Page last updated: 2024-10-06

Histidine degradation ( Histidine degradation )

Proteins (23)

ProteinSynonymsTaxonomy
4-trimethylaminobutyraldehyde dehydrogenaseTMABA-DH; TMABALDH; EC 1.2.1.47; Aldehyde dehydrogenase E3 isozyme; Aldehyde dehydrogenase family 9 member A1; 1.2.1.3; Gamma-aminobutyraldehyde dehydrogenase; 1.2.1.19; R-aminobutyraldehyde dehydrogenaseHomo sapiens (human)
Aldehyde dehydrogenase family 3 member A2EC 1.2.1.3; EC 1.2.1.94; Aldehyde dehydrogenase 10; Fatty aldehyde dehydrogenase; Microsomal aldehyde dehydrogenaseHomo sapiens (human)
Amine oxidase [flavin-containing] AEC 1.4.3.4; Monoamine oxidase type A; MAO-AHomo sapiens (human)
Amine oxidase [flavin-containing] BEC 1.4.3.4; Monoamine oxidase type B; MAO-BHomo sapiens (human)
Retinal dehydrogenase 1RALDH 1; RalDH1; EC 1.2.1.-; EC 1.2.1.36; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolicHomo sapiens (human)
Aldehyde dehydrogenase, mitochondrialEC 1.2.1.3; ALDH class 2; ALDH-E2; ALDHIHomo sapiens (human)
Formimidoyltransferase-cyclodeaminaseFormiminotransferase-cyclodeaminase; FTCD; LCHC1Homo sapiens (human)
Histamine N-methyltransferaseHMT; EC 2.1.1.8Homo sapiens (human)
Histidine decarboxylaseHDC; EC 4.1.1.22Homo sapiens (human)
Retina-specific copper amine oxidaseRAO; EC 1.4.3.21; Amine oxidase [copper-containing]; Semicarbazide-sensitive amine oxidase; SSAOHomo sapiens (human)
Membrane primary amine oxidaseEC 1.4.3.21; Copper amine oxidase; HPAO; Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1Homo sapiens (human)
Histidine--tRNA ligase, cytoplasmicEC 6.1.1.21; Histidyl-tRNA synthetase; HisRSHomo sapiens (human)
Histidine ammonia-lyaseHistidase; EC 4.3.1.3Homo sapiens (human)
Retinal dehydrogenase 2RALDH 2; RalDH2; EC 1.2.1.36; Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II)Homo sapiens (human)
Amiloride-sensitive amine oxidase [copper-containing]DAO; Diamine oxidase; EC 1.4.3.22; Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase; KAOHomo sapiens (human)
Aldehyde dehydrogenase X, mitochondrialEC 1.2.1.3; Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1Homo sapiens (human)
Aldehyde dehydrogenase, dimeric NADP-preferring EC 1.2.1.5; ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1Homo sapiens (human)
Aldehyde dehydrogenase family 1 member A3EC 1.2.1.36; Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3Homo sapiens (human)
Aldehyde dehydrogenase family 3 member B2EC 1.2.1.3; Aldehyde dehydrogenase 8Homo sapiens (human)
Beta-Ala-His dipeptidaseEC 3.4.13.20; CNDP dipeptidase 1; Carnosine dipeptidase 1; Glutamate carboxypeptidase-like protein 2; Serum carnosinaseHomo sapiens (human)
Aldehyde dehydrogenase family 3 member B1EC 1.2.1.28; EC 1.2.1.5; EC 1.2.1.7; Aldehyde dehydrogenase 7Homo sapiens (human)
Alpha-aminoadipic semialdehyde dehydrogenaseAlpha-AASA dehydrogenase; EC 1.2.1.31; Aldehyde dehydrogenase family 7 member A1; 1.2.1.3; Antiquitin-1; Betaine aldehyde dehydrogenase; 1.2.1.8; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenaseHomo sapiens (human)
Histidine--tRNA ligase, mitochondrialEC 6.1.1.21; Histidine--tRNA ligase-like; Histidyl-tRNA synthetase; HisRSHomo sapiens (human)

Compounds (25)

CompoundDescription
diphosphoric acid
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
histamineAn amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
5,6,7,8-tetrahydrofolic acidRN given refers to (DL)-isomer
1-methylimidazol-3-ylacetaldehyde
beta-alanineAn amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.
tele-methylhistaminehistamine methyltransferase antagonist
formiminoglutamic acidMeasurement of this acid in the urine after oral administration of histidine provides the basis for the diagnostic test of folic acid deficiency and of megaloblastic anemia of pregnancy.
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
histidineAn essential amino acid that is required for the production of HISTAMINE.
urocanic acid4-Imidazoleacrylic acid.
1H-imidazole-4-acetaldehyde
s-adenosylhomocysteine5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
carnosineA naturally occurring dipeptide neuropeptide found in muscles.
methylimidazoleacetic acidurinary metabolite of histamine & end product of histamine metabolism; RN given refers to parent cpd
imidazoleacetic acidRN given refers to cpd without specific location of acetic acid attachment identified; structure