Compounds > bu-e 75
Page last updated: 2024-11-10

bu-e 75

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

BU-E 75: structure given in first source; histamine H2 agonist; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3081063
CHEMBL ID60519
SCHEMBL ID7293538
MeSH IDM0189318

Synonyms (15)

Synonym
guanidine, n-(3-(3,4-difluorophenyl)-3-(2-pyridinyl)propyl)-n'-(3-(1h-imidazol-4-yl)propyl)-
bu-e 75
114667-74-2
bu-e-75
n(1)-(3-(3,4-difluorophenyl)-3-pyridine-2-ylpropyl)-n(2)-(3-(1h-imidazol-4-yl)propyl)guanidine
CHEMBL60519 ,
bua 75
1-[3-(3,4-difluorophenyl)-3-pyridin-2-ylpropyl]-2-[3-(1h-imidazol-5-yl)propyl]guanidine
bdbm50406056
SCHEMBL7293538
AKOS030602611
DTXSID30921451
n-[3-(3,4-difluorophenyl)-3-(pyridin-2-yl)propyl]-n'-[3-(1h-imidazol-5-yl)propyl]guanidine
1-(3-(1h-imidazol-5-yl)propyl)-3-(3-(3,4-difluorophenyl)-3-(pyridin-2-yl)propyl)guanidine
guanidine, n-[3-(3,4-difluorophenyl)-3-(2-pyridinyl)propyl]-n'-[3-(1h-imidazol-5-yl)propyl]-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID76023Increase in heart rate with maximal inotropic response in isolated perfused guinea pig heart1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
AID80503Intrinsic activity at H2 receptor in electrically stimulated guinea pig papillary muscle1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
AID80507H2 receptor agonist activity relative to histamine on isolated right atrium of guinea pig1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
AID80506Agonist activity at H2 receptor relative to histamine on electrically stimulated papillary muscle of guinea pig1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
AID78248Increase in coronary flow with maximal inotropic response in isolated perfused guinea pig heart1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
AID77503Relative potency with impromidine (100%) in isolated perfused guinea pig heart1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
AID80505Potency at H2 receptor compared to histamine from mean pD2 value in right atrium of guinea pig1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
AID80502H2 receptor agonistic activity in isolated right atrium of guinea pig compared to histamine1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
AID78247Chronotropic effect assessed from maximal increase in delta LV (dp/dtmax) in isolated perfused guinea pig heart1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
AID86892Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.05 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histamine
[no description available]		1.9810aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
cimetidine
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.. cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.		2.420aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
dimaprit
Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.		1.9810imidothiocarbamic ester
impromidine
Impromidine: A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.		2.8940
tiotidine
tiotidine: UD gives slightly different structure for this cpd; RN given refers to parent cpd; structure in first source		2.420thiazoles
arpromidine
arpromidine: structure given in first source		2.8940
thiourea
Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.		1.9810one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
pituitrin
Pituitrin: A substance or extract from the neurohypophysis (PITUITARY GLAND, POSTERIOR).		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Diffuse Large B-Cell Lymphoma
[description not available]		01.9910
Lymphoma, Large B-Cell, Diffuse
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.		01.9910
Cardiac Failure
[description not available]		01.9710
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.		01.9710