Page last updated: 2024-12-07

bl 5255

Description

BL 5255: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Synonym
bl-5255
bl 5255
CHEMBL14922
u6sf3u21bi ,
unii-u6sf3u21bi
2-(2-n-propoxyphenyl)-5-(5-1h-tetrazolyl)pyrimidin-4(3h)-one
4(1h)-pyrimidinone, 2-(2-propoxyphenyl)-5-(1h-tetrazol-5-yl)-
64634-09-9
NHBDYNVEEOSTIH-UHFFFAOYSA-N
2-(2-n-propoxyphenyl)-5-(5-1h-tetrazolyl) pyrimidin-4(3h)-one
SCHEMBL11625177
5-(1,2-dihydro-5h-tetrazol-5-ylidene)-2-(2-propoxyphenyl)pyrimidin-4(5h)-one
DTXSID70983235
4(3h)-pyrimidinone, 2-(2-propoxyphenyl)-5-(2h-tetrazol-5-yl)-

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID179618	Antiallergic activity in the passive cutaneous anaphylaxis (PCA) model in the rat was determined after iv administration	1982	Journal of medicinal chemistry, Oct, Volume: 25, Issue:10	Antiallergy agents. 2. 2-Phenyl-5-(1H-tetrazol-5-yl)pyrimidin-4(3H)-ones.
AID179619	Antiallergic activity in the passive cutaneous anaphylaxis (PCA) model in the rat was determined after oral administration	1982	Journal of medicinal chemistry, Oct, Volume: 25, Issue:10	Antiallergy agents. 2. 2-Phenyl-5-(1H-tetrazol-5-yl)pyrimidin-4(3H)-ones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
histamine [no description available]	1.96	1	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
cromolyn sodium Cromolyn Sodium: A chromone complex that acts by inhibiting the release of chemical mediators from sensitized MAST CELLS. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.. disodium cromoglycate : An organic sodium salt that is the disodium salt of cromoglycic acid.	2.36	2	organic sodium salt	anti-asthmatic drug; drug allergen
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	1.96	1
pyrimidinones Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.	2.87	4

Condition	Relationship Strength	Studies
Allergic Reaction [description not available]	2.36	2
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	2.36	2
Anaphylactic Reaction [description not available]	1.96	1
Atopic Hypersensitivity [description not available]	2.65	3
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	1.96	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.36	2
Airway Obstruction Any hindrance to the passage of air into and out of the lungs.	2.36	2