Familial Hypokalemic Periodic Paralysis

Synonym
HYPOKPP
Westphall Disease
HYPOPP
Familial Hypokalemic Periodic Paralysis
Paralysis, Hypokalemic Periodic
Primary Hypokalemic Periodic Paralysis
HOKPP
Hypokalemic Periodic Paralysis, Familial
Periodic Paralysis- Hypokalemic

Excerpt	Reference
"Familial hypokalemic periodic paralysis is an autosomal dominant disorder."	( Adachi, Y; Kumada, H; Kusumi, M; Nakashima, K, 2001)
"FHypoKPP is caused by mutations in ionic channel genes calcium (CACN1AS), sodium (SCN4A) and potassium (KCNE3)."	( Arnaldi, LA; Cerutti, JM; Dias Da Silva, MR; Maciel, RM, 2002)
"Familial hypokalemic periodic paralysis is an autosomal dominant genetic muscle disease characterized by periodic attacks of muscle weakness associated with a decrease in serum potassium."	( Ikeda, Y; Kawamura, S; Seki, K; Tomita, K; Watanabe, N, 2004)
"Familial hypokalemic periodic paralysis is an autosomal-dominant disorder with features of both genetic and phenotypic heterogeneity."	( Cho, KH; Kim, BC; Kim, JH; Kim, MK; Kim, SM; Lee, MC; Lee, SH; Park, MS, 2004)
"Interestingly, hypoPP is caused by both mutations affecting nearby codons as well as the change of an arginine into another amino acid."	( Eymard, B; Fontaine, B; Fournier, E; Hainque, B; Kuntzer, T; Laforet, P; Ochsner, F; Sternberg, D; Vicart, S, 2004)
"Clinically, hypoPP is characterised by episodes of often severe flaccid muscle paralysis, in which the muscle fibre membrane becomes electrically inexcitable, and which may be precipitated by low serum potassium levels."	( Hanna, MG; Matthews, E, 2010)
"HypoPP is genetically heterogeneous, with missense mutations of a calcium channel (Ca(V)1."	( Burns, DK; Cannon, SC; Fu, Y; Gray, HF; Hernández-Ochoa, EO; Mi, W; Schneider, MF; Struyk, AF; Wu, F, 2012)
"Primary hypokalemic periodic paralysis is an autosomal dominant skeletal muscle channelopathy."	( He, F; Huang, H; Jiang, Y; Ke, Q; Lu, L; Qi, M; Weng, C; Yi, X; Yu, P, 2015)
"Thyrotoxic hypokalemic periodic paralysis is a rare complication of hyperthyroidism."	( Diagne, N; Dieng, M; Djiba, B; Faye, A; Kane, BS; Ndao, AC; Pouye, A; Sow, M, 2020)
"HOKPP is a rare disease but symptoms can have a remarkable impact on patients' quality of life and can interfere with employment and educational opportunities."	( Colucci, MC; Corsino, M; D'Asdia, MC; Di Nardo, G; Evangelisti, M; Garibaldi, M; Parisi, P; Petrucci, S; Pugnaloni, F; Terrin, G; Triolo, MF, 2022)

Excerpt	Reference
"A 46-year-old man with hypokalemic periodic paralysis (HypoPP) and diabetes mellitus (DM) had worsened muscle weakness after acetazolamide (ACZ) treatment."	( Ichikawa, Y; Igarashi, O; Ikeda, K; Iwasaki, Y; Kinoshita, M; Satoyoshi, E; Yabuki, D, 2002)
"Thirty-four of 42 participants with hypokalemic periodic paralysis completed both treatment phases."	( Links, TP; Meola, G; Panzeri, M; Rose, MR; Sansone, V, 2008)
"Overweight/obesity people with primary hypokalemic periodic paralysis were administrated as disease group."	( Chen, DM; Yu, YR, 2013)
"Acute hypokalemic periodic paralysis (HPP), a clinical syndrome characterised by acute systemic weakness and low serum potassium (K+), is a rare but treatable cause of acute limb weakness."	( Arambewela, MH; Bodinayaka, CK; Pathirana, KD; Sumanathilaka, MR, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	3 (1.17)	23.3326
1990's	7 (2.73)	12.5806
2000's	117 (45.70)	18.1394
2010's	100 (39.06)	28.8240
2020's	29 (11.33)	9.53

Drug	Relationship Strength	Studies
carbamates	low	1
chlorine	low	1
glycine	low	4
histamine	low	1
iodine	low	3
1-propanol	low	1
uric acid	low	1
phenytoin	low	1
acetazolamide	low	21
albuterol	low	2
amiodarone	low	1
aristolochic acid i	low	1
atenolol	low	1
bay-k-8644	low	2
bumetanide	low	2
carbamazepine	low	1
diazoxide	low	1
dichlorphenamide	low	4
furosemide	low	3
guanidine	low	1
hydrochlorothiazide	low	1
hydroxychloroquine	low	1
indomethacin	low	1
lamotrigine	low	1
metoprolol	low	1
mexiletine	low	2
nimodipine	low	1
pinacidil	low	1
potassium chloride	low	27
propofol	low	1
propranolol	low	25
triamterene	low	3
prednisolone	low	1
thyroxine	low	13
spironolactone	low	6
aldosterone	low	2
triiodothyronine	low	3
glutamine	low	1
adenosine monophosphate	low	2
histidine	low	6
arginine	low	15
methylprednisolone	low	4
pyridostigmine bromide	low	1
betamethasone	low	1
potassium citrate	low	1
amiloride	low	1
iodinated glycerol	low	2
gadolinium	low	1
magnesium sulfate	low	1
barium sulfate	low	1
sodium sulfate	low	1
carbimazole	low	10
fludrocortisone	low	1
zidovudine	low	1
remifentanil	low	1
lamivudine	low	1
cromakalim	low	1
lopinavir	low	1
ezogabine	low	1
combivir	low	1
angiotensin ii	low	1
dihydropyridines	low	1
glycogen	low	1
ouabain	low	1
ryanodine	low	1
cocaine	low	1
tenofovir	low	1
sodium bicarbonate	low	3
benidipine	low	1
propylthiouracil	low	5
methimazole	low	14
D-fructopyranose	low	2
topiramate	low	2
barium	low	4
cysteine	low	1
pituitrin	low	1
nad	low	1
vendex	low	1
piperidines	low	1
toxin ii (anemonia sulcata)	low	1
angiotensin i	low	1
exudates	low	2
pyrimidinones	low	1

Protein Targets (955)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	8	0	0	8
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	6	0	6
thioredoxin reductase	15	0	0	15
GALC protein	4	0	0	4
GLI family zinc finger 3	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
glucocorticoid receptor [Homo sapiens]	23	0	0	23
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	13	0	0	13
estrogen-related nuclear receptor alpha	27	0	0	27
Carbonic anhydrase	0	4	0	4
Carbonic anhydrase	0	3	0	3
arylsulfatase A	10	0	0	10
Carbonic anhydrase	0	3	0	3
euchromatic histone-lysine N-methyltransferase 2	28	0	0	28
Bloom syndrome protein isoform 1	10	0	0	10
thyroid hormone receptor beta isoform a	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 1	20	0	0	20
geminin	26	0	0	26
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	8	0	0	8
muscleblind-like protein 1 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	7	4	5	16
ATP-binding cassette sub-family C member 3	0	24	0	24
Multidrug resistance-associated protein 4	0	24	0	24
Carbonic anhydrase	0	3	0	3
Solute carrier family 22 member 6	0	7	0	8
Carbonic anhydrase 12	0	7	1	16
Prolyl endopeptidase	0	3	0	3
Carbonic anhydrase-related protein 11	0	1	0	3
Bile salt export pump	0	33	0	33
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	2	0	2
Carbonic anhydrase 1	0	14	1	27
Carbonic anhydrase 2	0	15	2	29
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Carbonic anhydrase 3	0	7	1	13
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	6	0	7
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	4	0	4
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	12	0	12
5-hydroxytryptamine receptor 2A	0	4	0	4
Androgen receptor	0	9	0	10
Gamma-aminobutyric acid receptor subunit beta-1	7	4	5	16
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	7	4	5	16
Gamma-aminobutyric acid receptor subunit gamma-2	7	4	5	16
Gamma-aminobutyric acid receptor subunit alpha-5	7	4	5	16
Gamma-aminobutyric acid receptor subunit alpha-3	7	4	5	16
Cannabinoid receptor 1	0	2	0	2
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Cytochrome P450 2B6	0	1	1	2
Carbonic anhydrase 4	0	11	1	19
Carbonic anhydrase 6	0	7	1	15
Gamma-aminobutyric acid receptor subunit gamma-1	7	4	5	16
Gamma-aminobutyric acid receptor subunit alpha-2	7	4	5	16
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Adenosine receptor A1	0	2	0	4
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	7	4	5	16
Gamma-aminobutyric acid receptor subunit gamma-3	7	4	5	16
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	7	4	5	16
Adenosine receptor A2a	0	3	0	5
5-hydroxytryptamine receptor 2B	0	4	0	4
Sodium-dependent serotonin transporter	0	4	0	5
Delta-type opioid receptor	0	4	0	4
Cytochrome P450 2C19	0	6	0	6
Delta-type opioid receptor	0	4	1	5
Mu-type opioid receptor	0	7	0	7
Carbonic anhydrase 5A, mitochondrial	0	10	2	20
Carbonic anhydrase	0	6	0	8
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	7	1	15
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	3	0	6
D(2) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	7	4	5	16
Gamma-aminobutyric acid receptor subunit beta-3	7	4	5	16
Gamma-aminobutyric acid receptor subunit beta-2	7	4	5	16
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	4	0	4
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	5	1	8
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	10	1	19
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	4	0	4
Carbonic anhydrase	0	3	0	6
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	3	0	7
Carbonic anhydrase	0	3	0	7
Carbonic anhydrase	0	4	0	4
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	2	1	3
Renin	0	1	0	1
Carbonic anhydrase	0	3	0	6
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	8
GABA theta subunit	7	4	5	16
Canalicular multispecific organic anion transporter 1	0	23	0	23
Carbonic anhydrase 4	0	6	0	8
Carbonic anhydrase 15	0	4	0	7
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	7	0	14
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	4	5	16
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase 14	0	7	1	16
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	8	1	17
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
RAR-related orphan receptor gamma	14	0	0	14
AR protein	25	0	0	25
regulator of G-protein signaling 4	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	2
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Choline O-acetyltransferase	0	1	0	1
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	2	1	3
Adenylate kinase isoenzyme 1	0	1	0	2
P2Y purinoceptor 2	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	2
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	4	3	7
P2Y purinoceptor 11	0	0	1	1
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
ATP-dependent phosphofructokinase	12	0	0	12
glp-1 receptor, partial	7	0	0	7
GLS protein	10	0	0	10
estrogen nuclear receptor alpha	30	0	0	30
NPYLR7B	0	0	1	1
thyroid stimulating hormone receptor	3	0	0	3
flap endonuclease 1	6	0	0	6
Beta-2 adrenergic receptor	0	8	5	13
Beta-1 adrenergic receptor	0	8	5	13
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-3 adrenergic receptor	0	4	4	8
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Beta-2 adrenergic receptor	0	2	5	8
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	5	3	9
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	2
Guanine nucleotide-binding protein G	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
acid sphingomyelinase	1	0	0	1
acetylcholinesterase	8	0	0	8
TDP1 protein	24	0	0	24
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
thyroid stimulating hormone receptor	10	0	0	10
glucocerebrosidase	5	0	0	5
alpha-galactosidase	5	0	0	5
cytochrome P450 2D6 isoform 1	6	0	0	6
lysosomal alpha-glucosidase preproprotein	2	0	0	2
cytochrome P450 2C19 precursor	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
thyroid hormone receptor beta isoform 2	15	0	0	15
huntingtin isoform 2	2	0	0	2
lamin isoform A-delta10	25	0	0	25
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Prothrombin	0	1	1	2
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Cationic trypsin	0	1	0	1
Coagulation factor XI	0	1	0	1
Plasma kallikrein	0	1	0	3
Vitamin K-dependent protein C	0	1	0	1
Cellular tumor antigen p53	14	0	0	14
Urokinase-type plasminogen activator	0	2	0	2
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Sodium/hydrogen exchanger 1	0	2	0	2
Sodium/hydrogen exchanger 3	0	2	0	2
Adenosine receptor A2a	0	2	1	3
Trypsin-3	0	1	0	1
Amiloride-sensitive sodium channel subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Sodium/hydrogen exchanger 2	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	12	0	12
Sodium channel protein type 5 subunit alpha	0	6	0	6
Sodium/hydrogen exchanger 5	0	2	0	2
Solute carrier family 22 member 1	0	4	0	6
Solute carrier family 22 member 2	0	4	0	6
Acid-sensing ion channel 3	0	1	0	1
Sodium/hydrogen exchanger	0	1	0	1
phosphopantetheinyl transferase	8	0	0	8
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
SMAD family member 2	7	0	0	7
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	3	0	0	3
USP1 protein, partial	11	0	0	11
NFKB1 protein, partial	3	0	0	3
PPM1D protein	3	0	0	3
SMAD family member 3	7	0	0	7
Thrombopoietin	1	0	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
estrogen receptor 2 (ER beta)	10	0	0	10
progesterone receptor	16	0	0	16
EWS/FLI fusion protein	12	0	0	12
farnesoid X nuclear receptor	13	0	0	13
pregnane X nuclear receptor	20	0	0	20
G	11	0	0	11
cytochrome P450 2D6	7	0	0	7
polyprotein	3	0	0	3
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	12	0	0	12
caspase-3	4	0	0	4
Histone H2A.x	5	0	0	5
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C9 precursor	7	0	0	7
D(1A) dopamine receptor	7	0	0	7
chromobox protein homolog 1	12	0	0	12
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
heat shock protein beta-1	5	0	0	5
mitogen-activated protein kinase 1	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	8	0	0	8
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	11	0	0	11
cytochrome P450 3A4 isoform 1	7	0	0	7
muscarinic acetylcholine receptor M1	6	0	0	6
lethal factor (plasmid)	5	0	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Solute carrier organic anion transporter family member 1A4	0	2	0	5
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
5-hydroxytryptamine receptor 4	0	6	0	6
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	15	0	0	15
HLA class I histocompatibility antigen, B alpha chain	11	0	0	11
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin beta-3	2	0	0	2
Tyrosine-protein kinase Fyn	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M2	0	5	1	6
Muscarinic acetylcholine receptor M4	0	3	0	3
ATP-dependent translocase ABCB1	0	9	1	12
Integrin alpha-IIb	2	0	0	2
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	4	2	7
Adenosine receptor A3	0	4	1	5
Thyroid hormone receptor alpha	0	3	3	6
Thyroid hormone receptor beta	0	3	3	6
Muscarinic acetylcholine receptor M1	0	4	1	5
D(2) dopamine receptor	0	3	1	4
Alpha-1B adrenergic receptor	0	4	1	5
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	3	1	5
Thyroid hormone receptor beta	0	2	0	2
Muscarinic acetylcholine receptor M3	0	4	1	5
ATP-dependent translocase ABCB1	0	1	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	3	1	4
D(4) dopamine receptor	0	2	0	2
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	6	0	6
Histamine H2 receptor	0	3	2	5
Endothelin-1 receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	6	1	7
Lysine-specific demethylase 5A	0	1	0	1
B2 bradykinin receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	6	0	6
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	3	1	4
D(3) dopamine receptor	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	5	0	8
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	3	1	4
5-hydroxytryptamine receptor 2B	0	8	1	9
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	4	1	5
Histamine H2 receptor	7	0	1	8
5-hydroxytryptamine receptor 6	0	4	1	5
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	9	0	2	11
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Sodium-dependent dopamine transporter	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	7	0	7
Lysine-specific demethylase 7A	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	11	0	0	11
Sodium channel protein type 2 subunit alpha	0	4	0	4
Ataxin-2	8	0	0	8
Sigma non-opioid intracellular receptor 1	0	7	0	7
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	2	0	2
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	3	0	3
cytochrome P450 2C9, partial	11	0	0	11
DNA polymerase kappa isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	3	3	6
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
DNA polymerase iota isoform a (long)	7	0	0	7
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Microtubule-associated protein tau	6	0	0	6
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Cyclin-dependent kinase 2	0	1	0	1
Beta-1 adrenergic receptor	0	1	3	5
Fatty acid-binding protein, liver	0	2	0	2
Urease	0	1	0	1
5-hydroxytryptamine receptor 1A	0	6	3	10
Alpha-1D adrenergic receptor	0	3	1	5
Alpha-1A adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	1	1	3
TAR DNA-binding protein 43	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, Ferritin light chain	6	0	0	6
nonstructural protein 1	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
peripheral myelin protein 22 isoform 1	10	0	0	10
DNA polymerase beta	1	0	0	1
M-phase phosphoprotein 8	5	0	0	5
neuropeptide S receptor isoform A	6	0	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	0	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Rap guanine nucleotide exchange factor 4	3	0	0	3
pregnane X receptor	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
IDH1	6	0	0	6
aryl hydrocarbon receptor	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	15	0	0	15
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
galanin receptor type 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Glucocorticoid receptor	0	10	3	18
Glycine receptor subunit alpha-1	0	10	0	10
Glutamate receptor 2	9	0	0	11
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	1	1
Luciferase	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Solute carrier family 12 member 2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Vpr	3	0	0	3
Bile salt export pump	0	5	0	5
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	5	1	6
Sodium channel protein type 3 subunit alpha	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	0	1	3
Cytochrome P450 2J2	0	8	0	8
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Lactoperoxidase	0	2	0	2
vitamin D3 receptor isoform VDRA	5	0	0	5
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Solute carrier family 15 member 2	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	1	5
D	0	1	0	1
Alpha-2B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2A adrenergic receptor	0	1	1	2
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	4	1	5
5-hydroxytryptamine receptor 1B	0	3	0	3
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	6
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	1	6
Glutamate receptor ionotropic, NMDA 2C	0	3	1	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	1	6
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	1	6
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Transporter	0	2	0	2
ATP-binding cassette sub-family C member 9	0	0	2	2
ATP-binding cassette sub-family C member 8	0	1	2	3
ATP-sensitive inward rectifier potassium channel 11	0	1	2	3
ATP-sensitive inward rectifier potassium channel 8	0	0	1	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Glutamate receptor 1	0	0	0	2
Glutamate receptor 3	0	0	0	2
Glutamate receptor 4	0	0	0	2
Nicotinamide phosphoribosyltransferase	0	0	1	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	3
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	3
UDP-glucuronosyltransferase 1A9	0	0	1	2
UDP-glucuronosyltransferase 2B11	0	0	1	1
UDP-glucuronosyltransferase 2B17	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	1
UDP-glucuronosyltransferase 2B4	0	0	1	1
UDP-glucuronosyltransferase 2A1	0	0	1	1
UDP-glucuronosyltransferase 2A2	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	1	3
UDP-glucuronosyltransferase 1A4	0	0	1	2
UDP-glucuronosyltransferase 1A3	0	0	1	1
UDP-glucuronosyltransferase 1A5	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	0	1	1
UDP-glucuronosyltransferase 2B15	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 4	0	0	1	1
UDP-glucuronosyltransferase 2A3	0	0	1	1
UDP-glucuronosyltransferase 2B28	0	0	1	1
UDP-glucuronosyltransferase 1A7	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 5	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
Albumin	0	3	4	9
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Multidrug and toxin extrusion protein 1	0	3	0	3
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Solute carrier family 22 member 3	0	3	0	4
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
5-hydroxytryptamine receptor 1D	0	0	0	2
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Histamine H1 receptor	0	2	2	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Histamine H3 receptor	0	1	2	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Hsf1 protein	0	0	3	3
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	1	2	3
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	3	2	5
Replicase polyprotein 1ab	0	5	2	7
Alpha-2C adrenergic receptor	0	2	2	5
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Cruzipain	3	0	0	3
interleukin 8	3	0	0	3
67.9K protein	4	0	0	4
Parkin	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
ras-related protein Rab-9A	2	0	0	2
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Interleukin-8	0	1	0	1
Androgen receptor	0	5	2	7
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	1	0	2
Substance-P receptor	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	3	1	4
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	5	5
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
C-X-C chemokine receptor type 3	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	4
Prostaglandin G/H synthase 2	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 6	0	1	0	4
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	4
activating transcription factor 6	5	0	0	5
histone deacetylase 9 isoform 3	2	0	0	2
Capsid protein	0	1	2	3
Reverse transcriptase/RNaseH	0	2	4	11
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, PROTEASE RETROPEPSIN	0	1	0	1
Chain B, PROTEASE RETROPEPSIN	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Smad3	3	0	0	3
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Alpha-1D adrenergic receptor	0	2	1	3
Gag-Pol polyprotein	0	1	0	1
CAAX prenyl protease 1 homolog	0	1	0	1
Plasmepsin V	0	1	0	1
ATPase family AAA domain-containing protein 5	6	0	0	6
Protease	0	2	2	4
Polyphenol oxidase 2	0	2	0	3
Dopamine beta-hydroxylase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Beta-1 adrenergic receptor	0	3	2	6
Beta-1 adrenergic receptor	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
endonuclease IV	4	0	0	4
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Bile acid receptor	0	2	0	2
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
STAT3, partial	0	1	0	1
Kruppel-like factor 5	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	3
Gamma-aminobutyric acid	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	4	1	5
Progesterone receptor	0	4	1	6
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	1	4
thioredoxin glutathione reductase	1	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
D(3) dopamine receptor	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Myeloperoxidase	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Acetylcholinesterase	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
serine/threonine-protein kinase PLK1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Transthyretin	0	1	0	3
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Chain A, PAPAIN	1	0	0	1
putative alpha-glucosidase	1	0	0	1
pyruvate kinase	1	0	0	1
Janus kinase 2 (a protein tyrosine kinase)	0	1	0	1
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Cathepsin G	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Cyclin-dependent kinase 4	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Casein kinase I isoform alpha	0	1	0	1
Casein kinase I isoform delta	0	1	0	1
Casein kinase I isoform epsilon	0	1	0	1
Caspase-7	1	0	0	1
Pteridine reductase 1	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Thymidine kinase, cytosolic	0	2	0	3
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Familial Hypokalemic Periodic Paralysis

Synonyms(9)

Research Excerpts

Overview

Treatment

Research

Studies (256)

Protein Targets (955)

Familial Hypokalemic Periodic Paralysis

Synonyms(9)

Research Excerpts

Overview

Treatment

Research

Studies (256)

Drugs Studied (103)

Protein Targets (955)