Erythromelalgia

A peripheral arterial disease that is characterized by the triad of ERYTHEMA, burning PAIN, and increased SKIN TEMPERATURE of the extremities (or red, painful extremities). Erythromelalgia may be classified as primary or idiopathic, familial or non-familial. Secondary erythromelalgia is associated with other diseases, the most common being MYELOPROLIFERATIVE DISORDERS.

Synonym
Erythromelalgia

Excerpt	Reference
"Erythromelalgia is characterized by paroxysmal burning pain and redness of the distal extremities; primary and secondary forms exist."	( Blickstein, D; Krause, I; Yosipovitch, G, 1992)
"Erythromelalgia is a very rare vascular disease affecting children and is accompanied by severe burning pain in the extremities."	( Kandel, EI, 1990)
"Erythromelalgia is a vascular acrosyndrome affecting mainly the feet and triggered by elevation of room temperature."	( Hodara, M, 1988)
"Erythromelalgia is a syndrome characterized by erythema, burning pain and increased skin temperature of the affected extremities."	( Bosch, X; Esmatjes, E; Goday, A; Gomis, R; Nubiola, A; Vendrell, J; Vilardell, E, 1988)
"Erythromelalgia is causally related to thrombocythaemia; prompt relief of painful symptoms after treatment with aspirin is typical."	( Bauerschmitz, J; Knop, J, 1995)
"Erythromelalgia is an acrosyndrome characterized by paroxysmal manifestations associating erythema, local sensations of warmth and pain which improve with exposure to cold."	( Bonafé, JL; Lacombe, D; Lefebvre, D; Maleville, J; Martin, JC; Taïeb, A, 1994)
"Erythromelalgia is a rare syndrome characterized by pain, redness, and heat involving the lower and, less frequently, the upper extremities."	( Christensen, CR; Stubbs, DH, 1996)
"Erythromelalgia is a rare disorder characterized by burning pain of the extremities associated with red discoloration and increased temperature of the skin."	( Fukutake, T; Hattori, T; Kita, K; Sakakibara, R, 1996)
"The pathogenesis of erythromelalgia is unclear and precludes formulating a proposed mechanism by which nitroprusside has benefit in children."	( Allington, DR; Rivey, MP; Stone, JD, 1997)
"Erythromelalgia is a characteristic thrombotic complication in patients with the myeloproliferative disorders, essential thrombocythemia and polycythemia vera."	( Michiels, JJ; van Genderen, PJ, 1997)
"Erythromelalgia is a rare cutaneous disorder characterized by erythema, burning discomfort, and warmth of the extremities."	( Ahn, JS; Cho, KH; Eun, HC; Han, KH; Kim, SD; Suh, DH; Youn, JI, 2000)
"Erythromelalgia is a rare condition that has remained an enigma diagnostically and therapeutically for decades."	( Cohen, JS, 2000)
"Primary erythromelalgia is a rare condition, which is characterised by redness, burning pain, and increased temperature of the extremities."	( Goddard, JM; Harrison, CM; Rittey, CD, 2003)
"Erythromelalgia is the main, pathognomonic and presenting symptom in patients with essential thrombocythemia and thrombocythemia associated with polycythemia vera."	( Michiels, JJ, 2003)
"Erythromelalgia is a rare condition, but we managed to collect 12 primary cases for a double-blind, randomized, parallel-group pilot trial evaluating the effect of iloprost (n = 8) and placebo (n = 4)."	( Kalgaard, OM; Kvernebo, K; Mørk, C, 2003)
"Erythromelalgia is a rare, chronic, debilitating condition characterized by redness, warmth, and severe burning pain of the distal extremities."	( Guite, JW; Hehir, D; Milovcich, K; Nathan, A; Rose, JB, 2005)
"Erythromelalgia is a kind of cutaneous manifestation, which appears as a thrombotic complication in patients with myeloproliferative disorders such as essential thrombocythemia and polycythemia vera."	( Hur, JW; Jun, JB; Lee, WS; Lee, YY, 2005)
"Familial primary erythromelalgia is a rare autosomal dominant disease characterized by redness and painful episodes of the feet and hands, which is often triggered by heat or exercise."	( Hsieh, ST; Lee, MJ; Lu, CJ; Stephenson, DA; Yang, CC; Yu, HS, 2007)
"Primary erythromelalgia is an autosomal dominant pain disorder characterized by burning pain and skin redness in the extremities, with onset of symptoms during the first decade in the families whose mutations have been physiologically studied to date."	( Cheng, X; Dib-Hajj, SD; Tyrrell, L; Waxman, SG, 2008)
"Erythromelalgia is characterized by episodes of erythematous, warm, burning acral skin, which is exacerbated by heat and relieved by cold."	( Berk, DR; Eisen, AZ, 2008)
"Erythromelalgia is a rare chronic disorder characterized by intense burning pain, redness, swelling and increased skin temperature."	( Akkaya, VB; Ceyhan, AM; Gurses, I; Yildirim, M, 2010)
"Erythromelalgia is a rare condition characterized by episodic painful erythema and warmth often affecting, but not limited to, the distal extremities."	( Butler, IJ; Koenig, MK; Moody, S; Pacheco, S, 2012)
"Erythromelalgia is a rare disorder characterized by recurrent pain attacks, swelling and redness in the distal extremities."	( Berner, R; Creutzfeldt, R; Hufnagel, M; Jakob, A; Staszewski, O; Winterpacht, A, 2012)
"Erythromelalgia is an uncommon neurovascular disorder characterized by redness, increased skin temperature, and pain that usually occurs in the extremities."	( Davis, MD; Murphy, SL; Poterucha, TJ; Rho, RH; Sandroni, P; Warndahl, RA; Weiss, WT, 2013)
"Erythromelalgia is a rare disorder characterized by reddening, severe burning pain, and swelling of the extremities."	( Higashi, N; Katayama, Y; Nakajima, N; Ueda, M, 2013)
"Erythromelalgia is a rare clinical syndrome characterized by erythema, increased temperature, and severe burning pain that can be aggravated by warmth or relieved by cold."	( Choi, JY; Eun, LY; Huh, S; Jung, JW; Jung, MK, 2015)
"Erythromelalgia is a condition characterized by episodic pain, erythema and temperature of the extremities, which is relieved by cooling and aggravated by warming."	( King, T; Mann, N; Murphy, R, 2019)
"Erythromelalgia is an infrequent syndrome with a profound impact on quality of life."	( Altemir, A; Barrabés-Torrella, C; Iglesias-Sancho, M; Salleras-Redonnet, M; Sanchez-Regaña, M, 2022)
"Erythromelalgia is a rare neurovascular pain condition characterized by erythematous, warm, and painful extremities."	( Adams, AC; Montoya, L; Popenhagen, MP; Price, HN; Russi, DC; Singhal, NR, 2022)
"Erythromelalgia is a rare syndrome characterised by recurrent erythema, heat and burning pain in the extremities."	( Benetti, M; Caiza-Zambrano, F; Galarza, J; Gonzalez, F; Landriscina, P; León-Cejas, L; Reisin, R, 2023)

Excerpt	Reference
"Inherited erythromelalgia has recently been linked to mutations in the gene SCN9A, which encodes the voltage-gated sodium channel Nav1."	( Dib-Hajj, SD; Han, C; Lampert, A; Rush, AM; Wang, X; Waxman, SG; Yang, Y, 2007)
"Erythromelalgia has not been well characterized in the pediatric population."	( Cook-Norris, RH; Cruz-Inigo, AE; Davis, DM; Davis, MD; Sandroni, P; Tollefson, MM, 2012)

Excerpt	Reference
"Aspirin treatment of erythromelalgia in thrombocythemia patients resulted in the disappearance of the erythromelalgic, thrombotic signs and symptoms, correction of the shortened platelet survival times, and a significant reduction of the increased levels of beta-TG, PF4, TM and urinary TxB2 excretion to normal."	( Michiels, JJ, 2003)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	49 (20.42)	23.3326
1990's	57 (23.75)	12.5806
2000's	56 (23.33)	18.1394
2010's	66 (27.50)	28.8240
2020's	12 (5.00)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	11	0
glycine	low	1	0
histamine	low	2	0
inositol	low	1	0
niacin	low	2	0
triphosphoric acid	low	1	0
hydroxyindoleacetic acid	low	2	0
amitriptyline	low	6	0
aspirin	medium	57	2
bupivacaine	low	5	0
busulfan	medium	5	1
caffeine	low	1	0
verapamil	low	2	0
carbamazepine	low	8	0
chlorpheniramine	low	1	0
clomipramine	low	1	0
clonazepam	low	1	0
clonidine	low	1	0
cyproheptadine	low	1	0
dipyridamole	low	1	0
fentanyl	low	3	0
fluoxetine	low	1	0
furosemide	low	1	0
gabapentin	low	11	0
gliclazide	low	1	0
hydroxyurea	low	8	0
lidocaine	medium	13	1
imipramine	low	1	0
indomethacin	low	3	0
2-propanol	low	1	0
ketamine	low	7	0
labetalol	low	1	0
mepivacaine	low	1	0
metformin	low	1	0
mexiletine	low	12	0
midodrine	low	1	0
nicardipine	low	3	0
nifedipine	low	4	0
oxymetazoline	low	1	0
phenacetin	low	1	0
phenoxybenzamine	low	1	0
propranolol	low	4	0
riluzole	low	1	0
ticlopidine	low	1	0
prednisolone	low	2	0
thyroxine	low	1	0
prednisone	low	3	0
alanine	low	4	0
serine	low	1	0
glutamine	low	1	0
adenosine diphosphate	low	1	0
leucine	low	2	0
phenylalanine	low	3	0
valine	low	5	0
threonine	low	4	0
tryptophan	low	1	0
isoleucine	low	4	0
methylprednisolone	low	2	0
penicillanic acid	low	1	0
1,3-butadiene	low	1	0
cyclohexanol	low	4	0
pyrroles	low	1	0
ergotamine	low	1	0
1-naphthylamine	low	1	0
thiamine pyrophosphate	low	1	0
quinazolines	low	1	0
ephedrine	medium	1	1
hydrazine	low	1	0
methysergide	medium	3	1
phenylpropanolamine	low	1	0
alpha-aminopyridine	low	1	0
dihydroergotamine	low	1	0
malondialdehyde	low	1	0
vancomycin	low	1	0
mercury	low	1	0
magnesium sulfate	low	1	0
trolamine salicylate	medium	4	1
pizotyline	low	2	0
bromocriptine	low	2	0
phenyl acetate	low	2	0
glutamic acid	low	1	0
oxcarbazepine	low	1	0
etoposide	low	1	0
substance p	low	1	0
diltiazem	low	1	0
epirubicin	low	1	0
piperacillin	low	1	0
pergolide	low	1	0
fomesafen	low	3	0
dazoxiben	low	1	0
flupirtine	low	1	0
simvastatin	low	1	0
ranolazine	low	2	0
clopidogrel	low	1	0
atorvastatin	low	1	0
duloxetine hydrochloride	low	1	0
3-iodobenzylguanidine	low	1	0
capecitabine	low	1	0
adenosine	low	1	0
venlafaxine hydrochloride	low	4	0
cephalosporin c	low	1	0
sertraline	low	1	0
imatinib mesylate	low	1	0
proline	low	1	0
atropine	low	1	0
ropivacaine	low	1	0
cortisone	low	1	0
fibrin	low	1	0
pentazocine	low	1	0
buprenorphine	low	1	0
capsaicin	medium	4	1
thromboxane a2	medium	2	1
alprostadil	low	1	0
anandamide	low	1	0
misoprostol	medium	2	1
thromboxane b2	low	1	0
codeine	low	1	0
hydromorphone	low	1	0
morphine	low	2	0
iloprost	medium	2	1
cysteine	low	1	0
pregabalin	low	1	0
resiniferatoxin	low	1	0
xib 4035	low	2	0
tetrodotoxin	low	4	0
glucuronyl glucosamine glycan sulfate	low	1	0
ergoline	low	2	0
losartan potassium	low	1	0
cortisol succinate, sodium salt	low	1	0
piperacillin, tazobactam drug combination	low	1	0
cardiovascular agents	low	1	0
piroxicam	low	2	0
warfarin	low	2	0
cibinetide	medium	3	1
vitamin b 12	low	1	0
cyclosporine	low	3	0
bl 4162a	low	1	0
amg531	low	1	0
eye	low	1	0
phosphorus radioisotopes	low	1	0

Protein Targets (1,220)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	20	0	0	20
Chain A, HADH2 protein	13	0	0	13
Chain B, HADH2 protein	13	0	0	13
RAR-related orphan receptor gamma	32	0	0	32
GLI family zinc finger 3	34	0	0	34
AR protein	49	0	0	49
aldehyde dehydrogenase 1 family, member A1	25	0	0	25
thyroid stimulating hormone receptor	17	0	0	17
estrogen receptor 2 (ER beta)	19	0	0	19
nuclear receptor subfamily 1, group I, member 3	29	0	0	29
progesterone receptor	24	0	0	24
glucocorticoid receptor [Homo sapiens]	37	0	0	37
retinoic acid nuclear receptor alpha variant 1	40	0	0	40
estrogen-related nuclear receptor alpha	33	0	0	33
pregnane X nuclear receptor	38	0	0	38
estrogen nuclear receptor alpha	57	0	0	57
aryl hydrocarbon receptor	18	0	0	18
thyroid stimulating hormone receptor	16	0	0	16
activating transcription factor 6	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	21	0	0	21
v-jun sarcoma virus 17 oncogene homolog (avian)	23	0	0	23
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
thyroid hormone receptor beta isoform 2	36	0	0	36
nuclear factor erythroid 2-related factor 2 isoform 1	32	0	0	32
cytochrome P450 3A4 isoform 1	18	0	0	18
Gamma-aminobutyric acid receptor subunit pi	18	4	1	23
Voltage-dependent calcium channel gamma-2 subunit	20	0	0	20
Gamma-aminobutyric acid receptor subunit beta-1	18	4	1	23
Gamma-aminobutyric acid receptor subunit delta	18	4	1	23
Gamma-aminobutyric acid receptor subunit gamma-2	18	4	2	24
Glutamate receptor 2	20	2	2	24
Gamma-aminobutyric acid receptor subunit alpha-5	18	4	1	23
Gamma-aminobutyric acid receptor subunit alpha-3	18	4	1	23
Gamma-aminobutyric acid receptor subunit gamma-1	18	4	1	23
Gamma-aminobutyric acid receptor subunit alpha-2	18	4	1	23
Gamma-aminobutyric acid receptor subunit alpha-4	18	4	1	23
Gamma-aminobutyric acid receptor subunit gamma-3	18	4	1	23
Gamma-aminobutyric acid receptor subunit alpha-6	18	4	1	23
Gamma-aminobutyric acid receptor subunit alpha-1	18	5	2	25
Gamma-aminobutyric acid receptor subunit beta-3	18	4	1	23
Gamma-aminobutyric acid receptor subunit beta-2	18	4	2	24
Kelch-like ECH-associated protein 1	0	0	1	1
GABA theta subunit	18	4	1	23
Gamma-aminobutyric acid receptor subunit epsilon	18	4	1	23
Histone acetyltransferase KAT8	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
retinoid X nuclear receptor alpha	23	0	0	23
peroxisome proliferator-activated receptor delta	21	0	0	21
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	22	0	0	22
Histone H2A.x	13	0	0	13
thyroid hormone receptor beta isoform a	12	0	0	12
heat shock protein beta-1	13	0	0	13
lamin isoform A-delta10	35	0	0	35
dopamine D1 receptor	6	0	0	6
thioredoxin reductase	30	0	0	30
GLS protein	26	0	0	26
Thrombopoietin	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
cytochrome P450 2D6 isoform 1	14	0	0	14
cytochrome P450 2C19 precursor	9	0	0	9
ras-related protein Rab-9A	7	0	0	7
histone acetyltransferase KAT2A isoform 1	12	0	0	12
lethal factor (plasmid)	12	0	0	12
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	25	1	2	28
ATP-dependent phosphofructokinase	18	0	0	18
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	25	0	0	25
NPYLR7B	0	0	2	2
arylsulfatase A	15	0	0	15
IDH1	16	0	0	16
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	9	0	0	9
flap endonuclease 1	13	0	0	13
nuclear receptor ROR-gamma isoform 1	13	0	0	13
peripheral myelin protein 22	21	0	0	21
survival motor neuron protein isoform d	10	0	0	10
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	6	0	0	6
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	5	0	5
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	3	6
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	7	3	11
Heat shock 70 kDa protein 1A	0	2	1	3
Heat shock cognate 71 kDa protein	0	0	2	2
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	3
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	5	1	9
Adenosine receptor A3	0	3	0	3
Adenosine receptor A2a	0	5	4	11
Adenosine receptor A2b	0	1	1	4
Adenosine receptor A2b	0	3	2	6
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	5	3	11
Adenosine receptor A2a	0	7	2	13
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	5	0	6
Adenosine receptor A1	0	2	1	3
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	5	0	6
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	5	0	6
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	5	0	6
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	2	0	2
Mu-type opioid receptor	0	13	6	20
Delta-type opioid receptor	0	10	3	14
Kappa-type opioid receptor	0	12	4	17
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	10	0	0	10
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
P2Y purinoceptor 11	0	0	1	1
P2Y purinoceptor 12	0	1	1	2
Sensor protein kinase WalK	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Carbonic anhydrase 1	0	4	0	11
Carbonic anhydrase 2	0	5	0	14
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	2	0	4
Glutamate receptor ionotropic, NMDA 1	0	10	2	16
Proton-coupled amino acid transporter 1	0	7	0	8
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Kappa-type opioid receptor	0	6	1	8
Mu-type opioid receptor	0	5	1	6
Tyrosine-protein kinase	0	0	1	1
TDP1 protein	43	0	0	43
peroxisome proliferator activated receptor gamma	26	0	0	26
ATP-binding cassette sub-family C member 3	0	40	0	40
Multidrug resistance-associated protein 4	0	40	0	41
Bile salt export pump	0	53	0	53
Cellular tumor antigen p53	29	0	0	29
Thromboxane-A synthase	0	5	0	5
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Solute carrier organic anion transporter family member 2A1	0	1	0	4
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	41	0	42
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Luciferase	10	0	0	10
acetylcholinesterase	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	30	0	0	30
EWS/FLI fusion protein	28	0	0	28
farnesoid X nuclear receptor	15	0	0	15
G	20	0	0	20
cytochrome P450 2D6	27	0	0	27
vitamin D (1,25- dihydroxyvitamin D3) receptor	19	0	0	19
Solute carrier family 22 member 1	0	19	0	22
Solute carrier organic anion transporter family member 2B1	0	3	0	4
Interferon beta	30	0	0	30
HLA class I histocompatibility antigen, B alpha chain	20	0	0	20
Replicase polyprotein 1ab	0	4	2	6
Replicase polyprotein 1ab	0	4	3	7
Thrombopoietin receptor	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	28	0	28
Sodium channel protein type 5 subunit alpha	0	12	0	12
Inositol hexakisphosphate kinase 1	20	0	0	20
Solute carrier organic anion transporter family member 1B3	0	5	0	6
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	10	1	11
Solute carrier organic anion transporter family member 1B1	0	7	0	9
cytochrome P450 2C9, partial	20	0	0	20
USP1 protein, partial	21	0	0	21
NFKB1 protein, partial	9	0	0	9
D(1A) dopamine receptor	19	0	0	19
chromobox protein homolog 1	29	0	0	29
atrial natriuretic peptide receptor 2 precursor	10	0	0	10
serine/threonine-protein kinase mTOR isoform 1	12	0	0	12
muscarinic acetylcholine receptor M1	17	0	0	17
Polyunsaturated fatty acid lipoxygenase ALOX15B	10	0	0	10
Voltage-dependent L-type calcium channel subunit alpha-1F	0	9	0	9
5-hydroxytryptamine receptor 4	0	32	0	32
Albumin	0	0	5	5
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	18	0	18
Muscarinic acetylcholine receptor M2	0	15	3	23
Muscarinic acetylcholine receptor M4	0	16	1	20
Muscarinic acetylcholine receptor M1	0	7	1	10
Muscarinic acetylcholine receptor M3	0	7	1	10
Muscarinic acetylcholine receptor M4	0	6	1	9
5-hydroxytryptamine receptor 2C	0	10	0	10
Muscarinic acetylcholine receptor M5	0	7	1	10
Muscarinic acetylcholine receptor M5	0	18	1	22
Alpha-2A adrenergic receptor	0	31	5	37
Muscarinic acetylcholine receptor M2	0	7	1	11
Muscarinic acetylcholine receptor M1	0	18	2	25
Angiotensin-converting enzyme	0	10	0	10
D(2) dopamine receptor	0	23	3	27
5-hydroxytryptamine receptor 2A	0	13	0	13
Alpha-2B adrenergic receptor	0	28	2	31
Alpha-2C adrenergic receptor	0	25	3	29
5-hydroxytryptamine receptor 1A	0	30	2	33
Muscarinic acetylcholine receptor M3	0	15	2	20
D(1A) dopamine receptor	0	19	1	21
D(1B) dopamine receptor	0	2	0	3
UDP-glucuronosyltransferase 1A4	0	1	0	5
Sodium-dependent noradrenaline transporter	0	23	2	25
Histamine H2 receptor	0	11	2	13
Alpha-1D adrenergic receptor	0	25	5	31
5-hydroxytryptamine receptor 2A	0	32	3	35
5-hydroxytryptamine receptor 2C	0	34	3	37
5-hydroxytryptamine receptor 1B	0	29	1	30
5-hydroxytryptamine receptor 1D	0	5	1	6
5-hydroxytryptamine receptor 1F	0	5	1	6
5-hydroxytryptamine receptor 2B	0	10	0	10
5-hydroxytryptamine receptor 6	0	4	0	4
Histamine H1 receptor	0	5	1	6
Sodium-dependent serotonin transporter	0	20	3	23
5-hydroxytryptamine receptor 7	0	6	0	6
5-hydroxytryptamine receptor 5A	0	4	0	4
5-hydroxytryptamine receptor 5B	0	4	0	4
Histamine H1 receptor	0	15	3	18
D(3) dopamine receptor	0	23	0	24
Sodium channel protein type 1 subunit alpha	0	7	0	7
Sodium channel protein type 4 subunit alpha	0	10	0	11
UDP-glucuronosyltransferase 1A3	0	0	0	4
5-hydroxytryptamine receptor 3A	0	4	0	4
5-hydroxytryptamine receptor 2B	0	33	1	34
Alpha-1A adrenergic receptor	0	18	3	21
Histamine H2 receptor	15	3	1	21
D(1A) dopamine receptor	7	0	0	7
5-hydroxytryptamine receptor 6	0	25	1	26
5-hydroxytryptamine receptor 7	0	11	0	11
Voltage-dependent N-type calcium channel subunit alpha-1B	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1D	0	9	0	9
Sodium-dependent dopamine transporter	0	16	2	18
Voltage-dependent L-type calcium channel subunit alpha-1S	0	9	0	9
Voltage-dependent L-type calcium channel subunit alpha-1C	0	11	0	12
Sodium channel protein type 9 subunit alpha	0	11	0	11
Sigma non-opioid intracellular receptor 1	0	5	1	6
5-hydroxytryptamine receptor 4	0	4	0	4
Nuclear receptor subfamily 3 group C member 3	0	10	0	10
Sodium channel protein type 2 subunit alpha	0	7	0	7
Ataxin-2	26	0	0	26
Sigma non-opioid intracellular receptor 1	0	23	1	24
5-hydroxytryptamine receptor 3B	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	8	0	8
Sodium channel protein type 11 subunit alpha	0	6	0	6
Sodium channel protein type 8 subunit alpha	0	7	0	7
Histamine H3 receptor	0	4	2	6
Sodium channel protein type 10 subunit alpha	0	7	0	7
Chain A, Ferritin light chain	7	0	0	7
phosphopantetheinyl transferase	15	0	0	15
Bloom syndrome protein isoform 1	13	0	0	13
vitamin D3 receptor isoform VDRA	18	0	0	18
DNA polymerase kappa isoform 1	12	0	0	12
Fatty-acid amide hydrolase 1	0	2	0	2
Fatty-acid amide hydrolase 1	0	0	0	1
Potassium channel subfamily K member 3	0	6	0	6
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 1	0	2	2	4
Glutamate receptor 3	0	2	2	4
Glutamate receptor 4	0	2	2	4
Cannabinoid receptor 1	0	1	1	2
Cannabinoid receptor 1	0	2	0	3
Cannabinoid receptor 2	0	2	0	3
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Fatty-acid amide hydrolase 1	0	3	0	4
Fatty acid-binding protein 5	0	0	1	1
Corticotropin-releasing factor receptor 2	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Potassium channel subfamily K member 2	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	2	2	6
Cannabinoid receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	1	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	3	0	0	3
hypothetical protein, conserved	3	0	0	3
glucocerebrosidase	7	0	0	7
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	44	0	0	44
DNA polymerase iota isoform a (long)	13	0	0	13
Prostaglandin-H2 D-isomerase	0	2	0	2
Solute carrier family 22 member 6	0	5	0	5
Prostaglandin G/H synthase 1	0	3	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	3	1	1	5
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	6	0	7
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	1	1	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Substance-P receptor	0	4	0	4
Prostaglandin G/H synthase 2	0	8	1	9
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	6	0	0	6
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	1	5
Chain A, Cruzipain	5	0	0	5
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
caspase 7, apoptosis-related cysteine protease	8	0	0	8
caspase-3	8	0	0	8
Caspase-7	4	0	0	4
caspase-3	4	0	0	4
geminin	33	0	0	33
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
ATP-dependent translocase ABCB1	0	23	1	33
Insulin receptor	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Histone deacetylase 1	0	2	0	2
Histone deacetylase 2	0	2	0	2
Histone deacetylase 6	0	2	0	2
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	2	4
PPM1D protein	8	0	0	8
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
Genome polyprotein	0	1	1	2
ATAD5 protein, partial	16	0	0	16
Fumarate hydratase	14	0	0	14
polyprotein	14	0	0	14
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	10	0	0	10
ATP-dependent translocase ABCB1	0	8	0	8
Beta-1 adrenergic receptor	0	8	2	10
Cytochrome P450 3A4	0	15	1	19
5-hydroxytryptamine receptor 1A	0	6	0	6
Androgen receptor	0	5	0	5
D	0	9	0	9
D(3) dopamine receptor	0	10	0	10
Alpha-2B adrenergic receptor	0	13	4	17
ATP-dependent translocase ABCB1	0	8	0	9
Alpha-2C adrenergic receptor	0	13	4	17
Alpha-2A adrenergic receptor	0	13	4	17
D(1B) dopamine receptor	0	9	0	9
D(4) dopamine receptor	0	9	0	9
Alpha-synuclein	3	2	0	5
D(2) dopamine receptor	0	14	4	19
ATPase family AAA domain-containing protein 5	14	0	0	14
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	4	4	8
Potassium channel subfamily K member 9	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
15-lipoxygenase, partial	7	0	0	7
apical membrane antigen 1, AMA1	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
Matrix metalloproteinase-9	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	5	0	0	5
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	6	0	0	6
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	3	0	3
Amine oxidase [flavin-containing] B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Guanine deaminase	0	1	0	1
Liver carboxylesterase 1	0	0	0	2
Microtubule-associated protein tau	12	0	0	12
67.9K protein	9	0	0	9
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	3	1	4
Lysine-specific histone demethylase 1A	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
Cytochrome P450 1A2	0	5	1	8
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	3	1	4
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Chain A, Beta-lactamase	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	11
Vpr	1	0	0	1
Bile salt export pump	0	8	0	8
Major prion protein	0	0	3	3
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	3	0	3
Cytochrome P450 2C9	0	21	1	22
UDP-glucuronosyltransferase 2B7	0	1	0	4
Cytochrome P450 2B6	0	3	1	4
Cytochrome P450 2J2	0	16	0	16
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
MBT domain-containing protein 1	0	2	0	2
Solute carrier family 22 member 1	0	5	0	7
Lethal(3)malignant brain tumor-like protein 4	0	2	0	2
Lethal(3)malignant brain tumor-like protein 3	0	2	0	2
Chloroquine resistance transporter	0	2	0	2
Solute carrier family 22 member 2	0	3	0	4
Lethal(3)malignant brain tumor-like protein 1	0	2	0	2
Proteasome subunit beta type-11	0	0	0	1
Smad3	11	0	0	11
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	2
Adenylate cyclase type 1	0	2	0	2
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
cellular tumor antigen p53 isoform a	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	21	0	0	21
histone deacetylase 9 isoform 3	2	0	0	2
M-phase phosphoprotein 8	8	0	0	8
Proteasome subunit alpha type-7	0	0	0	1
Transmembrane protease serine 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Albumin	0	2	6	8
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	3	0	3
Procathepsin L	0	2	2	4
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Cytochrome P450 2D6	0	12	1	13
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Alpha-1B adrenergic receptor	0	13	2	15
Sphingomyelin phosphodiesterase	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
D(4) dopamine receptor	0	3	0	4
Adenylate cyclase type 3	0	2	0	2
Alpha-1D adrenergic receptor	0	13	2	15
Sodium-dependent dopamine transporter	0	8	0	8
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	4	0	4
Histamine H1 receptor	0	2	3	5
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	5	1	6
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	2	3
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	8	2	14
Glutamate receptor ionotropic, NMDA 2B	0	8	2	14
Glutamate receptor ionotropic, NMDA 2C	0	8	2	14
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	8	2	14
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	8	2	14
D	0	2	0	2
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 3A	0	8	2	14
Trypanothione reductase	0	1	0	1
Envelope glycoprotein	0	0	3	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	1	6
Gamma-aminobutyric acid receptor subunit beta-1	0	5	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	5	1	6
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	1	6
Gamma-aminobutyric acid receptor subunit beta-2	0	5	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	1	6
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
Beta-1 adrenergic receptor	0	1	3	5
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2C9 precursor	8	0	0	8
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	5	0	7
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	1	0	2
Delta-type opioid receptor	0	6	0	7
Alpha-1A adrenergic receptor	0	4	7	12
Alpha-1B adrenergic receptor	0	3	5	9
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Nischarin	0	2	0	2
Multidrug and toxin extrusion protein 1	0	11	0	11
Nischarin	0	2	0	2
nonstructural protein 1	9	0	0	9
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
Cytochrome P450 2C8	0	5	0	6
Cytochrome P450 2C19	0	8	0	9
Rap guanine nucleotide exchange factor 4	2	0	0	2
P2Y purinoceptor 12	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Kappa-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	4	1	7
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	3	3
endonuclease IV	4	0	0	4
pregnane X receptor	3	0	0	3
peripheral myelin protein 22 isoform 1	10	0	0	10
Glucocorticoid receptor	0	8	2	15
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
TAR DNA-binding protein 43	7	0	0	7
huntingtin isoform 2	4	0	0	4
chaperonin GroEL	2	0	0	2
Sodium-dependent noradrenaline transporter	0	3	0	3
Glycogen phosphorylase, brain form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Endothelin receptor type B	0	1	0	1
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	3	0	3
Histone-lysine N-methyltransferase SETD7	0	2	0	2
Transporter	0	6	0	6
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Thromboxane-A synthase	0	1	0	1
Prostacyclin synthase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Solute carrier family 22 member 2	0	5	0	6
Multidrug and toxin extrusion protein 2	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
acid sphingomyelinase	1	0	0	1
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
DNA polymerase III, partial	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
LANA	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	12	0	0	12
thyrotropin-releasing hormone receptor	3	0	0	3
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
serine/threonine-protein kinase PLK1	4	0	0	4
eyes absent homolog 2 isoform a	3	0	0	3
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
snurportin-1	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	9	0	0	9
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
muscleblind-like protein 1 isoform 1	5	0	0	5
caspase-1 isoform alpha precursor	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
kelch-like ECH-associated protein 1	0	0	0	2
neuropeptide S receptor isoform A	6	0	0	6
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-7	3	0	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Exopolyphosphatase PRUNE1	0	1	0	1
Single-stranded DNA cytosine deaminase	2	0	0	2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
glp-1 receptor, partial	9	0	0	9
urokinase-type plasminogen activator precursor	9	0	0	9
plasminogen precursor	9	0	0	9
urokinase plasminogen activator surface receptor precursor	9	0	0	9
Genome polyprotein	0	1	0	1
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Beta-2 adrenergic receptor	0	6	2	8
5-hydroxytryptamine receptor 1B	0	4	1	5
5-hydroxytryptamine receptor 5A	0	1	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	1	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	2	0	3
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	3	0	4
Serum paraoxonase/arylesterase 1	0	3	0	3
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	6	2	11
Kappa-type opioid receptor	0	3	1	5
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Sodium-dependent serotonin transporter	0	7	0	7
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Sigma intracellular receptor 2	0	5	0	5
Sodium-dependent dopamine transporter	0	2	0	2
Transporter	0	1	0	1
Beta-2 adrenergic receptor	0	3	2	7
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	2
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 4	0	0	0	1
Potassium voltage-gated channel subfamily KQT member 5	0	0	0	1
phosphoglycerate kinase	1	0	0	1
Carbonic anhydrase 12	0	1	0	5
Carbonic anhydrase 3	0	1	0	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Carbonic anhydrase 4	0	2	0	6
Carbonic anhydrase 6	0	1	0	5
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	6
Carbonic anhydrase 7	0	1	0	5
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Carbonic anhydrase 9	0	2	0	7
Carbonic anhydrase 13	0	1	0	5
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	1	0	5
Carbonic anhydrase 5B, mitochondrial	0	1	0	5
thioredoxin glutathione reductase	4	0	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	2
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
transcriptional regulator ERG isoform 3	1	0	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Aldo-keto reductase family 1 member C3	0	3	0	3
Aldo-keto reductase family 1 member C2	0	2	0	2
Aldo-keto reductase family 1 member C1	0	2	0	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	3	0	3
Amino acid transporter	0	3	0	3
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	6	0	7
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	3
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	2
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 15	0	0	0	3
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	2
Carboxylic ester hydrolase	0	0	0	1
alpha-galactosidase	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	3	0	3
Stromelysin-1	0	1	1	2
Urease subunit alpha	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	0	1	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	0	1	1
Prostacyclin receptor	0	1	1	2
Prostaglandin D2 receptor	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	0	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
Prostaglandin E synthase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	1
Multidrug resistance-associated protein 1	0	3	1	5
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
C-X-C chemokine receptor type 3	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Solute carrier family 22 member 6	0	4	0	4
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 8	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Amyloid-beta precursor protein	0	3	0	3
Sodium/myo-inositol cotransporter 2	0	1	0	1
Acetylcholinesterase	0	4	0	4
Cholinesterase	0	2	0	2
Beta-3 adrenergic receptor	0	2	2	4
Heparanase	0	0	1	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Dihydrofolate reductase	0	4	0	4
Dipeptidyl peptidase 4	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Polyphenol oxidase 2	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Quinolone resistance protein NorA	0	2	0	3
Malate dehydrogenase, cytoplasmic	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Phospholipase A2, membrane associated	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
mu-type opioid receptor isoform MOR-1	0	0	2	2
5-hydroxytryptamine receptor 2A	0	0	2	2
Cytochrome P450 1A2	0	0	0	2
UDP-glucuronosyltransferase 1-6	0	1	0	1
Arylacetamide deacetylase	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Phenylethanolamine N-methyltransferase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Solute carrier family 22 member 11	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Beta-1 adrenergic receptor	0	2	1	4
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Voltage-gated sodium channel Nav1.5 cardiac isoform	0	1	0	1
hemoglobin subunit beta	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
pyruvate kinase	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Pteridine reductase 1	0	2	0	2
Pyruvate kinase PKM	0	0	1	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
PINK1	1	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, Arginase 1	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (240)

Protein Targets (1,220)

Erythromelalgia

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (240)

Drugs Studied (156)

Protein Targets (1,220)