Duodenal Reflux

Retrograde flow of duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the STOMACH.

Synonym
Duodeno-Gastric Reflux
Duodenogastric Reflux
Duodenal Reflux

Excerpt	Reference
"Duodenogastric reflux is a naturally occurring sporadic event, the incidence, occurrence, and detrimental effects of which have been difficult to assess."	( Barlow, AP; DeMeester, TR; Fuchs, KH; Gupta, NC; Hinder, RA; Stein, HJ, 1991)
"Duodenogastric reflux is possible after the BIL but not after the ROUX procedure."	( Decosse, JJ; Deschner, EE; Merle, S; Salmon, RJ; Sherlock, P; Zafrani, B, 1985)
"Although duodenogastric reflux is a physiological event, excessive reflux may be a pathogenetic factor in several diseases of the foregut, including cancer."	( Adrian, TE; Gasslander, T; Herrington, MK; Hinder, RA; Mukaida, H, 1995)
"The gastroduodenal reflux is considered, to be one of the important factors in the pathogenesis of gastritis and gastric ulcers."	( Kamińska, B; Korzon, M; Lass, P; Szarszewski, A, 1995)
"Duodenogastric reflux is believed to cause damage to gastric mucosa."	( Kamiñska, B; Korzon, M; Lass, P; Szarszewski, A, 1999)
"Duodenogastric reflux is a risk factor for gastric carcinogenesis, but the pathogenesis is not fully understood."	( Aase, S; Grong, K; Svanes, K; Sørbye, H; Øvrebø, KK, 2002)
"Duodenogastric reflux is common after biliary surgery, including endoscopic sphincterotomy."	( Chrysos, E; Fountos, A; Karkavitsas, N; Katsamouris, A; Tsiaoussis, J; Xynos, E; Zoras, OJ, 2003)
"Primary duodenogastric reflux is a rare disorder in adults which has not yet been documented in children."	( Buts, JP; Collard, JM; Hermans, D; Romagnoli, R; Sokal, EM, 2003)
"primary duodenogastric reflux is a rare foregut disorder of unknown origin occurring in late childhood."	( Buts, JP; Collard, JM; Hermans, D; Romagnoli, R; Sokal, EM, 2003)
"Duodenogastric reflux is known to cause an increased frequency of cancer in the glandular portion of the stomach in rats."	( Maartmann-Moe, H; Viste, A; Waldum, H; Øvrebø, K, 2004)
"Although duodenogastric reflux is a prerequisite for bile in the oesophagus, little is known about its importance in GORD."	( Fein, M; Fuchs, KH; Maroske, J, 2006)
"Gastroduodenal reflux is implicated in esophageal carcinogenesis."	( Bonde, P; Chen, L; Gao, D; Harmon, JW; Miyashita, T; Montgomery, E; Wei, C, 2007)

Excerpt	Reference
"Duodenogastric reflux has a deleterious effect on the gastric mucosa."	( Di Lorenzo, C; Dooley, CP; Rezende-Filho, J; Valenzuela, JE, 1989)
"Increased duodenogastric reflux has been recognized as a cause of gastric mucosa damage."	( Iazigi, N; Rezende Filho, J; Troncon, LE, 1988)
"Duodenogastric reflux has been implicated in the pathogenesis of gastric mucosal disease but the relative toxicities of its constituents are not known."	( Armstrong, D; Dowling, RH; Farrell, M; Hanby, A; Murphy, GM, 1988)
"3."	( Lübke, HJ; Wienbeck, M, 1987)
"Duodenogastric reflux has been associated with these symptoms in some patients."	( Liron-Ruiz, R; Lujan-Mompean, JA; Parrilla-Paricio, P; Ramirez-Romero, P; Robles-Campos, R; Torralba-Martinez, JA, 1994)
"Duodenogastric reflux has long been considered to be important in the pathogenesis of many gastric disorders that exhibit regional variation within the stomach."	( Anggiansah, A; Manifold, DK; Marshall, RE; Owen, WJ, 2001)
"Duodenogastric reflux has been implicated in the pathogenesis of gastric ulcer and gastritis."	( Hananoki, M; Haruma, K; Hata, J; Kusunoki, H; Nogi, K; Okajima, M; Onoda, Y; Taniguchi, H; Yomota, E, 2001)
"Duodenogastric reflux has not been studied in CF but has been suggested to have a pathogenic role in producing alkaline injury to the esophageal mucosa."	( Fändriks, L; Hallberg, K; Strandvik, B, 2004)

Excerpt	Reference
"In this study, the amount of duodenogastric reflux was assessed in patients who previously underwent proximal gastric vagotomy (PGV group; n = 11) and PGV plus duodenoplasty (PGV+D group; n = 10) as a treatment for duodenal ulcer."	( Andrade, JI; Barbieri Neto, J; Ceneviva, R; Hsien, CT; Morais, EN; Vicente, WV, 1992)
"We have studied the effect of chronic duodenogastric reflux on gastric tumor promotion in rats treated with N-methyl-N'-nitrosoguanidine (MNNG) in an experimental design that avoids physical trauma to the glandular stomach."	( DeCosse, JJ; Deschner, EE; Ivankovic, S; Lehnert, T, 1988)
"When the duodenal reflux animals were treated with a nitrite trapping agent, thiazolidine- 4-carboxylic acid (thioproline, TPRO), the levels of O(6)-CM-dG and 3-ESA-dC were reduced to the same levels as in the sham operation animals."	( Chen, KH; Hattori, T; Mukaisho, K; Nishimura, K; Sugimura, T; Takamura-Enya, T; Terasaki, M; Totsuka, Y; Wakabayashi, K, 2008)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	112 (37.58)	23.3326
1990's	90 (30.20)	12.5806
2000's	81 (27.18)	18.1394
2010's	13 (4.36)	28.8240
2020's	2 (0.67)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	1	0
choline	low	1	0
chlorine	low	1	0
glycine	low	4	0
hydrogen carbonate	low	4	0
histamine	low	3	0
nitrites	low	3	0
pyridoxal phosphate	low	1	0
1-anilino-8-naphthalenesulfonate	medium	2	1
aspirin	low	3	0
baclofen	medium	1	1
benzocaine	low	1	0
celecoxib	low	1	0
cimetidine	medium	4	1
cisapride	medium	7	6
clebopride	medium	1	1
pentetic acid	low	2	0
domperidone	medium	3	2
famotidine	medium	1	1
guaifenesin	low	5	0
haloperidol	low	1	0
indomethacin	low	1	0
ketamine	low	1	0
lansoprazole	low	1	0
metformin	low	1	0
metoclopramide	low	5	0
nimesulide	low	1	0
omeprazole	medium	12	4
ondansetron	low	1	0
pantoprazole	low	1	0
phenolsulfonphthalein	medium	3	2
rabeprazole	medium	2	1
sumatriptan	low	1	0
trimebutine	low	1	0
thymidine	low	2	0
carbachol	low	1	0
diethylnitrosamine	low	1	0
apomorphine	low	2	0
bromodeoxyuridine	low	2	0
edetic acid	low	1	0
methylene blue	low	1	0
taurocholic acid	medium	4	1
quinoxalines	low	1	0
iminodiacetic acid	low	3	0
oxazoles	low	1	0
thiazoles	low	4	0
thiocyanate	low	1	0
thiazolidine-4-carboxylic acid	low	1	0
chenodeoxycholic acid	low	2	0
thiazolidines	low	1	0
glycochenodeoxycholic acid	medium	2	1
erythromycin	low	2	0
deoxycytidine	low	1	0
n-nitroso-2,6-dimethylmorpholine	low	1	0
s,n,n'-tripropylthiocarbamate	low	1	0
manganese	low	1	0
technetium	low	42	0
barium sulfate	low	2	0
thallium chloride	low	2	0
n-amyl-n-methylnitrosamine	low	2	0
ursodeoxycholic acid	medium	2	1
amoxicillin	low	1	0
substance p	low	2	0
ng-nitroarginine methyl ester	low	1	0
lidofenin	low	1	0
fomesafen	low	1	0
clarithromycin	low	1	0
peroxynitrous acid	low	1	0
imatinib mesylate	low	1	0
23-seleno-25-homotaurocholic acid	low	1	0
jte 522	low	1	0
technetium tc 99m pentetate	medium	3	1
atropine	medium	3	1
cholic acid	low	1	0
deoxycholic acid	low	1	0
lithium chloride	low	1	0
n-acetylneuraminic acid	low	1	0
carbenoxolone sodium	low	1	0
sulindac	low	1	0
ranitidine	medium	2	1
orlistat	medium	1	1
alpha-chymotrypsin	low	2	0
bilirubin	medium	60	6
dinoprostone	low	7	0
morphine	low	1	0
lysophosphatidylcholines	low	11	0
neurokinin a	low	1	0
tin	low	1	0
aluminum	medium	2	1
thallium	low	2	0
indium	low	1	0
selenium	low	1	0
gadolinium dtpa	low	1	0
sincalide	low	3	0
pentagastrin	low	5	0
bismuth tripotassium dicitrate	low	1	0
technetium tc 99m disofenin	low	13	0
technetium tc 99m mebrofenin	low	4	0
indocyanine green	low	1	0
cytochrome c-t	low	1	0
cholecystokinin	low	11	0
ceruletide	medium	1	1
motilin	low	1	0
gastrins	low	20	0
phosphatidylcholines	low	2	0
technetium tc 99m sestamibi	medium	4	1
sodium pertechnetate tc 99m	low	4	0
piperidines	medium	3	3
interleukin-8	low	1	0
vasoactive intestinal peptide	low	2	0
mobic	low	3	0
n,n'-bis(pyridoxal-5-phosphate)ethylenediamine-n,n'-diacetic acid	low	1	0
technetium tc 99m lidofenin	medium	28	2
cyclin d1	low	2	0
technetium tc 99m sulfur colloid	low	4	0
vitamin b 12	low	1	0
oxyntomodulin	low	1	0
technetium tc-99m tetrofosmin	low	5	0
deoxyguanosine	low	2	0
guanosine	low	1	0
8-hydroxyguanosine	low	1	0
methylnitronitrosoguanidine	low	11	0
8-hydroxy-2'-deoxyguanosine	low	1	0
cholestyramine resin	low	3	0

Protein Targets (967)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	12	0	0	12
USP1 protein, partial	13	0	0	13
TDP1 protein	26	0	0	26
vitamin D3 receptor isoform VDRA	10	0	0	10
importin subunit beta-1 isoform 1	2	0	0	2
flap endonuclease 1	6	0	0	6
serine/threonine-protein kinase PLK1	5	0	0	5
snurportin-1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	12	0	0	12
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	27	0	0	27
DNA polymerase kappa isoform 1	8	0	0	8
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
estrogen nuclear receptor alpha	40	0	0	40
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	0	1	1
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Chain A, Beta-lactamase	9	0	0	9
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
AR protein	34	0	0	34
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	1
ATP-binding cassette sub-family C member 3	0	24	0	24
Multidrug resistance-associated protein 4	0	25	0	26
Bile salt export pump	0	2	0	3
Bile salt export pump	0	33	0	34
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	8	0	8
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	3	0	4
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	6	0	6
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	22	0	22
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Luciferase	12	0	0	12
acetylcholinesterase	12	0	0	12
phosphopantetheinyl transferase	11	0	0	11
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
RAR-related orphan receptor gamma	24	0	0	24
GLS protein	10	0	0	10
GLI family zinc finger 3	22	0	0	22
Microtubule-associated protein tau	11	0	0	11
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
estrogen receptor 2 (ER beta)	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	19	0	0	19
progesterone receptor	18	0	0	18
regulator of G-protein signaling 4	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	25	0	0	25
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
estrogen-related nuclear receptor alpha	31	0	0	31
farnesoid X nuclear receptor	13	0	0	13
cytochrome P450 2D6	15	0	0	15
peroxisome proliferator-activated receptor delta	16	0	0	16
peroxisome proliferator activated receptor gamma	15	0	0	15
euchromatic histone-lysine N-methyltransferase 2	23	0	0	23
aryl hydrocarbon receptor	14	0	0	14
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
thyroid stimulating hormone receptor	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
Histone H2A.x	10	0	0	10
cytochrome P450 2D6 isoform 1	7	0	0	7
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C19 precursor	7	0	0	7
cytochrome P450 2C9 precursor	8	0	0	8
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
thyroid hormone receptor beta isoform 2	19	0	0	19
mitogen-activated protein kinase 1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
nuclear receptor ROR-gamma isoform 1	7	0	0	7
peripheral myelin protein 22	13	0	0	13
cytochrome P450 3A4 isoform 1	14	0	0	14
lethal factor (plasmid)	6	0	0	6
lamin isoform A-delta10	19	0	0	19
Gamma-aminobutyric acid receptor subunit pi	14	2	0	16
Solute carrier family 22 member 1	0	10	0	14
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
Voltage-dependent calcium channel gamma-2 subunit	18	0	0	18
Cellular tumor antigen p53	13	0	0	13
Integrin beta-3	1	2	0	3
Integrin alpha-IIb	1	2	0	3
5-hydroxytryptamine receptor 1A	0	7	1	8
5-hydroxytryptamine receptor 2C	0	8	0	8
Tryptophan 5-hydroxylase 1	0	1	0	1
D(2) dopamine receptor	0	13	3	20
5-hydroxytryptamine receptor 2A	0	8	1	9
Gamma-aminobutyric acid receptor subunit beta-1	14	2	0	16
Alpha-1B adrenergic receptor	0	12	0	12
Gamma-aminobutyric acid receptor subunit delta	14	2	0	16
Gamma-aminobutyric acid receptor subunit gamma-2	14	2	1	17
D	0	8	0	9
D(3) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 1A	0	10	1	11
Alpha-2B adrenergic receptor	0	6	0	6
Glutamate receptor 2	18	0	0	18
Gamma-aminobutyric acid receptor subunit alpha-5	14	2	0	16
Gamma-aminobutyric acid receptor subunit alpha-3	14	2	0	16
D(2) dopamine receptor	0	5	0	5
D(1A) dopamine receptor	0	7	2	12
D(4) dopamine receptor	0	5	2	10
D(1B) dopamine receptor	0	4	0	6
Alpha-2C adrenergic receptor	0	6	0	6
Alpha-2A adrenergic receptor	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	14	2	0	16
Gamma-aminobutyric acid receptor subunit alpha-2	14	2	0	16
Alpha-1D adrenergic receptor	0	8	0	8
D(1B) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 2A	0	12	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	14	2	0	16
Gamma-aminobutyric acid receptor subunit gamma-3	14	2	0	16
5-hydroxytryptamine receptor 1B	0	8	0	8
5-hydroxytryptamine receptor 1D	0	7	1	8
Gamma-aminobutyric acid receptor subunit alpha-6	14	2	0	16
D(4) dopamine receptor	0	5	1	6
5-hydroxytryptamine receptor 1F	0	6	0	6
5-hydroxytryptamine receptor 2B	0	7	0	7
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	4	0	4
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
D(3) dopamine receptor	0	13	2	18
5-hydroxytryptamine receptor 3A	0	10	1	11
Alpha-1A adrenergic receptor	0	12	0	12
Histamine H2 receptor	12	2	2	18
5-hydroxytryptamine receptor 7	0	6	0	6
Spike glycoprotein	12	0	0	12
D(2) dopamine receptor	0	14	3	18
Gamma-aminobutyric acid receptor subunit alpha-1	14	4	1	19
Gamma-aminobutyric acid receptor subunit beta-3	14	2	0	16
Gamma-aminobutyric acid receptor subunit beta-2	14	2	1	17
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 4	0	3	1	6
GABA theta subunit	14	2	0	16
D	0	3	0	3
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	11	0	0	11
Sigma non-opioid intracellular receptor 1	0	6	1	7
Gamma-aminobutyric acid receptor subunit epsilon	14	2	0	16
5-hydroxytryptamine receptor 3B	0	10	1	11
ATP-dependent phosphofructokinase	14	0	0	14
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
interleukin 8	5	0	0	5
thyroid stimulating hormone receptor	12	0	0	12
hypothetical protein, conserved	2	0	0	2
EWS/FLI fusion protein	15	0	0	15
glucocorticoid receptor [Homo sapiens]	19	0	0	19
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	2	2
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
Bloom syndrome protein isoform 1	7	0	0	7
muscarinic acetylcholine receptor M1	10	0	0	10
Prostaglandin-H2 D-isomerase	0	2	0	2
Solute carrier family 22 member 6	0	5	0	5
Prostaglandin G/H synthase 1	0	3	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Epidermal growth factor receptor	0	3	0	3
Carbonic anhydrase 1	0	9	0	10
Carbonic anhydrase 2	0	9	0	11
Fatty acid-binding protein, liver	0	1	0	1
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	6	0	7
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	8
Adenosine receptor A1	0	4	0	5
Adenosine receptor A2a	0	2	0	3
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	11	2	14
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	6	0	0	6
Ras-related protein Rab-2A	0	0	2	2
Prostaglandin G/H synthase 2	0	6	0	6
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	1	4
retinoid X nuclear receptor alpha	15	0	0	15
pregnane X nuclear receptor	16	0	0	16
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	10	1	11
Muscarinic acetylcholine receptor M2	0	5	3	12
Muscarinic acetylcholine receptor M4	0	5	3	11
Muscarinic acetylcholine receptor M1	0	8	2	14
Muscarinic acetylcholine receptor M3	0	8	2	13
Muscarinic acetylcholine receptor M4	0	7	1	11
Muscarinic acetylcholine receptor M5	0	7	1	11
Muscarinic acetylcholine receptor M5	0	6	3	12
Muscarinic acetylcholine receptor M2	0	8	1	13
Muscarinic acetylcholine receptor M1	0	6	3	13
Muscarinic acetylcholine receptor M1	0	1	1	3
Muscarinic acetylcholine receptor M3	0	5	3	11
Alpha-1D adrenergic receptor	0	8	0	8
5-hydroxytryptamine receptor 2C	0	11	0	11
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	1	2
Muscarinic acetylcholine receptor	0	4	1	5
ATAD5 protein, partial	8	0	0	8
NFKB1 protein, partial	4	0	0	4
67.9K protein	5	0	0	5
activating transcription factor 6	12	0	0	12
D(1A) dopamine receptor	5	0	0	5
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
glp-1 receptor, partial	6	0	0	6
G	14	0	0	14
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
TAR DNA-binding protein 43	7	0	0	7
Inositol hexakisphosphate kinase 1	14	0	0	14
cytochrome P450 2C9, partial	14	0	0	14
Chain A, Cruzipain	5	0	0	5
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	7	0	10
Solute carrier organic anion transporter family member 1B1	0	7	0	9
pregnane X receptor	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
arylsulfatase A	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear hormone receptor family member daf-12	0	0	1	1
chromobox protein homolog 1	14	0	0	14
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
oxysterols receptor LXR-beta isoform 1	0	0	1	1
survival motor neuron protein isoform d	5	0	0	5
Thymidine kinase, cytosolic	0	4	0	7
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
GALC protein	5	0	0	5
thyrotropin-releasing hormone receptor	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	5	0	6
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	4	0	5
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Delta-type opioid receptor	0	2	0	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-9	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
SMAD family member 2	10	0	0	10
PPM1D protein	3	0	0	3
SMAD family member 3	10	0	0	10
Smad3	4	0	0	4
caspase 7, apoptosis-related cysteine protease	5	0	0	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
caspase-3	5	0	0	5
Caspase-7	2	0	0	2
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	2
thyroid hormone receptor beta isoform a	7	0	0	7
caspase-3	2	0	0	2
heat shock protein beta-1	6	0	0	6
Prostaglandin E synthase	0	3	0	3
Histone deacetylase 3	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	0	3
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	2	0	2
Carbonic anhydrase 3	0	1	0	2
Procathepsin L	0	3	0	3
Aldo-keto reductase family 1 member B1	0	6	0	6
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	4	0	4
Cytochrome P450 2D6	0	6	0	6
Beta-3 adrenergic receptor	0	3	0	3
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	10	2	12
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 4	0	5	0	6
Carbonic anhydrase 6	0	1	0	2
Sodium-dependent noradrenaline transporter	0	6	1	7
Cruzipain	0	2	0	2
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	4	0	4
Sodium-dependent serotonin transporter	0	8	0	8
Sodium-dependent serotonin transporter	0	2	1	3
Delta-type opioid receptor	0	5	1	7
Mu-type opioid receptor	0	5	2	10
Bifunctional epoxide hydrolase 2	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase	0	5	0	6
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	1	0	3
Histone deacetylase 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	5	0	5
Prostaglandin G/H synthase 2	0	3	0	4
Histone deacetylase 1	0	1	0	1
Carbonic anhydrase 9	0	2	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	3	0	3
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase	0	1	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	2
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Histone deacetylase 2	0	1	0	1
Carbonic anhydrase 4	0	2	0	3
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Carbonic anhydrase 15	0	5	0	6
Histone deacetylase 8	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Carbonic anhydrase 14	0	1	0	2
Histone deacetylase 5	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Alpha-2A adrenergic receptor	0	8	3	11
Vitamin D3 receptor	0	4	4	8
Alpha-2C adrenergic receptor	0	6	2	8
Retinoic acid receptor RXR-alpha	0	0	1	1
Ileal sodium/bile acid cotransporter	0	4	0	6
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	1	6	7
Bile acid receptor	0	0	5	5
Ubiquitin carboxyl-terminal hydrolase 2	0	2	0	2
Phospholipase A2	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	5	2	8
Glutamate receptor ionotropic, NMDA 2A	0	5	2	8
Glutamate receptor ionotropic, NMDA 2B	0	5	2	8
Glutamate receptor ionotropic, NMDA 2C	0	6	2	9
Glutamate receptor ionotropic, NMDA 2D	0	5	2	8
G-protein coupled bile acid receptor 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	5	2	8
Glutamate receptor ionotropic, NMDA 3A	0	5	2	8
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	6	0	10
Solute carrier family 22 member 2	0	2	0	2
Acetylcholinesterase	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Solute carrier family 22 member 1	0	4	0	7
High affinity choline transporter 1	0	1	0	1
Solute carrier family 22 member 2	0	4	0	6
alpha-galactosidase	5	0	0	5
M-phase phosphoprotein 8	6	0	0	6
ATP-dependent translocase ABCB1	0	4	0	4
ATP-dependent translocase ABCB1	0	11	0	12
Cytochrome P450 3A4	0	9	2	13
Potassium-transporting ATPase alpha chain 1	0	2	0	2
ATP-dependent translocase ABCB1	0	4	0	4
Histamine H2 receptor	0	5	2	7
Histamine H1 receptor	0	1	3	4
Potassium-transporting ATPase subunit beta	0	2	0	2
Aldehyde oxidase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	3
Multidrug and toxin extrusion protein 2	0	4	0	4
Solute carrier family 22 member 8	0	3	0	5
Multidrug and toxin extrusion protein 1	0	8	0	8
Histamine H4 receptor	0	3	2	5
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	3	0	3
5-hydroxytryptamine receptor 3E	0	3	2	6
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	1	3
5-hydroxytryptamine receptor 3B	0	3	2	6
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
Angiotensin-converting enzyme	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	1
Insulin receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Gastrin/cholecystokinin type B receptor	1	3	2	6
5-hydroxytryptamine receptor 7	0	4	0	4
Alpha-1A adrenergic receptor	0	3	0	3
Alpha-1B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	10	0	10
5-hydroxytryptamine receptor 3A	0	4	2	7
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	1	3
Potassium voltage-gated channel subfamily H member 2	0	11	0	11
5-hydroxytryptamine receptor 4	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	1	3
Sodium channel protein type 5 subunit alpha	0	2	0	2
Neutral alpha-glucosidase AB	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
5-hydroxytryptamine receptor 3D	0	3	2	6
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 3C	0	3	2	6
Heparanase	0	0	1	1
streptokinase A precursor	0	0	2	2
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	2
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	3
Solute carrier family 22 member 7	0	0	0	1
Fumarate hydratase	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
polyprotein	3	0	0	3
peripheral myelin protein 22 isoform 1	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Retinoic acid receptor RXR-alpha	0	1	1	2
Histamine H1 receptor	0	6	2	8
Mu-type opioid receptor	0	6	2	9
Kappa-type opioid receptor	0	4	1	6
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	1	2	0	3
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	4	0	0	4
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
Albumin	0	3	2	5
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
60 kDa heat shock protein, mitochondrial	0	1	0	1
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	2	0	2
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	1	1	2
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Purine nucleoside phosphorylase	0	0	0	1
Adenosylhomocysteinase	0	1	0	2
15-lipoxygenase, partial	4	0	0	4
Thrombopoietin	1	0	0	1
nonstructural protein 1	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Beta-2 adrenergic receptor	0	3	0	3
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	3
Beta-1 adrenergic receptor	0	2	0	2
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
5-hydroxytryptamine receptor 3A	0	3	0	3
Beta-3 adrenergic receptor	0	2	0	2
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Histamine H1 receptor	0	5	1	6
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Kappa-type opioid receptor	0	4	1	6
5-hydroxytryptamine receptor 2A	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
5-hydroxytryptamine receptor 6	0	1	0	2
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	3	0	3
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	3	0	4
Plasma kallikrein	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
5-hydroxytryptamine receptor 1D	0	2	1	5
Metabotropic glutamate receptor 5	0	1	1	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Histamine H3 receptor	0	1	2	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Tyrosine-protein kinase ABL1	0	1	1	2
Cytochrome P450 2C8	0	0	0	1
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	0	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	2	0	3
Lactoylglutathione lyase	0	2	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	4	0	4
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	3
Replicase polyprotein 1ab	0	1	0	1
Microtubule-associated protein tau	0	2	1	3
Sodium/potassium-transporting ATPase subunit alpha-3	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-2	0	3	0	3
Cytochrome P450 2C19	0	3	0	4
Alpha-synuclein	3	0	0	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	0	1
Fatty acid synthase	0	10	0	10
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-3	0	3	0	3
Sodium/potassium-transporting ATPase subunit gamma	0	3	0	3
WD repeat-containing protein 5	0	3	0	3
Histone-lysine N-methyltransferase 2A	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-4	0	3	0	3
Cytosolic endo-beta-N-acetylglucosaminidase	0	3	0	3
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	4
inositol monophosphatase 1	1	0	0	1
Cholecystokinin receptor type A	1	4	0	5
Glycogen synthase kinase-3 beta	0	1	1	2
Chain A, Ferritin light chain	4	0	0	4
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
huntingtin isoform 2	2	0	0	2
pyruvate kinase PKM isoform a	2	0	0	2
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Vpr	1	0	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	3
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Translocator protein	0	1	1	2
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	3	1	5
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	2	5
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	2	2
Mu-type opioid receptor	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Neuromedin-K receptor	0	0	2	2
Substance-K receptor	0	1	2	3
Substance-K receptor	0	4	0	5
Substance-P receptor	0	3	1	4
Neuromedin-K receptor	0	2	2	4
Substance-K receptor	0	2	0	2
Substance-K receptor	0	2	0	2
Substance-K receptor	0	1	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Collagenase 3	0	1	0	1
Interstitial collagenase	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Aromatase	0	1	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
ClpP	1	0	0	1
Mcl-1	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Glutathione S-transferase omega-1	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Interleukin-6 receptor subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
Histamine H3 receptor	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Nischarin	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Phosphatidylserine lipase ABHD16A	0	1	0	1
Pancreatic triacylglycerol lipase	0	2	0	3
Lipoprotein lipase	0	1	0	1
Hepatic triacylglycerol lipase	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Proteasome subunit beta type-5	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Proteasome subunit beta type-2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Neutral cholesterol ester hydrolase 1	0	1	0	1
Diacylglycerol lipase-alpha	0	1	0	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Diacylglycerol lipase-beta	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Acyl-protein thioesterase 2	0	1	0	1
Diacylglycerol lipase-alpha	0	1	0	1
Endothelial lipase	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	3	3	6
endonuclease IV	1	0	0	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Insulin-degrading enzyme	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Cholecystokinin receptor type A	0	2	2	4
Substance-P receptor	0	2	0	2
Growth hormone secretagogue receptor type 1	0	0	1	1
Aldo-keto reductase family 1 member B10	0	1	0	1
Complement C5	0	0	1	1
Carboxypeptidase M	0	1	0	1
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
ATP-binding cassette sub-family C member 3	0	0	0	1
Sodium/bile acid cotransporter	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Sodium/bile acid cotransporter	0	2	0	3
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Glucocorticoid receptor	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (298)

Protein Targets (967)

Duodenal Reflux

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (298)

Drugs Studied (140)

Protein Targets (967)