Acanthosis Nigricans

A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.

Synonym
Acanthosis Nigricans

Excerpt	Reference
"Acanthosis nigricans is well recognized in its clinical association with several types of insulin-resistant syndromes, and skin involvement is usually unresponsive to local treatment or management of diabetes."	( Sherertz, EF, 1988)
"Acanthosis nigricans is a reaction pattern to over a dozen different causes."	( Stone, OJ, 1993)
"Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation, velvety cutaneous thickening, intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas."	( Böhm, M; Luger, TA; Metze, D, 1999)
"Acanthosis nigricans is an uncommon skin condition characterized by hyperkeratosis and skin hyperpigmentation."	( Anderson, SH; Hudson-Peacock, M; Muller, AF, 1999)
"Malignant acanthosis nigricans is recognized as a cutaneous sign of internal malignancy, usually an adenocarcinoma."	( Kennedy, A; Longshore, SJ; Nurko, S; Taylor, JS, 2003)
"Malignant acanthosis nigricans is a disease that has an abrupt onset and is most commonly associated with gastric adenocarcinoma."	( Greer, K; McGinness, J, 2006)
"Acanthosis nigricans is a mucocutaneous dermatosis characterized by hyperpigmentation and a velvety papillomatous hyperkeratosis."	( Anyfandakis, V; Christofidou, E; Gregoriou, S; Kontochristopoulos, G; Kontoleon, P; Rigopoulos, D, 2008)
"Acanthosis nigricans is a dermatosis characterized by thickened, hyperpigmented plaques, typically of the intertriginous surfaces and neck."	( Freemark, M; Higgins, SP; Prose, NS, 2008)
"Acanthosis nigricans is a likely forerunner of the finding of metabolic syndrome."	( Atwa, M; Balata, M; Bayoumy, N; Emara, A; Fiala, L; Sherif, A; Youssef, N, 2014)
"Benign acanthosis nigricans is associated with abnormal levels of lepin, adiponectin and sex hormone."	( Chen, T; Li, B; Li, J; Li, Y; Liu, X; Wang, Y; Wang, Z; Zhai, N, 2014)
"Pseudo-acanthosis nigricans is a common dermatological disorder that is usually difficult to treat secondary to maceration of the skin from excessive sweating, obesity, or associated with endocrine disorders."	( Essam, RM; Hilal, RF; Zaki, NS, 2018)
"Acanthosis nigricans is characterized as hyperpigmented skin and velvety surface on posterior and lateral folds of the neck and the intertriginous areas."	( Chaikul, T; Chaithirayanon, S; Chansakulporn, S; Treesirichod, A, 2021)
"Acanthosis nigricans is a common dermatological problem."	( Jurairattanaporn, N; Kanokrungsee, S; Leerapongnan, P; Udompataikul, M, 2020)
"Acanthosis nigricans is commonly associated with obesity."	( Chuenboonngarm, S; Kritsanaviparkporn, C; Treesirichod, A, 2022)

Excerpt	Reference
"Drug-induced acanthosis nigricans has been reported in the literature."	( Morren, MA; Peeters, C; Stals, H; Vercammen, C, 1994)

Excerpt	Reference
"We have successfully treated acanthosis nigricans in a patient with Lawrence-Seip syndrome."	( Halse, J; Mørk, NJ; Rajka, G, 1986)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	115 (33.33)	23.3326
1990's	68 (19.71)	12.5806
2000's	69 (20.00)	18.1394
2010's	62 (17.97)	28.8240
2020's	31 (8.99)	9.53

Drug	Relationship Strength	Studies	Trials
dinitrochlorobenzene	low	1	0
5-hydroxytryptophan	low	1	0
quinacrine	low	1	0
salicylic acid	low	7	0
gallic acid	low	1	0
lactic acid	low	2	0
glycine	low	2	0
glycolic acid	medium	4	1
histamine	low	2	0
hydroquinone	low	1	0
melatonin	low	1	0
niacinamide	low	1	0
niacin	low	10	0
palmitic acid	low	1	0
trimethyloxamine	low	1	0
uric acid	medium	2	1
urea	medium	5	2
mandelic acid	low	1	0
phenytoin	low	2	0
alendronate	low	1	0
aspirin	low	1	0
azathioprine	low	3	0
chloroquine	low	1	0
cyproheptadine	low	2	0
fluorouracil	low	1	0
flutamide	low	1	0
halothane	low	1	0
hydrochlorothiazide	low	1	0
2-propanol	low	2	0
ketoconazole	low	3	0
khellin	low	2	0
mechlorethamine	low	1	0
metformin	medium	22	1
metyrapone	low	1	0
mianserin	low	1	0
mirtazapine	low	1	0
pioglitazone	low	1	0
propranolol	low	1	0
succinylcholine	low	1	0
tazarotene	low	1	0
thalidomide	low	1	0
tolbutamide	low	1	0
troglitazone	low	1	0
prednisolone	low	4	0
sorbitol	low	1	0
thymidine	low	4	0
thyroxine	low	1	0
spironolactone	low	4	0
prednisolone acetate	low	1	0
aldosterone	low	1	0
prednisone	low	4	0
methylprednisolone acetate	low	1	0
dehydroepiandrosterone	low	5	0
biguanides	low	1	0
glutamine	low	1	0
lysine	low	3	0
ethinyl estradiol	low	4	0
tubocurarine	low	1	0
9,10-dimethyl-1,2-benzanthracene	low	2	0
methyltestosterone	low	1	0
leucine	low	1	0
androstenedione	low	8	0
methionine	low	2	0
colchicine	low	1	0
fluocinolone acetonide	low	1	0
norethindrone	low	2	0
17-alpha-hydroxyprogesterone	low	1	0
histidine	low	1	0
medroxyprogesterone acetate	low	1	0
valine	low	1	0
threonine	low	1	0
mestranol	low	1	0
tryptophan	low	1	0
arginine	low	4	0
trichloroacetic acid	low	3	0
methylprednisolone	low	2	0
penicillanic acid	low	1	0
nicotinyl alcohol	low	1	0
framycetin	low	1	0
3-o-methylglucose	low	1	0
thiazoles	low	1	0
pyrazines	low	1	0
ethynodiol diacetate	low	1	0
azacitidine	low	1	0
fluocinonide	low	1	0
betamethasone	low	2	0
cyproterone acetate	low	3	0
podophyllotoxin	low	1	0
dihydrotestosterone	low	1	0
dehydroepiandrosterone sulfate	low	5	0
deoxycytidine	low	1	0
d-alpha tocopherol	low	1	0
pimozide	low	1	0
erbium	medium	1	1
xenon	low	1	0
tetradecanoylphorbol acetate	low	2	0
lisuride	low	1	0
bromocriptine	low	2	0
triamcinolone	low	2	0
pregnanolone	low	1	0
zidovudine	low	1	0
paclitaxel	low	1	0
substance p	low	1	0
triazinate	low	1	0
epirubicin	low	1	0
propiconazole	low	1	0
piperacillin	low	1	0
cabergoline	low	1	0
imiquimod	low	1	0
adapalene	medium	1	1
gemcitabine	low	1	0
vanadates	low	1	0
glucose, (beta-d)-isomer	low	1	0
sc-11800 ee	low	1	0
octadecyl palmitate	low	1	0
rosiglitazone	medium	2	1
deoxyglucose	low	3	0
tazobactam	low	1	0
methotrexate	low	1	0
betamethasone-17,21-dipropionate	low	1	0
17-hydroxypregnanolone	low	1	0
sorafenib	low	1	0
ritonavir	low	1	0
carboplatin	low	1	0
inositol 3-phosphate	low	6	0
dironyl	low	1	0
tretinoin	medium	19	6
retinol	low	5	0
tacrolimus	low	1	0
zithromax	low	1	0
diethylstilbestrol	low	3	0
melphalan	low	1	0
bromochloroacetic acid	low	3	0
leuprolide	low	2	0
fusidic acid	low	1	0
sodium dodecyl sulfate	low	2	0
17-ketosteroids	low	4	0
bilirubin	low	1	0
luteolin	low	1	0
calcitriol	low	7	0
luteolin-7-glucoside	low	1	0
gamma-linolenic acid	low	1	0
etretinate	low	4	0
isotretinoin	low	3	0
phenylephrine hydrochloride	low	3	0
acitretin	low	4	0
cyproterone	low	1	0
nalmefene	medium	1	1
naloxone	medium	1	1
sirolimus	low	4	0
acipimox	low	1	0
clobetasol	low	3	0
lead	low	1	0
arsenic	low	1	0
naltrexone	medium	2	1
lisinopril	low	1	0
beryllium	low	1	0
cysteine	low	3	0
heroin	low	2	0
emerin	low	1	0
ergoline	low	1	0
pituitrin	low	1	0
podophyllin	low	1	0
acid phosphatase	low	1	0
glucagon	low	2	0
beta-endorphin	low	1	0
liraglutide	low	1	0
glucagon-like peptide 1	low	1	0
c-peptide	low	18	0
endothelin-1	low	1	0
(9R)-9-chloro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one	low	1	0
calcipotriene	low	7	0
minocycline	low	4	0
salicylates	low	1	0
warfarin	low	1	0
epidermal growth factor	low	1	0
1 alpha,24-dihydroxyvitamin d3	low	1	0
humulin s	low	1	0
insulin glargine	low	1	0
transforming growth factor alpha	low	3	0
guanosine triphosphate	low	1	0
didanosine	low	1	0
aprepitant	low	1	0
cholestyramine resin	low	2	0
eye	low	2	0
leptin	medium	15	1

Protein Targets (1,855)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
IDH1	25	0	0	25
chromobox protein homolog 1	34	0	0	34
geminin	64	0	0	64
acetylcholinesterase	19	0	0	19
pregnane X receptor	18	0	0	18
SMAD family member 2	25	0	0	25
SMAD family member 3	25	0	0	25
TDP1 protein	69	0	0	69
GLI family zinc finger 3	62	0	0	62
Microtubule-associated protein tau	24	0	0	24
AR protein	80	0	0	80
progesterone receptor	40	0	0	40
glucocorticoid receptor [Homo sapiens]	66	0	0	66
retinoic acid nuclear receptor alpha variant 1	65	0	0	65
retinoid X nuclear receptor alpha	47	0	0	47
estrogen-related nuclear receptor alpha	64	0	0	64
farnesoid X nuclear receptor	42	0	0	42
pregnane X nuclear receptor	58	0	0	58
estrogen nuclear receptor alpha	87	0	0	87
G	28	0	0	28
vitamin D (1,25- dihydroxyvitamin D3) receptor	39	0	0	39
arylsulfatase A	15	0	0	15
euchromatic histone-lysine N-methyltransferase 2	45	0	0	45
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	53	0	0	53
activating transcription factor 6	24	0	0	24
nuclear receptor subfamily 1, group I, member 2	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 1	56	0	0	56
survival motor neuron protein isoform d	17	0	0	17
histone acetyltransferase KAT2A isoform 1	24	0	0	24
lamin isoform A-delta10	43	0	0	43
Voltage-dependent calcium channel gamma-2 subunit	36	0	0	36
Interferon beta	42	0	0	42
HLA class I histocompatibility antigen, B alpha chain	28	0	0	28
Glucocorticoid receptor	0	32	4	43
Sex hormone-binding globulin	0	1	9	10
Glycine receptor subunit alpha-1	0	30	0	30
Corticosteroid-binding globulin	0	6	0	6
Adenosine receptor A3	0	14	1	15
Replicase polyprotein 1ab	0	5	3	8
Androgen receptor	0	30	1	32
Alpha-1B adrenergic receptor	0	19	3	22
Glutamate receptor 2	36	0	0	36
Glycine receptor subunit beta	0	30	0	30
Glycine receptor subunit alpha-2	0	30	0	30
Glycine receptor subunit alpha-3	0	30	0	30
Mitogen-activated protein kinase 3	0	2	2	4
Alpha-1A adrenergic receptor	0	20	3	23
Sodium-dependent dopamine transporter	0	8	0	8
TAR DNA-binding protein 43	15	0	0	15
Inositol hexakisphosphate kinase 1	28	0	0	28
cytochrome P450 2C9, partial	28	0	0	28
ATP-dependent phosphofructokinase	24	0	0	24
hypoxia-inducible factor 1 alpha subunit	19	0	0	19
RAR-related orphan receptor gamma	55	0	0	55
aldehyde dehydrogenase 1 family, member A1	43	0	0	43
peroxisome proliferator-activated receptor delta	40	0	0	40
v-jun sarcoma virus 17 oncogene homolog (avian)	33	0	0	33
Histone H2A.x	20	0	0	20
thyroid hormone receptor beta isoform a	24	0	0	24
heat shock protein beta-1	21	0	0	21
Chain A, Beta-lactamase	18	0	0	18
Chain A, HADH2 protein	17	0	0	17
Chain B, HADH2 protein	17	0	0	17
Chain A, JmjC domain-containing histone demethylation protein 3A	11	0	0	11
Chain A, Cruzipain	10	0	0	10
Luciferase	16	0	0	16
acid sphingomyelinase	2	0	0	2
ATAD5 protein, partial	26	0	0	26
apical membrane antigen 1, AMA1	7	0	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	16	0	0	16
thyroid stimulating hormone receptor	20	0	0	20
estrogen receptor 2 (ER beta)	36	0	0	36
nuclear receptor subfamily 1, group I, member 3	42	0	0	42
glucocerebrosidase	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
P53	4	0	0	4
peroxisome proliferator activated receptor gamma	42	0	0	42
aryl hydrocarbon receptor	27	0	0	27
thyroid stimulating hormone receptor	30	0	0	30
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	20	0	0	20
Caspase-7	9	0	0	9
serine-protein kinase ATM isoform a	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	11	0	0	11
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	9	0	0	9
caspase-3	9	0	0	9
thyroid hormone receptor beta isoform 2	58	0	0	58
mitogen-activated protein kinase 1	13	0	0	13
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
ras-related protein Rab-9A	9	0	0	9
urokinase-type plasminogen activator precursor	13	0	0	13
plasminogen precursor	13	0	0	13
urokinase plasminogen activator surface receptor precursor	13	0	0	13
nuclear receptor ROR-gamma isoform 1	27	0	0	27
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
cytochrome P450 3A4 isoform 1	23	0	0	23
caspase-1 isoform alpha precursor	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	23	3	1	27
Cellular tumor antigen p53	58	0	0	58
Gamma-aminobutyric acid receptor subunit beta-1	23	3	1	27
Gamma-aminobutyric acid receptor subunit delta	23	3	1	27
Gamma-aminobutyric acid receptor subunit gamma-2	23	3	1	27
Gamma-aminobutyric acid receptor subunit alpha-5	23	3	1	27
Gamma-aminobutyric acid receptor subunit alpha-3	23	3	1	27
Gamma-aminobutyric acid receptor subunit gamma-1	23	3	1	27
Gamma-aminobutyric acid receptor subunit alpha-2	23	3	1	27
Gamma-aminobutyric acid receptor subunit alpha-4	23	3	1	27
Gamma-aminobutyric acid receptor subunit gamma-3	23	3	1	27
Gamma-aminobutyric acid receptor subunit alpha-6	23	3	1	27
Nuclear receptor ROR-gamma	20	1	1	22
Caspase-7	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	23	4	1	28
Gamma-aminobutyric acid receptor subunit beta-3	23	3	1	27
Gamma-aminobutyric acid receptor subunit beta-2	23	3	1	27
GABA theta subunit	23	3	1	27
ATPase family AAA domain-containing protein 5	26	0	0	26
Ataxin-2	31	0	0	31
Gamma-aminobutyric acid receptor subunit epsilon	23	3	1	27
Fumarate hydratase	17	0	0	17
EWS/FLI fusion protein	31	0	0	31
polyprotein	17	0	0	17
ATP-binding cassette sub-family C member 3	0	47	0	47
Multidrug resistance-associated protein 4	0	48	0	50
Bile salt export pump	0	62	0	62
Hydroxycarboxylic acid receptor 2	0	2	2	4
Canalicular multispecific organic anion transporter 1	0	43	0	43
USP1 protein, partial	37	0	0	37
vitamin D3 receptor isoform VDRA	21	0	0	21
flap endonuclease 1	15	0	0	15
serine/threonine-protein kinase PLK1	6	0	0	6
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	7	0	0	7
peripheral myelin protein 22	37	0	0	37
Bile salt export pump	0	14	0	14
Rap guanine nucleotide exchange factor 3	7	0	0	7
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	19	0	0	19
Bloom syndrome protein isoform 1	18	0	0	18
60 kDa chaperonin	0	3	0	3
Retinoic acid receptor alpha	0	3	4	10
60 kDa heat shock protein, mitochondrial	0	3	0	3
Retinoic acid receptor beta	0	3	4	10
Retinoic acid receptor gamma	0	3	4	10
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Glycine receptor subunit alpha-1	0	0	3	3
Spike glycoprotein	27	1	3	31
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	20	0	0	20
Mineralocorticoid receptor	0	7	3	11
Mineralocorticoid receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	2
Guanine nucleotide-binding protein G	6	0	0	6
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Acetylcholinesterase	0	6	0	6
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
interleukin 8	17	0	0	17
Smad3	14	0	0	14
regulator of G-protein signaling 4	16	0	0	16
cytochrome P450 family 3 subfamily A polypeptide 4	43	0	0	43
nonstructural protein 1	7	0	0	7
peripheral myelin protein 22 isoform 1	14	0	0	14
potassium voltage-gated channel subfamily H member 2 isoform d	14	0	0	14
importin subunit beta-1 isoform 1	8	0	0	8
snurportin-1	8	0	0	8
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	26	0	0	26
muscleblind-like protein 1 isoform 1	11	0	0	11
neuropeptide S receptor isoform A	7	0	0	7
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	2	0	2
Aromatase	0	9	0	12
Gastrin/cholecystokinin type B receptor	0	0	0	1
Testosterone 17-beta-dehydrogenase 3	0	2	0	2
Alpha-synuclein	6	6	0	12
GALC protein	6	0	0	6
caspase 7, apoptosis-related cysteine protease	8	0	0	8
cytochrome P450 2D6	28	0	0	28
caspase-3	8	0	0	8
Cytochrome P450 3A4	0	22	2	28
Substance-P receptor	0	4	2	6
Neuromedin-K receptor	0	2	1	3
cGMP-dependent protein kinase 1	0	0	3	3
Substance-P receptor	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	29	0	0	29
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	31	0	0	31
phosphopantetheinyl transferase	21	0	0	21
NFKB1 protein, partial	5	0	0	5
GLS protein	21	0	0	21
alpha-galactosidase	7	0	0	7
cytochrome P450 2C19 precursor	8	0	0	8
muscarinic acetylcholine receptor M1	12	0	0	12
lethal factor (plasmid)	13	0	0	13
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
5-hydroxytryptamine receptor 3E	0	3	0	3
PPM1D protein	16	0	0	16
67.9K protein	23	0	0	23
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	7	0	0	7
lysosomal alpha-glucosidase preproprotein	5	0	0	5
mu-type opioid receptor isoform MOR-1	0	0	3	3
transcriptional regulator ERG isoform 3	7	0	0	7
5-hydroxytryptamine receptor 2A	0	0	3	3
Solute carrier family 22 member 2	0	6	0	7
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3B	0	3	0	3
ATP-dependent translocase ABCB1	0	13	1	17
5-hydroxytryptamine receptor 1A	0	8	4	12
5-hydroxytryptamine receptor 2C	0	6	0	7
Neuronal acetylcholine receptor subunit alpha-4	4	0	0	4
Neuronal acetylcholine receptor subunit beta-2	4	0	0	4
D(2) dopamine receptor	0	15	5	20
5-hydroxytryptamine receptor 2A	0	8	0	8
Alpha-2C adrenergic receptor	0	17	2	20
D	0	7	0	7
5-hydroxytryptamine receptor 1A	0	15	1	17
Muscarinic acetylcholine receptor M3	0	11	1	12
D(1A) dopamine receptor	0	12	1	13
D(4) dopamine receptor	0	3	1	4
D(1B) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	8	3	11
Alpha-1D adrenergic receptor	0	15	1	17
5-hydroxytryptamine receptor 2A	0	18	3	21
5-hydroxytryptamine receptor 2C	0	16	3	19
D(4) dopamine receptor	0	4	0	4
Histamine H1 receptor	0	2	3	5
Sodium-dependent serotonin transporter	0	16	0	16
5-hydroxytryptamine receptor 7	0	5	0	5
5-hydroxytryptamine receptor 7	0	7	1	8
Alpha-1A adrenergic receptor	0	5	2	8
Histamine H1 receptor	0	11	3	14
Alpha-1B adrenergic receptor	0	1	1	3
D(3) dopamine receptor	0	14	1	15
5-hydroxytryptamine receptor 2B	0	21	2	23
5-hydroxytryptamine receptor 3A	0	4	0	4
5-hydroxytryptamine receptor 6	0	17	1	19
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	10	3	13
Inositol monophosphatase 1	6	0	0	6
Potassium voltage-gated channel subfamily H member 2	0	12	0	12
5-hydroxytryptamine receptor 3D	0	3	0	3
Multidrug and toxin extrusion protein 2	0	5	0	5
5-hydroxytryptamine receptor 3C	0	3	0	3
Multidrug and toxin extrusion protein 1	0	10	0	10
Histamine H3 receptor	0	4	2	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	15	0	0	15
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase kappa isoform 1	20	0	0	20
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	5	0	6
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	4	2	6
Carbonic anhydrase 1	0	12	0	18
Carbonic anhydrase 2	0	16	1	24
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	8	2	0	10
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	5	0	5
Seed linoleate 13S-lipoxygenase-1	0	3	0	5
Integrin alpha-IIb	8	1	0	9
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	4	0	6
Adenosine receptor A2a	0	3	0	5
Substance-P receptor	0	5	0	5
Prostaglandin G/H synthase 2	0	5	1	6
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	1	1	2
glp-1 receptor, partial	18	0	0	18
Thrombopoietin	5	0	0	5
Parkin	5	0	0	5
hemoglobin subunit beta	4	0	0	4
cellular tumor antigen p53 isoform a	11	0	0	11
huntingtin isoform 2	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	9	0	0	9
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Adenosine receptor A2a	0	8	1	9
Adenosine receptor A1	0	4	0	4
D(1A) dopamine receptor	3	0	0	3
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Chain A, Ferritin light chain	13	0	0	13
thioredoxin glutathione reductase	10	0	0	10
M-phase phosphoprotein 8	9	0	0	9
Protein-arginine deiminase type-4	0	5	0	5
galanin receptor type 3	0	1	0	1
ORF73	0	0	2	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Solute carrier organic anion transporter family member 1B3	0	6	0	9
Solute carrier organic anion transporter family member 1B1	0	8	0	11
Genome polyprotein	0	2	1	3
dopamine D1 receptor	3	0	0	3
D(1A) dopamine receptor	9	0	0	9
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	12	0	0	12
5-hydroxytryptamine receptor 4	0	12	0	12
ATP-dependent translocase ABCB1	0	6	0	6
Beta-1 adrenergic receptor	0	8	1	9
Alpha-2A adrenergic receptor	0	18	2	21
Alpha-2B adrenergic receptor	0	18	1	20
D(3) dopamine receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	3	2	5
ATP-dependent translocase ABCB1	0	7	0	7
Alpha-2C adrenergic receptor	0	3	2	5
Alpha-2A adrenergic receptor	0	3	2	5
D(1B) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1B	0	11	0	11
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	7	1	9
Androgen receptor	0	13	5	21
Cytochrome P450 2D6	0	9	1	11
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	18	3	22
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	5	7
Cytochrome P450 2C19	0	8	1	9
Kappa-type opioid receptor	0	6	2	10
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	1	3
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	7	0	11
Carbonic anhydrase 3	0	6	0	9
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	7	0	11
Carbonic anhydrase 6	0	6	0	10
Carbonic anhydrase 5A, mitochondrial	0	6	0	10
Carbonic anhydrase 7	0	8	0	12
Carbonic anhydrase 9	0	7	0	11
Carbonic anhydrase 13	0	1	0	3
Poly [ADP-ribose] polymerase tankyrase-2	0	2	1	3
Carbonic anhydrase 14	0	6	0	10
Carbonic anhydrase 5B, mitochondrial	0	6	0	10
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	3	4
Replicase polyprotein 1ab	0	1	3	4
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	3	4
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	2	2
Amyloid-beta precursor protein	1	5	0	6
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	1	3	4
Muscarinic acetylcholine receptor M2	0	10	1	11
Muscarinic acetylcholine receptor M4	0	7	0	7
Muscarinic acetylcholine receptor M5	0	7	0	7
Replicase polyprotein 1a	0	1	3	4
Replicase polyprotein 1ab	0	1	3	4
Replicase polyprotein 1ab	0	2	3	5
Spike glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	10	1	11
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	2	5
DNA ligase 1	0	1	0	1
Serine/threonine-protein kinase mTOR	0	4	2	6
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	3	4
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
endonuclease IV	6	0	0	6
PAX8	0	0	0	2
cytochrome P450 2D6 isoform 1	7	0	0	7
nuclear receptor subfamily 0 group B member 1	0	2	0	2
cytochrome P450 2C9 precursor	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
steroidogenic factor 1	0	2	0	2
Solute carrier family 22 member 3	0	3	0	4
Tubulin alpha-1A chain	0	4	3	8
Tubulin beta chain	0	4	3	7
Plasma kallikrein	0	1	0	5
Tubulin beta-4A chain	0	4	4	11
Tubulin beta chain	0	4	4	11
Tubulin alpha-3C chain	0	4	4	11
Serine/threonine-protein kinase pim-1	0	2	2	4
Histamine H2 receptor	11	1	1	14
Tubulin alpha-1B chain	0	4	4	11
Tubulin alpha-4A chain	0	4	4	11
Tubulin beta-4B chain	0	4	4	11
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	5	4	12
Tubulin beta-2A chain	0	4	4	11
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	4	4	11
Tubulin beta-2B chain	0	3	1	6
Tubulin alpha-3E chain	0	4	4	11
Tubulin alpha-1A chain	0	4	4	11
Similar to alpha-tubulin isoform 1	0	2	1	5
Similar to alpha-tubulin isoform 1	0	2	0	4
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	4	4	11
Tubulin beta-6 chain	0	4	4	11
Tubulin beta-2B chain	0	4	4	11
Tubulin beta-1 chain	0	4	4	11
chaperonin GroEL	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Sodium-dependent noradrenaline transporter	0	1	0	1
Aldo-keto reductase family 1 member B1	0	15	0	15
Muscarinic acetylcholine receptor M1	0	3	3	6
Muscarinic acetylcholine receptor M3	0	3	3	6
Muscarinic acetylcholine receptor M4	0	3	3	6
Muscarinic acetylcholine receptor M5	0	4	3	7
Muscarinic acetylcholine receptor M2	0	3	3	6
Glycogen phosphorylase, brain form	0	1	2	3
Glycogen phosphorylase, muscle form	0	1	0	1
Angiotensin-converting enzyme	0	6	0	6
Endothelin receptor type B	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	2	0	4
Sodium-dependent noradrenaline transporter	0	14	1	15
Endothelin receptor type B	0	2	0	2
Histamine H2 receptor	0	15	2	17
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 2C	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
D(2) dopamine receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Histone-lysine N-methyltransferase SETD7	0	3	0	3
Transporter	0	5	0	5
Progesterone receptor	0	10	5	16
Adenosine receptor A2b	0	1	0	1
Mu-type opioid receptor	0	15	5	24
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	6	0	6
G-protein coupled bile acid receptor 1	0	0	3	3
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Steryl-sulfatase	0	1	0	2
Multidrug resistance-associated protein 1	0	0	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	4
ATP-binding cassette sub-family C member 11	0	0	0	2
Solute carrier family 22 member 11	0	0	0	3
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	2	4
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	3	3	9
Albumin	0	5	7	14
15-lipoxygenase, partial	9	0	0	9
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	1	6	7
Estrogen receptor	0	13	4	17
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Tyrosine-protein kinase Fyn	0	3	2	5
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Substance-K receptor	0	10	0	10
Thromboxane-A synthase	0	5	0	5
Vasopressin V1a receptor	0	5	1	6
Delta-type opioid receptor	0	13	5	22
Kappa-type opioid receptor	0	13	4	22
Estrogen-related receptor gamma	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	3	1	0	4
Aldehyde oxidase	0	3	0	3
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	5	3	8
Estrogen receptor beta	0	7	4	11
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	8	0	9
Cysteinyl leukotriene receptor 1	0	2	0	2
Chain A, Sex Hormone-Binding Globulin	0	0	1	1
thyrotropin-releasing hormone receptor	5	0	0	5
Progesterone receptor	0	1	0	1
Glucocorticoid receptor	0	2	1	3
Sex hormone-binding globulin	0	1	0	1
Androgen receptor	0	1	2	3
Angiotensin-converting enzyme	0	4	1	5
Cannabinoid receptor 2	0	1	1	2
Muscarinic acetylcholine receptor	0	1	0	1
Neuropeptide FF receptor 2	0	0	0	1
ALK tyrosine kinase receptor	0	1	1	2
Vpr	7	0	0	7
Glutathione S-transferase omega-1	0	1	0	1
D(3) dopamine receptor isoform e	1	0	0	1
Endothelin-1 receptor	0	3	1	4
Genome polyprotein	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	5
Cytochrome P450 2B1	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	6	0	9
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Amine oxidase [flavin-containing] A	0	5	0	5
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	3	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Cocaine esterase	0	1	0	2
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Cytochrome P450 2J2	0	7	0	7
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	5	0	5
Carbonic anhydrase 13	0	5	0	9
G-protein coupled receptor 35	0	2	2	4
CDGSH iron-sulfur domain-containing protein 1	0	6	0	6
Chain A, Type Iii Chloramphenicol Acetyltransferase	0	1	0	1
streptokinase A precursor	0	0	2	2
Estrogen receptor	0	0	2	2
Estrogen receptor beta	0	0	2	2
Canalicular multispecific organic anion transporter 1	0	2	0	3
large T antigen	0	3	1	4
fructose-bisphosphate aldolase A	1	0	0	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	1	1	0	2
Pancreatic triacylglycerol lipase	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
72 kDa type IV collagenase	0	2	0	2
Matrilysin	0	2	0	2
Angiotensin-converting enzyme	0	3	0	3
L-selectin	0	1	0	1
P-selectin	0	1	0	1
E-selectin	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	4	0	4
Dipeptidyl peptidase 4	0	3	0	3
Proteasome subunit beta type-5	0	2	0	2
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Squalene monooxygenase	0	1	0	1
Autoinducer 2-binding periplasmic protein LuxP	0	1	0	1
Anthrax toxin receptor 2	0	1	0	1
Lactoperoxidase	0	0	0	1
Polypeptide N-acetylgalactosaminyltransferase 2	0	1	1	2
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Carbonic anhydrase	0	3	0	3
Toll-like receptor 2	0	1	0	1
WRN	3	0	0	3
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
isocitrate dehydrogenase 1, partial	2	0	0	2
Free fatty acid receptor 1	0	0	3	3
Trypsin	0	1	0	1
Coagulation factor VII	0	2	0	2
Tissue factor	0	2	0	2
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Equilibrative nucleoside transporter 1	0	1	0	1
Glucagon-like peptide 1 receptor	0	0	1	1
Glucagon-like peptide 1 receptor	0	3	3	6
Glucagon receptor	0	0	1	1
Glucagon receptor	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	4
Amino acid transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	2	7
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	6
Glutamate receptor ionotropic, NMDA 2B	0	2	1	6
Glutamate receptor ionotropic, NMDA 2C	0	2	1	6
Large neutral amino acids transporter small subunit 1	0	6	0	6
Glutamate receptor ionotropic, NMDA 2D	0	2	1	6
Proton-coupled amino acid transporter 1	0	2	0	3
Glutamate receptor ionotropic, NMDA 3B	0	2	1	6
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	1	3	4
Glutamate receptor ionotropic, NMDA 3A	0	2	1	6
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	0	1	1
Chain B, Uracil Phosphoribosyltransferase	0	0	1	1
Chain C, Uracil Phosphoribosyltransferase	0	0	1	1
2-dehydropantoate 2-reductase	0	0	1	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Liver carboxylesterase 1	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 1	0	5	0	6
Macrophage migration inhibitory factor	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	3
Histamine H1 receptor	0	3	1	4
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Solute carrier family 22 member 1	0	1	0	3
Carbonic anhydrase	0	0	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	2
Carbonic anhydrase 15	0	2	0	5
Histamine H4 receptor	0	2	2	4
Histamine H3 receptor	0	1	0	2
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	1	0	1
Hsf1 protein	0	0	1	1
Carbonic anhydrase	0	1	0	1
Delta-type opioid receptor	0	5	3	10
Delta-type opioid receptor	0	6	3	9
Mu-type opioid receptor	0	7	3	10
Mu-type opioid receptor	0	6	2	9
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Nrf2	1	0	0	1
DNA polymerase III, partial	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
Acetylcholinesterase	0	2	0	2
Polyphenol oxidase 2	0	3	0	5
Tyrosinase	0	1	0	1
Tyrosinase	0	2	0	2
DNA polymerase beta	3	0	0	3
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
Toll-like receptor 7	0	0	1	1
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Mitogen-activated protein kinase 1	0	4	2	6
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
Cellular retinoic acid-binding protein 1	0	0	2	2
Estrogen receptor beta	0	1	0	2
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	3	0	3
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	2	0	2
Steroid 21-hydroxylase	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	3	0	3
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Translocator protein	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Estrogen receptor	0	1	0	2
Gonadotropin-releasing hormone receptor	0	3	1	4
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	1	4
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Cytochrome P450 1A1	0	5	0	5
Cytochrome P450 1B1	0	4	0	4
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	0	1
Type-2 angiotensin II receptor	0	4	0	4
Beta-2 adrenergic receptor	0	4	1	5
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein Kinase Ii Subunit Alpha	0	1	0	1
histidine kinase	0	1	0	1
BRCA1	2	0	0	2
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	2
Neuraminidase	0	3	0	3
galactokinase	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
POsterior Segregation	0	0	1	1
Aldo-keto reductase family 1 member B10	0	1	0	1
G2/mitotic-specific cyclin-B2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Cationic trypsin	0	1	0	1
Transthyretin	0	2	1	4
Interstitial collagenase	0	1	0	1
Cyclin-dependent kinase 1	0	1	2	3
Chemotaxis protein CheA	0	1	0	1
Tyrosine-protein kinase Yes	0	1	2	3
Neutrophil elastase	0	2	0	2
Stromelysin-1	0	3	1	4
Poly [ADP-ribose] polymerase 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Alpha-amylase 1A	0	1	0	1
Sialidase	0	1	0	1
Fatty acid synthase	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Urease subunit alpha	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
G2/mitotic-specific cyclin-B	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Casein kinase II subunit alpha'	0	1	2	3
Sodium-dependent dopamine transporter	0	2	1	3
Cyclin-dependent kinase 2	0	2	3	5
Cruzipain	0	1	0	1
Amine oxidase [flavin-containing] B	0	7	0	7
Cytosol aminopeptidase	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	3	2	5
Peroxisome proliferator-activated receptor gamma	0	1	4	5
Macrophage metalloelastase	0	1	0	1
Homeobox protein Nkx-2.5	0	1	0	1
Tyrosine-protein kinase SYK	0	1	3	4
Collagenase 3	0	1	0	1
1-deoxy-D-xylulose 5-phosphate reductoisomerase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	0	3
Fatty acid synthase	0	2	0	2
Glycogen synthase kinase-3 alpha	0	1	2	3
Glycogen synthase kinase-3 beta	0	2	2	4
Death-associated protein kinase 1	0	1	1	2
Mitogen-activated protein kinase 10	0	2	2	4
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	1	2
Urease subunit beta	0	2	0	2
Xanthine dehydrogenase/oxidase	0	4	0	5
Cyclin-dependent kinase 6	0	2	2	4
Cyclin-dependent-like kinase 5	0	1	2	3
Cyclin homolog	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Transcription factor GATA-4	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Substance-K receptor	0	2	0	2
Integrase	0	1	0	1
Protein polybromo-1	0	0	1	1
Casein kinase II subunit alpha 3	0	1	0	1
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
3-oxoacyl-acyl-carrier protein reductase	0	2	0	2
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	2	0	2
Aurora kinase B	0	1	2	3
MAP kinase-interacting serine/threonine-protein kinase 1	0	1	1	2
Cyclin-dependent kinase 1	0	1	0	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	2	1	3
NADPH oxidase 4	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
Sialidase-2	0	1	0	1
phosphoglycerate kinase	1	0	0	1
M1-family alanyl aminopeptidase	0	1	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
Tumor necrosis factor	0	0	1	1
Neuraminidase	0	1	0	1
Interleukin-2	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	3
heat shock 70kDa protein 1A	0	1	0	1
heat shock cognate 71 kDa protein isoform 1	0	1	0	1
dual specificity protein phosphatase 6	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
heat shock cognate 71 kDa protein isoform 2	0	1	0	1
Glutathione S-transferase Mu 1	0	1	0	1
PINK1	1	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
ClpP	2	0	0	2
Cytochrome P450 1A2	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Dihydrofolate reductase	0	5	0	6
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	3	3	6
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	2	3
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Kappa-type opioid receptor	0	4	3	7
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	4
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Dihydrofolate reductase	0	1	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
kappa-type opioid receptor isoform 1	0	1	0	1
Beta-galactosidase	0	0	1	1
Kappa-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	3	1	6
Sigma non-opioid intracellular receptor 1	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	4
UDP-glucuronosyltransferase 1A8	0	0	0	2
Nociceptin receptor	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Cytochrome P450 3A5	0	3	1	4
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	1	3
Integrin alpha-V	0	1	0	1
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Fibroblast growth factor receptor 1	0	2	2	4
Proto-oncogene tyrosine-protein kinase Src	0	2	2	4
UDP-glucuronosyltransferase 1-6	0	3	0	3
Cholecystokinin receptor type A	0	3	1	4
Melanocortin receptor 5	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	2	2	4
Beta-tubulin	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
Toll-like receptor 2	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	1	3
Tyrosine-protein phosphatase non-receptor type 1	0	6	0	8
Fatty acid-binding protein 5	0	2	1	3
Peroxisome proliferator-activated receptor alpha	2	3	3	9
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Gamma-aminobutyric acid	0	1	1	2
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium channel protein type 9 subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
XBP1	0	1	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Potassium channel subfamily K member 2	0	1	2	3
Sodium channel protein type 7 subunit alpha	0	1	0	1
WD repeat-containing protein 48	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
tyrosine-protein kinase Yes	3	0	0	3
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	2	0	2
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] A	0	3	0	3
Peroxisome proliferator-activated receptor alpha	0	2	1	3
Carnitine O-palmitoyltransferase 2, mitochondrial	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	6	7	16
Carnitine O-palmitoyltransferase 1, liver isoform	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
CDGSH iron-sulfur domain-containing protein 2	0	2	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	2	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	1	0	2
Beta-lactamase SHV-1	0	2	0	3
Beta-lactamase	0	1	0	2
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	3
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	1
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Calcium-activated potassium channel subunit alpha-1	0	1	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Beta-2 adrenergic receptor	0	2	0	3
Beta-3 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	3	1	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
N	0	1	0	1
NPYLR7B	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Major prion protein	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Trypanothione reductase	0	2	0	2
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Thromboxane-A synthase	0	0	0	1
Protease	0	3	2	7
Plasmepsin V	0	1	0	1
Protease	0	2	1	3
Glutamate receptor ionotropic, NMDA 2D	0	0	1	1
Glutamate receptor ionotropic, NMDA 3B	0	0	1	1
Catechol O-methyltransferase	0	0	1	1
C-C chemokine receptor type 2	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	2	1	3
Glutamate receptor ionotropic, NMDA 1	0	0	1	1
ATP-binding cassette sub-family C member 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
ATP-sensitive inward rectifier potassium channel 11	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	1	1
Thrombin	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	3
Solute carrier family 22 member 7	0	0	0	2
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	3
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	2	2
Cell division cycle 7-related protein kinase	0	0	2	2
Serine/threonine-protein kinase PLK4	0	1	2	3
ATP-dependent RNA helicase DDX3X	0	0	2	2
Pyridoxal kinase	0	0	2	2
Citron Rho-interacting kinase	0	0	2	2
Serine/threonine-protein kinase Chk1	0	0	2	2
Aurora kinase A	0	1	2	3
Cyclin-G-associated kinase	0	0	2	2
Ephrin type-B receptor 6	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 3	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 2	0	1	2	3
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	2	2
Dynamin-like 120 kDa protein, mitochondrial	0	0	2	2
Tyrosine-protein kinase JAK2	0	0	2	2
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	2	2
Ribosomal protein S6 kinase alpha-5	0	0	2	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	2	2
Cyclin-dependent kinase-like 5	0	0	2	2
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	0	3	3
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	0	2	2
High affinity nerve growth factor receptor	0	0	2	2
ADP/ATP translocase 2	0	0	2	2
Protein kinase C beta type	0	2	3	5
Insulin receptor	0	1	2	3
Tyrosine-protein kinase Lck	0	1	2	3
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	2	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Lyn	0	0	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	2	4
Insulin-like growth factor 1 receptor	0	0	2	2
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	2	2
Hepatocyte growth factor receptor	0	1	2	3
Tyrosine-protein kinase HCK	0	1	2	3
Platelet-derived growth factor receptor beta	0	1	2	3
Tyrosine-protein kinase Fgr	0	0	2	2
Serine/threonine-protein kinase A-Raf	0	1	2	3
Breakpoint cluster region protein	0	1	2	3
DNA topoisomerase 2-alpha	0	0	2	2
Cyclin-dependent kinase 4	0	1	2	3
ADP/ATP translocase 3	0	0	2	2
Inosine-5'-monophosphate dehydrogenase 2	0	0	2	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Serine/threonine-protein kinase B-raf	0	3	3	6
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	2	2
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	1	3	4
cAMP-dependent protein kinase catalytic subunit alpha	0	0	2	2
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	2	2
Ras-related protein Rab-6A	0	0	2	2
Ephrin type-A receptor 1	0	0	2	2
Multifunctional protein ADE2	0	0	2	2
cAMP-dependent protein kinase catalytic subunit beta	0	0	2	2
Ferrochelatase, mitochondrial	0	0	2	2
Ribosomal protein S6 kinase beta-1	0	0	2	2
Tyrosine-protein kinase JAK1	0	0	2	2
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-B receptor 2	0	0	2	2
Non-receptor tyrosine-protein kinase TYK2	0	0	2	2
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	2	2
Heme oxygenase 2	0	0	2	2
S-adenosylmethionine synthase isoform type-2	0	0	2	2
DnaJ homolog subfamily A member 1	0	0	2	2
RAC-alpha serine/threonine-protein kinase	0	0	2	2
RAC-beta serine/threonine-protein kinase	0	0	2	2
Dual specificity protein kinase TTK	0	0	2	2
DNA replication licensing factor MCM4	0	0	2	2
Myosin-10	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 2	0	0	2	2
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	0	2	2
Serine/threonine-protein kinase receptor R3	0	0	2	2
TGF-beta receptor type-2	0	0	2	2
Electron transfer flavoprotein subunit beta	0	0	2	2
Tyrosine-protein kinase CSK	0	0	2	2
Glycine--tRNA ligase	0	0	2	2
Protein kinase C iota type	0	0	3	3
Exosome RNA helicase MTR4	0	0	2	2
Tyrosine-protein kinase Tec	0	0	2	2
Tyrosine-protein kinase ABL2	0	0	2	2
Tyrosine-protein kinase FRK	0	0	2	2
G protein-coupled receptor kinase 6	0	0	2	2
26S proteasome regulatory subunit 6B	0	0	2	2
Mitogen-activated protein kinase 8	0	0	2	2
Mitogen-activated protein kinase 9	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Casein kinase I isoform alpha	0	1	2	3
Casein kinase I isoform delta	0	0	2	2
MAP kinase-activated protein kinase 2	0	0	2	2
Elongation factor Tu, mitochondrial	0	0	2	2
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	2	2
Casein kinase I isoform epsilon	0	0	2	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	2	2
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	2	2
Dual specificity protein kinase CLK3	0	0	2	2
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Ras-related protein Rab-27A	0	0	2	2
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Ribosomal protein S6 kinase alpha-3	0	0	2	2
Serine/threonine-protein kinase Nek2	0	0	2	2
Serine/threonine-protein kinase Nek3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase PLK1	0	1	2	3
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Tyrosine--tRNA ligase, cytoplasmic	0	0	2	2
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	1	2	3
Ephrin type-A receptor 4	0	0	2	2
Adenylate kinase 2, mitochondrial	0	0	2	2
Adenosine kinase	0	0	2	2
Ras-related protein Rab-10	0	0	2	2
Actin-related protein 3	0	0	2	2
Actin-related protein 2	0	0	2	2
GTP-binding nuclear protein Ran	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Casein kinase I isoform gamma-2	0	0	2	2
Cyclin-dependent kinase 16	0	0	2	2
Cyclin-dependent kinase 17	0	0	2	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 1	0	1	2	3
DNA topoisomerase 2-beta	0	0	2	2
Protein kinase C theta type	0	0	3	3
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	0	2	2
Focal adhesion kinase 1	0	0	2	2
Protein kinase C zeta type	0	0	3	3
Protein kinase C delta type	0	1	3	4
Tyrosine-protein kinase BTK	0	0	2	2
Cyclin-dependent kinase 18	0	0	2	2
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Serine/threonine-protein kinase 4	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
Integrin-linked protein kinase	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Maternal embryonic leucine zipper kinase	0	0	2	2
Structural maintenance of chromosomes protein 1A	0	0	2	2
Chromodomain-helicase-DNA-binding protein 4	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 1	0	0	2	2
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	0	2	2
Dual specificity testis-specific protein kinase 1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	0	2	2
Mitogen-activated protein kinase 11	0	0	2	2
Serine/threonine-protein kinase STK11	0	0	2	2
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
Discoidin domain-containing receptor 2	0	1	2	3
AP2-associated protein kinase 1	0	0	2	2
Myosin light chain kinase 3	0	0	2	2
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	2	2
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Acyl-CoA dehydrogenase family member 10	0	0	2	2
Serine/threonine-protein kinase N3	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	2	2
Uncharacterized protein FLJ45252	0	0	2	2
Acyl-CoA dehydrogenase family member 11	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	2	2
Serine/threonine-protein kinase TAO1	0	0	2	2
STE20-related kinase adapter protein alpha	0	0	2	2
Myosin-14	0	0	2	2
AarF domain-containing protein kinase 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
MAP kinase-activated protein kinase 5	0	0	2	2
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	2	2
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
ATP-dependent RNA helicase DDX1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
MAP/microtubule affinity-regulating kinase 4	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	2	2
Serine/threonine-protein kinase Nek1	0	0	2	2
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	2	2
EKC/KEOPS complex subunit TP53RK	0	0	2	2
Dual specificity testis-specific protein kinase 2	0	0	2	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	2	2
Serine/threonine-protein kinase D2	0	0	2	2
RNA cytidine acetyltransferase	0	0	2	2
Serine/threonine-protein kinase SIK2	0	0	2	2
STE20-like serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO3	0	0	2	2
dCTP pyrophosphatase 1	0	0	2	2
Dual specificity protein kinase CLK4	0	0	2	2
Casein kinase I isoform gamma-1	0	0	2	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	2	2
BMP-2-inducible protein kinase	0	0	2	2
Obg-like ATPase 1	0	0	2	2
Midasin	0	0	2	2
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Cyclin-dependent kinase 12	0	0	2	2
Serine/threonine-protein kinase 26	0	0	2	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	2	2
Serine/threonine-protein kinase NLK	0	0	2	2
Serine/threonine-protein kinase TBK1	0	0	2	2
Septin-9	0	0	2	2
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO2	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	2	2
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Thyroid hormone receptor-associated protein 3	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 3	0	1	2	3
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Serine/threonine-protein kinase 24	0	0	2	2
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
Bifunctional epoxide hydrolase 2	0	2	0	2
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
melanocortin receptor 4	0	1	1	2
Membrane-associated progesterone receptor component 1	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	1	2
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Mitogen-activated protein kinase 13	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	1	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	2	1	3
Platelet-derived growth factor receptor beta	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	1	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	1	1	2
Myosin light chain kinase, smooth muscle	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Vascular endothelial growth factor receptor 1	0	1	1	2
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
G1/S-specific cyclin-D1	0	1	0	1
Protein kinase C eta type	0	0	2	2
Cyclin-C	0	1	1	2
Activin receptor type-2A	0	0	1	1
Serine/threonine-protein kinase B-raf	0	1	0	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	1	1	2
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Vascular endothelial growth factor receptor 2	0	2	2	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	1	2
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
5-hydroxytryptamine receptor 5A	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	1	2
Cyclin-dependent kinase 8	0	1	1	2
Tyrosine-protein kinase Blk	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Mitogen-activated protein kinase 12	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Tubulin alpha-1A chain	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Protein delta homolog 1	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Protein kinase C epsilon type	0	2	2	4
Angiopoietin-1 receptor	0	1	1	2
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Serine/threonine-protein kinase ATR	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	1	1	2
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Serine/threonine-protein kinase D1	0	0	2	2
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
MAP kinase-activated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	1	1	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Rab-like protein 3	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	1	1	2
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	1	1	2
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	1	1	2
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Homeodomain-interacting protein kinase 2	0	1	1	2
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	1	1	2
Serine/threonine-protein kinase PLK3	0	1	1	2
Serine/threonine-protein kinase Nek6	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	1	1	2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Acetylcholinesterase	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	2	0	3
Beta-lactamase OXA-1	0	1	0	2
Metallo-beta-lactamase type 2	0	1	0	1
Metallo-beta-lactamase L1 type 3	0	1	0	1
Beta-lactamase TEM	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Protein kinase C gamma type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	4	0	7
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	3
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	2	0	4
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	1	0	3
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Albumin	0	0	2	2
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Nuclear receptor ROR-beta	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Forkhead box protein M1	0	2	0	2
UDP-glucuronosyltransferase 1A10	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Receptor-type tyrosine-protein phosphatase F	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
pyruvate kinase PKM isoform a	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
DNA polymerase beta	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (345)

Protein Targets (1,855)

Acanthosis Nigricans

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (345)

Drugs Studied (216)

Protein Targets (1,855)