histamine has been researched along with Parkinson Disease in 34 studies
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Diurnal fluctuation in histidine decarboxylase expression, the rate limiting enzyme for histamine production, and its disorder in neurodegenerative diseases." | 7.78 | Diurnal fluctuation in histidine decarboxylase expression, the rate limiting enzyme for histamine production, and its disorder in neurodegenerative diseases. ( Bao, AM; Hofman, MA; Shan, L; Swaab Dick, F; Van Someren, EJ; van Wamelen, DJ, 2012) |
| "We investigated histamine concentration in post-mortem brain samples of patients with Parkinson's disease (PD, n = 24), multiple system atrophy (MSA, n = 8) and age-matched controls (n = 27)." | 7.71 | Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy. ( Anichtchik, OV; Eriksson, KS; Kalimo, H; Kaslin, J; Panula, P; Rinne, JO; Röyttä, M; Tuomisto, L, 2002) |
| "Several hypotheses have been raised about the dual role of histamine in neurological disorders, and evidences have shown its crucial involvement in the modulation of microglia-mediated neuroinflammation." | 4.95 | Dual role of histamine on microglia-induced neurodegeneration. ( Barata-Antunes, S; Bernardino, L; Cristóvão, AC; Pires, J; Rocha, SM, 2017) |
| " Diurnal fluctuation in histidine decarboxylase expression, the rate limiting enzyme for histamine production, and its disorder in neurodegenerative diseases." | 3.78 | Diurnal fluctuation in histidine decarboxylase expression, the rate limiting enzyme for histamine production, and its disorder in neurodegenerative diseases. ( Bao, AM; Hofman, MA; Shan, L; Swaab Dick, F; Van Someren, EJ; van Wamelen, DJ, 2012) |
| "We investigated histamine concentration in post-mortem brain samples of patients with Parkinson's disease (PD, n = 24), multiple system atrophy (MSA, n = 8) and age-matched controls (n = 27)." | 3.71 | Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy. ( Anichtchik, OV; Eriksson, KS; Kalimo, H; Kaslin, J; Panula, P; Rinne, JO; Röyttä, M; Tuomisto, L, 2002) |
| "Blood histamine and serum histaminase activity were determined in a group of patients with Parkinson disease (PD) and in a group of healthy controls." | 3.68 | Decrease in blood histamine in drug-treated parkinsonian patients. ( Azevedo, MS; Coelho, MH; Manso, CF; Silva, IJ, 1991) |
| "Histamine was also found to damage the dopaminergic neurons in rat substantia nigra." | 1.38 | Histamine- and haloperidol-induced catalepsy in aged mice: differential responsiveness to L-DOPA. ( Ionov, ID; Severtsev, NN, 2012) |
| "Histamine content was significantly increased in the hypothalamus, hipocampus, and medulla oblongata." | 1.35 | Histaminergic activity in a rodent model of Parkinson's disease. ( Brus, H; Brus, R; Drab, J; Jochem, J; Körossy, E; Kostrzewa, RM; Noras, L; Nowak, P; Szkilnik, R, 2009) |
| "Histaminergic agents were given prior and daily for 1, 7 or 14 days after 6-OHDA infusion." | 1.34 | Involvement of brain endogenous histamine in the degeneration of dopaminergic neurons in 6-hydroxydopamine-lesioned rats. ( Chen, Z; Hu, DN; Liu, CQ; Liu, FX; Luo, JH, 2007) |
| "Histamine in human SN was stored in fibers and varicosities." | 1.31 | An altered histaminergic innervation of the substantia nigra in Parkinson's disease. ( Anichtchik, OV; Kalimo, H; Panula, P; Rinne, JO, 2000) |
| "Parkinson's disease is a major neurological disorder that primarily affects the nigral dopaminergic cells." | 1.31 | Modulation of histamine H3 receptors in the brain of 6-hydroxydopamine-lesioned rats. ( Anichtchik, OV; Haycock, JW; Huotari, M; Männistö, PT; Panula, P; Peitsaro, N, 2000) |
| "To estimate the effect of long-term administration of L-3,4-dihydroxyphenylalanine (L-Dopa) on methylation of compounds not formed from it, the urinary excretion of histamine and its methylated metabolites was studied in rats and guinea pigs fed L-Dopa in their diets and in patients with Parkinson's disease being treated with L-Dopa." | 1.25 | Effect of L-DOPA on endogenous histamine metabolism. ( Muenter, MD; Sharpless, NS; Tyce, GM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (23.53) | 18.7374 |
| 1990's | 5 (14.71) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 10 (29.41) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, A | 2 |
| Muresanu, DF | 2 |
| Patnaik, R | 1 |
| Menon, PK | 1 |
| Tian, ZR | 2 |
| Sahib, S | 1 |
| Castellani, RJ | 1 |
| Nozari, A | 2 |
| Lafuente, JV | 2 |
| Buzoianu, AD | 2 |
| Skaper, SD | 1 |
| Bryukhovetskiy, I | 1 |
| Manzhulo, I | 1 |
| Wiklund, L | 2 |
| Sharma, HS | 2 |
| Feng, L | 1 |
| Huang, H | 1 |
| Chen, L | 1 |
| Chen, YC | 2 |
| Baronio, D | 1 |
| Semenova, S | 2 |
| Abdurakhmanova, S | 1 |
| Panula, P | 5 |
| Zhou, P | 1 |
| Homberg, JR | 1 |
| Fang, Q | 1 |
| Wang, J | 1 |
| Li, W | 1 |
| Meng, X | 1 |
| Shen, J | 1 |
| Luan, Y | 1 |
| Liao, P | 1 |
| Swaab, DF | 3 |
| Shan, L | 5 |
| Liu, C | 2 |
| Bañuelos-Cabrera, I | 1 |
| Valle-Dorado, MG | 1 |
| Aldana, BI | 1 |
| Orozco-Suárez, SA | 1 |
| Rocha, L | 1 |
| Yang, X | 1 |
| Zhang, J | 1 |
| Han, H | 1 |
| Wang, X | 1 |
| Liu, Z | 1 |
| Xu, Y | 1 |
| Dauvilliers, Y | 1 |
| Siegel, JM | 1 |
| Rozov, S | 1 |
| Sundvik, M | 1 |
| Bonkowsky, JL | 1 |
| Barata-Antunes, S | 1 |
| Cristóvão, AC | 1 |
| Pires, J | 1 |
| Rocha, SM | 1 |
| Bernardino, L | 1 |
| Ionov, ID | 2 |
| Nowak, P | 1 |
| Noras, L | 1 |
| Jochem, J | 1 |
| Szkilnik, R | 1 |
| Brus, H | 1 |
| Körossy, E | 1 |
| Drab, J | 1 |
| Kostrzewa, RM | 1 |
| Brus, R | 1 |
| Liu, CQ | 2 |
| Balesar, R | 2 |
| Hofman, MA | 2 |
| Bao, AM | 3 |
| Bossers, K | 1 |
| Luchetti, S | 1 |
| Lethbridge, N | 1 |
| Chazot, PL | 1 |
| Severtsev, NN | 1 |
| van Wamelen, DJ | 1 |
| Van Someren, EJ | 1 |
| Swaab Dick, F | 1 |
| Chen, Z | 2 |
| Hu, WW | 1 |
| DENKER, P | 1 |
| EFFRON, AS | 1 |
| WINTHER, K | 1 |
| Liu, FX | 1 |
| Hu, DN | 1 |
| Luo, JH | 1 |
| Agúndez, JA | 1 |
| Luengo, A | 1 |
| Herráez, O | 1 |
| Martínez, C | 1 |
| Alonso-Navarro, H | 1 |
| Jiménez-Jiménez, FJ | 1 |
| García-Martín, E | 1 |
| Garbarg, M | 1 |
| Javoy-Agid, F | 1 |
| Schwartz, JC | 1 |
| Agid, Y | 1 |
| Baron, R | 1 |
| Feldmann, R | 1 |
| Lindner, V | 1 |
| Nakamura, S | 1 |
| Ohnishi, K | 1 |
| Nishimura, M | 1 |
| Suenaga, T | 1 |
| Akiguchi, I | 1 |
| Kimura, J | 1 |
| Kimura, T | 1 |
| Goodchild, RE | 1 |
| Court, JA | 1 |
| Hobson, I | 1 |
| Piggott, MA | 1 |
| Perry, RH | 1 |
| Ince, P | 1 |
| Jaros, E | 1 |
| Perry, EK | 1 |
| Anichtchik, OV | 3 |
| Rinne, JO | 2 |
| Kalimo, H | 2 |
| Huotari, M | 1 |
| Peitsaro, N | 1 |
| Haycock, JW | 1 |
| Männistö, PT | 1 |
| Eriksson, KS | 1 |
| Kaslin, J | 1 |
| Tuomisto, L | 1 |
| Röyttä, M | 1 |
| de Silva, L | 1 |
| Sharpless, NS | 1 |
| Muenter, MD | 1 |
| Tyce, GM | 1 |
| Prell, GD | 1 |
| Green, JP | 1 |
| Coelho, MH | 1 |
| Silva, IJ | 1 |
| Azevedo, MS | 1 |
| Manso, CF | 1 |
| Jones, DG | 2 |
| Turnbull, MJ | 2 |
| Lenman, JA | 2 |
| Robertson, MA | 2 |
| Zanini, AC | 1 |
8 reviews available for histamine and Parkinson Disease
| Article | Year |
|---|---|
Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy.
Topics: Corpus Striatum; Histamine; Humans; Imidazoles; Neuroprotective Agents; Parkinson Disease; Receptors | 2021 |
Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson's Disease.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Antibodies, Monoclonal; Brain; Drug Inverse Agonism; Histami | 2023 |
Role of histaminergic system in blood-brain barrier dysfunction associated with neurological disorders.
Topics: Alzheimer Disease; Blood-Brain Barrier; Epilepsy; Histamine; Humans; Inflammation; Mast Cells; Parki | 2014 |
Interactions of the histamine and hypocretin systems in CNS disorders.
Topics: Alzheimer Disease; Animals; Histamine; Histamine Agonists; Histamine H1 Antagonists; Histamine H3 An | 2015 |
Dual role of histamine on microglia-induced neurodegeneration.
Topics: Animals; Dopaminergic Neurons; Histamine; Humans; Inflammation; Lipopolysaccharides; Microglia; Neur | 2017 |
Self-amplification of nigral degeneration in Parkinson's disease: a hypothesis.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Cerebrovascular Circulation; Glutamic Acid; Histamine; | 2008 |
[Histamine and diseases of central nervous system].
Topics: Alzheimer Disease; Brain Ischemia; Epilepsy; Histamine; Humans; Parkinson Disease | 2004 |
[Pharmacology of the Parkinsonism syndrome].
Topics: Acetylcholine; Catecholamines; Histamine; Humans; Melanins; Nervous System; Parkinson Disease; Serot | 1967 |
26 other studies available for histamine and Parkinson Disease
| Article | Year |
|---|---|
Cerebral Dopamine Neurotrophic Factor Regulates Multiple Neuronal Subtypes and Behavior.
Topics: Animals; Behavior, Animal; Brain; Dopaminergic Neurons; GABAergic Neurons; Gene Deletion; Histamine; | 2020 |
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Brain; Corpus Striatum; Disease Models, Animal; Disease | 2019 |
Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson's disease and schizophrenia in Han Chinese: a case-control study.
Topics: Adult; Alleles; Asian People; Case-Control Studies; China; Female; Gene Frequency; Genetic Predispos | 2015 |
A Novel Developmental Role for Dopaminergic Signaling to Specify Hypothalamic Neurotransmitter Identity.
Topics: Animals; Dopaminergic Neurons; Histamine; Hypothalamus; Levodopa; Neurotransmitter Agents; Orexins; | 2016 |
Histaminergic activity in a rodent model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Animals, Newborn; Apomorphine; Brain; Disease Models, Animal; Dopamine; | 2009 |
Neuronal histamine production remains unaltered in Parkinson's disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus.
Topics: Biomarkers; Histamine; Humans; Hypothalamic Area, Lateral; Lewy Bodies; Neurites; Neurons; Parkinson | 2012 |
Alterations in the histaminergic system in the substantia nigra and striatum of Parkinson's patients: a postmortem study.
Topics: Aged; Aged, 80 and over; Corpus Striatum; Female; Histamine; Histamine N-Methyltransferase; Humans; | 2012 |
Histamine- and haloperidol-induced catalepsy in aged mice: differential responsiveness to L-DOPA.
Topics: Aging; Animals; Antiparkinson Agents; Catalepsy; Disease Models, Animal; Dopamine; Dose-Response Rel | 2012 |
Diurnal fluctuation in histidine decarboxylase expression, the rate limiting enzyme for histamine production, and its disorder in neurodegenerative diseases.
Topics: Alzheimer Disease; Case-Control Studies; Circadian Rhythm; Gene Expression; Histamine; Histidine; Hu | 2012 |
A comparative study of antihistaminic and other drugs in Parkinson's disease.
Topics: Histamine; Humans; Parkinson Disease; Parkinsonian Disorders | 1950 |
[Treatment of paralysis agitans with some new preparations: parpanit, diparcol, and phenergan].
Topics: Cyclopentanes; Histamine; Parkinson Disease; Parkinsonian Disorders; Phenothiazines; Promethazine | 1950 |
Involvement of brain endogenous histamine in the degeneration of dopaminergic neurons in 6-hydroxydopamine-lesioned rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Cell Count; Disease Models, Animal; Dopamine | 2007 |
Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Amine Oxidase (Copper-Containing); Female; Genetic Predisposition to | 2008 |
Brain histidine decarboxylase activity in Parkinson's disease.
Topics: Brain; Carboxy-Lyases; Histamine; Histidine Decarboxylase; Humans; Neurotransmitter Agents; Parkinso | 1983 |
Small fibre function in primary autonomic failure.
Topics: Afferent Pathways; Autonomic Nervous System; Axons; Female; Histamine; Humans; Hypotension, Orthosta | 1993 |
Large neurons in the tuberomammillary nucleus in patients with Parkinson's disease and multiple system atrophy.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Brain Chemistry; Cell Size; Female; Histamin | 1996 |
Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington's and Parkinson's disease cases.
Topics: Aged; Aged, 80 and over; Autoradiography; Female; Globus Pallidus; Histamine; Humans; Huntington Dis | 1999 |
An altered histaminergic innervation of the substantia nigra in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Cell Count; Dopamine; Female; Histamine; Histidine Decarboxylase; Hu | 2000 |
Modulation of histamine H3 receptors in the brain of 6-hydroxydopamine-lesioned rats.
Topics: Amygdala; Animals; Brain; Corpus Striatum; Disease Models, Animal; Functional Laterality; Gene Expre | 2000 |
Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy.
Topics: Aged; Brain; Brain Chemistry; Female; Globus Pallidus; Histamine; Humans; Immunohistochemistry; Male | 2002 |
Biochemical mechanisms and management of choreiform movement disorders.
Topics: Acetylcholine; Basal Ganglia; Chorea; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Extrapyra | 1977 |
Effect of L-DOPA on endogenous histamine metabolism.
Topics: Acetates; Adult; Aged; Animals; Carbidopa; Depression, Chemical; Female; Guinea Pigs; Histamine; Hum | 1975 |
Histamine metabolites and pros-methylimidazoleacetic acid in human cerebrospinal fluid.
Topics: Adult; Aged; Aging; Female; Histamine; Humans; Huntington Disease; Imidazoles; Male; Middle Aged; Pa | 1991 |
Decrease in blood histamine in drug-treated parkinsonian patients.
Topics: Adult; Aged; Amine Oxidase (Copper-Containing); Antiparkinson Agents; Carbidopa; Female; Histamine; | 1991 |
Effect of amantadine on the urinary excretion of some monoamines and metabolites in normal and Parkinsonian subjects.
Topics: Adult; Aged; Amantadine; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Hist | 1972 |
Proceedings: Effect of amantadine on the urinary excretion of some monoamines and metabolites in normal and parkinsonian subjects.
Topics: Amantadine; Amines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Histamine; Homovanillic Acid; Hum | 1972 |