Page last updated: 2024-11-13

kt2 962

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

6-isopropyl-3-(4-(4-chlorobenzenesulfonylamino)butyl)azulene-1-sulfonic acid sodium salt: structure given in first source; a prostaglandin endoperoxide receptor antagonist; RN given refers to the mono-sodium salt; RN for parent cpd not available 4/93 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID23661969
CHEMBL ID262655
SCHEMBL ID2920348
MeSH IDM0214979

Synonyms (19)

Synonym
kt 2-962
6-isopropyl-3-(4-(4-chlorobenzenesulfonylamino)butyl)azulene-1-sulfonic acid sodium salt
1-azulenesulfonic acid, 3-(4-(((4-chlorophenyl)sulfonyl)amino)butyl)-6-(1-methylethyl)-, monosodium salt
3-(4-(((4-chlorophenyl)sulfonyl)amino)butyl)-6-(1-methylethyl)-1-azulenesulfonic acid monosodium salt
unii-w9f1s1h9lp
kt2-962
129648-96-0
w9f1s1h9lp ,
kt2 962
CHEMBL262655 ,
SCHEMBL2920348
DTXSID40156212
J343.474E ,
kt2962
Q27292501
sodium;3-[4-[(4-chlorophenyl)sulfonylamino]butyl]-6-propan-2-ylazulene-1-sulfonate
kt-2962
6-isopropyl-3-(4-(4-chlorophenylsulfonylamino)butyl)azulene-1-sulfonic acid sodium salt
6-isopropyl-3-(4-(p- chlorobenzenesulfonylamino)-butyl)-azulene-1-sulfonic acid sodium salt
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID165498Compound was tested for agonist activity on rabbit aorta1993Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
AID165375Tested for the concentration that causes 50% relaxation when contraction in rabbit aorta was induced by 3 x 10 E -8 M of U-46619.1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Azulene derivatives: new non-prostanoid thromboxane A2 receptor antagonists.
AID232743Selectivity index for the TXA2 t-receptor was the difference between the IC50 values in the aggregation and contraction assay1993Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
AID165497Compound was tested for agonist activity on rabbit PRP1993Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
AID167793Compound was tested for the inhibition U-46619 (3 x10 E -8 M) induced vascular contraction (TXA2 tao receptor) in rabbit thoracic aorta1993Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
AID167807Displacement of specific binding of [3H]SQ-29,548 to rabbit gel-filtered platelets1993Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
AID167790Compound was tested for the inhibition U-46619 (3 x10 E -8 M) induced platelet aggregation (TXA2 alpha receptor) in rabbit platelet rich plasma1993Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
AID232748Selectivity index is the difference between the IC50 values in the aggregation and contraction assays1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Azulene derivatives: new non-prostanoid thromboxane A2 receptor antagonists.
AID92220Effect on TXB2 formation of human platelets1993Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
AID165374Tested for the concentration that cause 50% inhibition of the maximum aggregation with rabbit platelet-rich plasma induced by 2.5 x 10 E -6 M of U-466191990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Azulene derivatives: new non-prostanoid thromboxane A2 receptor antagonists.
AID179228Inhibition of U-46619 (3x10E-8 M) induced contraction in rat thoracic aorta1993Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (75.00)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.02 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]