Page last updated: 2024-12-05

aminoethylpiperazine

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Description

Aminoethylpiperazine is a chemical compound with the formula C6H14N2. It is a colorless liquid with a pungent amine odor. It is a derivative of piperazine, a heterocyclic compound with two nitrogen atoms. Aminoethylpiperazine is a building block for organic synthesis, and is used in the preparation of various pharmaceuticals. This compound is also commonly used in the production of various polymers and resins. The compound is widely used in chemical research and synthesis, and its importance lies in its potential applications in a variety of fields. Aminoethylpiperazine is studied because of its pharmacological properties and its potential therapeutic applications. Research on this compound includes investigations into its potential as an antihistamine, anticonvulsant, and antidepressant.'

aminoethylpiperazine: RN given refers to parent cpd with specified locant [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID8795
CHEMBL ID209790
SCHEMBL ID17210
MeSH IDM0102600

Synonyms (82)

Synonym
usaf do-46
1-piperazineethanamine
n-(aminoethyl)piperazine
nsc-38968
aminoethylpiperazine
nsc38968
1-aminoethylpiperazine
n-(.beta.-aminoethyl)piperazine
n-(2-aminoethyl)piperazine
wln: t6m dntj d2z
piperazine, 1-(2-aminoethyl)-
140-31-8
1-piperazineethylamine
1-(2-aminoethyl)piperazine
n-aminoethylpiperazine
mls000736991 ,
un2815
einecs 205-411-0
brn 0104363
2-piperazin-1-ylethanamine
nsc 38968
ccris 6678
2-piperazin-1-ylethylamine
ai3-52274
hsdb 5630
n-(beta-aminoethyl)piperazine
inchi=1/c6h15n3/c7-1-4-9-5-2-8-3-6-9/h8h,1-7h
1-(2-aminoethyl)piperazine, 99%
smr000393948
A0304
AKOS000118842
CHEMBL209790
NCGC00249192-01
28631-79-0
piperazineethanamine
tox21_302922
cas-140-31-8
dtxcid401997
NCGC00256327-01
dtxsid2021997 ,
tox21_202230
NCGC00259779-01
2-(piperazin-1-yl)ethanamine
STL163329
BBL011596
2-(1-piperazinyl)ethylamine
unii-i86052f9f6
i86052f9f6 ,
ec 205-411-0
n-aminoethylpiperazine [un2815] [corrosive]
5-23-01-00257 (beilstein handbook reference)
FT-0629105
2-(piperazin-1-yl)ethan-1-amine
LF-0556
2-piperazinylethylamine
n-(2-aminoethyl)piperazine [hsdb]
piperazineethanamine, 1-
n-(2-amino ethyl)piperazine
1-(2-aminoethyl)- piperazine
2-aminoethylpiperazine
n-(beta-aminoethyl)-piperazine
2-piperazin-1-yl-ethylamine
1-(2-aminoethyl)-piperazine
n-(2-aminoethyl)-piperazine
n-aminoethyl piperazine
4-(2-aminoethyl)piperazine
n-2-aminoethylpiperazine
n-(2-aminoethyl) piperazine
AM81364
SCHEMBL17210
un 2815
1-[2-aminoethyl]piperazine
2-(1-piperazinyl)ethanamine #
d.e.h. 39 (salt/mix)
W-109074
F2191-0297
mfcd00005971
Z57127897
n-(2-aminoethyl)pyperazine
Q3887815
1-(2-aminoethyl) piperazine
EN300-17952
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (39)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency30.63790.006038.004119,952.5996AID1159521; AID1159523
GLI family zinc finger 3Homo sapiens (human)Potency2.05110.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency25.98250.000221.22318,912.5098AID743042; AID743063
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency35.04240.003041.611522,387.1992AID1159552; AID1159553; AID1159555
estrogen nuclear receptor alphaHomo sapiens (human)Potency28.09810.000229.305416,493.5996AID1259244; AID1259248; AID743075; AID743079; AID743080
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency27.30600.001723.839378.1014AID743083
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency68.58960.000323.4451159.6830AID743067
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency15.35530.001557.789015,848.9004AID1259244
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency15.35530.001551.739315,848.9004AID1259244
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 12Homo sapiens (human)KA48.30000.24000.81921.6700AID318346; AID431566
Carbonic anhydrase 1Homo sapiens (human)Ka7.40000.02001.72197.4000AID1331203; AID1397319; AID268620; AID291061; AID307896; AID318343; AID365827; AID409984; AID431557; AID462829; AID691713; AID725228
Carbonic anhydrase 2Homo sapiens (human)Ka2.30070.01101.42737.8000AID1331204; AID1397320; AID268621; AID291063; AID307897; AID318344; AID365828; AID409986; AID414329; AID431558; AID462830; AID464319; AID691714; AID725229
Plasma kallikreinHomo sapiens (human)KA0.91000.04401.39744.3800AID305777
Carbonic anhydrase 3Homo sapiens (human)Ka0.32000.09100.72851.1200AID365829; AID409993; AID431559
Carbonic anhydrase 4Homo sapiens (human)Ka24.90000.07904.45607.3000AID365830; AID375786; AID431560
Carbonic anhydrase 6Homo sapiens (human)Ka9.54001.20005.82769.5400AID307898; AID431563; AID462831
Adenosine receptor A1Rattus norvegicus (Norway rat)KA2.30000.01101.32337.8000AID691714
Adenosine receptor A2aRattus norvegicus (Norway rat)KA2.30000.01101.32337.8000AID691714
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)KA6.04000.01002.79269.8100AID305776; AID431561
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)KA32.50000.71003.79009.7400AID291065
Carbonic anhydrase 7Homo sapiens (human)KA32.50000.71003.875610.0000AID291065; AID431564
Carbonic anhydraseSaccharomyces cerevisiae S288CKa9.30000.95005.12509.3000AID414331; AID464321
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)KA32.50000.71003.79009.7400AID291065
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)KA32.50000.71003.79009.7400AID291065
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)KA32.50000.71003.79009.7400AID291065
Carbonic anhydrase 9Homo sapiens (human)KA0.00900.00904.24939.7100AID318345; AID431565
Carbonic anhydrase-like protein, putativeTrypanosoma cruzi strain CL BrenerKA100.00000.14002.80507.5400AID1397322
Carbonic anhydraseCandida albicans SC5314KA17.30000.96003.95338.4000AID458784
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)KA32.50000.71003.79009.7400AID291065
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ka14.90007.10008.30009.5000AID464322
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)KA32.50000.71003.79009.7400AID291065
Carbonic anhydrase 15Mus musculus (house mouse)KA10.40004.00007.68579.5000AID375787
Carbonic anhydrase 13Mus musculus (house mouse)KA54.00000.01301.51404.6000AID268622; AID431567
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)KA32.50000.71003.79009.7400AID291065
Carbonic anhydrase 14Homo sapiens (human)KA18.30000.01002.28947.2100AID291067; AID431568
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)KA0.91000.04402.120510.0000AID305777; AID431562
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
estrous cycleCarbonic anhydrase 12Homo sapiens (human)
chloride ion homeostasisCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 1Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
Factor XII activationPlasma kallikreinHomo sapiens (human)
proteolysisPlasma kallikreinHomo sapiens (human)
blood coagulationPlasma kallikreinHomo sapiens (human)
zymogen activationPlasma kallikreinHomo sapiens (human)
plasminogen activationPlasma kallikreinHomo sapiens (human)
fibrinolysisPlasma kallikreinHomo sapiens (human)
positive regulation of fibrinolysisPlasma kallikreinHomo sapiens (human)
response to bacteriumCarbonic anhydrase 3Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 3Homo sapiens (human)
bicarbonate transportCarbonic anhydrase 4Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 4Homo sapiens (human)
detection of chemical stimulus involved in sensory perception of bitter tasteCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 7Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 7Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 7Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 7Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 7Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 7Homo sapiens (human)
response to hypoxiaCarbonic anhydrase 9Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 9Homo sapiens (human)
response to xenobiotic stimulusCarbonic anhydrase 9Homo sapiens (human)
response to testosteroneCarbonic anhydrase 9Homo sapiens (human)
secretionCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 14Homo sapiens (human)
response to bacteriumCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
zinc ion bindingCarbonic anhydrase 12Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 12Homo sapiens (human)
arylesterase activityCarbonic anhydrase 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 1Homo sapiens (human)
protein bindingCarbonic anhydrase 1Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 1Homo sapiens (human)
hydro-lyase activityCarbonic anhydrase 1Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
serine-type endopeptidase activityPlasma kallikreinHomo sapiens (human)
protein bindingPlasma kallikreinHomo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 3Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 3Homo sapiens (human)
nickel cation bindingCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 4Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 6Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 6Homo sapiens (human)
G protein-coupled adenosine receptor activityAdenosine receptor A2aRattus norvegicus (Norway rat)
carbonate dehydratase activityCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 9Homo sapiens (human)
molecular function activator activityCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Processvia Protein(s)Taxonomy
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
membraneCarbonic anhydrase 12Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 12Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 12Homo sapiens (human)
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
cytosolCarbonic anhydrase 1Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 1Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular regionPlasma kallikreinHomo sapiens (human)
extracellular spacePlasma kallikreinHomo sapiens (human)
plasma membranePlasma kallikreinHomo sapiens (human)
extracellular exosomePlasma kallikreinHomo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytoplasmCarbonic anhydrase 3Homo sapiens (human)
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
basolateral plasma membraneCarbonic anhydrase 4Homo sapiens (human)
rough endoplasmic reticulumCarbonic anhydrase 4Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentCarbonic anhydrase 4Homo sapiens (human)
Golgi apparatusCarbonic anhydrase 4Homo sapiens (human)
trans-Golgi networkCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
external side of plasma membraneCarbonic anhydrase 4Homo sapiens (human)
cell surfaceCarbonic anhydrase 4Homo sapiens (human)
membraneCarbonic anhydrase 4Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 4Homo sapiens (human)
transport vesicle membraneCarbonic anhydrase 4Homo sapiens (human)
secretory granule membraneCarbonic anhydrase 4Homo sapiens (human)
brush border membraneCarbonic anhydrase 4Homo sapiens (human)
perinuclear region of cytoplasmCarbonic anhydrase 4Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
extracellular regionCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
cytosolCarbonic anhydrase 6Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
Golgi membraneAdenosine receptor A2aRattus norvegicus (Norway rat)
mitochondrial matrixCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
cytosolCarbonic anhydrase 7Homo sapiens (human)
cytoplasmCarbonic anhydrase 7Homo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
nucleolusCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
membraneCarbonic anhydrase 9Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 9Homo sapiens (human)
microvillus membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
membraneCarbonic anhydrase 14Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 14Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 14Homo sapiens (human)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (70)

Assay IDTitleYearJournalArticle
AID365827Activation of human recombinant CA1 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID414331Activation of yeast recombinant CA by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID462832Activation of Stylophora pistillata carbonic anhydrase STPCA by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID464322Activation of Candida glabrata recombinant carbonic anhydrase by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID1281543Activation of Malassezia globosa beta-carbonic anhydrase incubated for 15 mins prior to testing by stopped flow CO2 hydrase method2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from Malassezia globosa with amines and amino acids.
AID318346Activation of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID691715Activity of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant CA expressed in Escherichia coli BL21(DE3) after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID268621Activation of human recombinant CA2 by CO2 hydrase assay2006Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
AID1331206Activation of Burkholderia pseudomallei gamma carbonic anhydrase at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID307898Activation of human recombinant CA6 by stopped flow CO2 hydrase method2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
AID431557Activation of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID431564Activation of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID409990Activation of Methanosarcina thermophila Zinc(2)-derived gamma-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID458787Activation of Cryptococcus neoformans beta-carbonic anhydrase Can2 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
AID1331210Activation of Burkholderia pseudomallei gamma carbonic anhydrase assessed as Kcat at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID458784Activation of Candida albicans beta-carbonic anhydrase Nce103 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
AID375786Activation of human recombinant carbonic anhydrase 4 lacking 20 amino terminal residues by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID431563Activation of human recombinant carbonic anhydrase 6 by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID375787Activation of membrane associated mouse recombinant carbonic anhydrase 15 isoform by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID464321Activation of Saccharomyces cerevisiae recombinant Nce103p by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID464320Activation of archaea Methanobacterium thermoautotrophicum recombinant carbonic anhydrase by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID409993Activation of human recombinant CA3 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID307896Activation of human recombinant CA1 by stopped flow CO2 hydrase method2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
AID725226Activation of Sulfurihydrogenibium azorense recombinant alpha carbonic anhydrase by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID318345Activation of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID305776Activation of human recombinant carbonic anhydrase 5A by stopped-flow CO2 hydrase method2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
AID1397320Activation of human CA2 by stopped-flow CO2 hydration assay
AID291067Activation of of human recombinant CA14 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID431567Activation of mouse recombinant carbonic anhydrase 13 by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID409988Activation of Methanobacterium thermoautotrophicum beta-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID462830Activation of human recombinant CA2by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID409986Activation of human recombinant CA2 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID365829Activation of human recombinant CA3 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID462829Activation of human recombinant CA1 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID431559Activation of human recombinant carbonic anhydrase 3 by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID431562Activation of human recombinant carbonic anhydrase 5B by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID691714Activity of human recombinant CA2 cytosolic isoform after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID431565Activation of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID725228Activation of human recombinant CA1 by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID431561Activation of human recombinant carbonic anhydrase 5A by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID291061Activation of human recombinant CA1 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID268622Activation of mouse recombinant CA13 by CO2 hydrase method2006Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
AID318344Activation of human recombinant CA2 by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID1397322Activation of Trypanosoma cruzi CA preincubated for 15 mins followed by CO2 addition by stopped-flow assay
AID409984Activation of human recombinant CA1 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID1331204Activation of recombinant human carbonic anhydrase 2 at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID307897Activation of human recombinant CA2 by stopped flow CO2 hydrase method2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
AID725229Activation of human recombinant CA2 by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID291063Activation of human recombinant CA2 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID365830Activation of human recombinant truncated CA4 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID431568Activation of human recombinant carbonic anhydrase 14 by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID414329Activation of human recombinant CA2 by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID464319Activation of human recombinant carbonic anhydrase isoenzyme 2 by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID409992Activation of Methanosarcina thermophila cobalt(2)-derived gamma-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID691713Activity of human recombinant CA1 cytosolic isoform after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID414330Activation of Methanothermobacter thermautotrophicus recombinant Cab by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID431558Activation of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID1331205Activation of recombinant Methanosarcina thermophila gamma carbonic anhydrase at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID431566Activation of human recombinant carbonic anhydrase 12 catalytic domain by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
AID462831Activation of human full length CA6 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID318343Activation of human recombinant CA1 by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID365828Activation of human recombinant CA2 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID1397321Activation of Leishmania donovani chagasi CA preincubated for 15 mins followed by CO2 addition by stopped-flow assay
AID291065Activation of human recombinant CA7 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID725227Activation of Sulfurihydrogenibium yellowstonense recombinant CA by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID305777Activation of human recombinant carbonic anhydrase 5B by stopped-flow CO2 hydrase method2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
AID1397319Activation of human CA1 by stopped-flow CO2 hydration assay
AID268620Activation of human recombinant CA1 by CO2 hydrase assay2006Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
AID1331203Activation of recombinant human carbonic anhydrase 1 at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID431560Activation of human recombinant carbonic anhydrase 4 by stopped flow CO2 hydration method2009Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (4.76)18.7374
1990's1 (4.76)18.2507
2000's11 (52.38)29.6817
2010's8 (38.10)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 39.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index39.46 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index5.61 (4.65)
Search Engine Demand Index51.14 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (39.46)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]