Meconium Aspiration Syndrome

A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.

Synonym
Meconium Aspiration Syndrome

Excerpt	Reference
""Meconium aspiration syndrome" is a condition resulting in respiratory distress and the occasional death of newborn human beings."	( Bildfell, R; Lopez, A, 1992)
"Meconium aspiration syndrome is related to mechanical obstruction of the airways and subsequent chemical pneumonitis."	( Bae, CW; Oh, MH, 2000)
"Meconium aspiration syndrome is still a frequent neonatal condition despite a codified prevention strategy."	( Chevalier, JY; Flamant, C; Hallalel, F; Nolent, P; Renolleau, S, 2004)
"Meconium aspiration syndrome is a serious condition of the newborn characterized by pulmonary inflammation with substantial neutrophil infiltration."	( Castellheim, A; Fung, M; Mollnes, TE; Pharo, A; Saugstad, OD, 2005)
"The meconium aspiration syndrome is an important cause of respiratory distress in newborn infants."	( Craig, S; Hoskin, D; Lopez, A; Markham, F, 2005)
"Severe meconium aspiration syndrome is difficult to manage and has a high mortality in developing countries."	( Green, DA, 2010)
"Meconium aspiration syndrome is associated with significant mortality."	( Dutta, S; Kumar, P; Louis, D; Mukhopadhyay, K; Sundaram, V, 2014)
"Meconium aspiration syndrome is attributed to the mechanical and chemical effects of aspirated meconium coupled with local and systemic fetal inflammation."	( Bosco, M; Chaiworapongsa, T; Gallo, DM; Gotsch, F; Jaiman, S; Jung, E; Ramón Y Cajal, CL; Romero, R; Suksai, M; Yoon, BH, 2023)

Excerpt	Reference
"Meconium aspiration syndrome has been for many years an important cause of neonatal respiratory distress in newborn babies and sporadically reported in animals."	( Dobbin, GV; Ireland, WP; Lopez, A; Martinez-Burnes, J; Wadowska, DW; Wright, GM, 2003)
"Meconium aspiration syndrome has a complex, poorly defined pathophysiology."	( Fung, M; Mollnes, TE; Salvesen, B; Saugstad, OD, 2008)
"Meconium aspiration syndrome has a complex pathophysiology."	( Harboe, M; Mollnes, TE; Nielsen, EW; Salvesen, B; Saugstad, OD, 2009)

Excerpt	Reference
"Therapeutic lung lavage is an emerging treatment for meconium aspiration syndrome (MAS), but the ideal fluid volume and lavage technique remain unclear."	( Copnell, B; Dargaville, PA; Gordon, MJ; Mills, JF; Morley, CJ; Tingay, DG, 2008)
"bolus surfactant treatment in meconium aspiration syndrome (MAS)."	( Alyamac Dizdar, E; Arayici, S; Canpolat, FE; Kadioglu Simsek, G; Oguz, SS; Sari, FN; Uras, N; Yarci, E, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	20 (3.99)	23.3326
1990's	124 (24.75)	12.5806
2000's	170 (33.93)	18.1394
2010's	129 (25.75)	28.8240
2020's	58 (11.58)	9.53

Drug	Relationship Strength	Studies	Trials
citric acid, anhydrous	low	1	0
salicylic acid	low	2	0
aminocaproic acid	low	1	0
lactic acid	low	7	0
hydrogen carbonate	low	1	0
histamine	low	6	0
nitrites	low	1	0
phosphorylcholine	low	1	0
succinic acid	low	1	0
urea	low	2	0
aspirin	low	1	0
cimetidine	low	1	0
fentanyl	low	1	0
furosemide	low	1	0
gentamicin	medium	4	1
glutaral	low	1	0
indomethacin	low	2	0
isoetharine	low	1	0
losartan	low	1	0
midazolam	low	1	0
milrinone	low	1	0
apnea	low	2	0
nifedipine	low	1	0
nitroglycerin	low	1	0
olprinone	low	2	0
pentoxifylline	low	3	0
rolipram	low	1	0
stearic acid	medium	1	1
tolazoline	low	2	0
prednisolone	low	1	0
aldosterone	low	2	0
tyrosine	medium	2	1
1,2-dipalmitoylphosphatidylcholine	low	1	0
ampicillin	medium	3	1
taurocholic acid	low	1	0
methylprednisolone	medium	5	2
penicillanic acid	medium	1	1
perfluorodecalin	low	1	0
aminophylline	low	6	0
perfluoromethylcyclohexane	low	1	0
perflubron	low	2	0
chenodeoxycholic acid	low	1	0
gentian violet	low	1	0
acetylcysteine	low	9	0
glycyrrhizic acid	low	1	0
manganese	low	1	0
gadolinium	low	1	0
helium	medium	2	2
magnesium sulfate	low	3	0
deuterium	low	1	0
phenyl acetate	low	1	0
dobutamine	low	1	0
amikacin	medium	2	1
ng-nitroarginine methyl ester	low	1	0
piperacillin	medium	1	1
captopril	low	3	0
atracurium	low	1	0
cephalosporin c	low	2	0
coproporphyrin i	medium	2	1
bosentan anhydrous	low	1	0
heliox	medium	2	2
methotrexate	low	1	0
tezosentan	low	2	0
varespladib	low	1	0
dipalmitoylphosphatidylcholine, hexadecanol, tyloxapol drug combination	low	1	0
angiotensin ii	low	2	0
atropine	low	2	0
3-nitrotyrosine	medium	2	1
oxytocin	medium	5	2
pancuronium	low	2	0
bq 123	low	2	0
cocaine	low	1	0
sodium bicarbonate	medium	2	1
bromochloroacetic acid	low	1	0
glucosylurea	low	1	0
bilirubin	low	2	0
dinoprostone	medium	2	1
thromboxane a2	low	1	0
alprostadil	low	1	0
6-ketoprostaglandin f1 alpha	low	1	0
pulmicort	medium	12	3
misoprostol	medium	3	3
thromboxane b2	low	1	0
naloxone	low	1	0
morphine	medium	237	25
iloprost	low	2	0
cefotaxime	low	1	0
saralasin	low	1	0
selenium	low	1	0
mocetinostat	low	3	0
act 058362	low	1	0
losartan potassium	low	1	0
indocyanine green	low	1	0
pituitrin	low	1	0
atrial natriuretic factor	low	2	0
angiotensinogen	low	2	0
ceftiofur	low	1	0
endothelin-1	medium	7	1
phosphatidylcholines	low	5	0
piperacillin, tazobactam drug combination	medium	1	1
interleukin-8	low	9	0
chymostatin	low	1	0
natriuretic peptide, brain	medium	1	1
heme	low	1	0
transforming growth factor beta	low	1	0
hirudin	low	1	0
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	low	1	0
refludan	low	1	0
exudates	low	2	0
cyclic gmp	low	1	0
deoxyguanosine	low	1	0
sildenafil citrate	low	8	0
8-hydroxy-2'-deoxyguanosine	low	1	0
carbadox	low	1	0
trypsinogen	medium	1	1
lucinactant	low	4	0

Protein Targets (980)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
phosphopantetheinyl transferase	11	0	0	11
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
pyruvate kinase PKM isoform a	1	0	0	1
geminin	20	0	0	20
Glycoprotein hormones alpha chain	1	0	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Tubulin--tyrosine ligase	0	2	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	6
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	6	0	0	6
dopamine D1 receptor	4	0	0	4
15-lipoxygenase, partial	5	0	0	5
pregnane X receptor	3	0	0	3
RAR-related orphan receptor gamma	18	0	0	18
USP1 protein, partial	11	0	0	11
NFKB1 protein, partial	4	0	0	4
Microtubule-associated protein tau	10	0	0	11
Thrombopoietin	4	0	0	4
AR protein	30	0	0	30
regulator of G-protein signaling 4	9	0	0	9
glucocorticoid receptor [Homo sapiens]	22	0	0	22
retinoic acid nuclear receptor alpha variant 1	17	0	0	17
retinoid X nuclear receptor alpha	13	0	0	13
farnesoid X nuclear receptor	11	0	0	11
estrogen nuclear receptor alpha	36	0	0	36
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
arylsulfatase A	10	0	0	10
Bloom syndrome protein isoform 1	9	0	0	9
D(1A) dopamine receptor	6	0	0	6
thyroid hormone receptor beta isoform a	7	0	0	7
thyroid hormone receptor beta isoform 2	12	0	0	12
heat shock protein beta-1	5	0	0	5
flap endonuclease 1	4	0	0	4
peripheral myelin protein 22	12	0	0	12
survival motor neuron protein isoform d	8	0	0	8
muscarinic acetylcholine receptor M1	6	0	0	6
Histone deacetylase 3	0	3	0	3
Solute carrier family 22 member 6	0	9	0	9
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	3	0	3
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
Ataxin-2	13	0	0	13
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
ATP-dependent phosphofructokinase	13	0	0	13
cytochrome P450 family 3 subfamily A polypeptide 4	24	0	0	24
cytochrome P450 2D6	13	0	0	13
Urotensin-2 receptor	0	2	0	2
Urotensin-2 receptor	0	2	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	4	4	8
Androgen receptor	0	8	0	8
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	4
TDP1 protein	20	0	0	20
peroxisome proliferator activated receptor gamma	14	0	0	14
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	20	0	24
Bile salt export pump	0	31	0	32
Cellular tumor antigen p53	20	0	0	20
Thromboxane-A synthase	0	3	0	3
Prostaglandin E2 receptor EP3 subtype	0	3	0	3
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin E2 receptor EP1 subtype	0	3	0	3
Prostacyclin receptor	0	5	3	8
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Canalicular multispecific organic anion transporter 1	0	17	0	17
Solute carrier organic anion transporter family member 2A1	0	0	0	3
Solute carrier organic anion transporter family member 2B1	0	1	0	2
Solute carrier organic anion transporter family member 3A1	0	0	0	1
histone acetyltransferase KAT2A isoform 1	7	0	0	7
lamin isoform A-delta10	20	0	0	20
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
Chain A, Ferritin light chain	3	0	0	3
Chain A, Apolipoprotein	0	0	1	1
ATAD5 protein, partial	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
EWS/FLI fusion protein	11	0	0	11
nonstructural protein 1	3	0	0	3
chromobox protein homolog 1	12	0	0	12
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Rap guanine nucleotide exchange factor 3	2	0	0	2
Plasminogen	0	2	1	3
Proton-coupled amino acid transporter 1	0	1	0	1
thioredoxin reductase	15	0	0	15
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	5	0	0	5
Chain A, Cruzipain	8	0	0	8
Beta-lactamase	0	1	0	3
acid sphingomyelinase	2	0	0	2
GLS protein	9	0	0	9
GLI family zinc finger 3	19	0	0	19
apical membrane antigen 1, AMA1	2	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	1	1	5
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
DNA polymerase beta	4	0	0	4
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	9	0	0	9
DNA polymerase kappa isoform 1	8	0	0	8
Carbonic anhydrase 1	0	10	0	14
Carbonic anhydrase 2	0	10	1	16
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	2
Solute carrier family 15 member 1	0	4	0	4
Solute carrier family 15 member 1	0	2	0	2
Spike glycoprotein	12	0	0	12
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	3
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	3
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	3
Histamine H3 receptor	0	1	0	4
Beta-lactamase class B VIM-2	0	1	1	5
Beta-lactamase VIM-1	0	0	0	3
glucocerebrosidase	5	0	0	5
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	6	4	10
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	7	1	8
Type-1 angiotensin II receptor	0	6	4	12
Type-2 angiotensin II receptor	0	5	1	6
Type-2 angiotensin II receptor	0	5	0	5
estrogen-related nuclear receptor alpha	18	0	0	18
neuropeptide S receptor isoform A	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	4	0	0	4
thyroid stimulating hormone receptor	10	0	0	10
hypothetical protein, conserved	3	0	0	3
peroxisome proliferator-activated receptor delta	11	0	0	11
Rac1 protein	0	0	1	1
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
lethal factor (plasmid)	4	0	0	4
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	4
Prostaglandin G/H synthase 2	0	2	0	3
Epidermal growth factor receptor	0	4	0	4
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	4	1	0	5
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	4
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	1	0	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	7
Adenosine receptor A1	0	3	0	5
Adenosine receptor A2a	0	5	0	7
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	7	1	8
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	6	0	0	6
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	6	2	0	8
Prostaglandin G/H synthase 2	0	4	0	4
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	8	1	9
Sigma non-opioid intracellular receptor 1	0	2	1	3
NPYLR7B	0	0	1	1
Amine oxidase [flavin-containing] A	0	0	1	1
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
pregnane X nuclear receptor	12	0	0	12
cystic fibrosis transmembrane conductance regulator	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	8	0	11
5-hydroxytryptamine receptor 4	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	1	9
Muscarinic acetylcholine receptor M4	0	4	1	8
Muscarinic acetylcholine receptor M1	0	5	1	8
Muscarinic acetylcholine receptor M3	0	4	1	7
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M5	0	4	1	7
Muscarinic acetylcholine receptor M5	0	4	1	8
Muscarinic acetylcholine receptor M2	0	4	1	8
Muscarinic acetylcholine receptor M1	0	4	1	9
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	4	1	8
Alpha-1D adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 2C	0	4	0	4
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	3	2	2	8
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
vitamin D3 receptor isoform VDRA	9	0	0	9
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Inositol monophosphatase 1	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	7	0	10
Solute carrier organic anion transporter family member 1B1	0	7	0	9
estrogen receptor 2 (ER beta)	9	0	0	9
progesterone receptor	11	0	0	11
G	13	0	0	13
activating transcription factor 6	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Bile salt export pump	0	6	0	7
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Endothelin receptor type B	0	1	0	1
Endothelin receptor type B	0	4	1	5
Endothelin-1 receptor	0	5	0	6
Endothelin-1 receptor	0	3	1	4
Endothelin receptor type B	0	0	1	1
Deoxyhypusine synthase	0	1	0	1
Sodium/bile acid cotransporter	0	3	0	4
Endothelin-1 receptor	0	3	0	3
Inositol hexakisphosphate kinase 1	13	0	0	13
cytochrome P450 2C9, partial	13	0	0	13
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Multidrug resistance-associated protein 6	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Canalicular multispecific organic anion transporter 1	0	3	0	5
Solute carrier organic anion transporter family member 1B2	0	1	0	4
thyroid stimulating hormone receptor	8	0	0	8
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
peripheral myelin protein 22 isoform 1	4	0	0	4
M-phase phosphoprotein 8	5	0	0	5
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Prothrombin	0	1	0	1
Renin	0	2	0	2
Neprilysin	0	1	0	1
Neprilysin	0	2	0	2
Leukotriene A-4 hydrolase	0	3	1	4
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	3	1	4
Angiotensin-converting enzyme	0	2	0	3
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Beta-lactamase TEM	0	1	0	1
Mu-type opioid receptor	0	7	2	9
TAR DNA-binding protein 43	4	0	0	4
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	0	1
thyrotropin-releasing hormone receptor	3	0	0	3
Histone H2A.x	5	0	0	5
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
streptokinase A precursor	0	0	1	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	2
Albumin	0	3	3	6
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	2
Kappa-type opioid receptor	0	6	1	9
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 6	0	4	0	6
Solute carrier family 22 member 7	0	1	0	4
Beta-lactamase	0	0	0	2
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	5	0	8
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 11	0	2	0	4
Solute carrier family 22 member 8	0	4	0	4
Solute carrier family 22 member 7	0	1	0	2
Luciferase	6	0	0	6
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
caspase 7, apoptosis-related cysteine protease	3	0	0	3
caspase-3	3	0	0	3
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Alpha-2A adrenergic receptor	0	3	2	5
Vitamin D3 receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	4	1	5
Alpha-2C adrenergic receptor	0	2	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Ileal sodium/bile acid cotransporter	0	2	0	3
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	2	2
Bile acid receptor	0	0	1	1
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 3A4 isoform 1	6	0	0	6
Solute carrier family 22 member 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	6	1	0	7
Solute carrier family 22 member 2	0	2	0	5
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	6	0	7
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	6	0	7
Cytochrome P450 3A4	0	6	2	8
Cytochrome P450 2D6	0	4	0	4
Cytochrome P450 2C9	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	6	1	0	7
Gamma-aminobutyric acid receptor subunit delta	6	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	6	1	0	7
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	6	1	0	7
Histamine H2 receptor	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-4	6	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	6	1	0	7
Histamine H1 receptor	0	1	4	5
Potassium-transporting ATPase subunit beta	0	1	0	1
Cytochrome P450 2J2	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-3	6	1	0	7
Gamma-aminobutyric acid receptor subunit beta-2	6	1	0	7
Aldehyde oxidase	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
Multidrug and toxin extrusion protein 2	0	1	0	1
GABA theta subunit	6	1	0	7
Multidrug and toxin extrusion protein 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	6	1	0	7
Histamine H4 receptor	0	2	2	4
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 4	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	4
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2B adrenergic receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2A adrenergic receptor	0	3	1	4
Liver carboxylesterase 1	0	0	0	2
Sodium-dependent noradrenaline transporter	0	5	0	5
Sodium-dependent dopamine transporter	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	6	1	8
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent serotonin transporter	0	7	0	8
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	3
Glutamate receptor ionotropic, NMDA 2B	0	1	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	3
Sodium-dependent dopamine transporter	0	6	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	6	1	7
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	6	1	8
Potassium voltage-gated channel subfamily H member 2	0	8	0	8
Leukotriene B4 receptor 1	1	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	3
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	1	1	0	3
Glutamate receptor ionotropic, NMDA 3A	0	1	0	3
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	3	0	3
Phosphodiesterase	0	2	0	2
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	7	0	8
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	8	0	9
67.9K protein	5	0	0	5
Thymidine kinase, cytosolic	0	1	0	2
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
mitogen-activated protein kinase 1	4	0	0	4
Prostaglandin E2 receptor EP1 subtype	0	2	2	4
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	3	1	4
Prostaglandin E2 receptor EP2 subtype	0	2	2	4
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
glp-1 receptor, partial	6	0	0	6
Fumarate hydratase	2	0	0	2
GALC protein	3	0	0	3
polyprotein	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
mu-type opioid receptor isoform MOR-1	0	0	2	2
huntingtin isoform 2	2	0	0	2
5-hydroxytryptamine receptor 2A	0	0	2	2
Carbonic anhydrase 12	0	3	0	7
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	2	0	2
Carbonic anhydrase 3	0	3	0	6
Beta-2 adrenergic receptor	0	2	1	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
POU domain, class 2, transcription factor 1	0	0	0	1
Carbonic anhydrase 4	0	6	0	10
Carbonic anhydrase 6	0	3	0	7
Carbonic anhydrase 5A, mitochondrial	0	4	0	8
D(3) dopamine receptor	0	5	0	5
Carbonic anhydrase 7	0	3	0	7
Carbonic anhydrase 9	0	4	0	8
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 15	0	4	0	6
Carbonic anhydrase 14	0	3	0	7
Carbonic anhydrase 5B, mitochondrial	0	4	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
D(2) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	7	1	10
Delta-type opioid receptor	0	8	3	12
Mu-type opioid receptor	0	8	4	15
Kappa-type opioid receptor	0	5	3	9
Histamine H1 receptor	0	3	2	5
Mu-type opioid receptor	0	9	4	15
Delta-type opioid receptor	0	7	2	11
Kappa-type opioid receptor	0	9	3	14
Mu-type opioid receptor	0	5	1	9
Sigma non-opioid intracellular receptor 1	0	3	0	3
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	1	3
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	1	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Carbonic anhydrase 13	0	2	0	5
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
alpha synuclein, partial	1	0	0	1
luciferase	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
cellular tumor antigen p53 isoform a	4	0	0	4
tumor necrosis factor	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
histone deacetylase 9 isoform 3	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	4	0	4
Alpha-1B adrenergic receptor	0	6	1	7
Glutamate receptor 2	6	0	0	6
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	3	0	3
Glutamate receptor ionotropic, kainate 1	1	0	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Adenosine receptor A2a	0	3	0	3
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Alpha-1A adrenergic receptor	0	6	1	7
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Fatty-acid amide hydrolase 1	1	0	0	1
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
ATPase family AAA domain-containing protein 5	9	0	0	9
Glycogen phosphorylase, muscle form	0	2	0	2
Asialoglycoprotein receptor 1	0	1	1	2
Pancreatic alpha-amylase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
High mobility group protein B1	0	0	3	3
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	5
High mobility group protein B1	0	0	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 2	0	1	1	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	2
Macrophage migration inhibitory factor	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	2
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase	0	3	0	5
Carbonic anhydrase	0	0	0	3
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carboxylic ester hydrolase	0	0	0	1
Histamine H3 receptor	0	1	2	3
Prostacyclin receptor	0	1	1	2
Prostaglandin D2 receptor	0	0	1	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	2	0	0	2
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C9 precursor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	3	0	3
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	2	0	2
Procathepsin L	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	2	0	4
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
beta-2 adrenergic receptor	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Thromboxane A2 receptor	0	1	0	2
Type-1 angiotensin II receptor	0	1	1	2
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	4	0	4
Platelet glycoprotein VI	0	1	1	3
Type-1 angiotensin II receptor	0	2	1	3
Smad3	2	0	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Kappa-type opioid receptor	0	4	1	7
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
snurportin-1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	2	3
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	2	0	4
Protein-arginine deiminase type-4	0	1	0	1
PPM1D protein	2	0	0	2
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Translocator protein	0	1	1	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Vpr	2	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	4	0	4
Aurora kinase A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	3	0	3
Dual specificity protein kinase TTK	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	3	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	3	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	4	0	5
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Aurora kinase B	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	3	0	3
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Adenosine receptor A1	0	3	0	3
UDP-glucuronosyltransferase 1A8	0	0	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Collagenase 3	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Potassium channel subfamily K member 2	0	0	1	1
Glutathione reductase, mitochondrial	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	4
Sodium channel protein type 5 subunit alpha	0	1	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
endonuclease IV	1	0	0	1
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Tumor necrosis factor	0	2	0	2
Cholinesterase	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	3	0	3
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	0	3
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
Retina-specific copper amine oxidase	0	1	0	1
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	4
Adenosine receptor A2b	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Phosphodiesterase	0	1	0	1
Protein cereblon	0	2	0	2
Phosphodiesterase	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	3
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Fatty acid-binding protein, adipocyte	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Lysine-specific demethylase 4E	0	1	0	1
Delta-aminolevulinic acid dehydratase	0	1	0	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Solute carrier family 13 member 3	0	1	0	1
Egl nine homolog 1	0	1	1	2
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Sodium/bile acid cotransporter	0	0	0	1
Sodium/bile acid cotransporter	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Alpha-1D adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 1B	0	1	0	1
Trace amine-associated receptor 1	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Group 10 secretory phospholipase A2	0	1	0	2
85/88 kDa calcium-independent phospholipase A2	0	1	0	2
Phospholipase A2	0	1	0	2
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2 group V	0	1	0	2
Phospholipase A2 group V	0	1	0	1
Putative inactive group IIC secretory phospholipase A2	0	1	0	2
Group XIIB secretory phospholipase A2-like protein	0	1	0	2
Group XIIA secretory phospholipase A2	0	1	0	2
Group IIF secretory phospholipase A2	0	1	0	2
Group 3 secretory phospholipase A2	0	1	0	2
Group IIE secretory phospholipase A2	0	1	0	2
Group IIE secretory phospholipase A2	0	1	0	1
Group 10 secretory phospholipase A2	0	1	0	1
Group IIF secretory phospholipase A2	0	1	0	1
Group IID secretory phospholipase A2	0	1	0	2
Group IID secretory phospholipase A2	0	1	0	1
Phospholipase A2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Meconium Aspiration Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (501)

Protein Targets (980)

Meconium Aspiration Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (501)

Drugs Studied (142)

Protein Targets (980)