Compounds > 1-butyrylglycerol
Page last updated: 2024-12-05

1-butyrylglycerol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-butyrylglycerol (1-BG) is a monoglyceride that is a naturally occurring lipid. It is found in dairy products, coconut oil, and other sources. 1-BG is a potent activator of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) which is a transcription factor that regulates lipid metabolism. 1-BG has been shown to have various effects on the body, including reducing blood triglyceride levels, increasing insulin sensitivity, and promoting weight loss. Studies on 1-BG are primarily focused on its potential therapeutic benefits for metabolic diseases, such as diabetes and obesity. Its mechanism of action is primarily related to its ability to activate PPARα and modulate lipid metabolism. '

monobutyrin : A 1-monoglyceride resulting from the formal esterification of butyric acid with one of the primary hydroxy groups of glycerol. The R enantiomer is bioactive. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID11188
CHEMBL ID1987276
CHEBI ID76503
SCHEMBL ID68553
MeSH IDM0176194

Synonyms (53)

Synonym
einecs 209-165-5
nsc 8451
0yt8423e8u ,
alpha-monobutyrin
2,3-dihydroxypropyl butyrate
glycerol-alpha-mono-n-butyrate
unii-0yt8423e8u
nsc-8451
butyrin, 1-mono-
nsc8451
butanoic acid,3-dihydroxypropyl ester
glycerol-.alpha.-mono-n-butyrate
.alpha.-monobutyrin
557-25-5
butanoic acid, 2,3-dihydroxypropyl ester
NCI60_041861
2,3-dihydroxypropyl butanoate
monobutyrin
26999-06-4
1-butyrylglycerol
FT-0693611
ai3-28578
einecs 248-160-2
butanoic acid, monoester with 1,2,3-propanetriol
butyric acid, monoester with propane-1,2,3-triol
butanoic acid 2,3-dihydroxypropyl ester
1-o-(butyryl)glycerol
1-mono-n-butyrin
butyrate de 2,3-dihydroxypropyle
CHEBI:76503 ,
1-monobutyrin
3-butyryloxypropane-1,2-diol
2,3-dihydroxypropylbutyrat
mono-n-butyrin
glycerol 1-monobutyrate
monobutyrin, (+/-)-
monobutyrin [mi]
glyceryl 3-monobutyrate
glycerol .alpha.-monobutyrate
SCHEMBL68553
AKOS025243286
2,3-dihydroxypropyl butyrate #
CHEMBL1987276
1-monobutyrin, aldrichcpr
DTXSID70871764
Q27146050
mag 4:0
AMY22513
1-monotetranoin
AS-56440
CS-0331773
mg 4:0
(-)-d-glycerol 1-butyrate

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" This study investigates whether a butyric acid ester, monobutyrin (MB) affects lipid profiles and gut barrier function in a dose-response manner in rats fed butter- or lard-based high-fat diets."( Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets.
Hållenius, FF; Nguyen, TD; Nyman, M; Prykhodko, O, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
1-monoglycerideA monoglyceride in which the acyl substituent is located at position 1.
fatty acid esterA carboxylic ester in which the carboxylic acid component can be any fatty acid.
diolA compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.
butyrate esterAny carboxylic ester where the carboxylic acid component is butyric acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (50.00)18.2507
2000's0 (0.00)29.6817
2010's4 (28.57)24.3611
2020's3 (21.43)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.64 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.47 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (6.67%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (93.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
butyric acid
Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.. butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.. butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.		2.9440fatty acid 4:0;
straight-chain saturated fatty acid		human urinary metabolite;
Mycoplasma genitalium metabolite
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		2.7130alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
histamine
[no description available]		1.9810aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
2,4-dinitrophenol
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed). dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.. 2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.		1.9910dinitrophenolallergen;
antiseptic drug;
bacterial xenobiotic metabolite;
geroprotector;
oxidative phosphorylation inhibitor
corticosterone
[no description available]		2.411011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
tributyrin
tributyrin: structure. tributyrin : A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by butyric acid.		2.4320butyrate ester;
triglyceride		antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor;
prodrug;
protective agent
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		1.9910benzenes;
phenyl acetates
alprostadil
[no description available]		1.9710prostaglandins Eanticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent
glucagon
Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511). glucagon : A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.		1.9910peptide hormone
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.2510
Angiogenesis, Pathologic
[description not available]		02.3820
Di Guglielmo Disease
[description not available]		01.9810
Granulocytic Leukemia
[description not available]		01.9810
Leukemia, Erythroblastic, Acute
A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.		01.9810
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		01.9810
Alloxan Diabetes
[description not available]		01.9810
Diabetic Retinopathy
Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.		01.9810