)	9.53

Drug	Relationship Strength	Studies	Trials
methane	low	1	0
salicylic acid	low	1	0
aminocaproic acid	low	1	0
lactic acid	low	2	0
dimethyl sulfoxide	low	1	0
glycerol	low	3	0
histamine	low	1	0
nitrous oxide	low	1	0
pyruvic acid	low	1	0
phenytoin	low	1	0
acetazolamide	low	2	0
theophylline	low	3	0
aspirin	low	2	0
azathioprine	low	1	0
baclofen	low	2	0
bupivacaine	low	2	0
caffeine	low	5	0
carmustine	low	1	0
pentetic acid	medium	12	2
erythrosine	low	1	0
furosemide	low	1	0
ibuprofen	low	1	0
lidocaine	low	3	0
iomeprol	low	1	0
iotrolan	low	1	0
isoflurane	low	1	0
ketamine	low	1	0
methadone	low	1	0
nicardipine	low	1	0
omeprazole	low	1	0
propofol	low	1	0
zolpidem	low	1	0
mitomycin	low	1	0
prednisolone	medium	4	1
phentolamine	low	1	0
prednisone	low	3	0
paramethasone	low	1	0
aspartic acid	low	1	0
lysine	low	1	0
mannitol	low	4	0
arginine	low	1	0
triamcinolone acetonide	low	1	0
methylprednisolone	low	5	0
ergotamine	low	1	0
fluorescein	low	1	0
n-methylaspartate	low	1	0
enbucrilate	low	2	0
technetium	low	1	0
gadolinium	medium	40	1
xenon	low	1	0
cresyl violet	low	1	0
fludrocortisone	low	2	0
transferrin	low	2	0
glutamic acid	low	2	0
ng-nitroarginine methyl ester	low	1	0
propiconazole	low	5	0
esmolol	low	1	0
adenosine	low	1	0
iopamidol	low	1	0
fluorodeoxyglucose f18	low	1	0
fibrinogen	low	1	0
acetylsalicylic acid lysinate	low	1	0
deriphyllin	low	1	0
methotrexate	low	2	0
technetium tc 99m pentetate	low	5	0
retinol	low	1	0
tacrolimus	low	1	0
bilirubin	low	2	0
dexmedetomidine	low	1	0
gadolinium dtpa	low	9	0
losartan potassium	low	1	0
technetium tc 99m exametazime	low	1	0
nad	low	1	0
cardiovascular agents	low	1	0
warfarin	low	1	0
phenprocoumon	low	1	0
cyclosporine	low	1	0
eye	medium	3	1

Protein Targets (922)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	15	0	0	15
GALC protein	4	0	0	4
GLI family zinc finger 3	25	0	0	25
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
glucocorticoid receptor [Homo sapiens]	25	0	0	25
retinoic acid nuclear receptor alpha variant 1	26	0	0	26
retinoid X nuclear receptor alpha	22	0	0	22
estrogen-related nuclear receptor alpha	26	0	0	26
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	13	0	0	13
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	28	0	0	28
Bloom syndrome protein isoform 1	12	0	0	12
thyroid hormone receptor beta isoform a	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
geminin	23	0	0	23
peripheral myelin protein 22	13	0	0	13
survival motor neuron protein isoform d	8	0	0	8
muscleblind-like protein 1 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	8	5	1	14
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	19	0	20
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	5	0	5
Carbonic anhydrase 12	0	4	1	9
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	24	0	24
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	4	0	4
Carbonic anhydrase 1	0	9	1	18
Carbonic anhydrase 2	0	9	2	19
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	4	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	6	0	7
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	11	0	11
5-hydroxytryptamine receptor 2A	0	2	0	2
Androgen receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	8	5	1	14
Translocator protein	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	8	5	1	14
Gamma-aminobutyric acid receptor subunit gamma-2	8	5	2	15
Gamma-aminobutyric acid receptor subunit alpha-5	8	5	1	14
Gamma-aminobutyric acid receptor subunit alpha-3	8	5	1	14
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Carbonic anhydrase 4	0	4	1	8
Carbonic anhydrase 6	0	4	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	8	5	1	14
Gamma-aminobutyric acid receptor subunit alpha-2	8	5	1	14
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	8	1	12
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	8	5	1	14
Gamma-aminobutyric acid receptor subunit gamma-3	8	5	1	14
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	8	5	1	14
Adenosine receptor A2a	0	8	2	15
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	2	0	3
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	4	1	9
Carbonic anhydrase	0	1	0	2
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	4	1	8
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	1	0	3
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	8	6	2	16
Gamma-aminobutyric acid receptor subunit beta-3	8	5	1	14
Gamma-aminobutyric acid receptor subunit beta-2	8	5	2	15
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	8	2	12
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	4	1	9
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	3
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	5
GABA theta subunit	8	5	1	14
Canalicular multispecific organic anion transporter 1	0	18	0	18
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 15	0	2	0	4
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	4	0	7
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	8	5	1	14
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	4	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	9
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	33	0	0	33
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	8	0	0	8
estrogen nuclear receptor alpha	34	0	0	34
NPYLR7B	0	0	1	1
IDH1	10	0	0	10
Histone H2A.x	7	0	0	7
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	3	0	0	3
flap endonuclease 1	9	0	0	9
nuclear receptor ROR-gamma isoform 1	10	0	0	10
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Rap guanine nucleotide exchange factor 3	3	0	0	3
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	4	0	4
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	5	2	8
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Glutamate receptor 2	11	3	1	15
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A3	0	4	0	4
Adenosine receptor A2a	0	5	5	13
Adenosine receptor A2b	0	2	1	6
Adenosine receptor A2b	0	4	1	7
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	5	4	14
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	3	1	4
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	8	0	0	8
Chain A, Apolipoprotein	0	0	1	1
15-lipoxygenase, partial	4	0	0	4
ATAD5 protein, partial	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
EWS/FLI fusion protein	14	0	0	14
nonstructural protein 1	6	0	0	6
D(1A) dopamine receptor	5	0	0	5
chromobox protein homolog 1	15	0	0	15
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	8	0	0	8
lamin isoform A-delta10	21	0	0	21
Plasminogen	0	2	1	3
Proton-coupled amino acid transporter 1	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	16	0	0	16
NFKB1 protein, partial	3	0	0	3
GLS protein	14	0	0	14
thyroid stimulating hormone receptor	10	0	0	10
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	6	0	0	6
DNA polymerase iota isoform a (long)	12	0	0	12
muscarinic acetylcholine receptor M1	9	0	0	9
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	11	0	0	11
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	3
Glutamate receptor ionotropic, NMDA 1	0	7	2	11
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	7	2	11
Glutamate receptor ionotropic, NMDA 2C	0	7	2	11
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	7	2	11
Glutamate receptor ionotropic, NMDA 3B	0	7	2	11
Glutamate receptor ionotropic, NMDA 3A	0	7	2	11
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	4	0	0	4
hypothetical protein, conserved	2	0	0	2
cytochrome P450 2D6	9	0	0	9
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	13	0	0	13
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA polymerase kappa isoform 1	9	0	0	9
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	2	1	1	4
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	2	1	1	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	5	0	5
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	5	0	0	5
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
acetylcholinesterase	9	0	0	9
RAR-related orphan receptor gamma	20	0	0	20
SMAD family member 2	7	0	0	7
Fumarate hydratase	4	0	0	4
SMAD family member 3	7	0	0	7
TDP1 protein	22	0	0	22
Microtubule-associated protein tau	9	0	0	9
thioredoxin glutathione reductase	3	0	0	3
farnesoid X nuclear receptor	12	0	0	12
pregnane X nuclear receptor	18	0	0	18
G	7	0	0	7
polyprotein	4	0	0	4
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	13	0	0	13
aryl hydrocarbon receptor	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
thyroid stimulating hormone receptor	6	0	0	6
activating transcription factor 6	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	22	0	0	22
heat shock protein beta-1	7	0	0	7
cytochrome P450 3A4 isoform 1	8	0	0	8
M-phase phosphoprotein 8	4	0	0	4
Bile salt export pump	0	6	0	6
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Cellular tumor antigen p53	24	0	0	24
Inositol hexakisphosphate kinase 1	7	0	0	7
ATPase family AAA domain-containing protein 5	11	0	0	11
Ataxin-2	12	0	0	12
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	7	0	0	7
67.9K protein	5	0	0	5
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, Cruzipain	2	0	0	2
USP1 protein, partial	13	0	0	13
vitamin D3 receptor isoform VDRA	8	0	0	8
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Inositol monophosphatase 1	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Solute carrier organic anion transporter family member 1B1	0	3	0	4
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	3	4
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
DNA polymerase beta	2	0	0	2
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Replicase polyprotein 1ab	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	3	0	3
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	2
Chitotriosidase-1	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	3	4
Endochitinase B1	0	2	0	2
Muscarinic acetylcholine receptor	0	1	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Guanine deaminase	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
endonuclease IV	4	0	0	4
huntingtin isoform 2	3	0	0	3
Glutathione reductase, mitochondrial	0	5	0	5
Alpha-synuclein	1	1	0	2
Glutathione reductase	0	1	0	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Reverse transcriptase/RNaseH	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
Alpha-2A adrenergic receptor	0	5	2	8
Alpha-1B adrenergic receptor	0	3	2	5
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	5	2	8
Alpha-2B adrenergic receptor	0	3	2	5
Alpha-2C adrenergic receptor	0	3	2	5
Alpha-2A adrenergic receptor	0	3	2	5
Alpha-1D adrenergic receptor	0	3	2	6
Alpha-1D adrenergic receptor	0	5	1	6
Alpha-1A adrenergic receptor	0	3	2	5
Histamine H2 receptor	5	0	1	6
Cereblon isoform 4	0	2	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Adenylate cyclase	0	1	0	1
5-hydroxytryptamine receptor 4	0	6	0	6
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
ATP-dependent translocase ABCB1	0	4	0	4
Beta-1 adrenergic receptor	0	4	0	4
D(2) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	4	1	6
5-hydroxytryptamine receptor 1A	0	4	0	4
ATP-dependent translocase ABCB1	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	1	1	2
Thromboxane-A synthase	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	6	0	6
5-hydroxytryptamine receptor 1B	0	2	0	2
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	6	0	6
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Genome polyprotein	0	1	1	2
Luciferase	5	0	0	5
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
thyrotropin-releasing hormone receptor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Beta-1 adrenergic receptor	0	0	1	1
progesterone receptor	15	0	0	15
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
estrogen receptor 2 (ER beta)	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
glp-1 receptor, partial	3	0	0	3
Skn7p	0	0	0	1
pregnane X receptor	4	0	0	4
Thrombopoietin	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Amyloid-beta precursor protein	1	1	0	2
Thymidylate synthase	0	3	0	3
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Albumin	0	3	3	6
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Cytochrome P450 2J2	0	5	0	5
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Spike glycoprotein	10	0	0	10
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	3	1	4
Glutamate receptor 3	0	3	1	4
Glutamate receptor 4	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	3	1	4
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	3	1	4
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	3	0	3
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Histamine H2 receptor	0	1	2	3
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Histamine H1 receptor	0	3	2	5
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Histamine H3 receptor	0	1	2	3
transcriptional regulator ERG isoform 3	4	0	0	4
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Albumin	0	1	0	1
Albumin	0	0	2	2
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
TAR DNA-binding protein 43	6	0	0	6
Solute carrier family 22 member 6	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 8	0	2	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	3	0	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Smad3	1	0	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
D(4) dopamine receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Mas-related G-protein coupled receptor member X2	0	0	1	1
Aldehyde oxidase 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
ClpP	3	0	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
PPM1D protein	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
Parkin	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
Hsf1 protein	0	0	1	1
estrogen receptor beta isoform 1	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Angiotensin-converting enzyme	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	2	1	3
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Nischarin	0	1	0	1
Gamma-aminobutyric acid	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	2	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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