Foot Rot

A disease of the horny parts and of the adjacent soft structures of the feet of cattle, swine, and sheep. It is usually caused by Corynebacterium pyogenes or Bacteroides nodosus (see DICHELOBACTER NODOSUS). It is also known as interdigital necrobacillosis. (From Black's Veterinary Dictionary, 18th ed)

Synonym
Foot Rot

Excerpt	Reference
"Foot rot in affected, vaccinated sheep was more severe in those which had received the alum precipitated vaccine than in those given the oil emulsion vaccine, but vaccinated sheep were always less severely affected than controls."	( Egerton, JR; Thorley, CM, 1981)

Excerpt	Reference
"Four methods of treatment for ovine foot rot were evaluated: foot trimming and topical treatment (brief, daily foot bathing in 10% zinc sulfate); vaccination with an oil-alum adjuvanted, multivalent, Bacteroides nodosus bacterin, vaccination with the bacterin plus foot trimming and brief foot bathing, and 1-hour 10% zinc sulfate foot soaks."	( Bulgin, MS; Lane, VM; Lincoln, SD; Matlock, M, 1986)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	52 (40.63)	23.3326
1990's	27 (21.09)	12.5806
2000's	16 (12.50)	18.1394
2010's	28 (21.88)	28.8240
2020's	5 (3.91)	9.53

Drug	Relationship Strength	Studies	Trials
formaldehyde	low	11	0
glycine	low	1	0
histamine	low	1	0
iodine	low	2	0
methanol	low	1	0
melatonin	low	4	0
nitrates	low	1	0
urea	low	1	0
ethylenediamine	low	3	0
glutaral	low	1	0
propidium	low	1	0
sulfamerazine	low	1	0
sulfamethazine	low	1	0
sulfanilamide	low	1	0
sulfathiazole	low	1	0
trimethoprim	low	1	0
xylazine	low	1	0
serine	low	1	0
chloramphenicol	low	3	0
edetic acid	low	1	0
leucine	low	1	0
phenylalanine	low	1	0
arginine	low	1	0
nitroblue tetrazolium	low	1	0
fusarium	low	1	0
malondialdehyde	low	1	0
congo red	low	1	0
erythromycin	medium	5	2
spectinomycin	medium	2	1
streptomycin	medium	3	1
zinc sulfate	medium	17	2
copper sulfate	low	4	0
trolamine salicylate	low	1	0
clonixin	low	2	0
iodine	low	1	0
sodium azide	low	1	0
azides	low	2	0
amoxicillin	low	1	0
flunixin	low	1	0
flunixin meglumine	low	1	0
isothiocyanic acid	low	1	0
octyl glucoside	low	1	0
glucose, (beta-d)-isomer	low	1	0
cephalosporin c	medium	3	2
enrofloxacin	low	1	0
atipamezole	low	1	0
fibrinogen	low	1	0
glycidyl nitrate	low	1	0
beta-lactams	low	2	0
proline	low	1	0
borneo	low	1	0
biotin	low	1	0
elastin	low	2	0
n-formylmethionine leucyl-phenylalanine	low	1	0
fosfomycin	low	1	0
potassium permanganate	low	1	0
dipyrone	low	1	0
lincomycin	medium	4	1
propidium monoazide	low	1	0
sodium dodecyl sulfate	low	4	0
thromboxane b2	low	1	0
naloxone	low	1	0
aluminum	low	3	0
arsenic	low	1	0
selenium	low	2	0
beta-escin	low	1	0
pituitrin	low	1	0
ceftiofur	medium	3	2
peptones	low	1	0
interleukin-8	low	1	0
tilmicosin	medium	1	1
tylosin	medium	1	1
leukotoxin	low	2	0
tetracycline	low	1	0
chlortetracycline	low	1	0
oxytetracycline, anhydrous	medium	12	6
gamithromycin	medium	3	1
agar	low	1	0
caseins	low	1	0
moxidectin	low	1	0
muramidase	low	1	0
exudates	low	2	0

Protein Targets (586)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, Beta-lactamase	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
AR protein	18	0	0	18
apical membrane antigen 1, AMA1	4	0	0	4
estrogen nuclear receptor alpha	26	0	0	26
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	7	0	0	7
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
DNA polymerase kappa isoform 1	4	0	0	4
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	8	0	8
Bile salt export pump	0	2	0	2
Bile salt export pump	0	14	0	14
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	4	0	4
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	2	1	4
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	4	0	4
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	7	0	7
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	5	0	0	5
phosphopantetheinyl transferase	6	0	0	6
NFKB1 protein, partial	2	0	0	2
GLS protein	3	0	0	3
thyroid stimulating hormone receptor	8	0	0	8
alpha-galactosidase	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	11	0	0	11
flap endonuclease 1	2	0	0	2
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	7	0	0	7
Cytochrome P450 3A4	0	2	0	3
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
GALC protein	2	0	0	2
TDP1 protein	10	0	0	10
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
progesterone receptor	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
glucocorticoid receptor [Homo sapiens]	8	0	0	8
farnesoid X nuclear receptor	5	0	0	5
G	3	0	0	3
cytochrome P450 2D6	6	0	0	6
peroxisome proliferator-activated receptor delta	5	0	0	5
peroxisome proliferator activated receptor gamma	8	0	0	8
aryl hydrocarbon receptor	8	0	0	8
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	11	0	0	11
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	3	0	3
Inositol hexakisphosphate kinase 1	3	0	0	3
Transporter	0	1	0	1
cytochrome P450 2C9, partial	3	0	0	3
Carbonic anhydrase 1	0	7	0	10
Carbonic anhydrase 2	0	7	1	12
Carbonic anhydrase 4	0	5	0	7
Carbonic anhydrase	0	5	0	7
Carbonic anhydrase 15	0	4	0	6
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
RAR-related orphan receptor gamma	15	0	0	15
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	5	0	0	5
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
pregnane X receptor	1	0	0	1
GLI family zinc finger 3	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
retinoid X nuclear receptor alpha	11	0	0	11
estrogen-related nuclear receptor alpha	13	0	0	13
pregnane X nuclear receptor	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
thyroid stimulating hormone receptor	4	0	0	4
thyroid hormone receptor beta isoform 2	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Glutamate receptor 2	6	0	0	6
interleukin 8	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
EWS/FLI fusion protein	6	0	0	6
geminin	11	0	0	11
streptokinase A precursor	0	0	4	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	4	1	5
30S ribosomal protein S7	0	4	1	5
50S ribosomal protein L15	0	4	1	5
50S ribosomal protein L10	0	4	1	5
50S ribosomal protein L11	0	4	1	5
50S ribosomal protein L7/L12	0	4	1	5
50S ribosomal protein L19	0	4	1	5
50S ribosomal protein L1	0	4	1	5
50S ribosomal protein L20	0	4	1	5
50S ribosomal protein L27	0	4	1	5
50S ribosomal protein L28	0	4	1	5
50S ribosomal protein L29	0	4	1	5
50S ribosomal protein L31	0	4	1	5
50S ribosomal protein L31 type B	0	4	1	5
50S ribosomal protein L32	0	4	1	5
50S ribosomal protein L33	0	4	1	5
50S ribosomal protein L34	0	4	1	5
50S ribosomal protein L35	0	4	1	5
50S ribosomal protein L36	0	4	1	5
30S ribosomal protein S10	0	4	1	5
30S ribosomal protein S11	0	4	1	5
30S ribosomal protein S12	0	4	1	5
30S ribosomal protein S13	0	4	1	5
30S ribosomal protein S16	0	4	1	5
30S ribosomal protein S18	0	4	1	5
30S ribosomal protein S19	0	4	1	5
30S ribosomal protein S20	0	4	1	5
30S ribosomal protein S2	0	4	1	5
30S ribosomal protein S3	0	4	1	5
30S ribosomal protein S4	0	4	1	5
30S ribosomal protein S5	0	4	1	5
30S ribosomal protein S8	0	4	1	5
30S ribosomal protein S9	0	4	1	5
50S ribosomal protein L13	0	4	1	5
50S ribosomal protein L14	0	4	1	5
50S ribosomal protein L16	0	4	1	5
50S ribosomal protein L23	0	4	1	5
30S ribosomal protein S15	0	4	1	5
50S ribosomal protein L17	0	4	1	5
50S ribosomal protein L21	0	4	1	5
50S ribosomal protein L30	0	4	1	5
50S ribosomal protein L6	0	4	1	5
30S ribosomal protein S14	0	4	1	5
30S ribosomal protein S17	0	4	1	5
30S ribosomal protein S1	0	4	1	5
50S ribosomal protein L18	0	4	1	5
50S ribosomal protein L2	0	4	1	5
50S ribosomal protein L3	0	4	1	5
50S ribosomal protein L24	0	4	1	5
50S ribosomal protein L4	0	4	1	5
50S ribosomal protein L22	0	4	1	5
50S ribosomal protein L5	0	4	1	5
30S ribosomal protein S21	0	4	1	5
50S ribosomal protein L25	0	4	1	5
50S ribosomal protein L36 2	0	4	1	5
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	6	0	6
Luciferase	6	0	0	6
serine/threonine-protein kinase PLK1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	4	0	0	4
peripheral myelin protein 22	3	0	0	3
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	2	0	2
acetylcholinesterase	6	0	0	6
Histone H2A.x	5	0	0	5
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	3	0	3
Chymotrypsinogen A	0	0	0	1
Beta-lactamase	0	1	0	1
Amyloid-beta precursor protein	0	3	0	3
Beta-lactamase	0	0	0	1
5-hydroxytryptamine receptor 2A	0	3	0	4
Beta-galactosidase	0	1	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
15-lipoxygenase, partial	1	0	0	1
USP1 protein, partial	8	0	0	8
Microtubule-associated protein tau	5	0	0	5
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Histamine H2 receptor	5	0	1	6
Spike glycoprotein	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
IDH1	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
lamin isoform A-delta10	8	0	0	8
TAR DNA-binding protein 43	2	0	0	2
Motilin receptor	0	0	1	1
acid sphingomyelinase	1	0	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Albumin	0	0	2	2
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Cytochrome P450 1B1	0	2	0	2
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	0	1	0	1
Protein farnesyltransferase subunit beta	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
twin arginine protein translocation system - TatA protein	0	0	0	1
ATAD5 protein, partial	3	0	0	3
glycogen synthase kinase-3 alpha	0	0	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
Nuclear receptor ROR-gamma	3	0	0	3
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	6
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	5
Glutamate receptor ionotropic, NMDA 2B	0	2	1	5
Glutamate receptor ionotropic, NMDA 2C	0	2	1	5
Large neutral amino acids transporter small subunit 1	0	3	0	4
Glutamate receptor ionotropic, NMDA 2D	0	2	1	5
Proton-coupled amino acid transporter 1	0	4	0	5
Glutamate receptor ionotropic, NMDA 3B	0	2	1	5
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Glutamate receptor ionotropic, NMDA 3A	0	2	1	5
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
regulator of G-protein signaling 4	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase 12	0	1	0	3
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	2
Carbonic anhydrase 3	0	1	0	3
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 6	0	2	0	4
Histamine H2 receptor	0	1	2	3
Adenosine receptor A1	0	0	0	2
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	0	0	2
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	2	1	3
Carbonic anhydrase 5A, mitochondrial	0	3	0	6
Histamine H1 receptor	0	2	2	4
Carbonic anhydrase 7	0	1	0	3
Carbonic anhydrase	0	1	0	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	3	0	5
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	4
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase	0	1	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	1	0	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 13	0	1	0	3
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Carbonic anhydrase 14	0	1	0	3
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
Histamine H3 receptor	0	2	2	4
histone deacetylase 9 isoform 3	1	0	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
ClpP	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
Bloom syndrome protein isoform 1	3	0	0	3
cytochrome P450 2D6 isoform 1	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	5	0	0	5
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	4	0	4
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Aromatase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	5	0	0	5
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	0	5
Acetylcholinesterase	0	4	0	4
Metabotropic glutamate receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	0	5
Acetylcholinesterase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	0	5
Mu-type opioid receptor	0	5	2	7
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-2	5	0	0	5
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
GABA theta subunit	5	0	0	5
Gamma-aminobutyric acid receptor subunit epsilon	5	0	0	5
Carboxylic ester hydrolase	0	1	0	1
thioredoxin glutathione reductase	3	0	0	3
Formyl peptide receptor-related sequence 1	0	0	1	1
fMet-Leu-Phe receptor	0	2	2	4
N-formyl peptide receptor 2	0	0	2	2
FML2_HUMAN	0	0	1	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
D(3) dopamine receptor	0	1	0	1
Adenosine receptor A1	0	1	0	1
Delta-type opioid receptor	0	3	1	5
Delta-type opioid receptor	0	3	2	5
Kappa-type opioid receptor	0	1	0	2
Kappa-type opioid receptor	0	1	2	3
Mu-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	2	5
Mu-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
thyroid hormone receptor beta isoform a	4	0	0	4
microphthalmia-associated transcription factor isoform 9	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
snurportin-1	1	0	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
phosphoglycerate kinase	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Glutamate 5-kinase	0	0	0	1
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
cytochrome P450 2C9 precursor	3	0	0	3
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Acetylcholinesterase	0	1	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	2	0	2
Laccase	0	1	0	1
Integrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Chain A, Cruzipain	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
5-hydroxytryptamine receptor 2C	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Protein argonaute-2	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Transcriptional activator protein LasR	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protein arginine N-methyltransferase 6	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-synuclein	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
endonuclease IV	1	0	0	1
dopamine D1 receptor	1	0	0	1
67.9K protein	1	0	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
arylsulfatase A	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Synonyms(1)

Research Excerpts

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Treatment

Research

Studies (128)

Drugs Studied (99)

Protein Targets (586)