histamine has been researched along with Neurofibromatosis 1 in 3 studies
Neurofibromatosis 1: An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Moreover, similar to wild-type littermates, Nf1± mice developed inflammation-induced heat and mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia." | 3.79 | Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. ( Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Brien, DE | 1 |
| Brenner, DS | 1 |
| Gutmann, DH | 1 |
| Gereau, RW | 1 |
| Yoshida, Y | 1 |
| Adachi, K | 1 |
| Yamamoto, O | 1 |
| Norris, JF | 1 |
| Smith, AG | 1 |
| Fletcher, PJ | 1 |
| Marshall, TL | 1 |
| Hand, MJ | 1 |
3 other studies available for histamine and Neurofibromatosis 1
| Article | Year |
|---|---|
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histam | 2013 |
Local mast cell histamine and plasma histamine levels in neurofibromatosis type 1.
Topics: Adolescent; Adult; Aged; Biomarkers; Child; Child, Preschool; Female; Histamine; Histamine Release; | 2010 |
Neurofibromatous dermal hypoplasia: a clinical, pharmacological and ultrastructural study.
Topics: Adult; Aged; Histamine; Humans; Male; Microscopy, Electron; Neurofibromatosis 1; Norepinephrine; Ski | 1985 |