Page last updated: 2024-09-28

Larva Migrans, Visceral

A condition produced in man by the prolonged migration of animal nematode larvae in extraintestinal tissues other than skin; characterized by persistent hypereosinophilia, hepatomegaly, and frequently pneumonitis, commonly caused by Toxocara canis and Toxocara cati.

Synonyms(2)

Synonym
Larva Migrans, Visceral
Visceral Larva Migrans Syndrome

Research Excerpts

Overview

ExcerptReference
"Visceral larva migrans is a disease in which the larvae of animal parasites invade human tissues but do not complete their life cycles."( Zinkham, WH, 1978)
"Visceral larva migrans is difficult to diagnose and to treat, and our best hope for control lies in prevention."( Tudor, RB, 1975)
"Visceral larva migrans is a syndrome caused by the extraintestinal migration of larval nematodes of wild and domestic animals through human tissues."( Bratt, DE; Tikasingh, ES, 1992)
"Visceral larva migrans is rare in adults."( Malik, AK; Sharma, BK; Singh, S, 1992)

Research

Studies (105)

TimeframeStudies, This Condition (%)All Conditions %
pre-199050 (47.62)23.3326
1990's19 (18.10)12.5806
2000's21 (20.00)18.1394
2010's13 (12.38)28.8240
2020's2 (1.90)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carbon monoxide0low10
histamine0low10
mercaptoethanol0low10
albendazole0medium301
carbamazepine0low10
diethylcarbamazine0low210
fenbendazole0low20
2-propanol0low10
mebendazole0low40
thiabendazole0medium251
prednisolone0low50
prednisone0low50
penicillin g0low10
sucrose0low10
sodium citrate, anhydrous0low10
methylprednisolone0low10
aminophylline0low10
copper gluconate0low10
trolamine salicylate0low40
levamisole0low10
tetrachloroethylene0low10
triclabendazole0low10
fibrinogen0low10
foxes0low40
methotrexate0low20
xylose0low10
borneo0low10
biotin0low10
retinol0low10
pica0low110
pyrantel pamoate0low10
lead0low20
antimony0low10
nitrofurantoin0low10
dextrothyroxine0low10
agar0low30
exudates0low20
eye0low20

Protein Targets (483)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma140014
GLI family zinc finger 3110011
AR protein160016
aldehyde dehydrogenase 1 family, member A15005
retinoic acid nuclear receptor alpha variant 1120012
retinoid X nuclear receptor alpha120012
estrogen nuclear receptor alpha180018
peroxisome proliferator-activated receptor delta8008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)7007
Histone H2A.x5005
thyroid hormone receptor beta isoform a4004
heat shock protein beta-15005
nuclear factor erythroid 2-related factor 2 isoform 1100010
lamin isoform A-delta10100010
Voltage-dependent calcium channel gamma-2 subunit8008
Glutamate receptor 28008
Chain A, Beta-lactamase5005
Luciferase5005
glp-1 receptor, partial4004
ATAD5 protein, partial5005
Fumarate hydratase3003
TDP1 protein120012
caspase 7, apoptosis-related cysteine protease3003
nuclear receptor subfamily 1, group I, member 3100010
progesterone receptor9009
glucocorticoid receptor [Homo sapiens]110011
estrogen-related nuclear receptor alpha140014
farnesoid X nuclear receptor7007
pregnane X nuclear receptor130013
polyprotein3003
67.9K protein3003
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
caspase-33003
IDH17007
euchromatic histone-lysine N-methyltransferase 27007
aryl hydrocarbon receptor9009
nuclear receptor subfamily 1, group I, member 25005
cellular tumor antigen p53 isoform a3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
chromobox protein homolog 13003
nuclear factor erythroid 2-related factor 2 isoform 28008
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 2110011
histone deacetylase 9 isoform 34004
mitogen-activated protein kinase 14004
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
geminin9009
Vif0001
peripheral myelin protein 229009
survival motor neuron protein isoform d4004
muscleblind-like protein 1 isoform 14004
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
neuropeptide S receptor isoform A3003
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40809
Bile salt export pump012012
Interferon beta5005
Cellular tumor antigen p53120012
Integrin beta-33003
Integrin alpha-IIb3003
Methionine aminopeptidase0404
Fatty-acid amide hydrolase 10404
Inositol monophosphatase 12002
Canalicular multispecific organic anion transporter 10808
ATPase family AAA domain-containing protein 5100010
Ataxin-2100010
thioredoxin reductase7007
USP1 protein, partial8008
Microtubule-associated protein tau7007
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, JmjC domain-containing histone demethylation protein 3A1001
apical membrane antigen 1, AMA12002
nonstructural protein 10101
green fluorescent protein, partial0101
vitamin D3 receptor isoform VDRA6006
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
pregnane X receptor5005
estrogen receptor 2 (ER beta)9009
thyroid stimulating hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
acetylcholinesterase4004
thyroid stimulating hormone receptor6006
Vpr2002
Bile salt export pump0303
Albumin0011
Major prion protein0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0303
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20202
Potassium voltage-gated channel subfamily H member 20101
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
P2X purinoceptor 40101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, Ferritin light chain4004
Chain A, Cruzipain3003
endonuclease IV1001
nonstructural protein 13003
glucocerebrosidase2002
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d5005
DNA polymerase beta2002
DNA polymerase iota isoform a (long)6006
M-phase phosphoprotein 82002
Spike glycoprotein4004
PPM1D protein3003
Smad32002
EWS/FLI fusion protein4004
Caspase-71001
caspase-31001
nuclear receptor ROR-gamma isoform 15005
Nuclear receptor subfamily 1 group I member 20022
Rap guanine nucleotide exchange factor 31001
Mitogen-activated protein kinase 140101
Nuclear receptor subfamily 1 group I member 20022
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
phosphopantetheinyl transferase6006
GALC protein2002
GLS protein1001
regulator of G-protein signaling 41001
bromodomain adjacent to zinc finger domain 2B2002
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Carbonic anhydrase 120001
Solute carrier family 22 member 30102
Carbonic anhydrase 10001
Carbonic anhydrase 20226
Plasma kallikrein0001
Carbonic anhydrase 30001
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40102
Carbonic anhydrase 60001
Histamine H2 receptor0123
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0001
Histamine H1 receptor0134
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0102
Histamine H1 receptor0224
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Histamine H2 receptor3014
Carbonic anhydrase0002
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90214
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0002
Carbonic anhydrase0103
Glutamate receptor ionotropic, NMDA 2D0001
Solute carrier family 22 member 10102
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Histamine H3 receptor0123
dopamine D1 receptor2002
cytochrome P450 2D63003
atrial natriuretic peptide receptor 1 precursor1001
flap endonuclease 12002
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Phospholipase A-2-activating protein0101
ATP-dependent phosphofructokinase3003
Vitamin D3 receptor0112
G-protein coupled bile acid receptor 10011
SMAD family member 24004
SMAD family member 34004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
cytochrome P450 family 3 subfamily A polypeptide 44004
G2002
cytochrome P450 2C9 precursor1001
huntingtin isoform 21001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
lethal factor (plasmid)2002
Tyrosine-protein kinase ABL10213
HLA class I histocompatibility antigen, B alpha chain 2002
Proto-oncogene tyrosine-protein kinase Src0202
Vascular endothelial growth factor receptor 20101
Disintegrin and metalloproteinase domain-containing protein 172002
Inositol hexakisphosphate kinase 12002
Calmodulin-domain protein kinase 10101
cytochrome P450 2C9, partial2002
Glutaminyl-peptide cyclotransferase0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase3003
acid sphingomyelinase1001
ClpP1001
15-lipoxygenase, partial3003
Thymidylate synthase 0101
alpha-galactosidase2002
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
importin subunit beta-1 isoform 11001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 13003
histone acetyltransferase KAT2A isoform 11001
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-72002
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 433003
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
thioredoxin glutathione reductase2002
cytochrome P450 3A4 isoform 14004
streptokinase A precursor0033
Gamma-aminobutyric acid receptor subunit pi4004
Estrogen receptor0022
Gamma-aminobutyric acid receptor subunit beta-14004
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Nuclear receptor ROR-gamma4004
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
60 kDa chaperonin 0101
Estrogen receptor beta0022
10 kDa chaperonin 0101
GABA theta subunit4004
Gamma-aminobutyric acid receptor subunit epsilon4004
CDGSH iron-sulfur domain-containing protein 10202
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 22 member 60101
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10101
Beta-lactamase TEM0102
Guanine nucleotide-binding protein G3003
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase VIM-1 0001
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)0101
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)0101
Chain A, Beta-arrestin 10011
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20002
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Cytochrome P450 3A40101
heat shock protein 90, putative0002
galactokinase1001
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
interleukin 81001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0101
Alpha-synuclein1102
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
Chain A, Methionine aminopeptidase0101
BRCA11001
P531001
pyruvate kinase1001
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
cytochrome P450 2C19 precursor1001
ras-related protein Rab-9A1001
Cytochrome P450 1A20101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Methionine aminopeptidase 20101
Methionine aminopeptidase 10112
Peptidyl-prolyl cis-trans isomerase FKBP1A0011
Reverse transcriptase/RNaseH 0101
Multidrug and toxin extrusion protein 10101
PINK11001
Parkin1001
hepatitis C virus polyprotein1001
Transthyretin0101
Cruzipain0101
Rap guanine nucleotide exchange factor 41001
Hsf1 protein0011
Aldo-keto reductase family 1 member B10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]