Page last updated: 2024-12-07

ru 31156

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

RU 31156: inhibitor or experimental immediate hypersensitivity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	125649
CHEMBL ID	1627190
MeSH ID	M0067170

Synonyms (10)

Synonym
ru-31156
ru 31156
66934-53-0
CHEMBL1627190
jbt8k7f1eg ,
unii-jbt8k7f1eg
5-hexyl-7-(s-methanesulfonimidoyl)-9-oxo-9h-xanthene-2-carboxylic acid--2-amino-2-(hydroxymethyl)propane-1,3-diol (1/1)
DTXSID10985612
sudexanox tromethamine
2-amino-2-(hydroxymethyl)propane-1,3-diol;5-hexyl-7-(methylsulfonimidoyl)-9-oxoxanthene-2-carboxylic acid

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" Both RU 31156 and DSCG inhibited anaphylactic bronchoconstriction in the rat, giving bell-shaped dose-response curves."	( Inhibition of experimental immediate hypersensitivity reactions by a novel xanthone, RU 31156. James, GW; Miller, P, 1978)	0.96

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID178800	Inhibition of the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction in rat after oral administration; Range 0.07-0.03	1988	Journal of medicinal chemistry, Jun, Volume: 31, Issue:6	Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and
AID178258	Inhibition of the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction in rat after intravenous administration; Range 0.004-0.006	1988	Journal of medicinal chemistry, Jun, Volume: 31, Issue:6	Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (75.00)	18.7374
1990's	1 (25.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.53 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	1.98	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
histamine [no description available]	3.06	1	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
ketotifen Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.. ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.	3.06	1	cyclic ketone; olefinic compound; organic heterotricyclic compound; organosulfur heterocyclic compound; piperidines; tertiary amino compound	anti-asthmatic drug; H1-receptor antagonist
5-nitro-2-(3-phenylpropylamino)benzoic acid 5-nitro-2-(3-phenylpropylamino)benzoic acid: structure given in first source; chloride channel antagonist	1.98	1	nitrobenzoic acid
tromethamine Tromethamine: An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)	1.95	1	primary amino compound; triol	buffer
xanthenes Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.	3.75	3	xanthene
cromolyn sodium Cromolyn Sodium: A chromone complex that acts by inhibiting the release of chemical mediators from sensitized MAST CELLS. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.. disodium cromoglycate : An organic sodium salt that is the disodium salt of cromoglycic acid.	3.76	3	organic sodium salt	anti-asthmatic drug; drug allergen

Condition	Relationship Strength	Studies
Allergic Reaction [description not available]	3.29	2
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	3.29	2
Dermatitis, Eczematous [description not available]	2.88	1
Anasarca [description not available]	2.88	1
Hay Fever [description not available]	2.88	1
Itching [description not available]	2.88	1
Hives [description not available]	2.88	1
Dermatitis Any inflammation of the skin.	2.88	1
Eczema A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).	2.88	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.88	1
Rhinitis, Allergic, Seasonal Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.	2.88	1
Pruritus An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.	2.88	1
Urticaria A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.	2.88	1
Anaphylactic Reaction [description not available]	1.95	1
Bronchospasm [description not available]	1.95	1
Atopic Hypersensitivity [description not available]	1.95	1
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	1.95	1
Bronchial Spasm Spasmodic contraction of the smooth muscle of the bronchi.	1.95	1
Carcinoma, Anaplastic [description not available]	1.98	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	1.98	1

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