Bile Reflux

Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (DUODENOGASTRIC REFLUX); to the esophagus (GASTROESOPHAGEAL REFLUX); or to the PANCREAS.

Synonym
Bile Reflux

Excerpt	Reference
"Both acid and bile reflux is significantly suppressed by proton pump inhibitor therapy with exceptions among individual esophagitis patients."	( Menges, M; Müller, M; Zeitz, M, 2001)
"Combined acid and bile reflux is associated with severe esophagitis."	( Markovic, S; Orel, R, 2003)
"The degree of bile reflux is an important index for clinical diagnosis of stomach diseases."	( Fan, YM; Huang, WL; Lo, RC, 2015)

Excerpt	Reference
"Bile reflux has been postulated to be an important factor contributing to gastroesophageal reflux disease in adults."	( Markovic, S; Orel, R, 2003)
"Bile reflux has recently been documented as an independent risk factor for NFκB-mediated hypopharyngeal squamous cell carcinoma."	( Doukas, PG; Doukas, SG; Judson, BL; Tsatsakis, A; Vageli, DP, 2022)

Excerpt	Reference
"It remains unclear how patients with treatment-resistant bile reflux should be managed."	( Brecelj, J; Heuschkel, R; Homan, M; Orel, R, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	98 (46.67)	23.3326
1990's	51 (24.29)	12.5806
2000's	34 (16.19)	18.1394
2010's	17 (8.10)	28.8240
2020's	10 (4.76)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
hydrochloric acid	low	2	0
glycine	low	2	0
hydrogen carbonate	low	3	0
histamine	low	4	0
nitrates	low	1	0
nitrites	low	2	0
1-anilino-8-naphthalenesulfonate	low	5	0
aspirin	low	3	0
baclofen	low	1	0
cimetidine	low	1	0
cisapride	low	1	0
pentetic acid	low	1	0
dipyridamole	low	1	0
domperidone	medium	3	2
famotidine	low	1	0
guaifenesin	low	3	0
haloperidol	low	1	0
indomethacin	low	1	0
lorglumide	low	1	0
metoclopramide	low	3	0
omeprazole	medium	6	2
ondansetron	low	1	0
pantoprazole	medium	3	1
procaine	low	1	0
proglumide	low	1	0
rabeprazole	medium	2	1
sulfobromophthalein	low	1	0
trimipramine	medium	1	1
thymidine	low	2	0
carbon tetrachloride	low	1	0
apomorphine	low	2	0
bromodeoxyuridine	low	2	0
taurocholic acid	low	8	0
iminodiacetic acid	low	3	0
isoxazoles	low	1	0
thiocyanate	low	1	0
chenodeoxycholic acid	medium	3	1
glycocholic acid	medium	1	1
erythromycin	low	1	0
sodium hydroxide	medium	2	1
n-nitroso-2,6-dimethylmorpholine	low	1	0
technetium	low	31	0
barium sulfate	low	4	0
ursodeoxycholic acid	medium	4	2
ng-nitroarginine methyl ester	low	2	0
diisopropanolnitrosamine	low	1	0
lidofenin	low	1	0
nitrosobis(2-oxopropyl)amine	low	2	0
fomesafen	low	1	0
aluminum phosphate	low	1	0
p-methoxy-n-methylphenethylamine	low	1	0
u 73122	low	1	0
caprylates	low	1	0
23-seleno-25-homotaurocholic acid	low	1	0
technetium tc 99m pentetate	low	2	0
atropine	medium	5	1
cholic acid	low	1	0
deoxycholic acid	medium	4	2
taurochenodeoxycholic acid	low	2	0
tretinoin	low	1	0
sodium bicarbonate	low	1	0
bromochloroacetic acid	low	1	0
curcumin	low	1	0
sodium taurodeoxycholate	low	5	0
ranitidine	medium	2	1
monooctanoin	low	1	0
bilirubin	medium	30	5
dinoprostone	medium	1	1
geranylgeranylacetone	low	1	0
etretinate	low	1	0
16,16-dimethylprostaglandin e2	low	1	0
morphine	low	1	0
lysophosphatidylcholines	low	8	0
tin	low	1	0
barium	medium	1	1
aluminum	low	1	0
indium	low	1	0
sulfur	low	1	0
selenium	low	1	0
sincalide	low	1	0
pentagastrin	low	1	0
gw 4064	low	1	0
technetium tc 99m disofenin	low	11	0
technetium tc 99m mebrofenin	low	2	0
nad	low	1	0
cholecystokinin	low	8	0
ceruletide	low	1	0
gastrins	medium	10	2
glucagon	low	2	0
cellulose	medium	1	1
phosphatidylcholines	low	5	0
technetium tc 99m sestamibi	low	3	0
piperidines	medium	1	1
interleukin-8	low	1	0
technetium tc 99m lidofenin	low	21	0
technetium tc 99m sulfur colloid	low	2	0
methylnitronitrosoguanidine	low	3	0
cholestyramine resin	medium	4	1
phosphorus radioisotopes	low	1	0

Protein Targets (893)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	3	0	0	3
thioredoxin reductase	12	0	0	12
USP1 protein, partial	11	0	0	11
TDP1 protein	19	0	0	19
vitamin D3 receptor isoform VDRA	12	0	0	12
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	5	0	0	5
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	9	0	0	9
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
geminin	19	0	0	19
DNA polymerase kappa isoform 1	10	0	0	10
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Luciferase	9	0	0	9
acetylcholinesterase	10	0	0	10
phosphopantetheinyl transferase	9	0	0	9
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
RAR-related orphan receptor gamma	23	0	0	23
GLS protein	7	0	0	7
GLI family zinc finger 3	17	0	0	17
Microtubule-associated protein tau	10	0	0	10
AR protein	27	0	0	27
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
estrogen receptor 2 (ER beta)	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	16	0	0	16
progesterone receptor	12	0	0	12
regulator of G-protein signaling 4	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	15	0	0	15
estrogen-related nuclear receptor alpha	23	0	0	23
farnesoid X nuclear receptor	12	0	0	12
estrogen nuclear receptor alpha	25	0	0	25
cytochrome P450 2D6	13	0	0	13
peroxisome proliferator-activated receptor delta	15	0	0	15
peroxisome proliferator activated receptor gamma	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	21	0	0	21
aryl hydrocarbon receptor	13	0	0	13
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
thyroid stimulating hormone receptor	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	7	0	0	7
cytochrome P450 2D6 isoform 1	7	0	0	7
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 2C19 precursor	7	0	0	7
cytochrome P450 2C9 precursor	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	10	0	0	10
thyroid hormone receptor beta isoform 2	20	0	0	20
mitogen-activated protein kinase 1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	16	0	0	16
nuclear receptor ROR-gamma isoform 1	8	0	0	8
peripheral myelin protein 22	13	0	0	13
cytochrome P450 3A4 isoform 1	10	0	0	10
lethal factor (plasmid)	7	0	0	7
lamin isoform A-delta10	15	0	0	15
Gamma-aminobutyric acid receptor subunit pi	10	2	0	12
Solute carrier family 22 member 1	0	11	0	13
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
ATP-binding cassette sub-family C member 3	0	16	0	16
Multidrug resistance-associated protein 4	0	20	0	21
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Bile salt export pump	0	26	0	29
Cellular tumor antigen p53	15	0	0	15
Integrin beta-3	2	2	0	4
Integrin alpha-IIb	2	2	0	4
5-hydroxytryptamine receptor 1A	0	5	0	5
5-hydroxytryptamine receptor 2C	0	6	0	6
Tryptophan 5-hydroxylase 1	0	1	0	1
D(2) dopamine receptor	0	11	3	18
5-hydroxytryptamine receptor 2A	0	6	1	7
Gamma-aminobutyric acid receptor subunit beta-1	10	2	0	12
Alpha-1B adrenergic receptor	0	11	0	11
Gamma-aminobutyric acid receptor subunit delta	10	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	10	2	1	13
D	0	8	0	9
D(3) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 1A	0	8	0	8
Alpha-2B adrenergic receptor	0	5	0	5
Glutamate receptor 2	11	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	10	2	0	12
D(2) dopamine receptor	0	5	0	5
D(1A) dopamine receptor	0	5	2	10
D(4) dopamine receptor	0	4	2	9
D(1B) dopamine receptor	0	4	0	6
Alpha-2C adrenergic receptor	0	5	0	5
Alpha-2A adrenergic receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	10	2	0	12
Alpha-1D adrenergic receptor	0	8	0	8
D(1B) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 2A	0	10	0	10
Gamma-aminobutyric acid receptor subunit alpha-4	10	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	10	2	0	12
5-hydroxytryptamine receptor 1B	0	6	0	6
5-hydroxytryptamine receptor 1D	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	10	2	0	12
D(4) dopamine receptor	0	5	1	6
5-hydroxytryptamine receptor 1F	0	6	0	6
5-hydroxytryptamine receptor 2B	0	6	0	6
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	4	0	4
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
D(3) dopamine receptor	0	12	2	17
5-hydroxytryptamine receptor 3A	0	8	1	9
Alpha-1A adrenergic receptor	0	11	0	11
Histamine H2 receptor	8	2	2	14
5-hydroxytryptamine receptor 7	0	7	0	7
Spike glycoprotein	10	0	0	10
D(2) dopamine receptor	0	10	2	13
Gamma-aminobutyric acid receptor subunit alpha-1	10	3	1	14
Gamma-aminobutyric acid receptor subunit beta-3	10	2	0	12
Gamma-aminobutyric acid receptor subunit beta-2	10	2	1	13
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 4	0	3	1	6
GABA theta subunit	10	2	0	12
Canalicular multispecific organic anion transporter 1	0	16	0	16
D	0	3	0	3
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	9	0	0	9
Sigma non-opioid intracellular receptor 1	0	6	1	7
Gamma-aminobutyric acid receptor subunit epsilon	10	2	0	12
5-hydroxytryptamine receptor 3B	0	8	1	9
ATP-dependent phosphofructokinase	10	0	0	10
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	12	0	0	12
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	6	0	0	6
thyroid stimulating hormone receptor	11	0	0	11
hypothetical protein, conserved	1	0	0	1
EWS/FLI fusion protein	12	0	0	13
glucocorticoid receptor [Homo sapiens]	19	0	0	19
glucocerebrosidase	5	0	0	5
Rac1 protein	0	0	1	1
IDH1	5	0	0	5
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	7	0	0	7
muscarinic acetylcholine receptor M1	9	0	0	9
Prostaglandin-H2 D-isomerase	0	2	0	2
Solute carrier family 22 member 6	0	5	0	5
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Epidermal growth factor receptor	0	2	0	2
Carbonic anhydrase 1	0	9	0	10
Carbonic anhydrase 2	0	9	0	11
Fatty acid-binding protein, liver	0	1	0	1
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	4	0	5
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	3	0	4
Adenosine receptor A2a	0	2	0	3
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	6	1	7
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	6	1	1	8
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	1	4
retinoid X nuclear receptor alpha	13	0	0	13
pregnane X nuclear receptor	14	0	0	14
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	10	1	11
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M4	0	3	1	6
Muscarinic acetylcholine receptor M1	0	6	1	9
Muscarinic acetylcholine receptor M3	0	6	1	9
Muscarinic acetylcholine receptor M4	0	5	1	8
Muscarinic acetylcholine receptor M5	0	5	1	8
Muscarinic acetylcholine receptor M5	0	4	1	7
Muscarinic acetylcholine receptor M2	0	6	1	10
Muscarinic acetylcholine receptor M1	0	4	1	8
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	3	1	6
Alpha-1D adrenergic receptor	0	8	0	8
5-hydroxytryptamine receptor 2C	0	10	0	10
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	2	1	3
ATAD5 protein, partial	6	0	0	6
NFKB1 protein, partial	5	0	0	5
67.9K protein	3	0	0	3
activating transcription factor 6	9	0	0	9
D(1A) dopamine receptor	6	0	0	6
histone acetyltransferase KAT2A isoform 1	10	0	0	10
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, Cruzipain	7	0	0	7
caspase-1 isoform alpha precursor	3	0	0	3
Caspase-7	3	0	0	3
Inositol monophosphatase 1	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	4	0	7
Solute carrier organic anion transporter family member 1B1	0	4	0	6
pregnane X receptor	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
arylsulfatase A	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Nuclear hormone receptor family member daf-12	0	0	1	1
chromobox protein homolog 1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	5
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
oxysterols receptor LXR-beta isoform 1	0	0	1	1
survival motor neuron protein isoform d	5	0	0	5
Thymidine kinase, cytosolic	0	3	0	5
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
Chain A, Beta-lactoglobulin	0	0	1	1
Chain A, Beta-lactoglobulin	0	0	1	1
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0	0	1	1
Cytochrome P450 2E1	0	1	0	1
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
caspase 7, apoptosis-related cysteine protease	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
caspase-3	4	0	0	4
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Alpha-2A adrenergic receptor	0	8	3	11
Vitamin D3 receptor	0	5	4	9
Alpha-2B adrenergic receptor	0	8	2	10
Alpha-2C adrenergic receptor	0	6	2	8
Retinoic acid receptor RXR-alpha	0	1	3	4
Ileal sodium/bile acid cotransporter	0	6	0	7
TAR DNA-binding protein 43	7	0	0	7
Bile acid receptor	0	0	2	2
G-protein coupled bile acid receptor 1	0	1	8	9
Bile acid receptor	0	1	6	8
Ubiquitin carboxyl-terminal hydrolase 2	0	2	0	2
Phospholipase A2	0	1	1	2
Glutamate receptor ionotropic, NMDA 1	0	3	2	6
Glutamate receptor ionotropic, NMDA 2A	0	3	2	6
Glutamate receptor ionotropic, NMDA 2B	0	3	2	6
Glutamate receptor ionotropic, NMDA 2C	0	4	2	7
Glutamate receptor ionotropic, NMDA 2D	0	3	2	6
G-protein coupled bile acid receptor 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	2	6
Glutamate receptor ionotropic, NMDA 3A	0	3	2	6
G	9	0	0	9
alpha-galactosidase	2	0	0	2
M-phase phosphoprotein 8	5	0	0	5
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	6	0	9
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	0	3
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
ATP-dependent translocase ABCB1	0	4	0	4
ATP-dependent translocase ABCB1	0	10	0	11
Cytochrome P450 3A4	0	7	4	12
Cytochrome P450 2D6	0	4	1	5
Cytochrome P450 2C9	0	5	1	6
Potassium-transporting ATPase alpha chain 1	0	2	0	2
ATP-dependent translocase ABCB1	0	4	0	4
Histamine H2 receptor	0	5	2	7
Histamine H1 receptor	0	1	3	4
Potassium-transporting ATPase subunit beta	0	2	0	2
Cytochrome P450 2J2	0	4	0	4
Aldehyde oxidase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 1	0	3	0	4
Multidrug and toxin extrusion protein 2	0	5	0	5
Solute carrier family 22 member 8	0	3	0	5
Inositol hexakisphosphate kinase 1	9	0	0	9
Multidrug and toxin extrusion protein 1	0	7	0	7
Histamine H4 receptor	0	3	2	5
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	3	0	3
cytochrome P450 2C9, partial	9	0	0	9
5-hydroxytryptamine receptor 3E	0	2	2	5
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	2	5
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
Angiotensin-converting enzyme	0	3	0	3
Beta-3 adrenergic receptor	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Insulin receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Gastrin/cholecystokinin type B receptor	0	3	2	5
Sodium-dependent serotonin transporter	0	6	0	6
5-hydroxytryptamine receptor 7	0	3	0	3
Alpha-1A adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	12	0	12
5-hydroxytryptamine receptor 3A	0	3	2	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
5-hydroxytryptamine receptor 4	0	2	2	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Neutral alpha-glucosidase AB	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
5-hydroxytryptamine receptor 3D	0	2	2	5
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 3C	0	2	2	5
Heparanase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Chain A, Ferritin light chain	6	0	0	6
Nrf2	1	0	0	1
15-lipoxygenase, partial	4	0	0	4
alkaline phosphatase, intestinal	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
Smad3	4	0	0	4
apical membrane antigen 1, AMA1	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
PINK1	1	0	0	1
Parkin	3	0	0	3
toll-like receptor 9	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
TPA: protein transporter TIM10	0	1	0	1
thyrotropin-releasing hormone receptor	3	0	0	3
lysosomal alpha-glucosidase preproprotein	2	0	0	2
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
thyroid hormone receptor beta isoform a	7	0	0	7
perilipin-1	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
heat shock protein beta-1	6	0	0	6
huntingtin isoform 2	2	0	0	2
pyruvate kinase PKM isoform a	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
tumor susceptibility gene 101 protein	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
hypothetical protein SA1422	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
Prostaglandin E synthase	0	2	0	2
Histone deacetylase 3	0	1	0	1
Acetylcholinesterase	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Amyloid-beta precursor protein	0	2	0	3
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cholinesterase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
60 kDa chaperonin	0	3	0	3
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Microtubule-associated protein tau	0	1	0	2
60 kDa heat shock protein, mitochondrial	0	3	0	3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	1	0	1
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Acetylcholinesterase	0	2	0	2
Heme oxygenase 2	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Proteasome subunit beta type-5	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-synuclein	2	2	1	5
Glycogen synthase kinase-3 beta	0	1	0	1
Histone deacetylase 4	0	1	0	1
Beta-secretase 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	3	0	3
Cholinesterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Lactoylglutathione lyase	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Histone deacetylase 1	0	2	0	2
Sodium/bile acid cotransporter	0	2	1	4
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thiosulfate sulfurtransferase	0	3	0	3
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
CREB-binding protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Histone deacetylase 8	0	2	0	2
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	5
Histone deacetylase 5	0	1	0	1
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	5
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	3
Solute carrier family 22 member 7	0	0	0	1
Chain A, Beta-lactamase	8	0	0	8
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
Fumarate hydratase	3	0	0	3
Thrombopoietin	2	0	0	2
DNA polymerase III, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
nonstructural protein 1	4	0	0	4
LANA	0	0	0	1
NPYLR7B	0	0	1	1
polyprotein	3	0	0	3
serine-protein kinase ATM isoform a	1	0	0	1
peripheral myelin protein 22 isoform 1	5	0	0	5
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
GALC protein	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Retinoic acid receptor RXR-alpha	0	2	3	5
Sodium-dependent noradrenaline transporter	0	4	0	4
Histamine H1 receptor	0	6	2	8
Mu-type opioid receptor	0	6	2	9
Kappa-type opioid receptor	0	4	1	6
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
streptokinase A precursor	0	0	1	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
Albumin	0	1	2	3
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	1	1	2
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	5
Solute carrier organic anion transporter family member 1A1	0	1	0	5
Multidrug resistance associated protein	0	1	0	3
Bile salt export pump	0	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
glp-1 receptor, partial	1	0	0	1
Adenylate cyclase type 1	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Beta-2 adrenergic receptor	0	3	0	3
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	3
Beta-1 adrenergic receptor	0	2	0	2
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
5-hydroxytryptamine receptor 3A	0	3	0	3
Beta-3 adrenergic receptor	0	2	0	2
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Histamine H1 receptor	0	5	1	6
Sodium-dependent serotonin transporter	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	5	2	10
5-hydroxytryptamine receptor 2C	0	1	0	1
Kappa-type opioid receptor	0	4	1	6
5-hydroxytryptamine receptor 2A	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
Kappa-type opioid receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
5-hydroxytryptamine receptor 6	0	1	0	2
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	5	0	5
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	0	0	1
Solute carrier family 22 member 3	0	3	0	4
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	6	0	7
Carbonic anhydrase 6	0	1	0	2
5-hydroxytryptamine receptor 1D	0	0	0	1
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase	0	6	0	7
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	2	0	3
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	4	0	5
Carbonic anhydrase 13	0	1	0	2
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
Histamine H3 receptor	0	1	2	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
ras-related protein Rab-9A	1	0	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Procathepsin L	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	3	0	3
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	2	0	3
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Cholecystokinin receptor type A	0	7	0	7
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Delta-type opioid receptor	0	1	0	2
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	2	5
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Collagenase 3	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
ClpP	1	0	0	1
Mcl-1	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Cytochrome P450 2C19	0	1	1	3
UDP-glucuronosyltransferase 2B10	0	1	0	1
Fatty acid synthase	0	6	0	6
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
WD repeat-containing protein 5	0	2	0	2
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Cytosolic endo-beta-N-acetylglucosaminidase	0	2	0	2
5-hydroxytryptamine receptor 3A	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Interleukin-6 receptor subunit alpha	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
Histamine H3 receptor	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Nischarin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	3	3	6
endonuclease IV	2	0	0	2
Histamine H2 receptor	0	1	0	1
Adenosine receptor A3	0	4	0	4
Insulin-degrading enzyme	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Cholecystokinin receptor type A	0	2	2	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Hematopoietic prostaglandin D synthase	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Bile salt export pump	0	0	0	2
Sodium/bile acid cotransporter	0	0	0	1
ATP-binding cassette sub-family C member 3	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Cytochrome P450 1A2	0	0	1	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Nuclear receptor ROR-beta	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Telomerase reverse transcriptase	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Glucocorticoid receptor	0	0	1	1
M1-family alanyl aminopeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (210)

Protein Targets (893)

Bile Reflux

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (210)

Drugs Studied (116)

Protein Targets (893)